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[PMID]:27775851
[Au] Autor:van Weert S; Reinhard R; Bloemena E; Buter J; Witte BI; Vergeer MR; Leemans CR
[Ad] Endereço:Department of Otolaryngology - Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
[Ti] Título:Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck.
[So] Source:Head Neck;39(3):456-463, 2017 Mar.
[Is] ISSN:1097-0347
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We examined the assumption in conventional teaching about metastatic adenoid cystic carcinoma (ACC) being an indolent type of disease. METHODS: A single center analysis of 105 cases of ACC was performed. Radiographs were reviewed and tumor response to chemotherapy was measured. Distant disease-free survival (DDFS) and time to death since distant metastases diagnosis were analyzed. RESULTS: Forty-two percent of the patients were diagnosed with distant metastases. DDFS showed significant negative associations with advanced T classification, N+ classification, solid type tumor, and positive surgical margins. Distant metastases (91%) developed in the first 5 years after presentation. Median distant metastatic survival was 13.8 months. The most frequent organ sited was the lung. Solid type ACC showed a preponderance for multiorgan metastases (17/28; 61%). Distant metastases seemed not to occur in case of clear surgical margins. Solid type ACC had a significant poorer survival after development of distant metastases. CONCLUSION: Metastatic ACC is not always an indolent disease. © 2016 Wiley Periodicals, Inc. Head Neck 39: 456-463, 2017.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/mortalidade
Carcinoma Adenoide Cístico/patologia
Causas de Morte
Neoplasias de Cabeça e Pescoço/mortalidade
Neoplasias de Cabeça e Pescoço/patologia
Linfonodos/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma Adenoide Cístico/diagnóstico por imagem
Carcinoma Adenoide Cístico/terapia
Estudos de Coortes
Intervalo Livre de Doença
Feminino
Seguimentos
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/terapia
Seres Humanos
Metástase Linfática
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Invasividade Neoplásica/patologia
Recidiva Local de Neoplasia/mortalidade
Recidiva Local de Neoplasia/patologia
Recidiva Local de Neoplasia/terapia
Estadiamento de Neoplasias
Estudos Retrospectivos
Análise de Sobrevida
Fatores de Tempo
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/hed.24613


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[PMID]:29390285
[Au] Autor:Zhang Y; Xin J; Ma Y; Li Q; Liu B
[Ad] Endereço:Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
[Ti] Título:Use of Univent tube for intermittent lung isolation during thoracoscopic mediastinal tracheal resection and reconstruction: A case report.
[So] Source:Medicine (Baltimore);96(50):e8945, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary tracheal adenoid cystic carcinoma of the trachea primary is a rare neoplasm and commonly misdiagnosed. Lung isolation during surgery and ventilation pose a tremendous challenge to anesthesiologists. PATIENT CONCERNS: The authors describe a novel technique of lung isolation and ventilation with a Univent tube during thoracoscopic mediastinal tracheal resection and reconstruction in a female patient. DIAGNOSES: Primary tracheal adenoid cystic carcinoma, nonsmall cell carcinoma. INTERVENTIONS: In this case, tracheal resection and reconstruction were performed. A bronchial blocker of the Univent tube was used as a guide to manipulate the depth of endotracheal tube. OUTCOMES: The intermittent 1-lung ventilation was established successfully. The patient recovered uneventfully and discharged after 10 days. LESSONS: The advantages of approach include a stable airway management without occupying the contracted space of thoracoscope and no potential risk of trapping or barotraumas.
[Mh] Termos MeSH primário: Manuseio das Vias Aéreas/métodos
Carcinoma Adenoide Cístico/cirurgia
Toracoscopia
Neoplasias da Traqueia/cirurgia
[Mh] Termos MeSH secundário: Carcinoma Adenoide Cístico/diagnóstico
Carcinoma Adenoide Cístico/patologia
Feminino
Seres Humanos
Intubação Intratraqueal
Meia-Idade
Neoplasias da Traqueia/diagnóstico
Neoplasias da Traqueia/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008945


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[PMID]:29277772
[Au] Autor:Ishibashi K; Ishii K; Sugiyama G; Sumida T; Sugiura T; Kamata YU; Seki K; Fujinaga T; Kumamaru W; Kobayashi Y; Hiyake N; Nakano H; Yamada T; Mori Y
[Ad] Endereço:Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
[Ti] Título:Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.
[So] Source:Anticancer Res;38(1):187-197, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Adenoid cystic carcinoma (AdCC) is a malignant tumor that occurs in the salivary glands and frequently metastasizes. The aim of this study was to identify factors mediating AdCC metastasis. MATERIALS AND METHODS: We established three AdCC cell lines by orthotropic transplantation and in vivo selection: parental, highly metastatic (ACCS-M-GFP), and lymph node metastatic (ACCS-LN-GFP) cells. RESULTS: We examined the three cell lines. DNA microarray indicated significantly altered processes in ACCS-LN-GFP cells: particularly, the expression of nicotinamide N-methyltransferase (NNMT) was enhanced the most. NNMT is associated with tumorigenesis and is a potential tumor biomarker. Concomitantly, we found-significant down-regulation of gap junction protein alpha-1. We suggest that ACCS-LN-GFP cells acquire cancer stem cell features involving the up-regulation of NNMT and the loss of gap junction protein alpha-1, leading to epithelial-mesenchymal transition and consequent AdCC metastasis. CONCLUSION: NNMT is a potential biomarker of AdCC.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/patologia
Conexina 43/metabolismo
Nicotinamida N-Metiltransferase/metabolismo
Neoplasias das Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Animais
Carcinoma Adenoide Cístico/metabolismo
Linhagem Celular Tumoral
Movimento Celular
Proliferação Celular
Feminino
Seres Humanos
Camundongos Nus
Neoplasias das Glândulas Salivares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexin 43); 0 (GJA1 protein, mouse); EC 2.1.1.1 (Nicotinamide N-Methyltransferase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:28954282
[Au] Autor:Andersson MK; Afshari MK; Andrén Y; Wick MJ; Stenman G
[Ad] Endereço:Sahlgrenska Cancer Center, Department of Pathology and Genetics, University of Gothenburg, Gothenburg, Sweden; Preclinical Research, South Texas Accelerated Research Therapeutics, San Antonio, TX.
[Ti] Título:Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling.
[So] Source:J Natl Cancer Inst;109(9), 2017 Sep 01.
[Is] ISSN:1460-2105
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Adenoid cystic carcinoma (ACC) is an aggressive cancer with no curative treatment for patients with recurrent/metastatic disease. The MYB-NFIB gene fusion is the main genomic hallmark and a potential therapeutic target. Methods: Oncogenic signaling pathways were studied in cultured cells and/or tumors from 15 ACC patients. Phospho-receptor tyrosine kinase (RTK) arrays were used to study the activity of RTKs. Effects of RTK inhibition on cell proliferation were analyzed with AlamarBlue, sphere assays, and two ACC xenograft models (n = 4-9 mice per group). The molecular effects of MYB-NFIB knockdown and IGF1R inhibition were studied with quantitative polymerase chain reaction, immunoblot, and gene expression microarrays. All statistical tests were two-sided. Results: The MYB-NFIB fusion drives proliferation of ACC cells and is crucial for spherogenesis. Intriguingly, the fusion is regulated through AKT-dependent signaling induced by IGF1R overexpression and is downregulated upon IGF1R-inhibition (% expression of control ± SD = 27.2 ± 1.3, P < .001). MYB-NFIB regulates genes involved in cell cycle control, DNA replication/repair, and RNA processing. The transcriptional program induced by MYB-NFIB affects critical oncogenic mediators normally controlled by MYC and is reversed by pharmacological inhibition of IGF1R. Co-activation of epidermal growth factor receptor (EGFR) and MET promoted proliferation of ACC cells, and combined targeting of IGFR1/EGFR/MET induced differentiation and synergistically inhibited the growth of patient-derived xenografted ACCs (ACCX5M1, % growth of control ± SD = 34.9 ± 20.3, P = .006; ACCX6, % growth of control ± SD = 24.1 ± 17.5, P = .04). Conclusions: MYB-NFIB is an oncogenic driver and a key therapeutic target in ACC that is regulated by AKT-dependent IGF1R signaling. Our studies uncover a new strategy to target an oncogenic transcriptional master regulator and provide new important insights into the biology and treatment of ACC.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/genética
Carcinoma Adenoide Cístico/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Proteínas Proto-Oncogênicas c-myb/metabolismo
Receptores de Somatomedina/metabolismo
Transdução de Sinais
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Apoptose
Biomarcadores Tumorais
Carcinoma Adenoide Cístico/tratamento farmacológico
Carcinoma Adenoide Cístico/patologia
Ciclo Celular
Proliferação Celular/genética
Análise por Conglomerados
Modelos Animais de Doenças
Feminino
Perfilação da Expressão Gênica
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Fator de Crescimento Insulin-Like II/farmacologia
Masculino
Meia-Idade
Gradação de Tumores
Proteínas de Fusão Oncogênicas/genética
Proteínas de Fusão Oncogênicas/metabolismo
Fosforilação
Inibidores de Proteínas Quinases/farmacologia
Proteínas Proto-Oncogênicas c-myb/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-myb/genética
Transdução de Sinais/efeitos dos fármacos
Transcrição Genética
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (IGF1R protein, human); 0 (MYB-NFIB fusion protein, human); 0 (Oncogene Proteins, Fusion); 0 (Protein Kinase Inhibitors); 0 (Proto-Oncogene Proteins c-myb); 0 (Receptors, Somatomedin); 67763-97-7 (Insulin-Like Growth Factor II); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1093/jnci/djx017


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[PMID]:28914715
[Au] Autor:Sajed DP; Faquin WC; Carey C; Severson EA; H Afrogheh A; A Johnson C; Blacklow SC; Chau NG; Lin DT; Krane JF; Jo VY; Garcia JJ; Sholl LM; Aster JC
[Ad] Endereço:*Department of Pathology, Massachusetts General Hospital ¶Department of Surgery, Massachusetts General Hospital ‡Department of Pathology, Brigham and Women's Hospital §Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School ∥Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA #Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN †Northern Institute for Cancer Research, University of Newcastle, Newcastle on Tyne, UK.
[Ti] Título:Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.
[So] Source:Am J Surg Pathol;41(11):1473-1482, 2017 Nov.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:NOTCH1 is frequently mutated in adenoid cystic carcinoma (ACC). To test the idea that immunohistochemical (IHC) staining can identify ACCs with NOTCH1 mutations, we performed IHC for activated NOTCH1 (NICD1) in 197 cases diagnosed as ACC from 173 patients. NICD1 staining was positive in 194 cases (98%) in 2 major patterns: subset positivity, which correlated with tubular/cribriform histology; and diffuse positivity, which correlated with a solid histology. To determine the relationship between NICD1 staining and NOTCH1 mutational status, targeted exome sequencing data were obtained on 14 diffusely NICD1-positive ACC specimens from 11 patients and 15 subset NICD1-positive ACC specimens from 15 patients. This revealed NOTCH1 gain-of-function mutations in 11 of 14 diffusely NICD1-positive ACC specimens, whereas all subset-positive tumors had wild-type NOTCH1 alleles. Notably, tumors with diffuse NICD1 positivity were associated with significantly worse outcomes (P=0.003). To determine whether NOTCH1 activation is unique among tumors included in the differential diagnosis with ACC, we performed NICD1 IHC on a cohort of diverse salivary gland and head and neck tumors. High fractions of each of these tumor types were positive for NICD1 in a subset of cells, particularly in basaloid squamous cell carcinomas; however, sequencing of basaloid squamous cell carcinomas failed to identify NOTCH1 mutations. These findings indicate that diffuse NICD1 positivity in ACC correlates with solid growth pattern, the presence of NOTCH1 gain-of-function mutations, and unfavorable outcome, and suggest that staining for NICD1 can be helpful in distinguishing ACC with solid growth patterns from other salivary gland and head and neck tumors.
[Mh] Termos MeSH primário: Biomarcadores Tumorais
Carcinoma Adenoide Cístico/química
Carcinoma Adenoide Cístico/genética
Neoplasias de Cabeça e Pescoço/química
Neoplasias de Cabeça e Pescoço/genética
Mutação
Receptor Notch1
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Carcinoma Adenoide Cístico/patologia
Carcinoma Adenoide Cístico/terapia
Proliferação Celular
Criança
Análise Mutacional de DNA
Diagnóstico Diferencial
Feminino
Predisposição Genética para Doença
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Cabeça e Pescoço/terapia
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Fenótipo
Valor Preditivo dos Testes
Receptor Notch1/análise
Receptor Notch1/genética
Neoplasias das Glândulas Salivares/química
Neoplasias das Glândulas Salivares/genética
Neoplasias das Glândulas Salivares/patologia
Neoplasias das Glândulas Salivares/terapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (NOTCH1 protein, human); 0 (Receptor, Notch1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000945


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[PMID]:28870928
[Au] Autor:Gutschenritter T; Machiorlatti M; Vesely S; Ahmad B; Razaq W; Razaq M
[Ad] Endereço:College of Medicine, Department of Medicine - Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.
[Ti] Título:Outcomes and Prognostic Factors of Resected Salivary Gland Malignancies: Examining a Single Institution's 12-year Experience.
[So] Source:Anticancer Res;37(9):5019-5025, 2017 09.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite adjuvant radiotherapy, survival outcomes remain poor in patients with salivary gland malignancies who have multiple poor prognostic factors. This study aimed to determine which patients may benefit from treatment intensification. PATIENTS AND METHODS: Patients who underwent curative resection with or without adjuvant radiotherapy between 2002 and 2014 were identified and a retrospective chart review was performed. Overall survival (OS) and disease-free survival (DFS) were the main outcomes measured. RESULTS: A total of 95 patients met the inclusion criteria. The median follow-up was 46.8 months. The median age was 60 years. Radiotherapy was given to 78 patients. Multivariate analysis revealed that male sex and perineural invasion significantly reduced overall and disease-free survival. Distant metastases comprised of 67% of recurrences and 33% were locoregional. CONCLUSION: Adjuvant chemoradiotherapy should be considered for patients with tumors with perineural invasion, especially in males with high-risk histopathology or high-grade, late-stage disease. To our knowledge, this is the first study to assess the impact of pack-year smoking history on survival outcomes.
[Mh] Termos MeSH primário: Adenocarcinoma/secundário
Carcinoma Adenoide Cístico/secundário
Carcinoma Mucoepidermoide/secundário
Carcinoma de Células Escamosas/secundário
Recidiva Local de Neoplasia/patologia
Neoplasias das Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/cirurgia
Idoso
Carcinoma Adenoide Cístico/cirurgia
Carcinoma Mucoepidermoide/cirurgia
Carcinoma de Células Escamosas/cirurgia
Feminino
Seguimentos
Seres Humanos
Metástase Linfática
Masculino
Meia-Idade
Gradação de Tumores
Recidiva Local de Neoplasia/cirurgia
Prognóstico
Estudos Retrospectivos
Neoplasias das Glândulas Salivares/cirurgia
Taxa de Sobrevida
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE


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[PMID]:28820917
[Au] Autor:Sant DW; Tao W; Field MG; Pelaez D; Jin K; Capobianco A; Dubovy SR; Tse DT; Wang G
[Ad] Endereço:John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States.
[Ti] Título:Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.
[So] Source:Invest Ophthalmol Vis Sci;58(6):BIO240-BIO246, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To identify genomic mutations in lacrimal gland adenoid cystic carcinoma (LGACC) samples from patients. Methods: Genomic DNA was extracted from LGACC specimens. Whole exome sequencing (exome-seq) was conducted to screen for mutations. Capillary sequencing was performed to verify mutations in genes shared by multiple samples. Luciferase assays were used to evaluate functional consequences of NOTCH1 mutations. Results: The mutation profile of LGACC was complicated. The most frequently mutated gene observed (28.6%) was bromodomain PHD finger transcription factor (BPTF). No mutation was identified in common cancer genes such as TP53, KRAS, and BRAF. However, mutations predicted to be functionally severe were accumulated in the Notch signaling pathway including NOTCH1 and NOTCH2, of which mutations have been reported in head/neck adenoid cystic carcinoma (ACC). Of 14 LGACC samples, five samples carry mutations in Notch pathway genes. Capillary sequencing verified all the mutations in the two NOTCH genes identified by exome-seq. Compared to the wild-type NOTCH1, three frame shifting mutations and two missense mutations (C387W and L1600Q) increased luciferase activity approximately 10- to 25-fold. Conclusions: Major genomic mutation profiles in LGACC were uncovered by exome-seq. Although preliminary in nature, the Notch pathway could be a potential therapeutic target for LGACC.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/genética
Exoma/genética
Neoplasias Oculares/genética
Genes Neoplásicos/genética
Doenças do Aparelho Lacrimal/genética
Receptor Notch1/genética
Receptor Notch2/genética
[Mh] Termos MeSH secundário: Western Blotting
DNA de Neoplasias/genética
Mutação da Fase de Leitura
Genes Reporter
Seres Humanos
Mutação de Sentido Incorreto
Plasmídeos
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Neoplasm); 0 (NOTCH1 protein, human); 0 (NOTCH2 protein, human); 0 (Receptor, Notch1); 0 (Receptor, Notch2)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170826
[Lr] Data última revisão:
170826
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21097


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[PMID]:28770621
[Au] Autor:Buchakjian MR; Davis AB; Sciegienka SJ; Pagedar NA; Sperry SM
[Ad] Endereço:1 Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals & Clinics, Iowa City, Iowa, USA.
[Ti] Título:Longitudinal Perioperative Pain Assessment in Head and Neck Cancer Surgery.
[So] Source:Ann Otol Rhinol Laryngol;126(9):646-653, 2017 Sep.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate perioperative pain in patients undergoing major head and neck cancer surgery and identify associations between preoperative and postoperative pain characteristics. METHODS: Patients undergoing head and neck surgery with regional/free tissue transfer were enrolled. Preoperative pain and validated screens for symptoms (neuropathic pain, anxiety, depression, fibromyalgia) were assessed. Postoperatively, patients completed a pain diary for 4 weeks. RESULTS: Twenty-seven patients were enrolled. Seventy-eight percent had pain prior to surgery, and for 38%, the pain had neuropathic characteristics. Thirteen patients (48%) completed at least 2 weeks of the postoperative pain diary. Patients with moderate/severe preoperative pain report significantly greater pain scores postoperatively, though daily pain decreased at a similar linear rate for all patients. Patients with more severe preoperative pain consumed greater amounts of opioids postoperatively, and this correlated with daily postoperative pain scores. Patients who screened positive for neuropathic pain also reported worse postoperative pain. CONCLUSION: Longitudinal perioperative pain assessment in head and neck patients undergoing surgery suggests that patients with worse preoperative pain continue to endorse worse pain postoperatively and require more narcotics. Patients with preoperative neuropathic pain also report poor pain control postoperatively, suggesting an opportunity to identify these patients and intervene with empiric neuropathic pain treatment.
[Mh] Termos MeSH primário: Dor do Câncer/fisiopatologia
Carcinoma de Células Escamosas/cirurgia
Neoplasias de Cabeça e Pescoço/cirurgia
Neuralgia/fisiopatologia
Procedimentos Cirúrgicos Otorrinolaringológicos
Dor Pós-Operatória/fisiopatologia
Neoplasias Cutâneas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Ameloblastoma/complicações
Ameloblastoma/cirurgia
Analgésicos Opioides/uso terapêutico
Ansiedade/psicologia
Dor do Câncer/etiologia
Dor do Câncer/psicologia
Carcinoma Adenoide Cístico/complicações
Carcinoma Adenoide Cístico/cirurgia
Carcinoma de Células Escamosas/complicações
Depressão/psicologia
Feminino
Neoplasias de Cabeça e Pescoço/complicações
Seres Humanos
Modelos Lineares
Estudos Longitudinais
Masculino
Melanoma/complicações
Melanoma/secundário
Melanoma/cirurgia
Meia-Idade
Neuralgia/etiologia
Neuralgia/psicologia
Medição da Dor
Dor Pós-Operatória/tratamento farmacológico
Dor Pós-Operatória/epidemiologia
Dor Pós-Operatória/psicologia
Neoplasias Parotídeas/complicações
Neoplasias Parotídeas/cirurgia
Período Perioperatório
Período Pré-Operatório
Índice de Gravidade de Doença
Neoplasias Cutâneas/complicações
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417723034


  9 / 5311 MEDLINE  
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[PMID]:28739497
[Au] Autor:Xu B; Aneja A; Ghossein R; Katabi N
[Ad] Endereço:Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
[Ti] Título:Salivary gland epithelial neoplasms in pediatric population: a single-institute experience with a focus on the histologic spectrum and clinical outcome.
[So] Source:Hum Pathol;67:37-44, 2017 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salivary gland epithelial neoplasms are rare in children and adolescents, with only a handful of large series having been published. A retrospective study was conducted for 57 cases in patients 20 years or younger. The tumors were located in the parotid (n=36), submandibular gland (n=7), and minor salivary glands (n=14). Nineteen (33%) tumors were pleomorphic adenoma, whereas the remaining (67%) were malignant. The histologic types of carcinomas were mucoepidermoid carcinoma (MEC, n=19, 33%), acinic cell carcinoma (n=7, 12%), adenoid cystic carcinoma (n=6, 11%), secretory carcinoma (mammary analogue) (SC, n=4, 7%), and myoepithelial carcinoma (n=2, 4%). Ninety-three percent (13/14) of the minor and 58% (25/43) of the major salivary gland tumors were malignant. A 7-year-old girl (2%) with a high-grade MEC died from her disease because of uncontrollable locoregional recurrence. Seven patients (16%) developed recurrence including 2 distant metastases from adenoid cystic carcinoma and 6 locoregional recurrences (2 pleomorphic adenomas, 1 SC, 1 myoepithelial carcinoma, 1 adenoid cystic carcinoma, and 1 MEC). The following parameters were associated with decreased disease-free survival in malignant tumors: elevated mitotic index of >4/10 high-power fields (log-rank test, P<.001), and advanced American Joint Committee on Cancer pT (P=.029) and pN stage (P<.001). In conclusion, myoepithelial carcinoma and SC can occur in the pediatric population and should be considered in the differential diagnosis. Salivary gland malignancies in children appear to have better clinical outcome, associated with a 10-year recurrence-free survival rate of 74% and a 10-year disease-specific survival of 94%.
[Mh] Termos MeSH primário: Adenoma/patologia
Carcinoma de Células Acinares/patologia
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/patologia
Mioepitelioma/patologia
Neoplasias das Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Adenoma/mortalidade
Adenoma/terapia
Adolescente
Fatores Etários
Biópsia
Carcinoma de Células Acinares/mortalidade
Carcinoma de Células Acinares/secundário
Carcinoma de Células Acinares/terapia
Carcinoma Adenoide Cístico/mortalidade
Carcinoma Adenoide Cístico/secundário
Carcinoma Adenoide Cístico/terapia
Carcinoma Mucoepidermoide/mortalidade
Carcinoma Mucoepidermoide/secundário
Carcinoma Mucoepidermoide/terapia
Criança
Pré-Escolar
Progressão da Doença
Intervalo Livre de Doença
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Mioepitelioma/mortalidade
Mioepitelioma/secundário
Mioepitelioma/terapia
Gradação de Tumores
Recidiva Local de Neoplasia
Cidade de Nova Iorque
Estudos Retrospectivos
Fatores de Risco
Neoplasias das Glândulas Salivares/mortalidade
Neoplasias das Glândulas Salivares/terapia
Centros de Atenção Terciária
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  10 / 5311 MEDLINE  
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[PMID]:28730646
[Au] Autor:Shirai K; Saitoh JI; Musha A; Abe T; Kobayashi D; Takahashi T; Tamaki T; Kawamura H; Takayasu Y; Shino M; Toyoda M; Takahashi K; Hirato J; Yokoo S; Chikamatsu K; Ohno T; Nakano T; Working Group on Head and Neck Tumors
[Ad] Endereço:Gunma University Heavy Ion Medical Center, Maebashi, Japan.
[Ti] Título:Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck.
[So] Source:Cancer Sci;108(10):2039-2044, 2017 Oct.
[Is] ISSN:1349-7006
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end-point was the 3-year local control rate, and the secondary end-points included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and three patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was dominant (60%). Four patients had local recurrence and five patients died. The 3-year local control and overall survival rates were 93% and 88%, respectively. Acute grade 2-3 radiation mucositis (65%) and dermatitis (31%) was common, which improved immediately with conservative therapy. Late mucositis of grade 2, grade 3, and grade 4 were observed in 11, one, and no patients, respectively. There were no adverse events of grade 5. Carbon-ion radiotherapy achieved excellent local control and overall survival rates for non-squamous cell carcinoma. However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/radioterapia
Neoplasias de Cabeça e Pescoço/radioterapia
Recidiva Local de Neoplasia/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma Adenoide Cístico/mortalidade
Intervalo Livre de Doença
Feminino
Neoplasias de Cabeça e Pescoço/mortalidade
Radioterapia com Íons Pesados/efeitos adversos
Seres Humanos
Masculino
Meia-Idade
Recidiva Local de Neoplasia/mortalidade
Estudos Prospectivos
Dosagem Radioterapêutica
Análise de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1111/cas.13325



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