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Pesquisa : C04.557.470.200.025.290.500 [Categoria DeCS]
Referências encontradas : 922 [refinar]
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  1 / 922 MEDLINE  
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[PMID]:29298151
[Au] Autor:Atri D; Furfaro D; Dhaliwal G; Feingold KR; Manesh R
[Ad] Endereço:From the Department of Medicine, Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore (D.A., D.F., R.M.); and the Department of Medicine, University of California, San Francisco, and the Medical Service, San Francisco Veterans Affairs Medical Center - both in San Francis
[Ti] Título:Going from A to Z.
[So] Source:N Engl J Med;378(1):73-79, 2018 01 04.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Diarreia/etiologia
Gastrinoma/diagnóstico
Neoplasias Hepáticas/secundário
Fígado/diagnóstico por imagem
Neoplasias Primárias Desconhecidas/diagnóstico
Síndrome de Zollinger-Ellison/diagnóstico
[Mh] Termos MeSH secundário: Abdome/diagnóstico por imagem
Dor Abdominal/etiologia
Idoso
Análise Química do Sangue
Doença Crônica
Diagnóstico Diferencial
Gastrinoma/complicações
Gastrinoma/diagnóstico por imagem
Seres Humanos
Fígado/patologia
Neoplasias Hepáticas/diagnóstico
Neoplasias Hepáticas/patologia
Imagem por Ressonância Magnética
Masculino
Neoplasias Primárias Desconhecidas/complicações
Policitemia/complicações
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Síndrome de Zollinger-Ellison/complicações
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


  2 / 922 MEDLINE  
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[PMID]:28705492
[Au] Autor:Chen Y; Deshpande V; Ferrone C; Blaszkowsky LS; Parangi S; Warshaw AL; Lillemoe KD; Fernandez-Del Castillo C
[Ad] Endereço:Department of Surgery, Massachusetts General Hospital, Boston, MA.
[Ti] Título:Primary lymph node gastrinoma: A single institution experience.
[So] Source:Surgery;162(5):1088-1094, 2017 Nov.
[Is] ISSN:1532-7361
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gastrinomas are rare neuroendocrine tumors that ectopically secrete gastrin and classically originate within the duodenum or pancreas. The presence of primary lymph node gastrinoma is controversial. We report on a single institution's experience with gastrinoma, with focus on primary lymph node tumors. METHODS: Patients who underwent operative resection of gastrinoma between 1992 and 2016 at a single institution were identified. A diagnosis of primary lymph node gastrinoma was defined as tumor confined to one or more resected peripancreatic lymph nodes, negative localization for any extra-nodal disease and normal gastrin postresection. RESULTS: In the study, 39 consecutive patients underwent operative resection of gastrinoma. Mean age was 53 years and 49% were male. 93% of patients had successful preoperative localization. Furthermore, 19 patients (49%) underwent enucleation of their tumor and 14 (35.9%) a pancreatic resection. Overall 5- and 10-year survival for all patients was 80.8% and 60.7%, respectively. Primary lymph node gastrinoma was identified in 11 cases (28.2%). The presentation of primary lymph node and non-primary lymph node patients were similar. There was no significant difference in operation type, tumor size, or overall survival. At median follow-up of 59 months, patients with primary lymph node gastrinoma were less likely to have persistent or recurrent disease (9.1% vs 42.9%, P = .04). CONCLUSION: This series supports the existence of primary lymph node gastrinomas, and indicates that as many as 1 in 4 patients with gastrinoma have this form of the disease. This entity should be considered when an isolated pathologic lymph node is identified, although thorough exploration is still recommended to exclude other occult disease.
[Mh] Termos MeSH primário: Gastrinoma/cirurgia
Linfonodos/patologia
Linfoma/cirurgia
[Mh] Termos MeSH secundário: Feminino
Gastrinoma/diagnóstico por imagem
Gastrinoma/patologia
Seres Humanos
Linfonodos/diagnóstico por imagem
Linfonodos/cirurgia
Linfoma/diagnóstico por imagem
Linfoma/patologia
Masculino
Meia-Idade
Sistema de Registros
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE


  3 / 922 MEDLINE  
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[PMID]:28566601
[Au] Autor:Murakami T; Usui T; Nakamoto Y; Nakajima A; Mochida Y; Saito S; Shibayama T; Yamazaki N; Hatoko T; Kato T; Yonemitsu S; Muro S; Oki S
[Ad] Endereço:Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
[Ti] Título:Challenging Differential Diagnosis of Hypergastremia and Hyperglucagonemia with Chronic Renal Failure: Report of a Case with Multiple Endocrine Neoplasia Type 1.
[So] Source:Intern Med;56(11):1375-1381, 2017.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A 53-year-old woman developed end-stage renal failure during a 15-year clinical course of primary hyperparathyroidism and was referred to our hospital for evaluation of suspected multiple endocrine neoplasia type 1 (MEN1). Genetic testing revealed a novel deletion mutation at codon 467 in exon 10 of the MEN1 gene. Systemic and selective arterial calcium injection (SACI) testing revealed hyperglucagonemia and hypergastrinemia with positive gastrin responses. A pathological examination revealed glucagonoma and a lymph node gastrinoma. The findings in this case indicate the importance of early diagnosis of MEN1 and demonstrate the utility of systemic and SACI testing in renal failure cases.
[Mh] Termos MeSH primário: Neoplasia Endócrina Múltipla Tipo 1/diagnóstico
Neoplasia Endócrina Múltipla Tipo 1/fisiopatologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Gastrinoma/diagnóstico
Glucagonoma/diagnóstico
Seres Humanos
Falência Renal Crônica/diagnóstico
Linfonodos/patologia
Meia-Idade
Neoplasia Endócrina Múltipla Tipo 1/genética
Neoplasias Pancreáticas/diagnóstico
Proteínas Proto-Oncogênicas
Insuficiência Renal Crônica/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MEN1 protein, human); 0 (Proto-Oncogene Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.56.7230


  4 / 922 MEDLINE  
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[PMID]:28540972
[Au] Autor:Lipinski M; Rydzewska G; Foltyn W; Andrysiak-Mamos E; Baldys-Waligórska A; Bednarczuk T; Blicharz-Dorniak J; Bolanowski M; Boratyn-Nowicka A; Borowska M; Cichocki A; Cwikla JB; Falconi M; Handkiewicz-Junak D; Hubalewska-Dydejczyk A; Jarzab B; Junik R; Kajdaniuk D; Kaminski G; Kolasinska-Cwikla A; Kowalska A; Król R; Królicki L; Kunikowska J; Kusnierz K; Lampe P; Lange D; Lewczuk-Myslicka A; Lewinski A; Londzin-Olesik M; Marek B; Nasierowska-Guttmejer A; Nowakowska-Dulawa E; Pilch-Kowalczyk J; Poczkaj K; Rosiek V; Ruchala M; Sieminska L; Sowa-Staszczak A; Starzynska T; Steinhof-Radwanska K; Strzelczyk J; Sworczak K; Syrenicz A; Szawlowski A; Szczepkowski M; Wachula E; Zajecki W; Zemczak A; Zgliczynski W
[Ti] Título:Gastroduodenal neuroendocrine neoplasms, including gastrinoma - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours).
[So] Source:Endokrynol Pol;68(2):138-153, 2017.
[Is] ISSN:2299-8306
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:This paper presents the updated Polish Neuroendocrine Tumour Network expert panel recommendations on the management of neuroendocrine neoplasms (NENs) of the stomach and duodenum, including gastrinoma. The recommendations discuss the epidemiology, pathogenesis, and clinical presentation of these tumours as well as their diagnosis, including biochemical, histopathological, and localisation diagnoses. The principles of treatment are discussed, including endoscopic, surgical, pharmacological, and radionuclide treatments. Finally, there are also recommendations on patient monitoring.
[Mh] Termos MeSH primário: Gerenciamento Clínico
Neoplasias Duodenais/diagnóstico
Gastrinoma/diagnóstico
Tumores Neuroendócrinos/diagnóstico
Sociedades Médicas
Neoplasias Gástricas/diagnóstico
[Mh] Termos MeSH secundário: Neoplasias Duodenais/etiologia
Neoplasias Duodenais/patologia
Neoplasias Duodenais/terapia
Endocrinologia
Feminino
Gastrinoma/terapia
Seres Humanos
Masculino
Oncologia
Tumores Neuroendócrinos/etiologia
Tumores Neuroendócrinos/patologia
Tumores Neuroendócrinos/terapia
Polônia
Neoplasias Gástricas/etiologia
Neoplasias Gástricas/patologia
Neoplasias Gástricas/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.5603/EP.2017.0016


  5 / 922 MEDLINE  
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[PMID]:28446479
[Au] Autor:Abu Ghanimeh M; Abuamr K; Sadeddin E; Yousef O
[Ad] Endereço:Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
[Ti] Título:Severe chronic diarrhoea secondary to primary lymph node gastrinoma.
[So] Source:BMJ Case Rep;2017, 2017 Apr 26.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The existence of primary lymph node (LN) gastrinoma is questionable and controversial. In fact, the presence of gastrinoma in such uncommon site raises the possibility of metastasis from another occult primary site. An extensive evaluation and careful follow-up is always warranted. A female aged 48 years presented with chronic abdominal pain and watery diarrhoea. Her serum gastrin and chromogranin were elevated, and an underlying gastrinoma was suspected. Further evaluation with an octreotide scan, an endoscopic ultrasound and a secretin stimulation test confirmed the diagnosis. Further evaluation for multiple endocrine neoplasia-1 syndrome was negative. She underwent a surgical enucleation near the head of the pancreas. No other lesions were found after careful exploration of the gastrinoma triangle. Histology showed a LN with a neuroendocrine tumour that tested positively with gastrin and chromogranin stains. Her symptoms resolved postoperatively, her serum gastrin normalised and a repeated octreotide scan was negative.
[Mh] Termos MeSH primário: Diarreia/etiologia
Gastrinoma/diagnóstico
Linfonodos/patologia
Tumores Neuroendócrinos/diagnóstico
[Mh] Termos MeSH secundário: Cromograninas/sangue
Feminino
Gastrinoma/metabolismo
Gastrinoma/cirurgia
Gastrinas/sangue
Seres Humanos
Linfonodos/cirurgia
Meia-Idade
Tumores Neuroendócrinos/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromogranins); 0 (Gastrins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  6 / 922 MEDLINE  
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[PMID]:28270118
[Au] Autor:Matsubayashi H; Kawata N; Kakushima N; Tanaka M; Takizawa K; Kiyozumi Y; Horiuchi Y; Sasaki K; Sugiura T; Uesaka K; Ono H
[Ad] Endereço:Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan. h.matsubayashi@scchr.jp.
[Ti] Título:A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.
[So] Source:BMC Gastroenterol;17(1):37, 2017 Mar 07.
[Is] ISSN:1471-230X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. Treatment for his esophageal stricture and ZES was discussed. CASE PRESENTATION: A 43-year-old man with progressive dysphagia and diarrhea was referred to the teaching hospital. He had a history of recurrent duodenojejunal perforations despite the anti-secretory medication. Blood examinations revealed elevated serum gastrin, calcium, and parathyroid hormone. Upper gastrointestinal endoscopy demonstrated a severe esophageal stricture, multiple gastroduodenal ulcer scars, and a duodenal submucosal tumor. Enhanced computed tomography showed multiple hypervascular tumors within the pancreas and duodenum, suggestive of MEN1. Genetic examination demonstrated a pathogenic MEN1 mutation. Repetitive endoscopic esophageal dilatation with intralesional corticosteroid injection, coupled with pancreatoduodenectomy were performed to improve the patient's symptoms and to treat pancreatic tumors. The histology of multiple tumors in the duodenum and pancreas were all consistent with neuroendocrine tumors. His hypergastrinemia subsided and he remained asymptomatic in his gastrointestinal tract after these treatments. CONCLUSION: For esophageal stenosis in case of MEN1/ZES, anti-secretory therapy and endoscopic dilatation with corticosteroid injection could be recommended. However, in refractory cases with repetitive and/or severe complications due to high acid secretion, surgical treatment could be considered as an option.
[Mh] Termos MeSH primário: Neoplasias Duodenais/cirurgia
Estenose Esofágica/terapia
Gastrinoma/cirurgia
Glucocorticoides/uso terapêutico
Neoplasias Pancreáticas/cirurgia
Triancinolona/uso terapêutico
Síndrome de Zollinger-Ellison/cirurgia
[Mh] Termos MeSH secundário: Adulto
Dilatação/métodos
Neoplasias Duodenais/complicações
Neoplasias Duodenais/diagnóstico por imagem
Estenose Esofágica/etiologia
Esofagite Péptica/etiologia
Esofagoscopia
Gastrinoma/complicações
Gastrinoma/diagnóstico por imagem
Seres Humanos
Injeções Intralesionais
Masculino
Neoplasia Endócrina Múltipla Tipo 1/complicações
Neoplasia Endócrina Múltipla Tipo 1/diagnóstico por imagem
Neoplasias Pancreáticas/complicações
Neoplasias Pancreáticas/diagnóstico por imagem
Pancreaticoduodenectomia/métodos
Tomografia Computadorizada por Raios X
Síndrome de Zollinger-Ellison/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 1ZK20VI6TY (Triamcinolone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1186/s12876-017-0597-6


  7 / 922 MEDLINE  
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[PMID]:28070096
[Au] Autor:Miura M; Kitamura K; Arai K; Kawaguchi K; Yamashita T; Sakai Y; Yamashita T; Mizukoshi E; Honda M; Kaneko S
[Ad] Endereço:Department of Gastroenterology, Kanazawa University Hospital.
[Ti] Título:Acute kidney injury following vomiting and diarrhea after endoscopy in a duodenal gastrinoma patient.
[So] Source:Nihon Shokakibyo Gakkai Zasshi;114(1):69-77, 2017.
[Is] ISSN:0446-6586
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 51-year-old woman complaining of weakness in the limbs was diagnosed as having a duodenal gastrinoma on performing a further evaluation. Surgical resection was performed with selective arterial calcium injection for localization. During preoperative hospitalization, she experienced recurrent severe vomiting and diarrhea after endoscopy, leading to acute kidney injury. To our knowledge, this is the first report of gastrinoma with post-endoscopy symptom exacerbation. Although the etiology is unknown, the findings in this case suggest that sufficient fluid replacement, sedation, and high-dose proton pump inhibitor administration should be taken into consideration when performing endoscopy in gastrinoma patients.
[Mh] Termos MeSH primário: Lesão Renal Aguda
Diarreia
Neoplasias Duodenais/cirurgia
Endoscopia Gastrointestinal
Gastrinoma/cirurgia
Complicações Pós-Operatórias
Vômito
[Mh] Termos MeSH secundário: Lesão Renal Aguda/etiologia
Lesão Renal Aguda/prevenção & controle
Diarreia/etiologia
Diarreia/prevenção & controle
Endoscopia Gastrointestinal/efeitos adversos
Feminino
Hidratação
Seres Humanos
Meia-Idade
Complicações Pós-Operatórias/etiologia
Complicações Pós-Operatórias/prevenção & controle
Inibidores da Bomba de Prótons/administração & dosagem
Vômito/etiologia
Vômito/prevenção & controle
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.11405/nisshoshi.114.69


  8 / 922 MEDLINE  
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[PMID]:27876341
[Au] Autor:Dromain C; Déandréis D; Scoazec JY; Goere D; Ducreux M; Baudin E; Tselikas L
[Ad] Endereço:Service de radiodiagnostic et radiologie interventionnelle, bureau CIBM 09-084, rue Bugnon 46, 1011 Lausanne, Switzerland. Electronic address: Clarisse.Dromain@chuv.ch.
[Ti] Título:Imaging of neuroendocrine tumors of the pancreas.
[So] Source:Diagn Interv Imaging;97(12):1241-1257, 2016 Dec.
[Is] ISSN:2211-5684
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Pancreatic neuroendocrine tumors (PNETs) are rare and represent a heterogeneous disease. PNET can be functioning or non-functioning with different clinical presentations and different prognosis based on WHO and pTNM classifications. The role of imaging includes the localization of small functioning tumor, differentiation of these tumors from adenocarcinoma, identification of signs of malignancy and evaluation of extent. PNETs have a broad spectrum of appearance. On CT and MRI, most of functioning PNETs are well defined small tumors with intense and homogeneous enhancement on arterial and portal phases. However, some PNETs with a more fibrous content may have a more delayed enhancement that is best depicted on the delayed phase. Other PNETs can present as purely cystic, complex cystic and solid tumors and calcified tumors. Non-functioning PNETs are larger with less intense and more heterogeneous enhancement. Functional imaging is useful for disease staging, to detect disease recurrence or the primary but also to select patient candidate for peptide receptor radiometabolic treatment. Somatostatin receptor scintigraphy (SRS) (Octreoscan ) is still the most available technique. Gallium 68-SST analogue PET have been demonstrated to be more sensitive than SRS-SPEC and it will be the future of functional imaging for NET. Finally, FDG PET/CT is indicated for more aggressive PNET as defined either by negative SRS and huge tumor burden or ki67 above 10% or poorly differentiated PNEC tumors.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética
Tumores Neuroendócrinos/diagnóstico por imagem
Neoplasias Pancreáticas/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Endossonografia
Gastrinoma/diagnóstico por imagem
Gastrinoma/patologia
Seres Humanos
Insulinoma/diagnóstico por imagem
Insulinoma/patologia
Metástase Linfática/diagnóstico por imagem
Metástase Linfática/patologia
Gradação de Tumores
Estadiamento de Neoplasias
Tumores Neuroendócrinos/patologia
Neoplasias Pancreáticas/patologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


  9 / 922 MEDLINE  
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[PMID]:27457843
[Au] Autor:Sparkman BK; Earl TM
[Ad] Endereço:General Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
[Ti] Título:Sporadic, Primary Lymph Node Gastrinoma.
[So] Source:Am Surg;82(7):155-7, 2016 Jul.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Gastrinoma/patologia
Linfonodos/patologia
Neoplasias Pancreáticas/patologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE


  10 / 922 MEDLINE  
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[PMID]:27348901
[Au] Autor:Okada K; Sudo T; Miyamoto K; Yokoyama Y; Sakashita Y; Hashimoto Y; Kobayashi H; Otsuka H; Sakoda T; Shimamoto F
[Ti] Título:The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report.
[So] Source:Hiroshima J Med Sci;65(1):13-7, 2016 Mar.
[Is] ISSN:0018-2052
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The localization and diagnosis of microgastrinomas in a patient with multiple endocrine neoplasia type 1 is difficult preoperatively. The selective arterial calcium injection (SACI) test is a valid diagnostic method for the preoperative diagnosis of these invisible microgastrinomas. We report a rare case of multiple invisible duodenal microgastrinomas with severe duodenal stenosis diagnosed preoperatively by using the SACI test. A 50-year-old man was admitted to our hospital with recurrent duodenal ulcers. His serum gastrin level was elevated to 730 pg/ml. It was impossible for gastrointestinal endoscopy to pass through to visualize the inferior part of the duodenum, because recurrent duodenal ulcers had resulted in severe duodenal stenosis. The duodenal stenosis also prevented additional endoscopic examinations such as endoscopic ultrasonography. Computed tomography did not show any tumors in the duodenum and pancreas. The SACI test provided the evidence for a gastrinoma in the vascular territory of the inferior pancreatic-duodenal artery. We diagnosed a gastrinoma in the peri- ampullary lesion, so we performed Subtotal Stomach-Preserving Pancreatico- duodenectomy with regional lymphadenectomy. Histopathological findings showed multiple duodenal gastrinomas with lymph node metastasis and nonfunctioning pancreatic neuroendocrine tumors. Twenty months after surgery, the patient is alive with no evidence of recurrence and a normal gastrin level. In conclusion, the SACI test can enhance the accuracy of preoperative localization and diagnosis of invisible microgastrinomas, especially in the setting of severe duodenal stenosis.
[Mh] Termos MeSH primário: Cálcio/administração & dosagem
Neoplasias Duodenais/diagnóstico
Úlcera Duodenal/complicações
Gastrinoma/diagnóstico
[Mh] Termos MeSH secundário: Constrição Patológica/etiologia
Neoplasias Duodenais/patologia
Gastrinoma/patologia
Seres Humanos
Injeções Intra-Arteriais
Metástase Linfática
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160628
[Lr] Data última revisão:
160628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE



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