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[PMID]:27772624
[Au] Autor:Chin-Hong PV
[Ad] Endereço:Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, CA. Electronic address: peter.chin-hong@ucsf.edu.
[Ti] Título:Human Papillomavirus in Kidney Transplant Recipients.
[So] Source:Semin Nephrol;36(5):397-404, 2016 09.
[Is] ISSN:1558-4488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human papillomavirus (HPV) is a common infection in kidney transplant recipients. HPV causes cervical, anal, vulvar, vaginal, penile and head and neck cancers. Kidney transplant recipients have a disproportionate burden of disease given prolonged immunosuppression. Given the long pre-invasive state of precancer lesions such as cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN) most HPV-cancers are preventable with screening and targeted treatment of disease. Pre-transplant vaccination of age-eligible kidney transplant recipients is otherwise ideal.
[Mh] Termos MeSH primário: Neoplasias do Ânus/virologia
Neoplasia Intraepitelial Cervical/virologia
Rejeição de Enxerto/prevenção & controle
Imunossupressores/efeitos adversos
Falência Renal Crônica/cirurgia
Transplante de Rim
Infecções por Papillomavirus/induzido quimicamente
Neoplasias do Colo do Útero/virologia
[Mh] Termos MeSH secundário: Neoplasias do Ânus/diagnóstico
Neoplasias do Ânus/prevenção & controle
Neoplasias do Ânus/terapia
Carcinoma in Situ/diagnóstico
Carcinoma in Situ/prevenção & controle
Carcinoma in Situ/terapia
Carcinoma in Situ/virologia
Neoplasia Intraepitelial Cervical/diagnóstico
Neoplasia Intraepitelial Cervical/prevenção & controle
Neoplasia Intraepitelial Cervical/terapia
Detecção Precoce de Câncer
Feminino
Seres Humanos
Masculino
Teste de Papanicolaou
Papillomaviridae
Infecções por Papillomavirus/diagnóstico
Infecções por Papillomavirus/prevenção & controle
Infecções por Papillomavirus/terapia
Vacinas contra Papillomavirus/uso terapêutico
Neoplasias do Colo do Útero/diagnóstico
Neoplasias do Colo do Útero/prevenção & controle
Neoplasias do Colo do Útero/terapia
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 14270 MEDLINE  
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[PMID]:29250968
[Au] Autor:Tóth G; Sándor GL; Gyenes A; Tóth J; Seitz B; Nagy ZZ; Szentmáry N
[Ad] Endereço:Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Ülloi út 26., 1085.
[Ti] Título:[Ocular surface squamous neoplasia].
[Ti] Título:Szemfelszíni laphám-neoplasia..
[So] Source:Orv Hetil;158(51):2011-2022, 2017 Dec.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:To summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be removed. In case of metastasis it may also be life-threatening. As local recurrences of ocular surface squamous neoplasias may occur, knowledge of intra- and postoperative adjuvant treatment options are indispensable and regular control examinations are necessary. Identification and adequate treatment of ocular surface squamous neoplasias are necessary in order to avoid its progression and to prevent recurrences. Orv Hetil. 2017; 158(51): 2011-2022.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/fisiopatologia
Neoplasias da Túnica Conjuntiva/fisiopatologia
[Mh] Termos MeSH secundário: Carcinoma in Situ/fisiopatologia
Carcinoma de Células Escamosas/terapia
Neoplasias da Túnica Conjuntiva/terapia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30939


  3 / 14270 MEDLINE  
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[PMID]:29299981
[Au] Autor:Zalewski K; Misiek M; Kowalik A; Bakula-Zalewska E; Kopczynski J; Zielinska A; Bidzinski M; Radziszewski J; Gózdz S; Kowalewska M
[Ad] Endereço:1 Department of Gynecologic Oncology, Holycross Cancer Center, Kielce, Poland.
[Ti] Título:Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma.
[So] Source:Tumour Biol;39(11):1010428317717140, 2017 Nov.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The role of circulating microRNAs as a promising tool for diagnosing cancer and monitoring anticancer therapies has been widely studied in the past decades. To date, no suitable reference microRNAs for normalizing quantitative real-time polymerase chain reaction assays has been identified in vulvar intraepithelial neoplasia lesions and vulvar squamous cell carcinoma. The purpose of this study was to select appropriate references for gene expression studies in plasma of patients with these lesions. Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples obtained from 17 patients with vulvar intraepithelial neoplasia lesion and 27 patients with vulvar squamous cell carcinoma. The expression stability of these candidate normalizers was assayed using geNorm algorithm. hsa-miR-93-5p was revealed as the most stably expressed reference in plasma samples of both vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma patients. The results pointed at hsa-miR-93-5p and hsa-miR-425-5p as microRNAs that retained the greatest robustness in plasma of vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma patients, respectively. Our work is the first report on reference microRNA selection for quantitative real-time polymerase chain reaction applications in vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma. The candidate microRNA stability values for the two types of lesions are provided and might serve for normalization of the future novel microRNA biomarkers in these rare entities.
[Mh] Termos MeSH primário: Carcinoma in Situ/genética
Carcinoma de Células Escamosas/genética
MicroRNA Circulante/genética
Regulação Neoplásica da Expressão Gênica
Neoplasias Vulvares/genética
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Carcinoma in Situ/sangue
Carcinoma de Células Escamosas/sangue
MicroRNA Circulante/sangue
Feminino
Perfilação da Expressão Gênica/métodos
Perfilação da Expressão Gênica/normas
Seres Humanos
MicroRNAs/sangue
MicroRNAs/genética
Meia-Idade
Valores de Referência
Neoplasias Vulvares/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Circulating MicroRNA); 0 (MIRN103 microRNA, human); 0 (MIRN16 microRNA, human); 0 (MIRN191 microRNA, human); 0 (MIRN423 microRNA, human); 0 (MIRN425 microRNA, human); 0 (MIRN93 microRNA, human); 0 (MicroRNAs)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317717140


  4 / 14270 MEDLINE  
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[PMID]:29244843
[Au] Autor:Tae BS; Jeong CW; Kwak C; Kim HH; Moon KC; Ku JH
[Ad] Endereço:Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
[Ti] Título:Pathology in repeated transurethral resection of a bladder tumor as a risk factor for prognosis of high-risk non-muscle-invasive bladder cancer.
[So] Source:PLoS One;12(12):e0189354, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The prognostic value of repeat transurethral resection of bladder tumor (TURBT) in patients with diagnosed high-risk, non-muscle-invasive bladder cancer (NMIBC) was investigated. We retrospectively reviewed the medical records of patients treated from October 2004 to December 2013 at Seoul National University who underwent repeated TURBT within 2-6 weeks after an initial resection. The study enrolled patients who had been diagnosed with NMIBC at both the initial and repeat TURBT; patients with muscle-invasive tumors on repeat TURBT were excluded. We used stepwise multivariate Cox regression models stratified by study to assess the independent effects of the predictive factors and estimated hazard ratios (HRs) from the Cox models. We investigated a total of 198 patients who were diagnosed with high-risk NMIBC. In logistic regression analyses, number of bladder tumors (2-7: OR, 2.319; 8≤: OR, 3.353; p<0.05), initially high tumor grade (OR, 2.435; p = 0.040), and presence of carcinoma in situ lesion (OR, 3.639; p = 0.017) correlated with residual tumor in the repeated-TURBT specimen. T1 stage in repeated-TURBT significantly correlated with recurrence (HR, 1.837; p = 0.010) and progression (HR, 2.806; p = 0.029) in multivariate analysis. The high grades of tumors in repeated-TURBT also significantly correlated with progression but not recurrence in the multivariate analysis (HR 2.152; p = 0.008). In this study, the pathologic findings in repeated-TURBT correlated with recurrence and progression in high-risk NMIBC. Repeated-TURBT is valuable because it can predict the recurrence and progression of high-risk NMIBC in addition to obtaining accurate pathologic findings.
[Mh] Termos MeSH primário: Carcinoma in Situ/patologia
Recidiva Local de Neoplasia/cirurgia
Neoplasias da Bexiga Urinária/patologia
[Mh] Termos MeSH secundário: Idoso
Carcinoma in Situ/mortalidade
Carcinoma in Situ/cirurgia
Cistectomia
Intervalo Livre de Doença
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Análise Multivariada
Invasividade Neoplásica
Recidiva Local de Neoplasia/mortalidade
Neoplasia Residual
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Neoplasias da Bexiga Urinária/mortalidade
Neoplasias da Bexiga Urinária/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189354


  5 / 14270 MEDLINE  
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[PMID]:29258095
[Au] Autor:Miyata T; Takenaka M; Omoto S; Kamata K; Minaga K; Yamao K; Imai H; Kudo M
[Ad] Endereço:Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
[Ti] Título:A Case of Pancreatic Carcinoma in situ Diagnosed by Repeated Pancreatic Juice Cytology.
[So] Source:Oncology;93 Suppl 1:98-101, 2017.
[Is] ISSN:1423-0232
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Repeated pancreatic juice cytology via endoscopic nasopancreatic drainage (ENPD) has a high diagnostic yield and might be useful for the diagnosis of early-stage pancreatic cancer. A 67-year-old man presented with a pancreatic cyst occasionally detectable in the body of the pancreas by ultrasonography (US). No obvious pancreatic tumor was detected by US, computed tomography (CT), magnetic resonance cholangiopancreatography, and endoscopic ultrasound (EUS) (although the latter did reveal a weak, low echoic area). Endoscopic retrograde pancreatography showed irregular narrowing of the main pancreatic duct (MPD) at the pancreatic body. Pancreatic juice cytology was also performed, but did not give evidence of a malignancy. Therefore, the patient was followed up. CT and EUS performed after 3 months showed the same findings as did endoscopic retrograde pancreatography; however, the results of repeated pancreatic juice cytology performed via ENPD tube revealed a suspected malignancy on 2 of 6 occasions. Therefore, we performed a central pancreatectomy. Histopathological examination of a resected specimen revealed carcinoma in situ in the narrow MPD at the body of the pancreas. In the current case, repeated pancreatic juice cytology via ENPD was effective. A weak low echoic area around the MPD stricture on EUS might be related to the inflammatory change accompanying carcinoma in situ of the pancreas.
[Mh] Termos MeSH primário: Carcinoma in Situ/patologia
Suco Pancreático/citologia
Neoplasias Pancreáticas/patologia
[Mh] Termos MeSH secundário: Idoso
Carcinoma in Situ/diagnóstico por imagem
Detecção Precoce de Câncer/métodos
Seres Humanos
Masculino
Neoplasias Pancreáticas/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1159/000481240


  6 / 14270 MEDLINE  
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[PMID]:29258080
[Au] Autor:Yamao K; Takenaka M; Nakai A; Omoto S; Kamata K; Minaga K; Miyata T; Imai H; Sakurai T; Watanabe T; Nishida N; Matsumoto I; Takeyama Y; Chikugo T; Kudo M
[Ad] Endereço:Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
[Ti] Título:Detection of High-Grade Pancreatic Intraepithelial Neoplasia without Morphological Changes of the Main Pancreatic Duct over a Long Period: Importance for Close Follow-Up for Confirmation.
[So] Source:Oncology;93 Suppl 1:81-86, 2017.
[Is] ISSN:1423-0232
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural history and time to progression of high-grade PanIN remain unclear. Herein, we report 2 cases of high-grade PanIN without morphological changes of the main pancreatic duct (MPD) over relatively long periods. In the first case, a 63-year-old man was identified with MPD dilation. Magnetic resonance cholangiopancreatography showed localized stenosis in the pancreatic body with distal MPD dilation. Endoscopic retrograde pancreatography (ERP) was attempted because of possible high-grade PanIN but was unsuccessful. At 15-month follow-up, there was no change in the form of the MPD in various images. However, ERP was re-performed because of possible high-grade PanIN, and cytology showed adenocarcinoma. Postoperative pathology indicated diffuse lesions corresponding to high-grade PanINs in the MPD stenosis and surrounding branches. Final diagnosis was high-grade PanIN. In the second case, a 77-year-old man was identified with MPD dilation. Magnetic resonance cholangiography showed localized stenosis in the MPD of the pancreatic head with distal MPD dilation. He was diagnosed with MPD stenosis caused by chronic pancreatitis, and further examination was not recommended. At 25 months, the patient was referred to our hospital because of a mild change in MPD dilation. ERP showed localized irregular stenosis in the MPD, and cytology showed suspected adenocarcinoma. Postoperative pathology indicated a localized lesion with high-grade PanIN in the branch duct around the MPD stenosis. Final diagnosis was high-grade PanIN. In conclusion, we report 2 cases of high-grade PanIN without morphological changes of the MPD over relatively long periods. Even if a definite diagnosis is not obtained at initial examination, a strict follow-up observational study should be performed. Re-examination, including ERP, should also be considered in cases with risk factors of pancreatic cancer, even if there is no change in MPD form.
[Mh] Termos MeSH primário: Carcinoma in Situ/diagnóstico
Carcinoma Ductal Pancreático/diagnóstico
Neoplasias Pancreáticas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Carcinoma in Situ/patologia
Carcinoma Ductal Pancreático/patologia
Seres Humanos
Masculino
Meia-Idade
Gradação de Tumores
Neoplasias Pancreáticas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1159/000481237


  7 / 14270 MEDLINE  
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[PMID]:29189063
[Au] Autor:Pittman ME; Rao R; Hruban RH
[Ti] Título:Classification, Morphology, Molecular Pathogenesis, and Outcome of Premalignant Lesions of the Pancreas.
[So] Source:Arch Pathol Lab Med;141(12):1606-1614, 2017 Dec.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Invasive pancreatic ductal adenocarcinoma has a greater than 90% mortality rate at 5 years. Understanding noninvasive, curable precursor lesions gives us the best hope for reducing mortality from pancreatic ductal adenocarcinoma. The 3 pancreatic precursor lesions that have been well studied include intraductal papillary mucinous neoplasm, mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia. OBJECTIVE: - To give an update on the latest clinical, molecular, and pathologic advances in intraductal papillary mucinous neoplasm, mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia for the general surgical pathologist. DATA SOURCES: - The current literature was analyzed and the authors' experiences with institutional and consult material were incorporated. CONCLUSIONS: - Our understanding of the molecular alterations that lead from pancreatic precursor lesion to invasive carcinoma continues to evolve. These advances aid clinicians in their treatment decisions and researchers in their search for actionable, druggable targets.
[Mh] Termos MeSH primário: Carcinoma Ductal Pancreático
Neoplasias Pancreáticas
Lesões Pré-Cancerosas
[Mh] Termos MeSH secundário: Carcinoma in Situ/classificação
Carcinoma in Situ/etiologia
Carcinoma in Situ/patologia
Carcinoma Ductal Pancreático/classificação
Carcinoma Ductal Pancreático/etiologia
Carcinoma Ductal Pancreático/patologia
Seres Humanos
Mutação
Invasividade Neoplásica/patologia
Neoplasias Pancreáticas/classificação
Neoplasias Pancreáticas/etiologia
Neoplasias Pancreáticas/patologia
Lesões Pré-Cancerosas/classificação
Lesões Pré-Cancerosas/etiologia
Lesões Pré-Cancerosas/patologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0426-RA


  8 / 14270 MEDLINE  
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[PMID]:29202150
[Au] Autor:Baumgarten HD; Showalter SL; Rochman CM; Keim-Malpass J
[Ad] Endereço:Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA.
[Ti] Título:Erythematous, friable nipple with loss of protrusion · history of breastfeeding · Dx?
[So] Source:J Fam Pract;66(12):758-760, 2017 Dec.
[Is] ISSN:1533-7294
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 34-year-old healthy woman presented to the breast surgical oncology clinic with skin changes to her left nipple after being referred by her primary care provider. She attributed the skin changes to shearing from breastfeeding her third child 5 years earlier. Physical examination revealed an erythematous and friable nipple with loss of protrusion. The patient reported routine bleeding from her nipple, but said the skin changes had remained stable and denied any breast masses. The patient's last mammogram was 2.5 years earlier and had only been remarkable for bilateral benign calcifications.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico
Carcinoma in Situ/diagnóstico
Carcinoma Ductal de Mama/diagnóstico
Mamilos
Doença de Paget Mamária/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biópsia por Agulha
Aleitamento Materno
Diagnóstico Diferencial
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Mamografia
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  9 / 14270 MEDLINE  
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[PMID]:29050937
[Au] Autor:Jiang S; Zhu L; Yang J; Hu L; Gu J; Xing X; Sun Y; Zhang Z
[Ad] Endereço:Shanghai Medical College of Fudan University, Shanghai 200032, PR China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, PR China.
[Ti] Título:Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer.
[So] Source:Biochem Biophys Res Commun;494(1-2):113-119, 2017 Dec 09.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dysregulated potassium (K ) channels have previously been shown to promote the development and progression of many types of cancers. Meanwhile, K channels are particularly important in regulating the endocrine and exocrine functions of pancreas. However, the expression pattern and prognostic significance of K channels in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC. by immunohistochemical analysis of pancreatic tissue sections from Pdx1-Cre; LSL-Kras mice (KC), Pdx1-Cre; LSL-Kras ; LSL-Trp53 mice (KPC) and human PDAC tissue microarrays, we found that Ca -activated K channel KCNN4 was significantly elevated in pancreatic intraepithelial neoplasia (PanIN) and PDAC epithelia compared with untransformed pancreas tissues. Higher epithelial KCNN4 expression was closely correlated with advanced TNM stages and predicted a poor prognosis in patients with PDAC. Elevated KCNN4 expression was significantly associated with shorter survival in univariable and multivariable analyses. Collectively, the identification of expression pattern of K channels in PDAC and its precursor PanIN demonstrates the importance of KCNN4 channel during the malignant transformation of PDAC. On the basis of the prognostic signals from two independent cohorts, KCNN4 should be considered as a promising therapeutic target.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Carcinoma Ductal Pancreático/genética
Carcinoma Ductal Pancreático/metabolismo
Canais de Potássio Ativados por Cálcio de Condutância Intermediária/genética
Neoplasias Pancreáticas/genética
Neoplasias Pancreáticas/metabolismo
[Mh] Termos MeSH secundário: Idoso
Animais
Biomarcadores Tumorais/metabolismo
Carcinoma in Situ/genética
Carcinoma in Situ/metabolismo
Carcinoma in Situ/patologia
Carcinoma Ductal Pancreático/patologia
Feminino
Perfilação da Expressão Gênica
Seres Humanos
Imuno-Histoquímica
Canais de Potássio Ativados por Cálcio de Condutância Intermediária/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Meia-Idade
Neoplasias Pancreáticas/patologia
Canais de Potássio de Domínios Poros em Tandem/genética
Canais de Potássio de Domínios Poros em Tandem/metabolismo
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Intermediate-Conductance Calcium-Activated Potassium Channels); 0 (KCNK1 protein, human); 0 (KCNN4 protein, human); 0 (Kcnk1 protein, mouse); 0 (Kcnn4 protein, mouse); 0 (Potassium Channels, Tandem Pore Domain)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE


  10 / 14270 MEDLINE  
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[PMID]:29020904
[Au] Autor:Pan Y; Adler NR; Wolfe R; McLean CA; Kelly JW
[Ad] Endereço:Victorian Melanoma Service, Alfred Hospital, Melbourne, VIC nikki.adler@monash.edu.
[Ti] Título:Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus.
[So] Source:Med J Aust;207(8):333-338, 2017 Oct 16.
[Is] ISSN:1326-5377
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To determine the frequency of naevus-associated melanoma among superficial spreading and nodular subtypes; and to investigate associations between naevus-associated melanoma and other clinico-pathological characteristics. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study of all patients with nodular and superficial spreading melanomas diagnosed between 1994 and 2015 at the Victorian Melanoma Service, Melbourne. METHODS AND MAIN OUTCOME MEASURES: Clinical and pathological characteristics of naevus-associated and de novo melanomas were assessed in univariable and multivariable logistic regression analyses. RESULTS: Of 3678 primary melanomas, 1360 (37.0%) were histologically associated with a naevus and 2318 (63.0%) were de novo melanomas; 71 of 621 nodular (11.4%) and 1289 of 3057 superficial spreading melanomas (42.2%) were histologically associated with a naevus. In multivariable analyses, the odds of being associated with a naevus were higher for melanomas located on the trunk (v head and neck: adjusted odds ratio [OR], 2.27; 95% CI, 1.73-2.96; P < 0.001), while the odds were lower for thicker tumours (adjusted OR, 0.75 per millimetre increase in Breslow thickness; 95% CI, 0.69-0.81; P < 0.001), amelanotic/hypomelanotic melanomas (adjusted OR, 0.68; 95% CI, 0.48-0.97; P = 0.035), and older age (patients 70 years or older v patients under 30 at diagnosis: adjusted OR, 0.28; 95% CI, 0.20-0.40; P < 0.001). After adjusting for confounders, the odds of an associated naevus was three times as high for superficial spreading melanomas as for nodular melanomas (adjusted OR, 3.05; 95% CI, 2.24-4.17; P < 0.001). CONCLUSION: Melanomas are most likely to arise in the absence of a pre-existing naevus, particularly nodular melanomas. Public health campaigns should therefore emphasise the detection of suspicious de novo lesions, as well as of changing lesions.
[Mh] Termos MeSH primário: Melanoma/patologia
Neoplasias Primárias Múltiplas/patologia
Nevo Pigmentado/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Carcinoma in Situ/patologia
Estudos Transversais
Feminino
Seres Humanos
Masculino
Melanoma/classificação
Meia-Idade
Invasividade Neoplásica
Segunda Neoplasia Primária/patologia
Fatores de Risco
Neoplasias Cutâneas/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE



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