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[PMID]:29382006
[Au] Autor:Li H; Wang F; Shen P; Zhou F
[Ad] Endereço:Department of Pathology.
[Ti] Título:Pure acinic cell carcinoma of the breast: A case report and literature review.
[So] Source:Medicine (Baltimore);96(47):e8866, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Acinic cell carcinoma (AcCC) of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation. PATIENT CONCERNS: A 52-year-old woman presented to the hospital with a palpable mass over the upper outer quadrant of the right breast. DIAGNOSES: Physical examination revealed an irregular mass in the lateral upper quadrant of the left breast, approximately 1.5 cm in diameter. Histologically, the tumor cells were round to oval, had displaced nuclei with striking single nucleoli and basophilic cytoplasm, and contained large coarse cytoplasmic granules. They showed an infiltrating growth pattern with a combination of cystic and cribriform feature. We diagnosed the tumor as AcCC of the breast. INTERVENTIONS: The patient was given a simple mastectomy and sentinel lymph node biopsy. After the surgery, AcCC of the breast was confirmed histologically. OUTCOMES: The patient was symptom free 3 months after surgery. LESSONS: AcCC of the breast is a very rare tumor, and its prognosis appears to be good. Thus, treatment followed the guidelines for invasive breast carcinoma and no further therapy was suggested by oncologists based on the tumor biology.
[Mh] Termos MeSH primário: Neoplasias da Mama/cirurgia
Carcinoma de Células Acinares/cirurgia
[Mh] Termos MeSH secundário: Neoplasias da Mama/patologia
Carcinoma de Células Acinares/patologia
Feminino
Seres Humanos
Mastectomia Simples
Meia-Idade
Biópsia de Linfonodo Sentinela
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008866


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[PMID]:28739497
[Au] Autor:Xu B; Aneja A; Ghossein R; Katabi N
[Ad] Endereço:Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
[Ti] Título:Salivary gland epithelial neoplasms in pediatric population: a single-institute experience with a focus on the histologic spectrum and clinical outcome.
[So] Source:Hum Pathol;67:37-44, 2017 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salivary gland epithelial neoplasms are rare in children and adolescents, with only a handful of large series having been published. A retrospective study was conducted for 57 cases in patients 20 years or younger. The tumors were located in the parotid (n=36), submandibular gland (n=7), and minor salivary glands (n=14). Nineteen (33%) tumors were pleomorphic adenoma, whereas the remaining (67%) were malignant. The histologic types of carcinomas were mucoepidermoid carcinoma (MEC, n=19, 33%), acinic cell carcinoma (n=7, 12%), adenoid cystic carcinoma (n=6, 11%), secretory carcinoma (mammary analogue) (SC, n=4, 7%), and myoepithelial carcinoma (n=2, 4%). Ninety-three percent (13/14) of the minor and 58% (25/43) of the major salivary gland tumors were malignant. A 7-year-old girl (2%) with a high-grade MEC died from her disease because of uncontrollable locoregional recurrence. Seven patients (16%) developed recurrence including 2 distant metastases from adenoid cystic carcinoma and 6 locoregional recurrences (2 pleomorphic adenomas, 1 SC, 1 myoepithelial carcinoma, 1 adenoid cystic carcinoma, and 1 MEC). The following parameters were associated with decreased disease-free survival in malignant tumors: elevated mitotic index of >4/10 high-power fields (log-rank test, P<.001), and advanced American Joint Committee on Cancer pT (P=.029) and pN stage (P<.001). In conclusion, myoepithelial carcinoma and SC can occur in the pediatric population and should be considered in the differential diagnosis. Salivary gland malignancies in children appear to have better clinical outcome, associated with a 10-year recurrence-free survival rate of 74% and a 10-year disease-specific survival of 94%.
[Mh] Termos MeSH primário: Adenoma/patologia
Carcinoma de Células Acinares/patologia
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/patologia
Mioepitelioma/patologia
Neoplasias das Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Adenoma/mortalidade
Adenoma/terapia
Adolescente
Fatores Etários
Biópsia
Carcinoma de Células Acinares/mortalidade
Carcinoma de Células Acinares/secundário
Carcinoma de Células Acinares/terapia
Carcinoma Adenoide Cístico/mortalidade
Carcinoma Adenoide Cístico/secundário
Carcinoma Adenoide Cístico/terapia
Carcinoma Mucoepidermoide/mortalidade
Carcinoma Mucoepidermoide/secundário
Carcinoma Mucoepidermoide/terapia
Criança
Pré-Escolar
Progressão da Doença
Intervalo Livre de Doença
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Mioepitelioma/mortalidade
Mioepitelioma/secundário
Mioepitelioma/terapia
Gradação de Tumores
Recidiva Local de Neoplasia
Cidade de Nova Iorque
Estudos Retrospectivos
Fatores de Risco
Neoplasias das Glândulas Salivares/mortalidade
Neoplasias das Glândulas Salivares/terapia
Centros de Atenção Terciária
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28547986
[Au] Autor:Rankovic B; Limbaeck-Stokin C; Dokic M; Stanisavljevic D; Volavsek M
[Ti] Título:Simultaneous occurrence of pancreatic mixed acinar-ductal adenocarcinoma and primary follicular lymphoma of the duodenum, accompanied by increased number of IgG4 plasma cells in tumor-free parenchyma as concomitant IgG4-related disease or reaction to tumor? A case report.
[So] Source:Pol J Pathol;68(1):86-91, 2017.
[Is] ISSN:1233-9687
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Mixed acinar-ductal carcinoma is rare among pancreatic cancers, as is duodenal involvement in follicular lymphoma (FL). Although usually a systemic disease, primary FL of the duodenum occurs, with superficial involvement of the intestinal wall and low risk of progression. We report on a unique case of mixed ductal-acinar carcinoma of the pancreatic head accompanied by low-grade duodenal FL and autoimmune pancreatitis-like changes in adjacent pancreatic parenchyma. To our knowledge this is the first report of concomitant pancreatic mixed acinar-ductal carcinoma and duodenal FL. Clinico-pathological features of this unusual case, possible relationship between the entities and differential diagnosis are discussed.
[Mh] Termos MeSH primário: Carcinoma de Células Acinares/patologia
Carcinoma Ductal Pancreático/patologia
Linfoma Folicular/patologia
Neoplasias Primárias Múltiplas/patologia
Neoplasias Pancreáticas/patologia
Plasmócitos/patologia
[Mh] Termos MeSH secundário: Neoplasias Duodenais/patologia
Seres Humanos
Imunoglobulina G
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE


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[PMID]:28484843
[Au] Autor:Larnaudie L; Compérat E; Conort P; Varinot J
[Ad] Endereço:Department of Pathology, Hopital Tenon, AP-HP, UPMC-Paris VI, 4 rue de la Chine, 75020, Paris, France.
[Ti] Título:HOXB13 a useful marker in pleomorphic giant cell adenocarcinoma of the prostate: a case report and review of the literature.
[So] Source:Virchows Arch;471(1):133-136, 2017 Jul.
[Is] ISSN:1432-2307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We report the case of an 81-year-old patient with a pleomorphic giant cell adenocarcinoma of the prostate. After diagnosis, he rapidly developed bone metastasis and died within 1 year. This variant of acinar adenocarcinoma is extremely rare and prognosis is poor. This entity has been included into the 2016 WHO classification. The principal differential diagnosis is urothelial carcinoma. To assess the prostatic origin, routine immunohistochemistry can be problematic. Loss of epitopes in this poorly differentiated entity can occur, such as loss of expression of PSA and p504s. We recently described a very sensitive and specific marker of prostate cancer, HOXB13, which once again has proven to be highly specific and sensitive. This is the first description of a pleomorphic giant cell prostate cancer expressing HOXB13.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Carcinoma de Células Acinares/diagnóstico
Proteínas de Homeodomínio/biossíntese
Neoplasias da Próstata/diagnóstico
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Células Gigantes/patologia
Proteínas de Homeodomínio/análise
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (HOXB13 protein, human); 0 (Homeodomain Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1007/s00428-017-2134-y


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[PMID]:28411376
[Au] Autor:Rooper LM; Onenerk M; Siddiqui MT; Faquin WC; Bishop JA; Ali SZ
[Ad] Endereço:Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
[Ti] Título:Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?
[So] Source:Cancer;125(8):627-634, 2017 Aug.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification. METHODS: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Clinical, cytologic, and histologic findings were tabulated for all cases. RESULTS: Twelve cases of oncocytosis were identified from 11 patients, including 11 parotid FNA specimens and 1 submandibular FNA specimen. On the original diagnoses, 6 specimens were classified as benign, 4 as atypical, and 2 as nondiagnostic. Oncocytosis was listed in the differential diagnosis in only 1 case. Among diagnostic aspirates, 8 demonstrated low cellularity and 2 demonstrated moderate cellularity. All 10 cases demonstrated oncocytic cells in small to medium groups, with single cells in just 1 case. Spindled and squamous morphology were each noted in 3 cases. Four cases demonstrated cystic change and 1 showed background mucin without goblet cells. No necrosis or mitoses were observed. CONCLUSIONS: Although oncocytosis demonstrates some overlap with Warthin tumor and oncocytoma, it lacks the diagnostic findings specific to oncocytic salivary gland malignancies such as salivary duct carcinoma, acinic cell carcinoma, mammary analog secretory carcinoma, and mucoepidermoid carcinoma. Despite current limitations in the understanding of oncocytic salivary gland lesions, the presence of a paucicellular specimen comprised of small groups of oncocytic cells should raise the possibility of oncocytosis in the differential diagnosis and can favor it in elderly patients with multiple salivary nodules. Cancer Cytopathol 2017;125:627-34. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Células Oxífilas/patologia
Doenças Parotídeas/patologia
Doenças da Glândula Submandibular/patologia
[Mh] Termos MeSH secundário: Adenolinfoma/diagnóstico
Adenolinfoma/patologia
Adenoma Oxífilo/diagnóstico
Adenoma Oxífilo/patologia
Idoso
Idoso de 80 Anos ou mais
Biópsia por Agulha Fina
Carcinoma/diagnóstico
Carcinoma/patologia
Carcinoma de Células Acinares/diagnóstico
Carcinoma de Células Acinares/patologia
Carcinoma Mucoepidermoide/diagnóstico
Carcinoma Mucoepidermoide/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças Parotídeas/diagnóstico
Doenças das Glândulas Salivares/diagnóstico
Doenças das Glândulas Salivares/patologia
Neoplasias das Glândulas Salivares/diagnóstico
Neoplasias das Glândulas Salivares/patologia
Doenças da Glândula Submandibular/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21865


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[PMID]:28257167
[Au] Autor:Rosenbaum MW; Cauley CE; Kulemann B; Liss AS; Castillo CF; Warshaw AL; Lillemoe KD; Thayer SP; Pitman MB
[Ad] Endereço:Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
[Ti] Título:Cytologic characteristics of circulating epithelioid cells in pancreatic disease.
[So] Source:Cancer;125(5):332-340, 2017 May.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed the cytomorphologic characteristics of CECs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict CEC origin. METHODS: Blood samples were collected from 9 healthy controls and 171 patients with pancreatic disease who were presenting for surgical evaluation before treatment. Blood was processed with the ScreenCell size-based filtration device. Evaluable CECs were analyzed in a blinded fashion for cytomorphologic characteristics, including cellularity; nucleoli; nuclear size, irregularity, variability, and hyperchromasia; and nuclear-to-cytoplasmic ratio. Statistical differences between variables were analyzed via the Fisher exact test. RESULTS: No CECs were identified among the 9 normal healthy controls. Of the 115 patients with CECs (positive or suspicious for), 25 had nonmalignant disease and 90 had malignancy. There were no significant differences in any of the cytologic criteria noted between groups divided by benign versus malignant, neoplastic versus nonneoplastic, or pancreatic ductal adenocarcinoma versus neuroendocrine tumor. CONCLUSIONS: CECs were observed in patients with malignant and nonmalignant pancreatic disease, but not in healthy controls. There were no morphologic differences observed between cells from different pancreatic diseases, suggesting that numerous conditions may be associated with CECs in the circulation and that care must be taken not to overinterpret cells identified by cytomorphology as indicative of circulating tumor cells of pancreatic cancer. Additional studies are required to determine the origin and clinical significance of these cells. Cancer Cytopathol 2017;125:332-340. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Adenoma/patologia
Neoplasias dos Ductos Biliares/patologia
Colangiocarcinoma/patologia
Neoplasias do Ducto Colédoco/patologia
Neoplasias Císticas, Mucinosas e Serosas/patologia
Células Neoplásicas Circulantes/patologia
Neoplasias Pancreáticas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/sangue
Adenoma/sangue
Ampola Hepatopancreática/patologia
Neoplasias dos Ductos Biliares/sangue
Carcinoma de Células Acinares/sangue
Carcinoma de Células Acinares/patologia
Carcinoma Ductal Pancreático/sangue
Carcinoma Ductal Pancreático/patologia
Estudos de Casos e Controles
Colangiocarcinoma/sangue
Neoplasias do Ducto Colédoco/sangue
Cistadenoma Seroso/sangue
Cistadenoma Seroso/patologia
Cisto Epidérmico
Seres Humanos
Neoplasias Císticas, Mucinosas e Serosas/sangue
Tumores Neuroendócrinos/sangue
Tumores Neuroendócrinos/patologia
Pancreatopatias/sangue
Pancreatopatias/patologia
Neoplasias Pancreáticas/sangue
Pancreatite Crônica/sangue
Pancreatite Crônica/patologia
Prognóstico
Esplenopatias
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21841


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[PMID]:28215484
[Au] Autor:Rezaei M; Hosseini A; Nikeghbalian S; Ghaderi A
[Ad] Endereço:Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Establishment and characterization of a new human acinar cell carcinoma cell line, Faraz-ICR, from pancreas.
[So] Source:Pancreatology;17(2):303-309, 2017 Mar - Apr.
[Is] ISSN:1424-3911
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Basic research in the field of acinar cell carcinoma (ACC) as a rare neoplasm of the pancreas is dependent on the availability of pragmatic model such as new pancreatic cancer cell lines. Thus, establishment and characterization of new pancreatic cancer cell lines from ACC origin are deemed important. METHODS: Faraz-ICR cell line was derived from a 58-years old woman with pancreatic acinar cell carcinoma by the collagenase digestion protocol. We characterized the cell line by examining its morphology and cytostructural and functional profile. RESULTS: Faraz-ICR has a doubling time of 35 hours and grows in soft agar with a colony-forming efficiency of 25%. The cell had nearly normal pattern of chromosomes in karyotype analysis and Comparative Genomic Hybridization (CGH) array analysis. Evaluation of cells by flowcytometry showed that Faraz-ICR is negative for EpCAM and mesenchymal markers in different passages, and has epithelial nature. Immunofluorescence staining revealed that cells were strongly positive for vimentin, desmin, ezrin, S100, nestin and they were negative for pan-cytokeratins, chromogranin and alpha smooth muscle actin. CONCLUSIONS: We were able to establish a new pancreatic carcinoma cell line with partial aspects of Epithelial-mesenchymal transition and aggressiveness. This cell line might be suitable for studying various anticancer drugs and protein profile aiming to see any possible tumor associated marker for ACC.
[Mh] Termos MeSH primário: Carcinoma de Células Acinares
Neoplasias Pancreáticas
[Mh] Termos MeSH secundário: Aneuploidia
Linhagem Celular Tumoral
Ensaios de Migração Celular
Proliferação Celular
Feminino
Citometria de Fluxo
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28214199
[Au] Autor:Zhang XP; Jiang GY; Zhang QF; Xu HT; Li QC; Wang EH
[Ad] Endereço:Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang 110001, China.
[Ti] Título:Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature.
[So] Source:Pathol Res Pract;213(4):405-409, 2017 Apr.
[Is] ISSN:1618-0631
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Salivary gland-type tumors are rare in the lung. Primary acinic cell carcinoma of the lung is extremely rare. Here, we report a case of primary acinic cell carcinoma of the lung with prominent psammoma bodies. A 31-year-old man came to our hospital with a tumor in the basal segment of the lower lobe of the right lung. The tumor tissue displayed solid, acinar, or microcystic structures at different regions. A large amount of psammoma bodies were scattered in more than half of the tumor. The majority of the tumor cells were round or polygonal in shape, with abundant acidophilic granular or vacuolated cytoplasm. The results of tumor tissue tests were positive for periodic acid Schiff (PAS), broad-spectrum cytokeratin, and cytokeratin 7 staining, but negative for P63, TTF-1, CD56, synaptophysin, HMB45, and PR staining. Based on the clinical information, histological features, and the immunohistochemical staining profile, the tumor was diagnosed as a primary acinic cell carcinoma of the lung. This is the first report of primary acinic cell carcinoma with prominent psammoma bodies in the lung.
[Mh] Termos MeSH primário: Carcinoma de Células Acinares/patologia
Neoplasias Pulmonares/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
Seres Humanos
Imuno-Histoquímica
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28212443
[Au] Autor:Barasch N; Gong X; Kwei KA; Varma S; Biscocho J; Qu K; Xiao N; Lipsick JS; Pelham RJ; West RB; Pollack JR
[Ad] Endereço:Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America.
[Ti] Título:Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma.
[So] Source:PLoS One;12(2):e0171265, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pathogenic gene fusions have been identified in several histologic types of salivary gland neoplasia, but not previously in acinic cell carcinoma (AcCC). To discover novel gene fusions, we performed whole-transcriptome sequencing surveys of three AcCC archival cases. In one specimen we identified a novel HTN3-MSANTD3 gene fusion, and in another a novel PRB3-ZNF217 gene fusion. The structure of both fusions was consistent with the promoter of the 5' partner (HTN3 or PRB3), both highly expressed salivary gland genes, driving overexpression of full-length MSANTD3 or ZNF217. By fluorescence in situ hybridization of an expanded AcCC case series, we observed MSANTD3 rearrangements altogether in 3 of 20 evaluable cases (15%), but found no additional ZNF217 rearrangements. MSANTD3 encodes a previously uncharacterized Myb/SANT domain-containing protein. Immunohistochemical staining demonstrated diffuse nuclear MSANTD3 expression in 8 of 27 AcCC cases (30%), including the three cases with MSANTD3 rearrangement. MSANTD3 displayed heterogeneous expression in normal salivary ductal epithelium, as well as among other histologic types of salivary gland cancer though without evidence of translocation. In a broader survey, MSANTD3 showed variable expression across a wide range of normal and neoplastic human tissue specimens. In preliminary functional studies, engineered MSANTD3 overexpression in rodent salivary gland epithelial cells did not enhance cell proliferation, but led to significant upregulation of gene sets involved in protein synthesis. Our findings newly identify MSANTD3 rearrangement as a recurrent event in salivary gland AcCC, providing new insight into disease pathogenesis, and identifying a putative novel human oncogene.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transdução de Sinal/genética
Carcinoma de Células Acinares/genética
Rearranjo Gênico
Neoplasias das Glândulas Salivares/genética
[Mh] Termos MeSH secundário: Adulto
Animais
Carcinoma de Células Acinares/patologia
Linhagem Celular Tumoral
Sequência Conservada
Perfilação da Expressão Gênica
Fusão Gênica
Seres Humanos
Ratos
Neoplasias das Glândulas Salivares/patologia
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (CNPY2 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171265


  10 / 887 MEDLINE  
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[PMID]:28186287
[Au] Autor:Ito M; Miyata Y; Yoshiya T; Tsutani Y; Mimura T; Murakami S; Ito H; Nakayama H; Okada M
[Ad] Endereço:Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
[Ti] Título:Second predominant subtype predicts outcomes of intermediate-malignant invasive lung adenocarcinoma†.
[So] Source:Eur J Cardiothorac Surg;51(2):218-222, 2017 02 01.
[Is] ISSN:1873-734X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Acinar predominant and papillary predominant invasive adenocarcinomas are likely to be classified as intermediate-malignant types. Although these two types of adenocarcinoma are distinguished morphologically, the differences between their malignant behaviours and prognoses are not clear. The aim of this study is to provide a prognostically relevant stratification of these similar subtypes based on pathological features. METHODS: We retrospectively reviewed 347 consecutive clinically N0M0 lung adenocarcinomas of ≤3 cm in diameter that were resected between April 2006 and December 2010 at two institutes. Acinar and papillary predominant adenocarcinomas were classified into acinar/papillary-lepidic type and acinar/papillary-non-lepidic type according to whether the second predominant component was a lepidic or invasive component. RESULTS: Fifty-four acinar and 59 papillary predominant adenocarcinoma cases were classified as acinar/papillary-lepidic type (n = 65) or acinar/papillary-non-lepidic type (n = 48) cases. Acinar/papillary-non-lepidic type cases were accompanied by more vascular invasion (13.8% vs 31.3%, P = 0.0451) and pleural invasion (9.2% vs 25.0%, P = 0.0450) than were acinar/papillary-lepidic type cases. Five-year overall survival (OS) and recurrence-free survival (RFS) also differed significantly between these types (5-year OS: acinar/papillary-lepidic type, 96.3% vs acinar/papillary-non-lepidic type, 61.8%, hazard ratio = 6.315, P = 0.00650; 5-year RFS: acinar/papillary-lepidic type, 91.4% vs acinar/papillary-non-lepidic type, 68.8%, hazard ratio = 2.967, P = 0.0210). Multivariate analysis revealed that a second predominant component was an independent prognostic factor for RFS (acinar/papillary-non-lepidic type: hazard ratio = 3.784, 95% confidence interval 1.091­13.128, P = 0.036). CONCLUSIONS: The pathological second predominant component allows intermediate-malignant adenocarcinomas to be subclassified with prognostic significance. It can be utilized when assessing postoperative risks for recurrence and when considering therapeutic strategies.
[Mh] Termos MeSH primário: Adenocarcinoma Papilar/patologia
Adenocarcinoma/patologia
Carcinoma de Células Acinares/patologia
Neoplasias Pulmonares/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/classificação
Adenocarcinoma/cirurgia
Adenocarcinoma Papilar/classificação
Adenocarcinoma Papilar/cirurgia
Adulto
Idoso
Idoso de 80 Anos ou mais
Vasos Sanguíneos/patologia
Carcinoma de Células Acinares/classificação
Carcinoma de Células Acinares/cirurgia
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Neoplasias Pulmonares/classificação
Neoplasias Pulmonares/cirurgia
Masculino
Meia-Idade
Invasividade Neoplásica
Pleura/patologia
Pneumonectomia/métodos
Prognóstico
Recidiva
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1093/ejcts/ezw318



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