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[PMID]:27775692
[Au] Autor:Aeffner F; Martin NT; Peljto M; Black JC; Major JK; Jangani M; Ports MO; Krueger JS; Young GD
[Ad] Endereço:Flagship Biosciences Inc., Westminster, CO, USA.
[Ti] Título:Quantitative assessment of pancreatic cancer precursor lesions in IHC-stained tissue with a tissue image analysis platform.
[So] Source:Lab Invest;96(12):1327-1336, 2016 12.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tissue image analysis (tIA) is emerging as a powerful tool for quantifying biomarker expression and distribution in complex diseases and tissues. Pancreatic ductal adenocarcinoma (PDAC) develops in a highly complex and heterogeneous tissue environment and, generally, has a very poor prognosis. Early detection of PDAC is confounded by limited knowledge of the pre-neoplastic disease stages and limited methods to quantitatively assess disease heterogeneity. We sought to develop a tIA approach to assess the most common PDAC precursor lesions, pancreatic intraepithelial neoplasia (PanIN), in tissues from Kras ; Trp53 ; Pdx-Cre (KPC) mice, a validated model of PDAC development. tIA profiling of training regions of PanIN and tumor microenvironment (TME) cells was utilized to guide identification of PanIN/TME tissue compartment stratification criteria. A custom CellMap algorithm implementing these criteria was applied to whole-slide images of KPC mice pancreata sections to quantify p53 and Ki-67 biomarker staining in each tissue compartment as a proof-of-concept for the algorithm platform. The algorithm robustly identified a higher percentage of p53-positive cells in PanIN lesions relative to the TME, whereas no difference was observed for Ki-67. Ki-67 expression was also quantified in a human pancreatic tissue sample available to demonstrate the translatability of the CellMap algorithm to human samples. Together, our data demonstrated the utility of CellMap to enable objective and quantitative assessments, across entire tissue sections, of PDAC precursor lesions in preclinical and clinical models of this disease to support efforts leading to novel insights into disease progression, diagnostic markers, and potential therapeutic targets.
[Mh] Termos MeSH primário: Adenocarcinoma in Situ/diagnóstico
Carcinoma Ductal Pancreático/diagnóstico
Pâncreas/patologia
Neoplasias Pancreáticas/diagnóstico
Lesões Pré-Cancerosas/diagnóstico
Proteína Supressora de Tumor p53/metabolismo
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/diagnóstico por imagem
Adenocarcinoma in Situ/metabolismo
Adenocarcinoma in Situ/patologia
Algoritmos
Animais
Automação Laboratorial
Carcinoma Ductal Pancreático/diagnóstico por imagem
Carcinoma Ductal Pancreático/metabolismo
Carcinoma Ductal Pancreático/patologia
Cruzamentos Genéticos
Modelos Animais de Doenças
Detecção Precoce de Câncer/métodos
Seres Humanos
Processamento de Imagem Assistida por Computador
Imuno-Histoquímica
Antígeno Ki-67/metabolismo
Camundongos Mutantes
Camundongos Transgênicos
Pâncreas/metabolismo
Neoplasias Pancreáticas/diagnóstico por imagem
Neoplasias Pancreáticas/metabolismo
Neoplasias Pancreáticas/patologia
Lesões Pré-Cancerosas/diagnóstico por imagem
Lesões Pré-Cancerosas/metabolismo
Lesões Pré-Cancerosas/patologia
Software
Organismos Livres de Patógenos Específicos
Bancos de Tecidos
Ultrassonografia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ki-67 Antigen); 0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2016.111


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[PMID]:27771840
[Au] Autor:Madubata CC; Liu Y; Goodman MS; Yun S; Yu J; Lian M; Colditz GA
[Ad] Endereço:Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8100, St. Louis, MO, 63110, USA.
[Ti] Título:Comparing treatment and outcomes of ductal carcinoma in situ among women in Missouri by race.
[So] Source:Breast Cancer Res Treat;160(3):563-572, 2016 12.
[Is] ISSN:1573-7217
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate whether treatment (surgery, radiation therapy, and endocrine therapy) contributes to racial disparities in outcomes of ductal carcinoma in situ (DCIS). PATIENTS AND METHODS: The analysis included 8184 non-Hispanic White and 954 non-Hispanic Black women diagnosed with DCIS between 1996 and 2011 and identified in the Missouri Cancer Registry. Logistic regression models were used to estimate odds ratios (ORs) of treatment for race. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) of ipsilateral breast tumor (IBT) and contralateral breast tumor (CBT) for race. RESULTS: There was no significant difference between Black and White women in utilization of mastectomy (OR 1.16; 95 % CI 0.99-1.35) or endocrine therapy (OR 1.19; 95 % CI 0.94-1.51). Despite no significant difference in underutilization of radiation therapy (OR 1.14; 95 % CI 0.92-1.42), Black women had higher odds of radiation delay, defined as at least 8 weeks between surgery and radiation (OR 1.92; 95 % CI 1.55-2.37). Among 9138 patients, 184 had IBTs and 326 had CBTs. Black women had a higher risk of IBTs (HR 1.69; 95 % CI 1.15-2.50) and a comparable risk of CBTs (HR 1.19; 95 % CI 0.84-1.68), which were independent of pathological features and treatment. CONCLUSION: Racial differences in DCIS treatment and outcomes exist in Missouri. This study could not completely explain the higher risk of IBTs in Black women. Future studies should identify differences in timely initiation and completion of treatment, which may contribute to the racial difference in IBTs after DCIS.
[Mh] Termos MeSH primário: Adenocarcinoma in Situ/mortalidade
Adenocarcinoma in Situ/terapia
Neoplasias da Mama/mortalidade
Neoplasias da Mama/terapia
Carcinoma Ductal de Mama/mortalidade
Carcinoma Ductal de Mama/terapia
Grupos Étnicos
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/diagnóstico
Adenocarcinoma in Situ/epidemiologia
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais
Neoplasias da Mama/diagnóstico
Neoplasias da Mama/epidemiologia
Carcinoma Ductal de Mama/diagnóstico
Carcinoma Ductal de Mama/epidemiologia
Terapia Combinada
Feminino
Seguimentos
Disparidades em Assistência à Saúde
Seres Humanos
Meia-Idade
Missouri/epidemiologia
Missouri/etnologia
Gradação de Tumores
Estadiamento de Neoplasias
Modelos de Riscos Proporcionais
Sistema de Registros
Programa de SEER
Resultado do Tratamento
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171209
[Lr] Data última revisão:
171209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE
[do] DOI:10.1007/s10549-016-4030-6


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[PMID]:29068976
[Au] Autor:Gao F; Li M; Sun Y; Xiao L; Hua Y
[Ad] Endereço:aDepartment of Radiology bDiagnostic and Treatment Center of Lung Small Nodules cDepartment of Pathology, Huadong Hospital affiliated with Fudan University, Shanghai, China.
[Ti] Título:Diagnostic value of contrast-enhanced CT scans in identifying lung adenocarcinomas manifesting as GGNs (ground glass nodules).
[So] Source:Medicine (Baltimore);96(43):e7742, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to explore the value of contrast-enhanced computed tomography (CT) scans in the differential diagnosis of atypical adenomatous hyperplasia, adenocarcinoma in situ, minimal invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC), which manifested as ground glass nodules (GGNs) or mixed GGNs.Unenhanced and contrast-enhanced presurgical CT images of 136 cases of GGNs were compared. The nodules were diagnosed based on their solid portions and maximum dimensions, and the findings obtained using both contrast-enhanced and unenhanced CT images were analyzed in corroboration with the pathological diagnosis.Most (53/56) preinvasive nodules showed increased mean CT values after contrast administration. In the MIA group, after contrast administration, enlargements of the solid portions were seen in 48 nodules (48/60), and the elevation of the mean CT value was observed in 12 nodules (12/60). The vast majority of IAC nodules (29/30) showed enlargement of the solid portions after contrast administration. Moreover, for group differences, findings obtained using this approach statistically match the pathological findings.Contrast-enhanced CT scans are more useful than unenhanced CT scans for the diagnosis of GGNs, especially for pure GGNs, before surgery.
[Mh] Termos MeSH primário: Adenocarcinoma/diagnóstico por imagem
Adenocarcinoma/patologia
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/patologia
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/diagnóstico por imagem
Adenocarcinoma in Situ/patologia
Meios de Contraste
Diagnóstico Diferencial
Seres Humanos
Hiperplasia/diagnóstico por imagem
Hiperplasia/patologia
Pulmão/diagnóstico por imagem
Pulmão/patologia
Invasividade Neoplásica
Intensificação de Imagem Radiográfica
Estudos Retrospectivos
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007742


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[PMID]:28953685
[Au] Autor:Cao Y; Li J; Shen L; Wang J; Xia Z; Tao K; Wang G; Cai K
[Ad] Endereço:Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:Gastric cancer in a situs inversus totalis patient with multiple intestinal and vessel variations related to gastrectomy surgery: A case report and literature review.
[So] Source:Medicine (Baltimore);96(39):e8209, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Situs inversus totalis (SIT) is a rare congenital anomaly characterized by complete inversion of the abdominal and thoracic organs, and often involves multiple genetic mutations. The most suitable surgical technique for patients with multiple vessel and organ variations as well as SIT remains unclear. Furthermore, there has been insufficient clinical evidence that demonstrates which surgical techniques achieve the best outcomes. Finally, the standard of care has not yet been determined. We present the case of a 60-year-old man with SIT, who was diagnosed with moderately and poorly differentiated adenocarcinoma at the gastroesophageal junction. We further describe the advantage of using robotic-assisted laparoscopic surgery in patients with this anomaly. PATIENT CONCERNS: A 60-year-old man complained of pain in his upper abdomen for 3 months. Physical examination revealed an apex beat in the right fifth intercostal space, and vascular anomalies were noted on abdominal angiographic computed tomography. DIAGNOSES: Moderately and poorly differentiated adenocarcinoma at the gastroesophageal junction with SIT. INTERVENTIONS: Robot-assisted total gastrectomy with D2 lymph node dissection and hand-sewn Roux-en-Y anastomosis was performed. OUTCOMES: The postoperative course was uneventful, and the patient was discharged on the seventh postoperative day. LESSONS: Robotic surgery for gastric cancer is a safe and feasible alternative to laparoscopic surgery and it can be successfully used to treat gastric cancer in patients with SIT with multiple anatomic variations. As exemplified by our case, SIT might be accompanied by multiple anatomic variations. Detailed preoperative detailed imaging of the blood vessels and gastrointestinal tract is useful in these patients.
[Mh] Termos MeSH primário: Adenocarcinoma in Situ
Junção Esofagogástrica/patologia
Gastrectomia/métodos
Cuidados Pré-Operatórios/métodos
Situs Inversus
Neoplasias Gástricas
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/patologia
Adenocarcinoma in Situ/fisiopatologia
Adenocarcinoma in Situ/cirurgia
Angiografia por Tomografia Computadorizada/métodos
Anormalidades do Sistema Digestório/diagnóstico
Seres Humanos
Laparoscopia/métodos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Robóticos/métodos
Situs Inversus/diagnóstico
Situs Inversus/fisiopatologia
Neoplasias Gástricas/patologia
Neoplasias Gástricas/fisiopatologia
Neoplasias Gástricas/cirurgia
Resultado do Tratamento
Malformações Vasculares/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008209


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[PMID]:28574670
[Au] Autor:Ge Y; Christensen P; Luna E; Armylagos D; Schwartz MR; Mody DR
[Ad] Endereço:Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
[Ti] Título:Performance of Aptima and Cobas HPV testing platforms in detecting high-grade cervical dysplasia and cancer.
[So] Source:Cancer;125(8):652-657, 2017 Aug.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS: Between January 1 and December 31, 2015, 2041 Papanicolaou (Pap) tests with biopsy confirmation were analyzed along with HPV tests performed on Cobas or Aptima platforms. A biopsy diagnosis of grade 2 cervical intraepithelial neoplasia was confirmed with p16/Ki-67 immunohistochemistry. RESULTS: In total, 1866 and 175 Pap cases were tested on Cobas and Aptima platforms, respectively. Both platforms were highly sensitive (97% for both) for biopsy-confirmed ≥HSIL. Cobas HPV testing had higher positive rates for the diagnosis of benign lesions (84% vs 51%) and low-grade squamous intraepithelial lesions (89% vs 63%) on biopsy compared with Aptima. Aptima testing had significantly higher specificity for ≥HSIL than Cobas (41% vs 13%; P < .0001). Overall, performance of the Aptima platform was superior to that of the Cobas platform in detecting biopsy-confirmed ≥HSIL, resulting from its significantly higher positive predictive value (25% vs 16%; P < .03) and overall accuracy (50% vs 26%; P < .0001). CONCLUSIONS: Although both the Cobas and Aptima platforms offer highly sensitive tests for high-grade cervical lesions, Aptima HPV testing demonstrated significantly higher specificity and positive predictive value than Cobas testing for biopsy-confirmed ≥HSIL. The considerable difference may be related to the significant increase in E6/E7 expression after HPV DNA integration. The significantly higher specificity and overall accuracy of Aptima testing for ≥HSIL, resulting in the identification of high-risk populations that require immediate treatment and close follow-up, may prove useful in clinical risk stratification. Cancer Cytopathol 2017;125:652-7. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Adenocarcinoma in Situ/diagnóstico
Adenocarcinoma/diagnóstico
Carcinoma de Células Escamosas/diagnóstico
Neoplasia Intraepitelial Cervical/diagnóstico
Testes de DNA para Papilomavírus Humano/instrumentação
Infecções por Papillomavirus/diagnóstico
Lesões Intraepiteliais Escamosas Cervicais/diagnóstico
Neoplasias do Colo do Útero/diagnóstico
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adenocarcinoma in Situ/patologia
Carcinoma de Células Escamosas/patologia
Neoplasia Intraepitelial Cervical/patologia
Bases de Dados Factuais
Feminino
Testes de DNA para Papilomavírus Humano/métodos
Seres Humanos
Gradação de Tumores
Teste de Papanicolaou
Estudos Retrospectivos
Sensibilidade e Especificidade
Lesões Intraepiteliais Escamosas Cervicais/patologia
Neoplasias do Colo do Útero/patologia
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21875


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[PMID]:28394803
[Au] Autor:Talia KL; Stewart CJR; Howitt BE; Nucci MR; McCluggage WG
[Ad] Endereço:*Department of Pathology, Box Hill Hospital, Melbourne, Vic. †Department of Histopathology, King Edward Memorial Hospital, Perth, WA, Australia ‡Department of Pathology, Brigham and Women's Hospital, Boston, MA §Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.
[Ti] Título:HPV-negative Gastric Type Adenocarcinoma In Situ of the Cervix: A Spectrum of Rare Lesions Exhibiting Gastric and Intestinal Differentiation.
[So] Source:Am J Surg Pathol;41(8):1023-1033, 2017 Aug.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years, a number of benign and malignant cervical glandular lesions exhibiting gastric differentiation have been described but premalignant gastric-type lesions have not been well characterized. We report a series of 9 cases of a rare form of cervical adenocarcinoma in situ (AIS) distinguished by gastric and sometimes intestinal differentiation and lack of association with human papillomavirus (HPV) infection. The lesions occurred in women aged 25 to 73 years (mean age 51 y). All cases were located at (or just proximal to) the cervical transformation zone and there was extension to the lower uterine segment in 3 cases, 2 of which also involved the endometrium. In all cases, the normal cervical glandular architecture was largely preserved but in 5 cases there was a mild degree of increased intraglandular architectural complexity. The glandular epithelium ranged from almost purely gastric in type (4 cases) to mixed gastric and intestinal (5 cases), with varying proportions of intermixed goblet cells. In contrast to the basophilic cytoplasm of normal endocervical glands, the gastric-type epithelium was typically predominantly composed of cells with eosinophilic or pale pink cytoplasm, but conspicuous foamy or clear cell cytoplasm was present in some cases. Nuclear atypia was present in all cases but was considered low-grade in 8. High-grade features such as marked nuclear pleomorphism and hyperchromasia were evident in only 1 case. Mitotic activity and apoptotic bodies were present but both were noted to be less frequent than in usual type (HPV-related) AIS. Immunohistochemically, there was usually positive staining with CK 7 (7/7 cases) and MUC 6 (7/8 cases) and some cases were positive with CK 20 (3/7), CDX2 (5/9), PAX 8 (5/9) and CEA (2/6). Estrogen receptor and progesterone receptor were usually negative, although Estrogen receptor was positive in 3 of 9 cases. p16 was negative or exhibited mosaic-type staining (nonblock staining) in all cases and there was mutation-type p53 staining in 2 of 9 cases. HPV molecular testing was negative in all 4 cases tested. We believe this unusual subtype of AIS, which we term "gastric-type AIS (gAIS)," represents a precursor to gastric-type adenocarcinoma of the cervix and suggest that gAIS and so-called "atypical lobular endocervical glandular hyperplasia" are related entities within a spectrum of premalignant gastric-type lesions for which we propose the umbrella term gAIS. The malignant potential and optimal management of gAIS are currently unknown but in one of our cases a gastric-type adenocarcinoma developed 6 years after removal of a cervical polyp which contained gAIS. The introduction of HPV vaccination will result in a relative increase in incidence of premalignant and malignant cervical glandular lesions exhibiting gastric differentiation and these will not be detected by HPV-based screening programs.
[Mh] Termos MeSH primário: Adenocarcinoma in Situ/patologia
Lesões Pré-Cancerosas/patologia
Neoplasias do Colo do Útero/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/classificação
Adulto
Idoso
Diferenciação Celular
Feminino
Seres Humanos
Intestinos/patologia
Meia-Idade
Papillomaviridae
Estômago/patologia
Neoplasias do Colo do Útero/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000855


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[PMID]:28301226
[Au] Autor:Zhao C; Crothers BA; Tabatabai ZL; Li Z; Ghofrani M; Souers RJ; Husain M; Fan F; Shen R; Ocal IT; Booth CN; Goodrich K; Russell D; Davey DD; College of American Pathologists Cytopathology Committee
[Ti] Título:False-Negative Interpretation of Adenocarcinoma In Situ in the College of American Pathologists Gynecologic PAP Education Program.
[So] Source:Arch Pathol Lab Med;141(5):666-670, 2017 May.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Adenocarcinoma in situ (AIS) is difficult to correctly interpret on Papanicolaou (Pap) cytology slides and false-negative interpretations of AIS can cause significant problems in daily practice. OBJECTIVE: - To investigate the false-negative interpretation rate of AIS and the factors related to false-negative interpretation through responses in an educational environment. DESIGN: - We retrospectively evaluated 11 337 responses in the PAP Education Program (PAP-Edu) from 173 AIS slides from 2011 to 2015. The false-negative interpretation rate, most common false-negative interpretations, and related other factors were evaluated. RESULTS: - The overall false-negative rate was 6.9% (784 of 11 337). Respondents correctly interpreted AIS 50.0% (5667 of 11 337) of the time; high-grade intraepithelial lesion (HSIL) and malignancies (adenocarcinoma, squamous cell carcinoma, and other carcinomas) accounted for 42.7% (4842 of 11 337) and low-grade intraepithelial lesion accounted for 0.4% (44 of 11 337) of responses. Overall, 92.7% (10 509 of 11 337) of responses were HSIL and above. Among 784 false-negative responses, negative for intraepithelial lesion or malignancy was the most common (61.5% [482 of 784]), followed by reparative changes (24.1% [189 of 784]) and atrophic vaginitis (7.7% [60 of 784]). Overall, pathologists' responses showed a significantly higher false-negative rate than cytotechnologists' responses (8.3%, 403 of 4835 versus 5.7%, 275 of 4816; P < .001). The false-negative response rates were not statistically different among preparation types. CONCLUSIONS: - The low correct interpretation rate and higher false-negative rate for AIS demonstrate the difficulty in interpreting AIS on Pap cytology, which may cause clinical consequences. The higher false-negative rate with pathologists than with cytotechnologists suggests cytotechnologists' higher screening sensitivity for AIS or cautious interpretation to avoid false-positive results by pathologists.
[Mh] Termos MeSH primário: Adenocarcinoma in Situ/patologia
Vaginite Atrófica/patologia
Carcinoma de Células Escamosas/patologia
Patologia Clínica/educação
Patologia Molecular/educação
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/diagnóstico
American Medical Association
Vaginite Atrófica/diagnóstico
Carcinoma de Células Escamosas/diagnóstico
Erros de Diagnóstico
Reações Falso-Negativas
Feminino
Seres Humanos
Teste de Papanicolaou
Estudos Retrospectivos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0234-CP


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[PMID]:28125627
[Au] Autor:Jiang Y; Chen C; Li L
[Ad] Endereço:Department of Gynecology, Liuzhou People's Hospital, Liuzhou, China.
[Ti] Título:Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis.
[So] Source:PLoS One;12(1):e0170587, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of this systematic review was to conduct a more comprehensive literature search and meta-analysis of original studies to evaluate the efficacy and safety of the loop electrosurgical excision procedure (LEEP) versus cold-knife conization (CKC) in conservative surgical treatment of cervical adenocarcinoma in situ (ACIS) for women who have not completed childbearing. METHODS: Systematic searches were conducted in the PUBMED, EMBASE, Cochrane, and China National Knowledge Infrastructure (CNKI) databases to identify all potential studies involving patients with ACIS treated with LEEP versus CKC published until December 2015. RESULTS: Eighteen retrospective studies were included in this systematic review. All the 18 included studies reported the rate of positive margins, and the results of the individual studies varied. The positive margins were 44% (267/607) after LEEP and 29% (274/952) after CKC. The pooled meta-analysis exhibited significantly different outcome (RR, 1.55; 95% CI, 1.34-1.80, P<0.00001) without significant heterogeneity (P = 0.34). The residual rate following LEEP was 9.1% (17/186) and 11% (39/350) after CKC in re-cone or hysterectomy cases. Recurrent ACIS following LEEP was reported in 10 of 142 (7.0%) cases compared to 10 of 177 (5.6%) cases following CKC. There were no significant differences in the residual rate (RR, 1.02; 95% CI, 0.60-1.72, P = 0.95) or recurrence rate (RR, 1.13; 95% CI, 0.46-2.79; P = 0.79) between the two procedures. CONCLUSIONS: The present systematic review demonstrates that both LEEP and CKC are safe and effective for the conservative treatment of ACIS. LEEP appears to be as equally effective as CKC regarding the residual and recurrence rates. Due to the findings showing that LEEP achieves comparable oncologic outcomes with fewer obstetric complications to that of CKC, LEEP may be the preferred option in patients whose fertility preservation is important. However, further prospective studies with a larger sample size and longer follow-up periods are needed to establish the superiority of either procedure.
[Mh] Termos MeSH primário: Adenocarcinoma in Situ/cirurgia
Criocirurgia
Eletrocirurgia
Neoplasias do Colo do Útero/cirurgia
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/epidemiologia
Adenocarcinoma in Situ/patologia
China
Conização
Feminino
Preservação da Fertilidade
Seres Humanos
Histerectomia
Recidiva Local de Neoplasia
Neoplasias do Colo do Útero/epidemiologia
Neoplasias do Colo do Útero/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170587


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[PMID]:28074620
[Au] Autor:Kanzawa M; Sanuki T; Onodera M; Fujikura K; Itoh T; Zen Y
[Ad] Endereço:Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
[Ti] Título:Double immunostaining for maspin and p53 on cell blocks increases the diagnostic value of biliary brushing cytology.
[So] Source:Pathol Int;67(2):91-98, 2017 Feb.
[Is] ISSN:1440-1827
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Our objective is to elucidate the usefulness of maspin/p53 double immunostaining on biliary brushing cytology specimens. We first examined the expression of maspin in the biliary epithelium with variable degrees of dysplasia using surgically resected specimens (n = 56). Maspin appeared to be overexpressed in a stepwise manner from benign to malignant cholangiocytes: the reactive epithelium (20%), biliary intraepithelial neoplasia (~50%), and invasive cholangiocarcinomas (>90%). Next, an automated sequential double immunostaining protocol for maspin and p53 was applied to paraffin-embedded cell blocks of the biliary brushing cytology specimens obtained from 58 consecutive patients. Cell block preparation was successful in 44 cases (76%), which were morphologically diagnosed as adenocarcinoma (n = 16), atypical cells not diagnostic for malignancy (n = 10), and benign (n = 18). Double positive cells were observed in 14/16 (88%) morphologically malignant, 6/10 (60%) borderline, and 0/18 benign cases. All 20 positive cases were proven to have pancreatobiliary malignancies by subsequent imaging or pathological analyses. A similar staining protocol for S100P and p53 was also applied to the same cohort; however, the positive frequency was slightly lower than those of maspin and p53 (36% vs. 45%). In conclusion, Maspin/p53 double immunostaining on cell blocks contributes to the detection of malignant cells in biliary brushing cytology specimens.
[Mh] Termos MeSH primário: Neoplasias dos Ductos Biliares/diagnóstico
Biomarcadores Tumorais/análise
Colangiocarcinoma/diagnóstico
Citodiagnóstico/métodos
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/diagnóstico
Adulto
Idoso
Feminino
Seres Humanos
Imuno-Histoquímica/métodos
Masculino
Meia-Idade
Serpinas/análise
Serpinas/biossíntese
Proteína Supressora de Tumor p53/análise
Proteína Supressora de Tumor p53/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (SERPIN-B5); 0 (Serpins); 0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1111/pin.12505


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[PMID]:28060456
[Au] Autor:Patadji S; Li Z; Pradhan D; Zhao C
[Ad] Endereço:Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
[Ti] Título:Significance of high-risk HPV detection in women with atypical glandular cells on Pap testing: Analysis of 1857 cases from an academic institution.
[So] Source:Cancer;125(3):205-211, 2017 Mar.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The role of high-risk human papillomavirus (hrHPV) testing in women with various types of atypical glandular cells (AGC) on Papanicolaou (Pap) test is undetermined. METHODS: Herein, the authors retrospectively searched their pathology database for cases of AGC with concurrent hrHPV testing and histological follow-up results within 1 year between January 2008 and December 2013. RESULTS: Among 3709 AGC cases occurring during the study period, 2287 had concurrent Hybrid Capture 2 HPV testing results. The overall rate of hrHPV positivity (hrHPV+) was 27.7%. Of these 2287 cases, 1857 cases (81.2%) had histological follow-up results within 1 year, including 529 hrHPV + cases and 1328 hrHPV-negative (hrHPV-) cases. Among the hrHPV + cases, 16.8% had cervical intraepithelial neoplasia 2/3 (CIN2/3), 5.7% had cervical adenocarcinoma in situ (AIS)/adenocarcinoma (ADC), and 1.1% had an endometrial carcinoma. Among the hrHPV- cases, 0.6% had CIN2/3, 0.2% had AIS/ADC, and 3.8% had an endometrial carcinoma. The rate of high-grade cervical lesions (CIN2/3, AIS, or ADC) was significantly higher in women who were hrHPV + compared with hrHPV- women for all age groups. Endometrial carcinoma was most commonly present in women aged ≥50 years. CONCLUSIONS: To the authors' knowledge, the current study is the largest follow-up study published to date regarding women with AGC cytology and HPV testing. The study data indicate that hrHPV testing is useful for predicting the risk of high-grade cervical neoplasia in women with AGC, but has no significant value in evaluating the risk of endometrial carcinoma. The combination of cytology, hrHPV testing, and patient age can significantly aid in the appropriate management of these individuals. Cancer Cytopathol 2017;125:205-211. © 2016 American Cancer Society.
[Mh] Termos MeSH primário: Células Epiteliais/virologia
Teste de Papanicolaou
Papillomaviridae/isolamento & purificação
[Mh] Termos MeSH secundário: Adenocarcinoma in Situ/virologia
Adulto
Neoplasias do Endométrio/virologia
Células Epiteliais/patologia
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Estudos Retrospectivos
Neoplasias do Colo do Útero/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21791



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