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[PMID]:29362916
[Au] Autor:Tanaka T; Voigt MD
[Ad] Endereço:Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA, USA. tomohiro-tanaka@uiowa.edu.
[Ti] Título:Decision tree analysis to stratify risk of de novo non-melanoma skin cancer following liver transplantation.
[So] Source:J Cancer Res Clin Oncol;144(3):607-615, 2018 Mar.
[Is] ISSN:1432-1335
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Non-melanoma skin cancer (NMSC) is the most common de novo malignancy in liver transplant (LT) recipients; it behaves more aggressively and it increases mortality. We used decision tree analysis to develop a tool to stratify and quantify risk of NMSC in LT recipients. METHODS: We performed Cox regression analysis to identify which predictive variables to enter into the decision tree analysis. Data were from the Organ Procurement Transplant Network (OPTN) STAR files of September 2016 (n = 102984). RESULTS: NMSC developed in 4556 of the 105984 recipients, a mean of 5.6 years after transplant. The 5/10/20-year rates of NMSC were 2.9/6.3/13.5%, respectively. Cox regression identified male gender, Caucasian race, age, body mass index (BMI) at LT, and sirolimus use as key predictive or protective factors for NMSC. These factors were entered into a decision tree analysis. The final tree stratified non-Caucasians as low risk (0.8%), and Caucasian males > 47 years, BMI < 40 who did not receive sirolimus, as high risk (7.3% cumulative incidence of NMSC). The predictions in the derivation set were almost identical to those in the validation set (r = 0.971, p < 0.0001). Cumulative incidence of NMSC in low, moderate and high risk groups at 5/10/20 year was 0.5/1.2/3.3, 2.1/4.8/11.7 and 5.6/11.6/23.1% (p < 0.0001). CONCLUSIONS: The decision tree model accurately stratifies the risk of developing NMSC in the long-term after LT.
[Mh] Termos MeSH primário: Técnicas de Apoio para a Decisão
Árvores de Decisões
Transplante de Fígado/efeitos adversos
Neoplasias Cutâneas/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Imunossupressores/uso terapêutico
Incidência
Transplante de Fígado/estatística & dados numéricos
Masculino
Meia-Idade
Neoplasia de Células Basais/epidemiologia
Neoplasia de Células Basais/etiologia
Neoplasias de Células Escamosas/epidemiologia
Neoplasias de Células Escamosas/etiologia
Medição de Risco
Fatores de Risco
Neoplasias Cutâneas/epidemiologia
Condicionamento Pré-Transplante/efeitos adversos
Condicionamento Pré-Transplante/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1007/s00432-018-2589-5


  2 / 1505 MEDLINE  
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[PMID]:29085074
[Au] Autor:Rolfo C; Raez L
[Ad] Endereço:Phase I-Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital & Center for Oncology Research (CORE) Antwerp University, Antwerp, Belgium.
[Ti] Título:New targets bring hope in squamous cell lung cancer: neurotrophic tyrosine kinase gene fusions.
[So] Source:Lab Invest;97(11):1268-1270, 2017 Nov.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurotrophic tyrosine kinase genes encode for the Trk-family proteins TrkA, TrkB, and TrkC, which have an important role in the development of the nervous system; however, they have been identified as oncogenic fusions in solid tumors (NTK-1, NTRK-2, and NTRK-3) and are associated with poor survival in lung cancer. These three new fusions can be detected by fluorescent in situ hybridization or next-generation sequencing in less than 5% of the lung tumors. There are several ongoing clinical trials of NTRK oncogenes in lung cancer and other tumors. The agents entrectinib (RXDX-101), a multi-kinase small molecule inhibitor that selectively inhibits NTRK1, NTRK2, and NTRK3, ROS1 and ALK, and LOXO-101, an ATP-competitive pan-NTRK inhibitor, have shown responses in patients with lung cancer with an acceptable toxicity profile. Although these oncogenic fusions are not very prevalent, the high prevalence of lung cancer makes these findings very relevant and suggests the feasibility of these oncogenes as targets in lung cancer. New data from Ozono and collaborators presented in this issue suggest that BDNF/TrkB signal promotes proliferating migratory and invasive phenotypes and cellular plasticity in squamous cell carcinoma (SCC) of the lung but that it also represents a druggable target that may bring hope to squamous lung cancer patients.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias de Células Escamosas/tratamento farmacológico
Proteínas de Fusão Oncogênicas/antagonistas & inibidores
Receptores Proteína Tirosina Quinases/genética
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/efeitos adversos
Seres Humanos
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/metabolismo
Glicoproteínas de Membrana/antagonistas & inibidores
Glicoproteínas de Membrana/genética
Glicoproteínas de Membrana/metabolismo
Terapia de Alvo Molecular/efeitos adversos
Neoplasias de Células Escamosas/genética
Neoplasias de Células Escamosas/metabolismo
Proteínas de Fusão Oncogênicas/genética
Proteínas de Fusão Oncogênicas/metabolismo
Receptor trkA/antagonistas & inibidores
Receptor trkA/genética
Receptor trkA/metabolismo
Receptor trkB/antagonistas & inibidores
Receptor trkB/genética
Receptor trkB/metabolismo
Receptor trkC/antagonistas & inibidores
Receptor trkC/genética
Receptor trkC/metabolismo
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Membrane Glycoproteins); 0 (Oncogene Proteins, Fusion); 0 (TRKA protein, human); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (Receptor, trkA); EC 2.7.10.1 (Receptor, trkB); EC 2.7.10.1 (Receptor, trkC); EC 2.7.10.1 (tropomyosin-related kinase-B, human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171101
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2017.91


  3 / 1505 MEDLINE  
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[PMID]:28982887
[Au] Autor:Fujimoto Y; Nakashima Y; Sasaki S; Jogo T; Hirose K; Edahiro K; Korehisa S; Taniguchi D; Kudou K; Nakaji YU; Nakanishi R; Ando K; Saeki H; Oki E; Fujiwara M; Oda Y; Maehara Y
[Ad] Endereço:Department of Surgery and Science, Graduate School of Medical Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
[Ti] Título:Chemoradiotherapy for Solitary Skeletal Muscle Metastasis from Oesophageal Cancer: Case Report and Brief Literature Review.
[So] Source:Anticancer Res;37(10):5687-5691, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The incidence of skeletal muscle metastasis from oesophageal cancer is very low, and the treatment strategy has not been established. CASE REPORT: A 77-year-old man underwent oesophagectomy following neoadjuvant chemotherapy for oesophageal squamous cell carcinoma (CT-pT3 N0 M0, CT-pStage II). Fourteen months after surgery, he became aware of a subcutaneous tumour in his left forearm. Computed tomography and fluorodeoxyglucose positron-emission tomography revealed a 65×75 mm intramuscular nodular lesion with a standardized uptake value of 8.5. Further examination by biopsy strongly suggested this was a solitary metastasis from oesophageal cancer. The patient received chemoradiotherapy with two cycles of 5-fluorouracil combined with cisplatin and radiation. Clinical complete response was confirmed by imaging 7 months after chemoradiation and no recurrence has occurred at 20 months since chemoradiation. CONCLUSION: Radiotherapy or chemoradiotherapy can be an alternative locoregional therapy to surgery for solitary skeletal muscle metastasis.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Quimiorradioterapia
Neoplasias Esofágicas/patologia
Neoplasias Musculares/secundário
Neoplasias Musculares/terapia
Músculo Esquelético/patologia
Neoplasias de Células Escamosas/secundário
Neoplasias de Células Escamosas/terapia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Biópsia
Carcinoma de Células Escamosas
Cisplatino/administração & dosagem
Fluoruracila/administração & dosagem
Antebraço
Seres Humanos
Imuno-Histoquímica
Imagem por Ressonância Magnética
Masculino
Neoplasias Musculares/química
Músculo Esquelético/química
Estadiamento de Neoplasias
Neoplasias de Células Escamosas/química
Tomografia por Emissão de Pósitrons
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor); Q20Q21Q62J (Cisplatin); U3P01618RT (Fluorouracil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  4 / 1505 MEDLINE  
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[PMID]:28938008
[Au] Autor:Hebbrecht T; Van Audenhove I; Zwaenepoel O; Verhelle A; Gettemans J
[Ad] Endereço:Department of Biochemistry, Faculty of Medicine and Health Sciences, Rommelaere Campus, Ghent University, Ghent, Belgium.
[Ti] Título:VCA nanobodies target N-WASp to reduce invadopodium formation and functioning.
[So] Source:PLoS One;12(9):e0185076, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Invasive cancer cells develop small actin-based protrusions called invadopodia, which perform a primordial role in metastasis and extracellular matrix remodelling. Neural Wiskott-Aldrich syndrome protein (N-WASp) is a scaffold protein which can directly bind to actin monomers and Arp2/3 and is a crucial player in the formation of an invadopodium precursor. Expression modulation has pointed to an important role for N-WASp in invadopodium formation but the role of its C-terminal VCA domain in this process remains unknown. In this study, we generated alpaca nanobodies against the N-WASp VCA domain and investigated if these nanobodies affect invadopodium formation. By using this approach, we were able to study functions of a selected functional/structural N-WASp protein domain in living cells, without requiring overexpression, dominant negative mutants or siRNAs which target the gene, and hence the entire protein. When expressed as intrabodies, the VCA nanobodies significantly reduced invadopodium formation in both MDA-MB-231 breast cancer and HNSCC61 head and neck squamous cancer cells. Furthermore, expression of distinct VCA Nbs (VCA Nb7 and VCA Nb14) in PC-3 prostate cancer cells resulted in reduced overall matrix degradation without affecting MMP9 secretion/activation or MT1-MMP localisation at invadopodial membranes. From these results, we conclude that we have generated nanobodies targeting N-WASp which reduce invadopodium formation and functioning, most likely via regulation of N-WASp-Arp2/3 complex interaction, indicating that this region of N-WASp plays an important role in these processes.
[Mh] Termos MeSH primário: Neoplasias/metabolismo
Neoplasias/patologia
Podossomos/metabolismo
Anticorpos de Domínio Único/metabolismo
Proteína Neuronal da Síndrome de Wiskott-Aldrich/imunologia
Proteína Neuronal da Síndrome de Wiskott-Aldrich/metabolismo
[Mh] Termos MeSH secundário: Complexo 2-3 de Proteínas Relacionadas à Actina/metabolismo
Actinas/metabolismo
Afinidade de Anticorpos
Neoplasias da Mama/metabolismo
Neoplasias da Mama/patologia
Linhagem Celular Tumoral
Matriz Extracelular/metabolismo
Células HEK293
Neoplasias de Cabeça e Pescoço/metabolismo
Neoplasias de Cabeça e Pescoço/patologia
Seres Humanos
Espaço Intracelular/metabolismo
Masculino
Membranas Mitocondriais/metabolismo
Membranas Mitocondriais/patologia
Neoplasias de Células Escamosas/metabolismo
Neoplasias de Células Escamosas/patologia
Podossomos/patologia
Neoplasias da Próstata/metabolismo
Neoplasias da Próstata/patologia
Ligação Proteica
Domínios Proteicos
Anticorpos de Domínio Único/imunologia
Proteína Neuronal da Síndrome de Wiskott-Aldrich/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actin-Related Protein 2-3 Complex); 0 (Actins); 0 (Single-Domain Antibodies); 0 (WASL protein, human); 0 (Wiskott-Aldrich Syndrome Protein, Neuronal)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185076


  5 / 1505 MEDLINE  
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[PMID]:28739712
[Au] Autor:Reiter M; Harréus U
[Ad] Endereço:Department of Otolaryngology and Head and Neck Surgery, Ludwig Maximilians University, Munich, Germany maximilian.reiter@med.uni-muenchen.de.
[Ti] Título:Total Glossectomy Without Laryngectomy for Advanced Squamous Cell Cancer of the Tongue: Functional and Oncological Results.
[So] Source:Anticancer Res;37(8):4233-4237, 2017 08.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Total glossectomy without laryngectomy for large tongue carcinomas still remains controversial, as these defects may go along with dramatic effects on respiration, speech and swallowing. As a consequence, these procedures significantly impact quality of life. Therefore, larger case series are rare. Nevertheless, with the development of free tissue transfer, functional reconstruction has become increasingly popular and encouraging results are reported in the literature. PATIENTS AND METHODS: We present our experience with complete glossectomy without laryngectomy and free flap reconstruction. A retrospective monocenter cohort-study was conducted. Reconstructive principles, which in our view lead to optimal functional results, are presented. Oncologic, as well as functional results are reported. Functional results were assessed in terms of swallowing ability, decannulation and intelligible speech. RESULTS: A total of 14 patients met the inclusion criteria. All patients were reconstructed using an anterolateral thigh flap. Complications occurred in 4 patients, 3 of which developed fistula formation. Oral feeding without the need for a gastrostomy tube was resumed in 11 patients (78.6%), 12 patients (85.7%) were able to be permanently decannulated and speech was at least acceptable in 12 patients (85.7%). The three-year survival was 57.1%. CONCLUSION: Following meticulous reconstructive principles, as well as a proper patient selection, total glossectomy without laryngectomy is a feasible treatment option for advanced cancer of the tongue.
[Mh] Termos MeSH primário: Glossectomia/métodos
Neoplasias de Células Escamosas/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Neoplasias da Língua/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Intervalo Livre de Doença
Feminino
Seres Humanos
Laringectomia
Masculino
Meia-Idade
Estadiamento de Neoplasias
Neoplasias de Células Escamosas/patologia
Complicações Pós-Operatórias/patologia
Neoplasias da Língua/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  6 / 1505 MEDLINE  
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[PMID]:28631575
[Au] Autor:Zhang Y; Hu H
[Ad] Endereço:Department of Otolaryngology, Huaihe Hospital of Henan University, Kaifeng, China.
[Ti] Título:Long non-coding RNA CCAT1/miR-218/ZFX axis modulates the progression of laryngeal squamous cell cancer.
[So] Source:Tumour Biol;39(6):1010428317699417, 2017 Jun.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Long non-coding RNAs have been proved to be closely associated with different cancers. This study was designed to elucidate the function and mechanisms of colon cancer-associated transcript-1 in the progression of human laryngeal squamous cell cancer. Expressions of colon cancer-associated transcript-1, microRNA-218, and zinc finger protein, X-linked messenger RNA were measured using quantitative real-time polymerase chain reaction, and the expression level of zinc finger protein, X-linked protein was detected using western blot. Proliferation and invasion of laryngeal squamous cell cancer cell lines were detected by Cell Counting Kit-8 assay and Transwell invasion assay, respectively. Luciferase assay was used to confirm whether microRNA-218 is a target of colon cancer-associated transcript-1 and whether microRNA-218 directly binds to 3'-untranslated region of zinc finger protein, X-linked messenger RNA. Effect of colon cancer-associated transcript-1 on tumor growth was observed through xenograft mice models in vivo. The results showed that expressions of colon cancer-associated transcript-1 and zinc finger protein, X-linked were significantly higher while microRNA-218 expression was significantly lower in the laryngeal squamous cell cancer tissues than those in the adjacent normal tissues. MicroRNA-218 overexpression or zinc finger protein, X-linked silencing significantly suppressed proliferation and invasion of laryngeal squamous cell cancer cells. Moreover, knockdown of colon cancer-associated transcript-1 significantly inhibited proliferation and invasion of laryngeal squamous cell cancer cells, which were reversed by microRNA-218 downregulation or zinc finger protein, X-linked upregulation. Finally, colon cancer-associated transcript-1 silencing inhibited xenograft tumor growth of laryngeal squamous cell cancer in vivo. In conclusion, colon cancer-associated transcript-1 knockdown inhibits proliferation and invasion of laryngeal squamous cell cancer cells through enhancing zinc finger protein, X-linked by sponging microRNA-218, elucidating a novel colon cancer-associated transcript-1-microRNA-218-zinc finger protein, X-linked regulatory axis in laryngeal squamous cell cancer and providing a promising therapeutic target for laryngeal squamous cell cancer patients.
[Mh] Termos MeSH primário: Fatores de Transcrição Kruppel-Like/biossíntese
Neoplasias Laríngeas/genética
MicroRNAs/biossíntese
Neoplasias de Células Escamosas/genética
RNA Longo não Codificante/biossíntese
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas
Apoptose/genética
Linhagem Celular Tumoral
Proliferação Celular/genética
Progressão da Doença
Feminino
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Fatores de Transcrição Kruppel-Like/genética
Neoplasias Laríngeas/patologia
Masculino
MicroRNAs/genética
Invasividade Neoplásica/genética
Neoplasias de Células Escamosas/patologia
RNA Longo não Codificante/genética
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (CCAT1 long noncoding RNA, human); 0 (Kruppel-Like Transcription Factors); 0 (MIRN218 microRNA, human); 0 (MicroRNAs); 0 (RNA, Long Noncoding); 0 (zinc finger protein, X-linked)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317699417


  7 / 1505 MEDLINE  
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[PMID]:28528688
[Au] Autor:Harden ME; Munger K
[Ad] Endereço:Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, 02115, USA; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, 02111, USA.
[Ti] Título:Human papillomavirus molecular biology.
[So] Source:Mutat Res Rev Mutat Res;772:3-12, 2017 Apr - Jun.
[Is] ISSN:1388-2139
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses.
[Mh] Termos MeSH primário: Epitélio/virologia
Papillomaviridae/genética
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/prevenção & controle
Carcinoma de Células Escamosas/virologia
Epitélio/patologia
Genoma Viral
Seres Humanos
Biologia Molecular
Neoplasias Bucais/patologia
Neoplasias Bucais/virologia
Neoplasias de Células Escamosas/prevenção & controle
Neoplasias de Células Escamosas/virologia
Papillomaviridae/classificação
Papillomaviridae/fisiologia
Vacinas contra Papillomavirus/uso terapêutico
Proteínas Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Papillomavirus Vaccines); 0 (Viral Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


  8 / 1505 MEDLINE  
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[PMID]:28428509
[Au] Autor:Kubo Y
[Ad] Endereço:Dept. of Dermatology, Tokushima University Hospital.
[Ti] Título:[I. Molecular Carcinogenesis of the Skin - An Update].
[So] Source:Gan To Kagaku Ryoho;44(4):299-301, 2017 Apr.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Transformação Celular Neoplásica/genética
Melanoma/genética
Neoplasias de Células Escamosas/genética
Neoplasias Cutâneas/genética
[Mh] Termos MeSH secundário: Seres Humanos
Mutação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


  9 / 1505 MEDLINE  
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[PMID]:28422883
[Au] Autor:Huang JW; Lin YY; Wu NY; Tsai CH
[Ad] Endereço:aDepartment of Surgery, National Yang-Ming University Hospital, Yilan bInstitute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University cDepartment of Pediatrics, Heping Fuyou Branch, Taipei City Hospital dInstitute of Biomedical Informatics, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
[Ti] Título:Transverse rectus abdominis myocutaneous flap for postpneumonectomy bronchopleural fistula: A case report.
[So] Source:Medicine (Baltimore);96(16):e6688, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Numerous types of flap coverage have been reported to prevent or to repair bronchopleural fistulas. Most of the flaps were harvested from chest area. However, these pedicled flaps might not be optimal for the patient who has undergone previous radiotherapy on pulmonary parenchyma because the pedicle artery of the flap might have been injured by irradiation. Therefore, an alternative flap outside of the chest area is necessary. PATIENT CONCERNS: A 61-year-old male was diagnosed of squamous cell carcinoma in right upper lobe lung (cT3N2M0, stage IIIa). After completing the neoadjuvant chemoradiotherapy, he underwent video-assisted thoracoscopic surgery with right side intrapericardial pneumonectomy. DIAGNOSIS: Persistent air leak due to postpneumonectomy bronchopleural fistula. INTERVENTIONS: Pedicled transverse rectus abdominis myocutaneous (TRAM) flap was used to repair the bronchial stump. OUTCOMES: The bronchial stump was repaired successfully, the bronchopleural fistula was obliterated, and the patient was free from air leak after following for 12 months. LESSONS: This case demonstrated that pedicled TRAM flap is a feasible alternative to repair bronchopleural fistula.
[Mh] Termos MeSH primário: Fístula Brônquica/etiologia
Fístula Brônquica/cirurgia
Pneumonectomia/efeitos adversos
Reto do Abdome
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias Pulmonares/cirurgia
Masculino
Meia-Idade
Neoplasias de Células Escamosas/cirurgia
Complicações Pós-Operatórias/cirurgia
Cirurgia Torácica Vídeoassistida
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006688


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[PMID]:28420894
[Au] Autor:Shirakawa Y; Noma K; Maeda N; Tanabe S; Kuroda S; Kagawa S; Katsui K; Katayama N; Kanazawa S; Fujiwara T
[Ad] Endereço:Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.yasuwr@md.okayama-u.ac.jp.
[Ti] Título:Outcome of Radiation Monotherapy for High-risk Patients with Stage I Esophageal Cancer.
[So] Source:Acta Med Okayama;71(2):127-133, 2017 Apr.
[Is] ISSN:0386-300X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified.
[Mh] Termos MeSH primário: Adenocarcinoma/radioterapia
Neoplasias Esofágicas/radioterapia
Neoplasias de Células Escamosas/radioterapia
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adulto
Idoso
Idoso de 80 Anos ou mais
Quimiorradioterapia
Terapia Combinada
Neoplasias Esofágicas/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estadiamento de Neoplasias
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.18926/AMO/54981



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