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[PMID]:29279559
[Au] Autor:Kanzaki A; Ansai SI; Ueno T; Kawana S; Shimizu A; Naito Z; Saeki H
[Ad] Endereço:Department of Dermatology, Nippon Medical School.
[Ti] Título:A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin.
[So] Source:J Nippon Med Sch;84(6):286-290, 2017.
[Is] ISSN:1347-3409
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Histology of the biopsy showed a nodular and morpheic basal cell carcinoma (BCC). A chest computed tomography (CT) scan showed multiple lung tumors. CT-guided biopsy of the lung and the cervical lymph node revealed metastatic basal cell carcinoma (MBCC). The primary skin tumor was resected and a total of 10 courses of cisplatin (25 mg/m /day×75%) and adriamycin (50 mg/m ×75%) were administered for metastatic basal cell carcinoma (MBCC). The patient died 5 years and 3 months after his first visit. Autopsy revealed MBCC in the lung, kidney, pancreas, several lymph nodes, liver and bone. A portion of the tumor cells were composed of squamoid cells with eosinophilic cytoplasm, large nuclei, lack of the characteristic peripheral palisading and retraction artifacts, and variable cytoplasmic keratinization. These pathological findings were compatible with basosquamous cell carcinoma. Chemotherapy was effective for MBCC in this patient.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Carcinoma Basocelular/secundário
Carcinoma Basocelular/terapia
Neoplasias Pulmonares/secundário
Neoplasias Pulmonares/terapia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Idoso
Carcinoma Basocelular/diagnóstico por imagem
Cisplatino/administração & dosagem
Terapia Combinada
Procedimentos Cirúrgicos Dermatológicos
Doxorrubicina/administração & dosagem
Evolução Fatal
Seres Humanos
Neoplasias Pulmonares/diagnóstico por imagem
Metástase Linfática
Masculino
Radiografia Torácica
Tomografia Computadorizada por Raios X
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
80168379AG (Doxorubicin); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1272/jnms.84.286


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[PMID]:29328583
[Au] Autor:Jovic MS; Dimitrijevic MM; Dimitrijevic AM; Stojkovic GG
[Ti] Título:Analysis of reconstructive methods in surgical treatment of nasal skin defects.
[So] Source:Vojnosanit Pregl;73(8):723-7, 2016 Aug.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Surgeons often face with the problem when selecting a reconstructive method for nasal skin defects. The aim of this study was to determine functional and aesthetic character-istics of different reconstructive methods used for skin defects in different regions of the nose. Methods: The study involved 44 patients with basocellular carcinoma in nasal area. The nasal skin was divided into four subunits: the tip, the alar lobules, the side-walls and the dorsum. The average skin defect size was 10 mm in diameter. Local flaps and full thickness skin grafts were used in the study. We analyzed the functional and esthetic results of dif-ferent reconstructive methods used for nasal defects in different regions of the nose 12 months after the surgery. Results: The study shows that different reconstructive methods produce dif-ferent functional and esthetic results in the same nasal subunits and that the same reconstructive method produces different re-sults in different nasal subunits. Conclusions: Estimation the postoperative functional and esthetic characteristics of different reconstructive methods is one of the basic preconditions of suc-cessful reconstruction.
[Mh] Termos MeSH primário: Carcinoma Basocelular/cirurgia
Neoplasias Nasais/cirurgia
Rinoplastia/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estética
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias Cutâneas/cirurgia
Transplante de Pele
Retalhos Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP140829052J


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[PMID]:28468139
[Au] Autor:Simsek T; Engin MS; Yildirim K; Kodalak EA; Demir A
[Ad] Endereço:Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
[Ti] Título:Reconstruction of Extensive Orbital Exenteration Defects Using an Anterolateral Thigh/Vastus Lateralis Chimeric Flap.
[So] Source:J Craniofac Surg;28(3):638-642, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neglected malignant tumors within the orbital region can invade the eyeball, extraocular muscles, and bone substance surrounding the eye. Such patients require orbital exenteration, which may involve extraocular skeletal structures (even exposing paranasal sinuses), resulting in 3-dimensional defects requiring reconstruction. This study presents our experience with anterolateral thigh vastus lateralis (ALT/VL) chimeric free flaps for the reconstruction of extensive orbital exenteration defects involving various paranasal sinuses.Between 2012 and 2016, 4 patients with extensive 3-dimensional orbital defects with sinus involvement were treated using the ALT/VL chimeric flap. The ALT component (117-170 cm) was used to resurface the cutaneous defect while the VL component (105-243 cm) was used to obliterate the cavitary defect. The flaps were all based on the common descending pedicle, and branches to separate components were individually dissected. Recipient vessels were in the neck region, to which the donor pedicles were passed through a tunnel for anastomosis.All cavitary and surface defects were simultaneously reconstructed via the ALT/VL chimeric flap. Within an average of 17 months, no complications associated with flap surgery were observed. One patient received postoperative adjuvant radiotherapy with no complications. With its separate components supplied by a common vascular pedicle, the ALT/VL chimeric free flap allows the surgeon to conveniently reconstruct separate spatial and volumetric defects resulting from extensive orbital exenteration.
[Mh] Termos MeSH primário: Carcinoma Basocelular/cirurgia
Carcinoma de Células Escamosas/cirurgia
Neoplasias Oculares/cirurgia
Retalhos de Tecido Biológico/transplante
Exenteração Orbitária
Músculo Quadríceps/transplante
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Coxa da Perna/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003430


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[PMID]:29310408
[Au] Autor:Fan B; Liu JJ; Wang BF; Sun YJ; Li GY
[Ad] Endereço:Department of Ophthalmology, Second Hospital of JiLin University, ChangChun.
[Ti] Título:Case report repairing orbital skin defects using composite flaps after giant eyelid-derived tumor excision and orbital exenteration.
[So] Source:Medicine (Baltimore);96(48):e8978, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy. PATIENT CONCERNS: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Clinical examination revealed a huge pigmented, nonhealing ulcerated lesion, approximately 52×44×40 mm in size. Case 2 was a 52-year old rural male complaining of a huge tumor in the right eyelid. Patient medical history revealed that the mass was initially the size of a soybean and gradually grew over 3 years to the size of a fist. DIAGNOSES: Histopathological examination of the tumors revealed that one was a basal cell carcinoma and the other a sebaceous gland carcinoma. INTERVENTIONS: The two cases of giant malignant eyelid tumors were surgically excised using rapid frozen section margin control. Different pedicle myocutaneous flaps were used to repair the orbital skin defects. OUTCOMES: Postoperative follow-up showed perfect healing of the pedicle flaps and good patient compliance. The results of these cases indicate that covering exposed orbital cavities with composite pedicle mycuaneous flaps is a simple and practical strategy for orbital reconstruction. Not only does this help maintain orbital stability, but it also provides opportunities for patients to return to normal lives. LESSONS: Although surgical management is often the first option for treatment of giant eyelid tumors, recurrence and mortality due to the tumors is still high after long-term follow-up. Therefore, early discovery and treatment is the best way to control the progression of giant eyelid tumors and enhance survivability.
[Mh] Termos MeSH primário: Carcinoma Basocelular/cirurgia
Neoplasias Palpebrais/cirurgia
Pálpebras/cirurgia
Neoplasias das Glândulas Sebáceas/cirurgia
Neoplasias Cutâneas/cirurgia
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Idoso
Carcinoma Basocelular/diagnóstico por imagem
Carcinoma Basocelular/patologia
Neoplasias Palpebrais/diagnóstico por imagem
Neoplasias Palpebrais/patologia
Pálpebras/diagnóstico por imagem
Pálpebras/patologia
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Reconstrutivos
Neoplasias das Glândulas Sebáceas/diagnóstico por imagem
Neoplasias das Glândulas Sebáceas/patologia
Neoplasias Cutâneas/diagnóstico por imagem
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008978


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[PMID]:29199268
[Au] Autor:Di Lorenzo S; Zabbia G; Corradino B; Tripoli M; Pirrello R; Cordova A
[Ad] Endereço:Department of Surgical, Oncological and Dental Disciplinary, Plastic Surgery Section, University of Palermo, Palermo, Italy.
[Ti] Título:A Rare Case of Giant Basal Cell Carcinoma of the Abdominal Wall: Excision and Immediate Reconstruction with a Pedicled Deep Inferior Epigastric Artery Perforator (DIEP) Flap.
[So] Source:Am J Case Rep;18:1284-1288, 2017 Dec 04.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Basal cell carcinoma (BCC) greater than 5 cm in diameter is called giant basal cell carcinoma (GBCC), or super giant basal cell carcinoma if it has a diameter larger than 20 cm. Giant BCC only accounts for 0.5% of BCCs and super giant BCC is exceedingly rare. On account of their rarity, there are no established guidelines for GBCC treatment. CASE REPORT We describe a peculiar case of an 82-year-old woman with a GBCC carcinoma of the lower abdominal wall. The tumor was surgically removed with ipsilateral inguinal lymph nodes and the abdominal wall was reconstructed immediately with a pedicled deep inferior epigastric artery perforator (DIEP) flap. CONCLUSIONS Treatment of giant basal cell carcinoma is often difficult, especially in elderly patients with poor general health and multiple pathologies. The pedicled DIEP flap is rotated to cover the loss of substance without tension, and it is easy to harvest and transfer. This flap allowed a good result without local or systemic complication. We present this report as a reminder of the occasional occurrence of extremely aggressive BCCs. We believe that, especially for rare tumors like these, it is very useful for the entire scientific community to publish these cases and the therapeutic strategies used to treat them.
[Mh] Termos MeSH primário: Parede Abdominal/patologia
Carcinoma Basocelular/patologia
Retalho Perfurante
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Parede Abdominal/cirurgia
Idoso de 80 Anos ou mais
Carcinoma Basocelular/cirurgia
Feminino
Seres Humanos
Invasividade Neoplásica
Retalho Perfurante/irrigação sanguínea
Doenças Raras
Neoplasias Cutâneas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:26782918
[Au] Autor:Furdová A; Horkovicová K; Babál P; Kobzová D; Ondrusová M
[Ti] Título:[Non-melanotic Tumors of the Eyelids Skin and Inner Corner - Basocellular Carcinoma].
[Ti] Título:Nemelanómové nádory koze mihalníc a vnútorného kútika - bazocelulárny karcinóm..
[So] Source:Cesk Slov Oftalmol;71(6):293-301, 2015.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:AIM: Non-melanoma skin cancer cases in the European population are increasing. Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer of the eyelids and in the inner corner of the eyelid. Due to the latest statistics compiled and published in 2008 in the Slovak Republic (SR) there were registered 5,173 cases of non-melanoma skin cancer (C44 according to ICD-10) in both sexes together (of which women accounted for 51.2 %). The proportion of non-melanoma skin cancer accounted for 17.2 % (16.3 % of men and 18 % of women) of the total number of all reported cancer cases (n = 30,144). The aim of this study is to evaluate the number of clinical relapses in a group of patients. MATERIAL: Retrospectively analyzed data from the medical records of patients with newly detected basal cell carcinoma in period between Jan. 1 2008 to Dec. 31 2013 who underwent surgery and outpatient follow-up at the Department of Ophthalmology and the University Hospital in Bratislava. METHODS: The incidence of relapse was evaluated up to date Dec. 31 2014. We followed the following parameters: location and tumor size, TNM classification, histopathological degree of differentiation, the edges of excised tissue and evaluated recurrence rate separately for each parameter. Statistics were analyzed by chi2 test, which was found to be significant for P < 0.05. The results of continuous parameters were expressed as arithmetic mean ± standard deviation. RESULTS: At the Department of Ophthalmology Faculty of Medicine and UNB, Ruzinov Hospital, in Bratislava, in the period 2008 - 2013 were treated 219 basal cell carcinomas in 217 patients and basal cell carcinoma was histologically confirmed. Basal cell carcinomas were divided into groups according to the stage: G1 (n = 139), G 1-2 (n = 41) and G 2 (n = 39). Localization was more frequent on left side (n = 112) compared to the right one (n = 107). We recorded significantly lower incidence (n = 5) in the area - angulus externus, prevalent occurrence was in the inner area - angulus internus (n = 65). The incidence in the lower eyelid (palpebra inferior) was recorded more frequently (n = 127) as in the upper eyelid (palpebra superior) - (n = 24). During these six years period we have seen 11 recurrences (5.02 %). Exenteration of the orbit was indicated in 5 cases (2.7 %). CONCLUSION: When monitoring patients with newly detected eyelid basal cell carcinoma, operated at the Department of Ophthalmology Faculty of Medicine and UNB in period 2008-2013, incidence of recurrence was recorded in 11 cases, accounting for 5.02 %, which is about one percentage point lower share than in the previous reporting period from period 2005 -2007 from the same Department. The occurrence of relapses corresponds to those in the literature. None of the clinical parameters statistically did affect significantly the incidence of relapses. KEY WORDS: eyelid basal cell carcinoma, non-melanoma skin cancer, tumors eyelashes.
[Mh] Termos MeSH primário: Carcinoma Basocelular/patologia
Neoplasias Palpebrais/patologia
Recidiva Local de Neoplasia/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma Basocelular/epidemiologia
Carcinoma Basocelular/cirurgia
Neoplasias Palpebrais/epidemiologia
Neoplasias Palpebrais/cirurgia
Feminino
Seres Humanos
Incidência
Meia-Idade
Recidiva Local de Neoplasia/epidemiologia
Recidiva Local de Neoplasia/cirurgia
Prevalência
Estudos Retrospectivos
Neoplasias Cutâneas/epidemiologia
Neoplasias Cutâneas/cirurgia
Eslováquia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160120
[St] Status:MEDLINE


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[PMID]:27658974
[Au] Autor:Zikmund L
[Ti] Título:[Local Rotating Flaps in Oculoplastic Surgery].
[Ti] Título:Místní otocné laloky v okuloplastice..
[So] Source:Cesk Slov Oftalmol;72(3):72-79, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:AIM: In the contemporary medicine, strong emphasis is put on early closing of body surface defects, which contributes to good and early healing, but, of course, closes the entrance gate for possible infection as well. The easiest closing of the defect is the direct suture of the emerged wound. But some defects are of such an extent, so their closure is necessary to handle other way than simple suture, e.g. by rotating flap plastic surgery. In the paper are evaluated results of flap surgery technique in 56 patients. MATERIAL AND METHODS: It is a retrospective overview of 56 patients operated on by the author in the years 2011-2012, in whom the rotating flap plastic surgery was used as surgery technique. In 46 patients, the reason of flap plastic surgery technique was tumor of the eyelids. In 35 patients, it was due to the basalioma of the lower eyelid, in 8 patients due to the basalioma of the upper eyelid, and in three patients due to the basalioma of the medial cantus region. In 10 patients, the reason of the surgery was ectropion of the lower eyelid, and in two of them bilaterally. The paper is supplemented by surgical procedures photographs, and by a table, with detailed analysis of the sizes of tumors and corresponding flaps as well. RESULTS: According to the experience with 56 rotating flap plastic surgeries, performed by author during the period of two years at the Department of Ophthalmology, Masaryk Hospital in Ústí nad Labem, Czech Republic. E.U., the results of the use of rotating skin flaps in 46 eyelids basalioma, of correcting 12 ectropions of the lower eyelid, and reliability of the tumors excision with 2 mm surrounding healthy tissue rim were followed-up. Using the mentioned surgery technique, it was possible in all patients to secure the closing of the eyelid defect, or to return to normal and correct anatomical position of the eyelids in ectropions. In two patients with basalioma of the lower eyelid, the additional technique of lateral cantotomy was used to relieve the tension in the wound. Statistical results of recurrences number in tumors excisions with 2 mm safety margin in to the healthy tissue confirm the relative safety of such wide excision, and our results (4.34 %) differ only slightly from the results published in the literature (4.0 %). KEY WORDS: flap plastic surgery, basalioma, ectropion.
[Mh] Termos MeSH primário: Blefaroplastia/métodos
Carcinoma Basocelular/cirurgia
Ectrópio/cirurgia
Neoplasias Palpebrais/cirurgia
Pálpebras/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


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[PMID]:29072946
[Au] Autor:Stanoszek LM; Wang GY; Harms PW
[Ad] Endereço:From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
[Ti] Título:Histologic Mimics of Basal Cell Carcinoma.
[So] Source:Arch Pathol Lab Med;141(11):1490-1502, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. OBJECTIVE: - To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. DATA SOURCES: - Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. CONCLUSIONS: - In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.
[Mh] Termos MeSH primário: Carcinoma Basocelular/diagnóstico
Neoplasias Cutâneas/diagnóstico
Pele/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/diagnóstico
Adenocarcinoma Sebáceo/imunologia
Adenocarcinoma Sebáceo/metabolismo
Adenocarcinoma Sebáceo/patologia
Biomarcadores Tumorais/metabolismo
Carcinoma Basocelular/imunologia
Carcinoma Basocelular/metabolismo
Carcinoma Basocelular/patologia
Diagnóstico Diferencial
Hamartoma/diagnóstico
Hamartoma/imunologia
Hamartoma/metabolismo
Hamartoma/patologia
Histiocitoma Fibroso Benigno/diagnóstico
Histiocitoma Fibroso Benigno/imunologia
Histiocitoma Fibroso Benigno/metabolismo
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
Imuno-Histoquímica/tendências
Imunofenotipagem/tendências
Pele/imunologia
Pele/metabolismo
Neoplasias Cutâneas/imunologia
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0222-RA


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[PMID]:29020905
[Au] Autor:Pandeya N; Olsen CM; Whiteman DC
[Ad] Endereço:QIMR Berghofer Medical Research Institute, Brisbane, QLD david.whiteman@qimrberghofer.edu.au.
[Ti] Título:The incidence and multiplicity rates of keratinocyte cancers in Australia.
[So] Source:Med J Aust;207(8):339-343, 2017 Oct 16.
[Is] ISSN:1326-5377
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To assess the incidence and multiplicity of keratinocyte cancers (basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]) excised in Australia, and to examine variations by age, sex, state, and prior skin cancer history. DESIGN: Analysis of individual-level Medicare data for keratinocyte cancer treatments (identified by eight specific MBS item codes) during 2011-2014. Histological data from the QSkin prospective cohort study were analysed to estimate BCC and SCC incidence. SETTING: A 10% systematic random sample of all people registered with Medicare during 1997-2014. PARTICIPANTS: People aged at least 20 years in 2011 who made at least one claim for any MBS medical service during 2011-2014 (1 704 193 individuals). MAIN OUTCOME MEASURES: Age-standardised incidence rates (ASRs) and standardised incidence ratios (SIRs). RESULTS: The person-based incidence of keratinocyte cancer excisions in Australia was 1531 per 100 000 person-years; incidence increased with age, and was higher for men than women (SIR, 1.43; 95% CI, 1.42-1.45). Lesion-based incidence was 3154 per 100 000 person-years. The estimated ASRs for BCC and SCC were 770 per 100 000 and 270 per 100 000 person-years respectively. During 2011-2014, 3.9% of Australians had one keratinocyte cancer excised, 2.7% had more than one excised; 74% of skin cancers were excised from patients who had two or more lesions removed. Multiplicity was strongly correlated with age; most male patients over 70 were treated for multiple lesions. Keratinocyte cancer incidence was eight times as high among people with a prior history of excisions as among those without. CONCLUSIONS: The incidence and multiplicity of keratinocyte cancer in Australia are very high, causing a large disease burden that has not previously been quantified.
[Mh] Termos MeSH primário: Carcinoma Basocelular/epidemiologia
Carcinoma de Células Escamosas/epidemiologia
Neoplasias Cutâneas/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Austrália/epidemiologia
Carcinoma Basocelular/patologia
Carcinoma Basocelular/cirurgia
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/cirurgia
Feminino
Seres Humanos
Incidência
Queratinócitos/patologia
Masculino
Meia-Idade
Programas Nacionais de Saúde
Neoplasias Primárias Múltiplas/epidemiologia
Neoplasias Primárias Múltiplas/patologia
Neoplasias Primárias Múltiplas/cirurgia
Distribuição por Sexo
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


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Fotocópia
[PMID]:28982862
[Au] Autor:Hu WP; Kuo KK; Senadi GC; Chang LS; Wang JJ
[Ad] Endereço:Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C. wphu@kmu.edu.tw.
[Ti] Título:Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells.
[So] Source:Anticancer Res;37(10):5499-5505, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Cancer is one of the most dreadful diseases in humans and among them non-melanoma skin cancer (NMSC) is an increasing problem in the world, that occurs more frequently in people with fair skin. Photodynamic therapy (PDT), a non-invasive treatment is widely used for the prevention and treatment of BCC cells. We previously reported an efficient synthesis of novel indolines-fused-triazoles and studied their photophysical studies. This study delineated the signaling pathways involved in the PDT effect of triazoles on BCC cells under UVA irradiation. MATERIALS AND METHODS: Cell survival was evaluated by the MTT assay. The uptake of in BCC cells was determined by using its fluorescence properties. Intracellular ROS and mitochondrial membrane potential (ΔΨ ) were measured using DCFH-DA probe and DiOC dye, respectively. Cytochrome c release was determined using immunofluorescent staining. RESULTS: Our data disclosed that treatment of BCC cells with -UVA resulted in increased ROS generation, loss of mmp (ΔΨ ), decreased levels of Bcl-2 and Bcl-xL, increased levels of Bax and Bad, cytochrome c release, and caspase-3/PARP degradation to identify apoptotic cell death. CONCLUSION: The present study suggest that -PDT may serve as a potential ancillary modality for the treatment of NMSC.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Carcinoma Basocelular/tratamento farmacológico
Indóis/farmacologia
Mitocôndrias/efeitos dos fármacos
Fotoquimioterapia
Fármacos Fotossensibilizantes/farmacologia
Neoplasias Cutâneas/tratamento farmacológico
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Proteínas Reguladoras de Apoptose/metabolismo
Carcinoma Basocelular/metabolismo
Carcinoma Basocelular/patologia
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mitocôndrias/metabolismo
Mitocôndrias/patologia
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apoptosis Regulatory Proteins); 0 (Indoles); 0 (Photosensitizing Agents); 0 (Reactive Oxygen Species); 0 (Triazoles); 496-15-1 (indoline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE



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