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  1 / 1099 MEDLINE  
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[PMID]:29183000
[Au] Autor:van Netten JP; Cann SH; Thornton IG; Finegan RP
[Ad] Endereço:University of Victoria, Canada. Electronic address: jpvannetten@shaw.ca.
[Ti] Título:The lymphatics in infiltrating ductal carcinoma (IDC) of the breast.
[So] Source:Cancer Treat Rev;62:97, 2018 01.
[Is] ISSN:1532-1967
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias da Mama
Vasos Linfáticos
[Mh] Termos MeSH secundário: Carcinoma Ductal
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


  2 / 1099 MEDLINE  
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[PMID]:28457729
[Au] Autor:Seipel AH; Whitington T; Delahunt B; Samaratunga H; Mayrhofer M; Wiklund P; Grönberg H; Lindberg J; Egevad L
[Ad] Endereço:Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
[Ti] Título:Genetic profile of ductal adenocarcinoma of the prostate.
[So] Source:Hum Pathol;69:1-7, 2017 11.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite being discovered almost 50 years ago, little is known regarding the genetic profile of ductal adenocarcinoma of the prostate (DAC). In recent years, progress has been made in the understanding of the genetics of acinar adenocarcinomas, and at least 7 genetically different subtypes have been identified. DAC is known to present at an advanced stage with a high rate of extraprostatic extension and seminal vesicle invasion, and a decreased interval to biochemical recurrence and the development of metastatic disease when compared with acinar adenocarcinoma. Our aim was to investigate the genetic profile of DAC to determine whether there is a genomic rationale for the aggressive behavior associated with this tumor type. Frozen tissue from 11 cases of DAC with paired benign tissue was analyzed. After DNA extraction, copy-number alteration analysis was performed, as well as identification of mutations and indels. We compared the fraction of the DAC genome with copy-number alteration to previous results from 74 primary acinar adenocarcinomas of the prostate. The alteration rate in DAC was comparable to that of acinar adenocarcinoma of high Gleason score. DAC harbored somatic changes seen in advanced and/or metastatic castration-resistant acinar adenocarcinoma, which likely accounts for its aggressive biological behavior.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Carcinoma Ductal/genética
Perfilação da Expressão Gênica/métodos
Neoplasias de Próstata Resistentes à Castração/genética
Neoplasias da Próstata/genética
Transcriptoma
[Mh] Termos MeSH secundário: Idoso
Carcinoma Ductal/secundário
Variações do Número de Cópias de DNA
Análise Mutacional de DNA
Dosagem de Genes
Predisposição Genética para Doença
Seres Humanos
Mutação INDEL
Masculino
Meia-Idade
Gradação de Tumores
Invasividade Neoplásica
Estadiamento de Neoplasias
Fenótipo
Neoplasias da Próstata/patologia
Neoplasias de Próstata Resistentes à Castração/patologia
Carga Tumoral
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  3 / 1099 MEDLINE  
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[PMID]:29091571
[Au] Autor:Oide T; Mitsuishi T
[Ad] Endereço:Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan oide.takashi@twmu.ac.jp.
[Ti] Título:Pigmented Macule - A Skin Manifestation of Invasive Breast Cancer.
[So] Source:N Engl J Med;377(18):1777, 2017 Nov 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Carcinoma Ductal/patologia
Mamilos/patologia
Síndromes Paraneoplásicas/patologia
Pigmentação da Pele
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Invasividade Neoplásica/patologia
Pele/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171102
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1704791


  4 / 1099 MEDLINE  
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[PMID]:28813661
[Au] Autor:Zhu Y; Herndon JM; Sojka DK; Kim KW; Knolhoff BL; Zuo C; Cullinan DR; Luo J; Bearden AR; Lavine KJ; Yokoyama WM; Hawkins WG; Fields RC; Randolph GJ; DeNardo DG
[Ad] Endereço:Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; ICCE Institute, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
[Ti] Título:Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
[So] Source:Immunity;47(2):323-338.e6, 2017 Aug 15.
[Is] ISSN:1097-4180
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tumor-associated macrophages (TAMs) are essential components of the cancer microenvironment and play critical roles in the regulation of tumor progression. Optimal therapeutic intervention requires in-depth understanding of the sources that sustain macrophages in malignant tissues. In this study, we investigated the ontogeny of TAMs in murine pancreatic ductal adenocarcinoma (PDAC) models. We identified both inflammatory monocytes and tissue-resident macrophages as sources of TAMs. Unexpectedly, significant portions of pancreas-resident macrophages originated from embryonic development and expanded through in situ proliferation during tumor progression. Whereas monocyte-derived TAMs played more potent roles in antigen presentation, embryonically derived TAMs exhibited a pro-fibrotic transcriptional profile, indicative of their role in producing and remodeling molecules in the extracellular matrix. Collectively, these findings uncover the heterogeneity of TAM origin and functions and could provide therapeutic insight for PDAC treatment.
[Mh] Termos MeSH primário: Carcinogênese
Carcinoma Ductal/imunologia
Macrófagos/imunologia
Pâncreas/patologia
Neoplasias Pancreáticas/imunologia
[Mh] Termos MeSH secundário: Animais
Carcinoma Ductal/patologia
Diferenciação Celular
Linhagem Celular Tumoral
Movimento Celular
Matriz Extracelular/metabolismo
Desenvolvimento Fetal
Fibrose
Hematopoese
Macrófagos/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Monócitos/imunologia
Neoplasias Pancreáticas/patologia
Microambiente Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


  5 / 1099 MEDLINE  
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[PMID]:28699202
[Au] Autor:Vinceneux A; Bruyère F; Haillot O; Charles T; de la Taille A; Salomon L; Allory Y; Ouzaid I; Choudat L; Rouprêt M; Comperat E; Houede N; Beauval JB; Vourc'h P; Fromont G
[Ad] Endereço:Department of Pathology, CHU de tours, Université François Rabelais, Tours, France.
[Ti] Título:Ductal adenocarcinoma of the prostate: Clinical and biological profiles.
[So] Source:Prostate;77(12):1242-1250, 2017 Sep.
[Is] ISSN:1097-0045
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ductal adenocarcinoma (DAC) is a rare and aggressive subtype of prostate cancer (PCa). In the present study, we analyzed the clinical and biological characteristics of DAC, in comparison with high grade conventional acinar PCa. METHODS: Samples and data were retrospectively collected from seven institutions and centrally reviewed. Immunohistochemistry was performed on tissue microarrays to assess the expression of candidate proteins, based on the molecular classification of PCa, including ERG, PTEN, and SPINK1. SPOP mutations were investigated from tumor DNA by Sanger sequencing. Relationships with outcome were analyzed using log-rank analysis and multivariable Cox regression. RESULTS: Among 56 reviewed prostatectomy specimens, 45 cases of DAC were finally confirmed. The pathological stage was pT3 in more than 66% of cases. ERG was expressed in 42% of DAC, SPINK1 in 9% (all ERG-negative), and two cases (ERG-negative) harbored a SPOP mutation. Compared to high grade conventional PCa matched for the pathological stage, cell proliferation was higher (P = 0.04) in DAC, and complete PTEN loss more frequent (P = 0.023). In multivariate analysis, SPINK1 overexpression (P = 0.017) and loss of PSA immunostaining (P = 0.02) were significantly associated with biochemical recurrence. CONCLUSION: these results suggest that, despite biological differences that highlighted DAC aggressiveness, the molecular classification recently proposed in conventional PCa could also be applied in DAC.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/biossíntese
Carcinoma Ductal/diagnóstico
Carcinoma Ductal/metabolismo
Neoplasias da Próstata/diagnóstico
Neoplasias da Próstata/metabolismo
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/genética
Carcinoma Ductal/genética
Seres Humanos
Masculino
Meia-Idade
Estadiamento de Neoplasias/métodos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1002/pros.23383


  6 / 1099 MEDLINE  
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[PMID]:28618949
[Au] Autor:Zhao HY; Han Y; Wang J; Yang LH; Zheng XY; Du J; Wu GP; Wang EH
[Ad] Endereço:Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
[Ti] Título:IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
[So] Source:Tumour Biol;39(6):1010428317705769, 2017 Jun.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IQ-domain GTPase-activating protein 1 is a scaffolding protein with multidomain which plays a role in modulating dishevelled (Dvl) nuclear translocation in canonical Wnt pathway. However, the biological function and mechanism of IQ-domain GTPase-activating protein 1 in invasive ductal carcinoma (IDC) remain unknown. In this study, we found that IQ-domain GTPase-activating protein 1 expression was elevated in invasive ductal carcinoma, which was positively correlated with tumor grade, lymphatic metastasis, and poor prognosis. Coexpression of IQ-domain GTPase-activating protein 1 and Dvl in the nucleus and cytoplasm of invasive ductal carcinoma was significantly correlated but not in the membrane. Postoperative survival in the patients with their coexpression in the nucleus and cytoplasm was obviously lower than that without coexpression. The positive expression rates of c-myc and cyclin D1 were significantly higher in the patients with nuclear coexpression of Dvl and IQ-domain GTPase-activating protein 1 than that with cytoplasmic coexpression, correlating with poor prognosis. IQ-domain GTPase-activating protein 1 significantly enhanced cell proliferation and invasion in invasive ductal carcinoma cell lines by interacting with Dvl in cytoplasm to promote Dvl nuclear translocation so as to upregulate the expression of c-myc and cyclin D1. Collectively, our data suggest that IQ-domain GTPase-activating protein 1 may promote the malignant phenotype of invasive ductal carcinoma via canonical Wnt signaling, and it could be used as a potential prognostic biomarker for breast cancer patients.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Neoplasias da Mama/genética
Carcinoma Ductal/genética
Proteínas Ativadoras de ras GTPase/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasias da Mama/patologia
Neoplasias da Mama/cirurgia
Carcinoma Ductal/patologia
Carcinoma Ductal/cirurgia
Ciclina D1/genética
Feminino
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Metástase Linfática
Meia-Idade
Invasividade Neoplásica/genética
Prognóstico
Proteínas Proto-Oncogênicas c-myc/genética
Análise de Sobrevida
Via de Sinalização Wnt/genética
beta Catenina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CCND1 protein, human); 0 (IQ motif containing GTPase activating protein 1); 0 (MYC protein, human); 0 (Proto-Oncogene Proteins c-myc); 0 (beta Catenin); 0 (ras GTPase-Activating Proteins); 136601-57-5 (Cyclin D1)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317705769


  7 / 1099 MEDLINE  
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[PMID]:28591263
[Au] Autor:Rodrigues FT; Klemig LR; Cardozo MRP; Alves PC; Aguiar VM; Lessa CS
[Ad] Endereço:Universidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:Myiasis associated with an invasive ductal carcinoma of the left breast: case study.
[So] Source:Rev Inst Med Trop Sao Paulo;59:e35, 2017 Jun 01.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Most breast cancers originate in the ductal epithelium and are referred to as invasive ductal carcinoma. In this study we report on the clinical procedures adopted to diagnose myiasis in association with infiltrating metastatic breast carcinoma in a female patient. A 41 years old woman came to the Federal Hospital of Andaraí complaining of intense itching, warmth, redness and hardening of the breast, which had acquired the aspect of an orange peel. A lesion in the left breast was cavitated, dimpled, had fetid odor, and had fibrotic and infected air nodules filled with exudate and Dipteran larvae. The tissue was cleaned and 33 larvae were extracted. The patient was hospitalized and received Ivermectin. Eighteen of the larvae extracted from the patient were placed in 70% alcohol, and twelve were placed in a container with sterile wood shavings under controlled conditions until they metamorphosed into adults. The taxonomic identification of the flies revealed that the culprit was Cochliomyia hominivorax. A histopathological exam conducted three months earlier had revealed infiltrating ductal carcinoma. Two months after the myiasis treatment, the breast tissue had healed. The patient had waited ten days from the onset of the myiasis to seek treatment, and that delay interfered negatively in the prognosis of both the neoplasm and the myiasis. This study is relevant to public health in view of the strong social impact of myiasis.
[Mh] Termos MeSH primário: Neoplasias da Mama/complicações
Carcinoma Ductal/complicações
Miíase/complicações
[Mh] Termos MeSH secundário: Adulto
Animais
Antiparasitários/uso terapêutico
Neoplasias da Mama/parasitologia
Carcinoma Ductal/parasitologia
Feminino
Seres Humanos
Ivermectina/uso terapêutico
Larva
Miíase/diagnóstico
Miíase/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Antiparasitic Agents); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  8 / 1099 MEDLINE  
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[PMID]:28422303
[Au] Autor:Tang B; Han CT; Gan HL; Zhang GM; Zhang CZ; Yang WY; Shen Y; Zhu Y; Ye DW
[Ad] Endereço:Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
[Ti] Título:Smoking increased the risk of prostate cancer with grade group ≥ 4 and intraductal carcinoma in a prospective biopsy cohort.
[So] Source:Prostate;77(9):984-989, 2017 Jun.
[Is] ISSN:1097-0045
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the association between smoking and different prostate cancer (PCa) pathological subtypes incidence in Chinese men. PATIENTS AND METHODS: We prospectively included 1795 patients who underwent prostate biopsies in one tertiary center between March 2013 and April 2016. Clinical data and biopsy outcomes were collected. Logistic regression was used to evaluate the association between cigarette smoking and PCa incidence. RESULTS: A total of 737 men, 480 men and 58 men were diagnosed with PCa, high-grade PCa (HGPCa, grade group ≥ 4 as accepted by the 2014 ISUP) and intraductal carcinoma of the prostate (IDC-P), respectively. Current smokers had a significantly higher risk of HGPCa than never smokers (OR = 1.89, 95%CI: 1.44-2.48). No such association was observed for low-grade disease and cigarette smoking (OR = 0.84, 95%CI: 0.61-1.16). In a sub-analysis, men who had smoked longer than 30 years had a higher risk of HGPCa, compared with men who had smoked fewer than 30 years (OR = 1.50, 95%CI: 1.09-2.06). Current smokers were more likely to develop IDC-P than never smokers (OR = 2.29, 95%CI: 1.14-4.59). CONCLUSION: Among men in this Chinese biopsy cohort, current smoking was associated with highly malignant PCa incidence, such as HGPCa and IDC-P. The duration of smoking may be associated with HGPCa.
[Mh] Termos MeSH primário: Carcinoma Ductal
Próstata/patologia
Neoplasias da Próstata
Fumar/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Biópsia/métodos
Biópsia/estatística & dados numéricos
Carcinoma Ductal/epidemiologia
Carcinoma Ductal/patologia
China/epidemiologia
Seres Humanos
Incidência
Masculino
Meia-Idade
Estudos Prospectivos
Neoplasias da Próstata/epidemiologia
Neoplasias da Próstata/patologia
Fatores de Risco
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1002/pros.23354


  9 / 1099 MEDLINE  
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[PMID]:28353089
[Au] Autor:Ihrler S; Guntinas-Lichius O; Agaimy A; Wolf A; Mollenhauer M
[Ad] Endereço:Laboratory for Dermatohistology and Oral Pathology, Munich, Germany. Ihrler@dermpath-muenchen.de.
[Ti] Título:Histological, immunohistological and molecular characteristics of intraductal precursor of carcinoma ex pleomorphic adenoma support a multistep carcinogenic process.
[So] Source:Virchows Arch;470(6):601-609, 2017 Jun.
[Is] ISSN:1432-2307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In recent years, multistep carcinogenesis of carcinoma ex pleomorphic adenoma (CEPA) has been identified, starting with intraductal neoplasia within pre-existent pleomorphic adenoma (PA). However, as yet there is no consensus regarding clinical relevance and appropriate terminology of precursor lesions in CEPA. We therefore decided to investigate precursor lesions, especially intraductal carcinoma, in a series of 85 cases of CEPA. Intraductal carcinoma confined by benign myoepithelial cells was found in 60 cases and mostly exhibited high-grade cellular atypia, increased cellular proliferation and frequent genetic alterations (TP53, Her2-neu, androgen receptor). Intraductal carcinoma was absent only in the myoepithelial type of CEPA. In 26 cases, purely intraductal CEPA with extensive intraductal expansion was found. This suggests that there is a long period of intraductal growth before extraductal intracapsular infiltration of the PA. We identified two different histomorphological types of intraductal carcinoma, which we call 'clinging' and 'solid' types. In summary, combined histological, immunohistological and molecular data strongly support multistep carcinogenesis starting with intraductal carcinoma for all non-myoepithelial types of CEPA. The clinical significance of our finding of two histomorphological types of intraductal carcinoma (clinging and solid) is not yet clear. Intraductal carcinoma, intracapsular invasive CEPA and minor extracapsular invasive CEPA (up to about 6 mm) all show favourable prognosis and together comprise half of the cases in our study.
[Mh] Termos MeSH primário: Adenoma Pleomorfo/patologia
Carcinoma in Situ/patologia
Carcinoma Ductal/patologia
Lesões Pré-Cancerosas/patologia
Neoplasias das Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Proteínas de Ciclo Celular/análise
Proteínas de Ciclo Celular/biossíntese
Feminino
Seres Humanos
Imuno-Histoquímica
Hibridização In Situ
Masculino
Meia-Idade
Receptor ErbB-2/análise
Receptor ErbB-2/biossíntese
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cell Cycle Proteins); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, ErbB-2)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1007/s00428-017-2106-2


  10 / 1099 MEDLINE  
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[PMID]:28331027
[Au] Autor:Symington M; Davies L; Kaltsas G; Weickert MO
[Ad] Endereço:The ARDEN NET Centre, ENETS CoE, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
[Ti] Título:Malignant hypercalcaemia related to parathyroid hormone-related peptide (PTHrP) secretion from a metastatic pancreatic neuroendocrine tumour (NET).
[So] Source:BMJ Case Rep;2017, 2017 Mar 22.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 54-year-old woman presented to our centre with acute abdominal pain and vomiting. Routine blood tests showed severe hypercalcaemia (>4 mmol/L). Serum parathyroid hormone (PTH) was suppressed. CT scan detected a pancreatic mass and some liver lesions, initially suspicious for metastatic pancreatic adenocarcinoma. Liver biopsy however revealed the presence of a well-differentiated, grade 1, metastatic neuroendocrine tumour (NET) where prognosis is considerably better. Serum PTHrP was raised, indicating paraneoplastic hypercalcaemia, most likely secondary to the pancreatic NET. Following injection of a short-acting somatostatin analogue octreotide, serum PTHrP levels normalised within 24 hours, causing a rapid drop of serum calcium below the lower limit of normal and an immediate compensatory rise of serum PTH. Ongoing treatment with long-acting somatostatin analogues together with replacement with calcium carbonate, vitamin D3 and once weekly alendronic acid resulted in stable normal adjusted calcium levels over a 3-month follow-up period.
[Mh] Termos MeSH primário: Hipercalcemia
Tumores Neuroendócrinos/complicações
Neoplasias Pancreáticas/complicações
Síndromes Paraneoplásicas
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Neoplasias da Mama/diagnóstico
Neoplasias da Mama/cirurgia
Carcinoma Ductal/diagnóstico
Carcinoma Ductal/cirurgia
Feminino
Fármacos Gastrointestinais/uso terapêutico
Seres Humanos
Imagem por Ressonância Magnética
Meia-Idade
Tumores Neuroendócrinos/diagnóstico
Tumores Neuroendócrinos/terapia
Octreotida/uso terapêutico
Neoplasias Pancreáticas/diagnóstico
Neoplasias Pancreáticas/patologia
Hormônio Paratireóideo/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrointestinal Agents); 0 (Parathyroid Hormone); RWM8CCW8GP (Octreotide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE



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