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[PMID]:28741159
[Au] Autor:Schmitz EJ; Herwig-Carl MC; Holz FG; Loeffler KU
[Ad] Endereço:Department of Ophthalmology, University Eye Hospital Bonn, University of Bonn, Ernst-Abbe Str. 2, 53127, Bonn, Germany. eva.schmitz@ukb.uni-bonn.de.
[Ti] Título:Sebaceous gland carcinoma of the ocular adnexa - variability in clinical and histological appearance with analysis of immunohistochemical staining patterns.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(11):2277-2285, 2017 Nov.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of the study was to evaluate the characteristics of sebaceous gland carcinoma (SGC) of the ocular adnexae, which is due to a high variability in clinical, histological and immunohistochemical characteristics often challenging to diagnose. METHODS: Records of six patients with SGC were reviewed, who underwent surgical excision and who were histologically diagnosed with SGC. For comparison, there were specimens from four patients with basal cell carcinoma (BCC) and four patients with squamous cell carcinoma (SCC). Histological and immunohistochemical analysis included stains for HE, cytokeratins (CKpan, Cam5.2), epithelial membrane antigen (EMA), androgen receptor (AR441), perforin and adipophilin. RESULTS: SGC's were located in the upper (n = 2) or lower (n = 4) eyelid and were associated with various presenting clinical signs including chalazion-like lesions with pyogenic granuloma (n = 1), papillomatous conjunctival tumors (n = 3), a hyperkeratotic exophytic neoplasm (n = 1) and an ulcerating crusted lesion resembling chronic blepharitis (n = 1). The treatment was tumor resection, followed (if necessary) by adjuvant therapy with topical Mitomycin C (n = 2). Histologic characteristics included basophilic pleomorphic cells with vacuolated cytoplasm, prominent nucleoli, mitotic figures and in some cases pagetoid spread (n = 2). CKpan, EMA and Cam5.2 showed strong positive immunoreactivity in all specimens (SGC, BCC, SCC). Perforin immunostaining showed a varying, but overall weak, non-specific cytoplasmatic staining reaction in all lesions. AR441 positivity was noted with variable intensity in almost all lesions and in particular in pagetoid spread in contrast to non-tumor cells. Adipophilin showed an annular staining of lipid granules in immature sebaceous cells in SGC in contrast to a more granular staining pattern in BCC and SCC. CONCLUSION: SGCs display a variety of clinical signs and may mimic many other lesions. Tumor resection, followed by histological and immunohistochemical analysis, leads to the diagnosis and initiation of the proper treatment regimen. Herein, immunohistochemistry showed an unequivocal profile in SGC and did not allow for an exact differentiation from BCC and SCC by immunohistochemical means only. An extended evaluation of HE stains remains essential. However, immunohistochemistry can make relevant contributions to the diagnosis of SGC, especially in cases of inconclusive histology, by positive staining for adipophilin in immature sebaceous cells or by AR441 labeling in cases of pagetoid spread.
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/patologia
Biomarcadores Tumorais/metabolismo
Neoplasias Palpebrais/patologia
Estadiamento de Neoplasias
Neoplasias das Glândulas Sebáceas/patologia
Glândulas Sebáceas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/metabolismo
Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Palpebrais/metabolismo
Feminino
Seguimentos
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Perilipina-2/metabolismo
Estudos Retrospectivos
Neoplasias das Glândulas Sebáceas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Perilipin-2)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3738-2


  2 / 391 MEDLINE  
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[PMID]:29072946
[Au] Autor:Stanoszek LM; Wang GY; Harms PW
[Ad] Endereço:From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
[Ti] Título:Histologic Mimics of Basal Cell Carcinoma.
[So] Source:Arch Pathol Lab Med;141(11):1490-1502, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. OBJECTIVE: - To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. DATA SOURCES: - Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. CONCLUSIONS: - In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.
[Mh] Termos MeSH primário: Carcinoma Basocelular/diagnóstico
Neoplasias Cutâneas/diagnóstico
Pele/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/diagnóstico
Adenocarcinoma Sebáceo/imunologia
Adenocarcinoma Sebáceo/metabolismo
Adenocarcinoma Sebáceo/patologia
Biomarcadores Tumorais/metabolismo
Carcinoma Basocelular/imunologia
Carcinoma Basocelular/metabolismo
Carcinoma Basocelular/patologia
Diagnóstico Diferencial
Hamartoma/diagnóstico
Hamartoma/imunologia
Hamartoma/metabolismo
Hamartoma/patologia
Histiocitoma Fibroso Benigno/diagnóstico
Histiocitoma Fibroso Benigno/imunologia
Histiocitoma Fibroso Benigno/metabolismo
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
Imuno-Histoquímica/tendências
Imunofenotipagem/tendências
Pele/imunologia
Pele/metabolismo
Neoplasias Cutâneas/imunologia
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0222-RA


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[PMID]:28323778
[Au] Autor:Broekaert SM; Flux K; Kyrpychova L; Kacerovska D; Ivan D; Schön MP; Ströbel P; Michal M; Denisjuk N; Kerl K; Kazakov DV
[Ad] Endereço:*Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany; †Dermatohistology and Oral Pathology Laboratory, Munich, Germany; ‡Department of Pathology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic; §Bioptical Laboratory, Pilsen, Czech Republic; ¶Department of Pathology, University of Texas-MD Anderson Cancer Center, Houston, TX; ‖Department of Pathology, University Medical Center Göttingen, Göttingen, Germany; **Dermatopathology Laboratory, Zurich, Switzerland; and ††Department of Dermatology, University Hospital, Zurich, Switzerland.
[Ti] Título:Squared-Off Nuclei and "Appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 46 Patients.
[So] Source:Am J Dermatopathol;39(4):275-278, 2017 Apr.
[Is] ISSN:1533-0311
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma.
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/patologia
Neoplasias Oculares/patologia
Neoplasias das Glândulas Sebáceas/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1097/DAD.0000000000000651


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[PMID]:28267391
[Au] Autor:Shafi F; Rathore D; Johnson A; Mehta P; Ahluwalia HS
[Ad] Endereço:a University Hospital of Coventry & Warwickshire , Coventry , West Midlands , United Kingdom.
[Ti] Título:Medial canthal defects following tumour excision: To reconstruct or not to reconstruct?
[So] Source:Orbit;36(2):64-68, 2017 Apr.
[Is] ISSN:1744-5108
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Laissez-faire following excision of peri-ocular tumours has been described, but is not universally well established. We describe our experience with laissez-faire for managing medial canthal defects following tumour excision and compare our outcomes with full thickness skin grafts. Retrospective comparative case series of 68 patients who underwent reconstruction of a medial canthal defect using laissez-faire with sutured Sorbsan (LFS) (n = 36) or a full thickness skin graft (FTSG) (n = 32) at the same centre. Tumour diagnosis, defect size, time taken to epithelialise, functional and cosmetic outcomes, complications, follow-up duration and any secondary interventions were recorded. Basal call carcinoma was the most common neoplasm excised (63/68, 93%). Defect size ranged from 7 × 5 mm to 25 × 10 mm. Mean time for wound epithelialisation in LFS group was 33 days. Mean duration of follow-up was 32 months (range 1-80 months) for LFS and 30 months (range 6-60 months) for FTSG. Good functional and cosmetic outcomes were achieved in all 68 patients. Review of clinical photographs showed epicanthic fold in 2 patients and visible scar in 1 patient in the LFS group and 3 cases of hypopigmented scar and 7 hypertrophic scars in the FTSG group. No cases required secondary intervention. There were no cases of postoperative infection. LFS in the medial canthal region is less likely to lead to hypertrophic scarring or cicatricial sequelae compared to FTSG (p = 0.02). Both techniques are associated with excellent functional and aesthetic outcomes even for larger defects.
[Mh] Termos MeSH primário: Neoplasias Palpebrais/cirurgia
Doenças do Aparelho Lacrimal/cirurgia
Aparelho Lacrimal/cirurgia
Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos
Procedimentos Cirúrgicos Reconstrutivos/métodos
Neoplasias Cutâneas/cirurgia
Transplante de Pele/métodos
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/cirurgia
Adulto
Idoso
Idoso de 80 Anos ou mais
Alginatos
Bandagens
Doença de Bowen/cirurgia
Carcinoma Basocelular/cirurgia
Carcinoma de Células Escamosas/cirurgia
Feminino
Seres Humanos
Aparelho Lacrimal/patologia
Doenças do Aparelho Lacrimal/etiologia
Masculino
Meia-Idade
Estudos Retrospectivos
Técnicas de Sutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (sorbsan)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1080/01676830.2017.1279654


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[PMID]:28221180
[Au] Autor:Wu W; Modi GM; Mir MR; Srivastava D
[Ad] Endereço:Department of Dermatology, Houston Methodist Hospital, Houston, Texas The Surgery Center at Plano Dermatology, Plano, Texas Department of Dermatology, Kelsey-Seybold Clinic, Houston, Texas Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
[Ti] Título:Sebaceous Carcinoma Arising Within a Nevus Sebaceus Excised by Mohs Micrographic Surgery.
[So] Source:Dermatol Surg;43(9):1181-1184, 2017 09.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/cirurgia
Cirurgia de Mohs
Nevo/cirurgia
Neoplasias das Glândulas Sebáceas/cirurgia
Neoplasias Cutâneas/cirurgia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/patologia
Biópsia
Feminino
Seres Humanos
Meia-Idade
Nevo/patologia
Couro Cabeludo
Neoplasias das Glândulas Sebáceas/patologia
Neoplasias Cutâneas/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001058


  6 / 391 MEDLINE  
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[PMID]:28027201
[Au] Autor:Tolkachjov SN; Schmitt AR; Muzic JG; Weaver AL; Baum CL
[Ad] Endereço:*Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
[So] Source:Dermatol Surg;43(1):116-124, 2017 Jan.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data. OBJECTIVE: To determine the incidence of several rare nonmelanoma skin cancers. MATERIALS AND METHODS: The authors conducted a retrospective chart review of a population-based cohort between the years 2000 and 2010. Residents of Olmsted County, Minnesota, who were diagnosed with a biopsy-proven nonmelanoma skin cancer-excluding basal cell carcinoma and squamous cell carcinoma-were included in this study. The primary outcome was tumor incidence. Additionally, the authors extracted patient demographics, tumor characteristics, treatment modalities, and outcomes. RESULTS: The age-adjusted and sex-adjusted incidences per 100,000 persons of multiple rare cutaneous malignancies were: atypical fibroxanthoma (1.8), sebaceous carcinoma (0.8), dermatofibrosarcoma protuberans (0.4), microcystic adnexal carcinoma (0.7), eccrine carcinoma (0.4), eccrine porocarcinoma (0.2), and leiomyosarcoma (0.2). CONCLUSION: The authors report population-based incidences and clinical characteristics for these rare cutaneous malignancies. The immune status and smoking status of patients and the treatment and outcomes of these tumors are reported. Additional studies in a broader population are needed to further define the epidemiology and outcomes of these malignancies.
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/epidemiologia
Dermatofibrossarcoma/epidemiologia
Porocarcinoma Écrino/epidemiologia
Leiomiossarcoma/epidemiologia
Neoplasias de Anexos e de Apêndices Cutâneos/epidemiologia
Doenças Raras/epidemiologia
Neoplasias Cutâneas/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Minnesota/epidemiologia
Estudos Retrospectivos
Neoplasias das Glândulas Sebáceas/epidemiologia
Neoplasias das Glândulas Sudoríparas/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000000936


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[PMID]:26882058
[Au] Autor:Zoroquiain P; Alghamdi S; Arthurs B; Levin L; Sheppard DC; Ralph B; Burnier J; Burnier MN
[Ad] Endereço:*Henry C. Witelson Ocular Pathology Laboratory, McGill University, Montreal, Quebec, Canada; †Pathology Department, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile; ‡Ophthalmology Department, and §Departments of Medicine, Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
[Ti] Título:Eyelid Mycetoma Masquerading as Sebaceous Carcinoma.
[So] Source:Ophthal Plast Reconstr Surg;33(3S Suppl 1):S101-S104, 2017 May/Jun.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 56-year-old Asian woman presented with an upper eyelid mass. The lesion was exposed after eversion of the eyelid revealing a thickened tarsus with yellowish areas. Working diagnosis was sebaceous carcinoma. Biopsy was performed. Histopathological studies showed a mycotic eumycetoma with Splendore-Hoeppli phenomena and - microbiologic cultures grew Scedosporium apiospermum. The patient was started on voriconazole 200 mg po bid with adequate serum levels. A complete response was observed after 18 weeks of voriconazole therapy. To the best of our knowledge, this is the first published case of S. apiospermum eumycotic mycetoma of the eyelid. It is important to consider mycotic infection in the differential diagnosis of eyelid tumors even in healthy patients.
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/diagnóstico
Infecções Oculares Fúngicas/diagnóstico
Doenças Palpebrais/diagnóstico
Neoplasias Palpebrais/diagnóstico
Micetoma/diagnóstico
Scedosporium/isolamento & purificação
Neoplasias das Glândulas Sebáceas/diagnóstico
[Mh] Termos MeSH secundário: Antifúngicos/uso terapêutico
Biópsia
Diagnóstico Diferencial
Infecções Oculares Fúngicas/tratamento farmacológico
Infecções Oculares Fúngicas/microbiologia
Doenças Palpebrais/tratamento farmacológico
Doenças Palpebrais/microbiologia
Pálpebras/microbiologia
Pálpebras/patologia
Feminino
Seres Humanos
Meia-Idade
Micetoma/tratamento farmacológico
Micetoma/microbiologia
Voriconazol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160217
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000000657


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[PMID]:26020718
[Au] Autor:Stagner AM; Jakobiec FA
[Ad] Endereço:*David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye & Ear Infirmary; and †Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, U.S.A.
[Ti] Título:Demonstration of a Borst-Jadassohn-Like Phenomenon in Sebaceous Carcinoma of the Eyelid.
[So] Source:Ophthal Plast Reconstr Surg;33(3S Suppl 1):S63-S66, 2017 May/Jun.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 77-year-old male presented with a diffuse, papular erythematous conjunctival mass that demonstrated on pathologic examination lobules of tumor in the conjunctival substantia propria and tarsus. The cells displayed numerous cytoplasmic vacuoles with extreme nuclear pleomorphism, consistent with sebaceous carcinoma. The overlying palpebral conjunctival epithelium exhibited regions of carcinoma in situ containing some vacuolated cells, alternating with a more classical appearance of pagetoid spread among normal surviving keratinocytes. Further analysis disclosed vesicular positivity for adipophilin and positive nuclear staining for androgen receptor. One tumor focus harbored exaggerated collections of intraepithelial tumor cells. These simulated the Borst-Jadassohn phenomenon of large nests of alien appearing cells normally encountered within the epidermis of the skin. This is the first description of this pattern created by an eyelid sebaceous carcinoma growing within the conjunctival epithelium.
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/diagnóstico
Túnica Conjuntiva/patologia
Neoplasias Palpebrais/diagnóstico
Pálpebras/patologia
Neoplasias das Glândulas Sebáceas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Biópsia
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150529
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000000493


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[PMID]:27745640
[Au] Autor:Kim RH; Nagler AR; Meehan SA
[Ad] Endereço:Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
[Ti] Título:Universal immunohistochemical screening of sebaceous neoplasms for Muir-Torre syndrome: Putting the cart before the horse?
[So] Source:J Am Acad Dermatol;75(5):1078-1079, 2016 Nov.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/diagnóstico
Reparo de Erro de Pareamento de DNA/genética
Enzimas Reparadoras do DNA/análise
Detecção Precoce de Câncer
Imuno-Histoquímica
Instabilidade de Microssatélites
Síndrome de Muir-Torre/diagnóstico
Neoplasias das Glândulas Sebáceas/diagnóstico
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/química
Adenocarcinoma Sebáceo/genética
Neoplasias Colorretais/genética
Testes Diagnósticos de Rotina
Detecção Precoce de Câncer/ética
Detecção Precoce de Câncer/métodos
Seres Humanos
Síndrome de Muir-Torre/enzimologia
Síndrome de Muir-Torre/genética
Guias de Prática Clínica como Assunto
Neoplasias das Glândulas Sebáceas/química
Neoplasias das Glândulas Sebáceas/genética
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
EC 6.5.1.- (DNA Repair Enzymes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


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[PMID]:27590119
[Au] Autor:Takahashi Y; Takahashi E; Nakakura S; Kitaguchi Y; Mupas-Uy J; Kakizaki H
[Ad] Endereço:Department of Oculoplastic, Orbital, & Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Aichi, Japan.
[Ti] Título:Risk Factors for Local Recurrence or Metastasis of Eyelid Sebaceous Gland Carcinoma After Wide Excision With Paraffin Section Control.
[So] Source:Am J Ophthalmol;171:67-74, 2016 Nov.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To identify risk factors for local recurrence and metastasis of sebaceous gland carcinoma (SGC) after wide excision with paraffin section control. DESIGN: Retrospective, observational case-control study. METHODS: Setting: Single institution. PATIENT POPULATION: Thirty-four patients with SGC who had undergone excision with 5-mm surgical margins and paraffin section pathologic analysis. Observational Procedures: The following were considered potential risk factors for local recurrence/metastasis of SGC: patient's sex, patient's age, initial diagnosis at other clinics, topical treatments at other clinics, interval between appearance of symptoms and referral to our institution, tumor location, tumor origin, tumor presentation pattern, T category, tumor size, presence/or absence of pagetoid spread, tumor differentiation, mitosis grade, growth pattern. Logistic regression analysis was performed to identify the actual risk factors. MAIN OUTCOME MEASURES: Risk factors for local recurrence or metastasis of SGC after wide excision with paraffin section control. RESULTS: Involvement of both upper and lower eyelids, topical treatments at other clinics, multicentric origin, diffuse pattern, stage T3a, large tumor size, and a nonlobular pattern significantly influenced local recurrence/metastasis (P < .050). Pagetoid spread tended to affect local recurrence/metastasis (P = .052). The other items did not significantly influence local recurrence/metastasis (P > .050). CONCLUSIONS: This study identified risk factors for local recurrence or metastasis of SGC after wide excision with paraffin section pathologic analysis. The results of this study will be helpful to surgeons when planning additional management, such as map biopsy or adjuvant treatment.
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/secundário
Neoplasias Palpebrais/secundário
Recidiva Local de Neoplasia/epidemiologia
Procedimentos Cirúrgicos Oftalmológicos/métodos
Medição de Risco/métodos
Neoplasias das Glândulas Sebáceas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/diagnóstico
Adenocarcinoma Sebáceo/cirurgia
Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Palpebrais/diagnóstico
Neoplasias Palpebrais/cirurgia
Feminino
Seguimentos
Seres Humanos
Incidência
Japão/epidemiologia
Masculino
Meia-Idade
Metástase Neoplásica
Estudos Retrospectivos
Fatores de Risco
Neoplasias das Glândulas Sebáceas/cirurgia
Taxa de Sobrevida/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE



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