Base de dados : MEDLINE
Pesquisa : C04.557.470.200.240.250 [Categoria DeCS]
Referências encontradas : 8891 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 890 ir para página                         

  1 / 8891 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29505536
[Au] Autor:Founta C; Papagiannakis E; Ratnavelu N; Feusi A; Natsis S; Bradbury M; Fisher A; Naik R
[Ad] Endereço:Northern Gynaecological Oncology Centre, Queen Elizabeth Hospital Gateshead, Gateshead.
[Ti] Título:Diagnostic accuracy of colposcopy with dynamic spectral imaging for cytology-negative/high-risk HPV positive (failed test of cure) after large loop excision of the transformation zone (LLETZ) of the cervix: Results of the DySIS colposcopy 1 study.
[So] Source:Medicine (Baltimore);97(1):e9560, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to colposcopy. This pilot study assessed the incidence of residual/recurrent CIN and the diagnostic accuracy of colposcopy with dynamic spectral imaging (DSI) mapping in their detection.This was a prospective service evaluation carried out in a UK National Health Service (NHS) colposcopy clinic. All women, referred with negative cytology/HR-HPV positive result following treatment for CIN from March 2013 until November 2014, who were examined with the DSI digital colposcope were included. We excluded 3 cases because of poor-quality imaging from user errors. Everyday clinical practice was followed. Initial colposcopic impression, DSI map indication, and biopsy site selections were recorded. CIN2+ was considered the primary outcome and CIN of any grade a secondary outcome.A total of 105 women were included of which 5 (4.8%) had CIN2+ histology and 24 (22.9%) had CIN1. Pre-DSI map colposcopy suggested normal/low grade in all 5 of the CIN2+ cases and DSI suggested high-grade (HG) CIN in 4 of the 5 cases. Sensitivity of standard colposcopy for CIN2+ was 0%, improving to 80% with the incorporation of the DSI map.The CIN burden in this population is higher than previously expected. Colposcopic identification of HG CIN appears to improve significantly with DSI in this cohort leading to refinement in patient management. A larger, multicentric prospective study (DySIS colposcopy 2) is planned to confirm these initial findings.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/diagnóstico
Colposcopia/estatística & dados numéricos
Recidiva Local de Neoplasia/diagnóstico
Neoplasias do Colo do Útero/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasia Intraepitelial Cervical/cirurgia
Neoplasia Intraepitelial Cervical/virologia
Colposcopia/métodos
Feminino
Seres Humanos
Meia-Idade
Recidiva Local de Neoplasia/virologia
Papillomaviridae
Projetos Piloto
Estudos Prospectivos
Análise Espectral
Neoplasias do Colo do Útero/cirurgia
Neoplasias do Colo do Útero/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009560


  2 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29487080
[Au] Autor:Cruickshank M
[Ad] Endereço:Institute of Applied Health Sciences, School of Medicine, University of Aberdeen, Aberdeen AB25 7ZD, UK.
[Ti] Título:Treatment or surveillance for CIN2?
[So] Source:BMJ;360:k771, 2018 02 27.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical
Colposcopia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Papillomaviridae
Infecções por Papillomavirus
Neoplasias do Colo do Útero
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k771


  3 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29385144
[Au] Autor:Lang Kuhs KA; Lin SW; Hua X; Schiffman M; Burk RD; Rodriguez AC; Herrero R; Abnet CC; Freedman ND; Pinto LA; Hamm D; Robins H; Hildesheim A; Shi J; Safaeian M
[Ad] Endereço:National Cancer Institute, NIH, Bethesda, Maryland, United States of America.
[Ti] Título:T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study.
[So] Source:PLoS One;13(1):e0178167, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is unknown why a minority of women fail to clear human papillomavirus (HPV) and develop precancer/cancer. Differences in T-cell receptor (TCR) repertoires may identify HPV16-infected women at highest-risk for progression to cancer. We conducted a proof-of-principle study nested within the Guanacaste HPV Natural History Study to evaluate the utility of next-generation sequencing for interrogating the TCR repertoires among women who cleared and failed to clear cervical HPV16. METHODS: TCR repertoires of women with HPV16-related intraepithelial neoplasia grade 3 or higher (CIN3+; n = 25) were compared to women who cleared an incident HPV16 infection without developing precancer/cancer (n = 25). TCR diversity (richness and evenness) and relative abundance (RA) of gene segment (V [n = 51], D [n = 2], J [n = 13]) usage was evaluated; receiver operating curve analysis assessed the ability to differentiate case-control status. RESULTS: TCR repertoire richness was associated with CIN3+ status (P = 0.001). Relative abundance (RA) of V-gene segments was enriched for associations between cases and controls. A single V-gene (TRBV6-7) was significantly associated with CIN3+ status (RA = 0.11%, 0.16%, among cases and controls, respectively, Bonferroni P = 0.0008). The estimated area under the curve using richness and V-gene segment RA was 0.83 (95% confidence interval: 0.73-0.90). CONCLUSIONS: Substantial differences in TCR repertoire among women with CIN3+ compared to women who cleared infection were observed. IMPACT: This is the first study to use next-generation sequencing to investigate TCR repertoire in the context of HPV infection. These findings suggest that women with HPV16-associated cervical lesions have significantly different TCR repertoires from disease-free women who cleared HPV16 infection.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/imunologia
Papillomavirus Humano 16/imunologia
Infecções por Papillomavirus/imunologia
Receptores de Antígenos de Linfócitos T/imunologia
Neoplasias do Colo do Útero/imunologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Neoplasia Intraepitelial Cervical/virologia
Estudos de Coortes
Feminino
Seres Humanos
Infecções por Papillomavirus/virologia
Reprodutibilidade dos Testes
Neoplasias do Colo do Útero/virologia
VDJ Recombinases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Antigen, T-Cell); EC 2.7.7.- (VDJ Recombinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178167


  4 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27772624
[Au] Autor:Chin-Hong PV
[Ad] Endereço:Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, CA. Electronic address: peter.chin-hong@ucsf.edu.
[Ti] Título:Human Papillomavirus in Kidney Transplant Recipients.
[So] Source:Semin Nephrol;36(5):397-404, 2016 09.
[Is] ISSN:1558-4488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human papillomavirus (HPV) is a common infection in kidney transplant recipients. HPV causes cervical, anal, vulvar, vaginal, penile and head and neck cancers. Kidney transplant recipients have a disproportionate burden of disease given prolonged immunosuppression. Given the long pre-invasive state of precancer lesions such as cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN) most HPV-cancers are preventable with screening and targeted treatment of disease. Pre-transplant vaccination of age-eligible kidney transplant recipients is otherwise ideal.
[Mh] Termos MeSH primário: Neoplasias do Ânus/virologia
Neoplasia Intraepitelial Cervical/virologia
Rejeição de Enxerto/prevenção & controle
Imunossupressores/efeitos adversos
Falência Renal Crônica/cirurgia
Transplante de Rim
Infecções por Papillomavirus/induzido quimicamente
Neoplasias do Colo do Útero/virologia
[Mh] Termos MeSH secundário: Neoplasias do Ânus/diagnóstico
Neoplasias do Ânus/prevenção & controle
Neoplasias do Ânus/terapia
Carcinoma in Situ/diagnóstico
Carcinoma in Situ/prevenção & controle
Carcinoma in Situ/terapia
Carcinoma in Situ/virologia
Neoplasia Intraepitelial Cervical/diagnóstico
Neoplasia Intraepitelial Cervical/prevenção & controle
Neoplasia Intraepitelial Cervical/terapia
Detecção Precoce de Câncer
Feminino
Seres Humanos
Masculino
Teste de Papanicolaou
Papillomaviridae
Infecções por Papillomavirus/diagnóstico
Infecções por Papillomavirus/prevenção & controle
Infecções por Papillomavirus/terapia
Vacinas contra Papillomavirus/uso terapêutico
Neoplasias do Colo do Útero/diagnóstico
Neoplasias do Colo do Útero/prevenção & controle
Neoplasias do Colo do Útero/terapia
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29285941
[Au] Autor:Koiss R; Boncz I; Hernádi Z; Szentirmay Z
[Ad] Endereço:Szülészet-Nogyógyászati Osztály, Egyesített Szent István és Szent László Kórház Budapest, Nagyvárad tér 1., 1096.
[Ti] Título:[Proposal for the modernization of cervical screening procedure in Hungary].
[Ti] Título:Javaslat a hazai méhnyakszurési eljárásrend korszerusítésére..
[So] Source:Orv Hetil;158(52):2062-2067, 2017 Dec.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:Two main considerations played roles in creation of new cervical screening system. One was the proven fact that high-risk human papilloma virus infection plays a role in the development of cervical cancer and pre-cancerous lesions. The other was the implementation of the HPV infection's biological behavior in the new screening strategy. The new screening procedure faithfully reflects the cervical carcinogenesis. An organised, population-based and age differentiated screening method could increase attendance of screening and could decrease the possibility of interval cancer rate due to increased sensitivity. Orv Hetil. 2017; 158(52): 2062-2067.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/diagnóstico
Detecção Precoce de Câncer/métodos
Programas de Rastreamento/organização & administração
Infecções por Papillomavirus/diagnóstico
[Mh] Termos MeSH secundário: Fatores Etários
Neoplasia Intraepitelial Cervical/prevenção & controle
Feminino
Seres Humanos
Hungria
Infecções por Papillomavirus/prevenção & controle
Neoplasias do Colo do Útero/diagnóstico
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30896


  6 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29350503
[Au] Autor:Golubovic M; Lopicic M; Terzic N; Durovic M; Mugosa B; Mijovic G
[Ti] Título:Presence of histopathological premalignant lesions and infection caused by high-risk genotypes of human papillomavirus in patients with suspicious cytological and colposcopy results: A prospective study.
[So] Source:Vojnosanit Pregl;74(1):24-30, 2017 Jan.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: In patients with premalignant cervical lesions, human papillomavirus (HPV) infection, at any moment, may be spontaneously eliminated, or may persist or transform cervical epithelium from a lower to a higher degree. Due to that, it is necessary to wisely select the patients who are at high risk of cancer development. The aim of the study was to establish the interdependence between a suspicious Papanicolaou (Pap) test and colposcopy with the infection caused by high-risk genotypes of human papillomavirus and the presence of premalignant cervical lesions. Methods: This prospective study used cytological, colposcopy, real-time polymerase chain reaction (PCR) of high-risk genotypes of human papillomavirus and histopathological analysis of cervical biopsy specimen. Out of 2,578 female patients sent to cytological analyses in Clinical Center of Montenegro, during 2012, 2013 and 2014, the study included 80 women who had to submit their biopsy specimens due to a suspicious Pap test and atypical colposcopy results. Results: In the group of 80 (3.1%; n = 80/2,578) of the selected female patients with suspicious Pap test and colposcopy, 2/3 or 56 (70%) of them had cervicitis, and 1/3 or 24 (30%) had cervical intraepithelial neoplasia. The most common type in cervical intraepithelial neoplasia was HPV16 in 8 female patients, ie 61.53% out of the number of infected, or 33.33% out of the total number of premalignant lesions Conclusion: Patients with suspicious Papanicolaou test, colposcopy results and infection which is caused by high-risk HPV infection (HPV 16 in particular) often have premalignant cervical lesions. In these cases, histopathological confirmation of lesions is mandatory, since it serves as a definitive diagnostic procedure.
[Mh] Termos MeSH primário: Células Escamosas Atípicas do Colo do Útero/patologia
Neoplasia Intraepitelial Cervical/patologia
Colposcopia
DNA Viral/genética
Testes de DNA para Papilomavírus Humano
Teste de Papanicolaou
Papillomaviridae/genética
Infecções por Papillomavirus/virologia
Lesões Pré-Cancerosas/patologia
Lesões Intraepiteliais Escamosas Cervicais/patologia
Neoplasias do Colo do Útero/patologia
Esfregaço Vaginal
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Células Escamosas Atípicas do Colo do Útero/virologia
Biópsia
Neoplasia Intraepitelial Cervical/virologia
Criança
Pré-Escolar
Feminino
Genótipo
Seres Humanos
Lactente
Meia-Idade
Estadiamento de Neoplasias
Infecções por Papillomavirus/patologia
Lesões Pré-Cancerosas/virologia
Valor Preditivo dos Testes
Estudos Prospectivos
Reação em Cadeia da Polimerase em Tempo Real
Lesões Intraepiteliais Escamosas Cervicais/virologia
Neoplasias do Colo do Útero/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150205143G


  7 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27777126
[Au] Autor:Luxembourg A; Kjaer SK; Nygard M; Ellison MC; Group T; Marshall JB; Radley D; Saah A
[Ad] Endereço:Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: alain_luxembourg@merck.com.
[Ti] Título:Design of a long-term follow-up effectiveness, immunogenicity and safety study of women who received the 9-valent human papillomavirus vaccine.
[So] Source:Contemp Clin Trials;52:54-61, 2017 01.
[Is] ISSN:1559-2030
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The 9-valent human papillomavirus (HPV) (9vHPV) vaccine targets four HPV types (6/11/16/18) also covered by the quadrivalent HPV (qHPV) vaccine and five additional types (31/33/45/52/58). Vaccine efficacy to prevent HPV infection and disease was established in a Phase III clinical study in women 16-26years of age. A long-term follow-up (LTFU) study has been initiated as an extension of the Phase III clinical study to assess effectiveness of the 9vHPV vaccine up to at least 14years after the start of vaccination. It includes participants from Denmark, Norway and Sweden and uses national health registries from these countries to assess incidence of cervical pre-cancers and cancers due to the 7 oncogenic types in the vaccine (HPV 16/18/31/33/45/52/58). Incidences will be compared to the estimated incidence rate in an unvaccinated cohort of similar age and risk level. This LTFU study uses a unique design: it is an extension of a Phase III clinical study and also has elements of an epidemiological study (i.e., endpoints based on standard clinical practice; surveillance using searches from health registries); it uses a control chart method to determine whether vaccine effectiveness may be waning. Control chart methods which were developed in industrial and manufacturing settings for process and production monitoring, can be used to monitor disease incidence in real-time and promptly detect a decrease in vaccine effectiveness. Experience from this innovative study design may be applicable to other medicinal products when long-term outcomes need to be assessed, there is no control group, or outcomes are rare.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/prevenção & controle
Imunogenicidade da Vacina
Infecções por Papillomavirus/prevenção & controle
Vacinas contra Papillomavirus/uso terapêutico
Lesões Pré-Cancerosas/prevenção & controle
Neoplasias do Colo do Útero/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Neoplasia Intraepitelial Cervical/epidemiologia
Neoplasia Intraepitelial Cervical/virologia
Ensaios Clínicos Fase III como Assunto
Dinamarca/epidemiologia
Feminino
Seguimentos
Seres Humanos
Incidência
Noruega/epidemiologia
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Vacinas contra Papillomavirus/imunologia
Lesões Pré-Cancerosas/epidemiologia
Lesões Pré-Cancerosas/virologia
Ensaios Clínicos Controlados Aleatórios como Assunto
Suécia/epidemiologia
Resultado do Tratamento
Neoplasias do Colo do Útero/epidemiologia
Neoplasias do Colo do Útero/virologia
Neoplasias Vaginais/epidemiologia
Neoplasias Vaginais/prevenção & controle
Neoplasias Vaginais/virologia
Neoplasias Vulvares/epidemiologia
Neoplasias Vulvares/prevenção & controle
Neoplasias Vulvares/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  8 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29369205
[Au] Autor:Lili E; Chatzistamatiou K; Kalpaktsidou-Vakiani A; Moysiadis T; Agorastos T
[Ad] Endereço:4th Department of Obstetrics and Gynecology.
[Ti] Título:Low recurrence rate of high-grade cervical intraepithelial neoplasia after successful excision and routine colposcopy during follow-up.
[So] Source:Medicine (Baltimore);97(4):e9719, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the present cohort study was to assess the long-term (follow-up period up to 22 years) recurrence rate of preinvasive disease and the newly detected invasive disease rate in a cohort of women treated with excisional methods for high-grade cervical intraepithelial neoplasia (CIN).Women treated with large loop excision of the transformation zone (LLETZ) and cold knife conization (CKC) for histologically proven high-grade CIN were followed up for up to 22 years. Surgical specimens underwent histological examination and the status of endocervical as well as ectocervical margins was recorded. Follow-up protocol included conventional Pap test, colposcopy and pelvic examination at 3, 6, and 12 months after the initial treatment, and every 12 months thereafter, provided that the results were normal. In case of high-grade cytological findings and/or atypical colposcopic impression, multiple punch biopsies were taken in order to verify or exclude recurrent disease.In total, 804 women were followed for a mean time of 77.1 months (range: 6-266). LLETZ was used in 569 (70.7%) and CKC in 235 cases (29.2%). No woman developed invasive cervical cancer. Recurrent high-grade disease, developed in 9 women (1.1%, 95% confidence interval 0.5-2.2). Median treatment-to-recurrence time was 46.5 months (range: 6-235.3). One woman treated for squamous CIN2 on clear margins developed adenocarcinoma in situ 59.2 months post-treatment.Women having undergone excisional treatment for high-grade CIN indicate a very low risk for recurrent disease and potentially negligible risk for invasive cancer, provided that a strict and vigorous follow-up is offered after treatment.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/cirurgia
Colposcopia/métodos
Recidiva Local de Neoplasia/epidemiologia
Neoplasias do Colo do Útero/cirurgia
[Mh] Termos MeSH secundário: Adulto
Neoplasia Intraepitelial Cervical/patologia
Colo do Útero/patologia
Colo do Útero/cirurgia
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Gradação de Tumores
Recidiva Local de Neoplasia/patologia
Estudos Retrospectivos
Resultado do Tratamento
Neoplasias do Colo do Útero/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009719


  9 / 8891 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28470689
[Au] Autor:Agorastos T; Chatzistamatiou K; Moysiadis T; Kaufmann AM; Skenderi A; Lekka I; Koch I; Soutschek E; Boecher O; Kilintzis V; Angelidou S; Katsiki E; Hagemann I; Boschetti Gruetzmacher E; Tsertanidou A; Angelis L; Maglaveras N; Jansen-Duerr P
[Ad] Endereço:4th Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece.
[Ti] Título:Human papillomavirus E7 protein detection as a method of triage to colposcopy of HPV positive women, in comparison to genotyping and cytology. Final results of the PIPAVIR study.
[So] Source:Int J Cancer;141(3):519-530, 2017 08 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of the presented cross-sectional-evaluation-screening study is the clinical evaluation of high-risk(hr)HPVE7-protein detection as a triage method to colposcopy for hrHPV-positive women, using a newly developed sandwich-ELISA-assay. Between 2013-2015, 2424 women, 30-60 years old, were recruited at the Hippokratio Hospital, Thessaloniki/Greece and the Im Mare Klinikum, Kiel/Germany, and provided a cervical sample used for Liquid Based Cytology, HPV DNA genotyping, and E7 detection using five different E7-assays: "recomWell HPV16/18/45KJhigh", "recomWell HPV16/18/45KJlow", "recomWell HPV39/51/56/59", "recomWell HPV16/31/33/35/52/58" and "recomWell HPVHRscreen" (for 16,18,31,33,35,39,45,51,52,56,58,59 E7), corresponding to different combinations of hrHPVE7-proteins. Among 1473 women with eligible samples, those positive for cytology (ASCUS+ 7.2%), and/or hrHPV DNA (19.1%) were referred for colposcopy. Cervical Intraepithelial Neoplasia grade 2 or worse (CIN2+) was detected in 27 women (1.8%). For HPV16/18-positive women with no triage, sensitivity, positive predictive value (PPV) and the number of colposcopies needed to detect one case of CIN2+ were 100.0%, 11.11% and 9.0 respectively. The respective values for E7-testing as a triage method to colposcopy ranged from 75.0-100.0%, 16.86-26.08% and 3.83-5.93. Sensitivity and PPV for cytology as triage for hrHPV(non16/18)-positive women were 45.45% and 27.77%; for E7 test the respective values ranged from 72.72-100.0% and 16.32-25.0%. Triage of HPV 16/18-positive women to colposcopy with the E7 test presents better performance than no triage, decreasing the number of colposcopies needed to detect one CIN2+. In addition, triage of hrHPV(non16/18)-positive women with E7 test presents better sensitivity and slightly worse PPV than cytology, a fact that advocates for a full molecular screening approach.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/diagnóstico
Colposcopia/métodos
Papillomaviridae/genética
Proteínas E7 de Papillomavirus/metabolismo
Infecções por Papillomavirus/complicações
Triagem/métodos
Neoplasias do Colo do Útero/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Neoplasia Intraepitelial Cervical/virologia
Ensaio de Imunoadsorção Enzimática
Feminino
Genótipo
Seres Humanos
Meia-Idade
Estadiamento de Neoplasias
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/virologia
Prognóstico
Neoplasias do Colo do Útero/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Papillomavirus E7 Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30761


  10 / 8891 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29320507
[Au] Autor:Hermansson RS; Olovsson M; Hoxell E; Lindström AK
[Ad] Endereço:Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
[Ti] Título:HPV prevalence and HPV-related dysplasia in elderly women.
[So] Source:PLoS One;13(1):e0189300, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: In Sweden, where screening ends at the age of 60, about 30% of the cervical cancer cases occur in women older than 60. The aim of the present study was to investigate the prevalence of HPV and cervical dysplasia in women of 60 years and above. PATIENTS AND METHODS: From September 2013 until June 2015, 1051 women aged 60-89 years (mean 68 years) were sampled for an HPV test when attending an outpatient gynecology clinic. Women with positive results had a second HPV test and liquid based cytology (LBC), after 3.5 months on average. Those with a positive second HPV test were examined by colposcopy, and biopsy and a sample for LBC was obtained. RESULTS: The prevalence of HPV was 4.1%, (95%CI 3.0-5.5, n = 43) at the first test, and at the second test 2.6% remained positive (95%CI 1.7-3.8, n = 27). The majority of women positive in both HPV tests, had dysplasia in histology, 81.5% (22/27) (4 CIN 2-0.4%, 18 CIN 1-1.7%). HPV-related dysplasia was found in 2.1%, (95%CI 1.3-3.2, n = 22) of the 1051 women. Four of the 22 women with positive HPV tests also had abnormal cytology, one ASCUS and three CIN 1. No cancer or glandular dysplasia was detected. CONCLUSION: A significant proportion of elderly women were found to have a persistent cervical HPV infection. Among them there was a high prevalence of CIN diagnosed by histology. The HPV test showed high sensitivity and specificity in detecting CIN in elderly women, while cytology showed extremely low sensitivity.
[Mh] Termos MeSH primário: Alphapapillomavirus/isolamento & purificação
Neoplasia Intraepitelial Cervical/diagnóstico
Infecções por Papillomavirus/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Alphapapillomavirus/patogenicidade
Neoplasia Intraepitelial Cervical/epidemiologia
Neoplasia Intraepitelial Cervical/virologia
Feminino
Seres Humanos
Meia-Idade
Reação em Cadeia da Polimerase Multiplex
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Prevalência
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189300



página 1 de 890 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde