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[PMID]:29400034
[Au] Autor:Kharoubi S
[Ti] Título:[Benign tumors of the nasal cavity, new classification and review of the literature. Report of 54 cases].
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(4):131-42, 2015.
[Is] ISSN:0035-1334
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Benign tumors of the nasal cavity is an uncommon disease and very diverse about histological variety. Theses tumors are seen at any age without specificity in semiological aspect. The diagnostic approach is based on nasal endoscopy, imaging (CT-MRI) and biopsy. In some anatomo clinical varieties the result of biopsy is so difficult and we must analyze all the tumor specimen after surgery with modern biological procedure (immunohistochemistry, molecular biology). The treatment is surgery especially with endonasal endoscopic procedure. Our series included 54 benign endonasal tumors between January 1998 and December 2008. The mean age of our population is 28 years with a female sex ratio of 1.16. Endoscopic examina­tion and a CT scan of facial bones were systematic. The tumors of nasal septum were predominant. The histological variety are dominated by vascular tumors (hemangioma) in 36 cases (66.6%) and papilloma (papilloma and inverted papilloma) in 15 cases (27.7%), two cases of fibroma (37%) and one case of leiomyoma. The treatment was surgical with an endonasal approach in 37 cases (68.5%), endonasal and endoscopic in 11 cases (20.3%) and external 6 cases (11.1%). A review of the literature on tumors of the nasal cavity is made during this study.
[Mh] Termos MeSH primário: Cavidade Nasal/patologia
Neoplasias Nasais/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Endoscopia
Feminino
Fibroma/patologia
Fibroma/cirurgia
Hemangioma/patologia
Hemangioma/cirurgia
Seres Humanos
Leiomioma/patologia
Leiomioma/cirurgia
Masculino
Meia-Idade
Cavidade Nasal/cirurgia
Neoplasias Nasais/cirurgia
Papiloma/patologia
Papiloma/cirurgia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


  2 / 9357 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28746592
[Au] Autor:Ferrari AP; Martins FP
[Ad] Endereço:Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
[Ti] Título:Endoscopic surveillance of extensive esophageal papillomatosis not amenable to endoscopic therapy.
[So] Source:Einstein (Sao Paulo);15(3):363-365, 2017 Jul-Sep.
[Is] ISSN:2317-6385
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:We present two cases of esophageal papillomatosis, a very rare reported disease leading to dysphagia and did not improve after endoscopic treatment. Both patients refused surgery and they were followed-up for 3 years, but no significant clinical or endoscopic changes were seen.
[Mh] Termos MeSH primário: Transtornos de Deglutição/diagnóstico
Endoscopia do Sistema Digestório
Neoplasias Esofágicas/diagnóstico
Papiloma/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Transtornos de Deglutição/etiologia
Endoscopia do Sistema Digestório/efeitos adversos
Neoplasias Esofágicas/complicações
Feminino
Seres Humanos
Papiloma/complicações
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  3 / 9357 MEDLINE  
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[PMID]:28470939
[Au] Autor:Miyoshi R; Menju T; Yoshizawa A; Date H
[Ad] Endereço:Department of Thoracic Surgery, Kyoto University Hospital, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan.
[Ti] Título:Expression of p16 in mixed squamous cell and glandular papilloma of the lung.
[So] Source:Pathol Int;67(6):306-310, 2017 Jun.
[Is] ISSN:1440-1827
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Mixed squamous cell and glandular papilloma (mixed papilloma) of the lung is an extremely rare neoplasm, with only 21 cases reported in the English literature. Although the expression of p16 has been analyzed in only two cases of mixed papilloma, they were negative for p16 . Therefore, the significance of p16 overexpression in mixed papilloma remains unclear. This is the first case of mixed papilloma with positive p16 expression in a 72-year-old male smoker. The 20 mm sized tumor was histologically diagnosed as mixed papilloma following right upper lobectomy. Immunohistochemically, cytokeratin 5 and p40 positivity was predominant in basal cells of the glandular component and squamous cells, while thyroid transcription factor-1, p53, and Ki-67 were focally positive. Both glandular and squamous components were diffusely positive for p16 . This finding could be important to clarify the pathogenesis and biology of mixed papilloma.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Inibidor p16 de Quinase Dependente de Ciclina/metabolismo
Neoplasias Pulmonares/diagnóstico por imagem
Papiloma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Células Epiteliais/metabolismo
Células Epiteliais/patologia
Seres Humanos
Imuno-Histoquímica
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/patologia
Masculino
Papiloma/metabolismo
Papiloma/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cyclin-Dependent Kinase Inhibitor p16); 0 (P16 protein, human)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/pin.12531


  4 / 9357 MEDLINE  
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[PMID]:29020597
[Au] Autor:Barrios DM; LaDuca JR
[Ad] Endereço:State University of New York Upstate Medical University, Syracuse, NY dulcebarriosms@gmail.com.
[Ti] Título:Lingual Papillomas.
[So] Source:N Engl J Med;377(15):e22, 2017 Oct 12.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Síndrome do Hamartoma Múltiplo/diagnóstico
Papiloma/patologia
Neoplasias da Língua/patologia
Língua/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
Mutação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1700204


  5 / 9357 MEDLINE  
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[PMID]:28949246
[Au] Autor:de la Fuente J; Garrett CG; Ossoff R; Vinson K; Francis DO; Gelbard A
[Ad] Endereço:1 Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
[Ti] Título:A Case Series of the Probability Density and Cumulative Distribution of Laryngeal Disease in a Tertiary Care Voice Center.
[So] Source:Ann Otol Rhinol Laryngol;126(11):748-754, 2017 Nov.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To examine the distribution of clinic and operative pathology in a tertiary care laryngology practice. METHODS: Probability density and cumulative distribution analyses (Pareto analysis) was used to rank order laryngeal conditions seen in an outpatient tertiary care laryngology practice and those requiring surgical intervention during a 3-year period. RESULTS: Among 3783 new clinic consultations and 1380 operative procedures, voice disorders were the most common primary diagnostic category seen in clinic (n = 3223), followed by airway (n = 374) and swallowing (n = 186) disorders. Within the voice strata, the most common primary ICD-9 code used was dysphonia (41%), followed by unilateral vocal fold paralysis (UVFP) (9%) and cough (7%). Among new voice patients, 45% were found to have a structural abnormality. The most common surgical indications were laryngotracheal stenosis (37%), followed by recurrent respiratory papillomatosis (18%) and UVFP (17%). CONCLUSIONS: Nearly 55% of patients presenting to a tertiary referral laryngology practice did not have an identifiable structural abnormality in the larynx on direct or indirect examination. The distribution of ICD-9 codes requiring surgical intervention was disparate from that seen in clinic. Application of the Pareto principle may improve resource allocation in laryngology, but these initial results require confirmation across multiple institutions.
[Mh] Termos MeSH primário: Doenças da Laringe/diagnóstico
Doenças da Laringe/cirurgia
Atenção Terciária à Saúde
[Mh] Termos MeSH secundário: Efeitos Psicossociais da Doença
Tosse/diagnóstico
Tosse/cirurgia
Disfonia/diagnóstico
Disfonia/cirurgia
Seres Humanos
Laringoestenose/diagnóstico
Laringoestenose/cirurgia
Papiloma/diagnóstico
Papiloma/cirurgia
Neoplasias do Sistema Respiratório/diagnóstico
Neoplasias do Sistema Respiratório/cirurgia
Tennessee
Centros de Atenção Terciária
Estenose Traqueal/diagnóstico
Estenose Traqueal/cirurgia
Paralisia das Pregas Vocais/diagnóstico
Paralisia das Pregas Vocais/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417728945


  6 / 9357 MEDLINE  
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[PMID]:28845940
[Au] Autor:Loran OB; Sinyakova LA; Gundorova LV; Kosov VA; Kosova IV; Pogodina IE; Kolbasov DN
[Ad] Endereço:Department of Urology and Surgical Andrology RMACPE, Moscow, Russia.
[Ti] Título:[High oncogenic risk human papillomavirus and urinary bladder cancer].
[So] Source:Urologiia;(3):60-66, 2017 Jul.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To determine the role of human papillomavirus (HPV) of high oncogenic risk in the development of urinary bladder cancer. MATERIALS AND METHODS: 100 patients (72 men and 28 women) aged 38 to 90 years (mean age 65+/-10 years) diagnosed with bladder cancer were examined and underwent treatment. Clinical assessment was complemented by enzyme-linked immunosorbent assays for the presence of antiviral antibodies to herpes simplex virus (HSV) type 1 and type 2, cytomegalovirus (CMV), Epstein-Barr virus (EBV), urethra scraping for detecting high oncogenic risk HPV. Tumor tissue was sampled for PCR virus detection. Semi-quantitative analysis was used to evaluate the components of lymphocyte-plasmocyte and leukocyte infiltrates and cytopathic changes in tumor tissue. RESULTS: There were positive correlations between cytopathic cell changes (koylocytosis and intranuclear inclusions, as manifestations of HPV) and the level of antiviral antibodies, the presence of viruses in the tumor, as well as with the components of the lymphoid-plasmocyte infiltrate. Negative correlations were found between the presence of papillomatosis and the above changes. CONCLUSION: Human papillomavirus is believed to be a trigger for the initiation of a tumor in young patients with a latent infection (CMV and EBV, HSV, HPV). Cytopathic changes (kylocytosis and intranuclear inclusions) were associated with the activity and morphological features of herpes-viral infections. Their degree varied depending on the stage of the process, but not on the anaplasia degree. Papillomatosis is associated with a more favorable course of the tumor process.
[Mh] Termos MeSH primário: Papiloma/virologia
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/virologia
Neoplasias da Bexiga Urinária/virologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Antivirais/sangue
Efeito Citopatogênico Viral
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Masculino
Meia-Idade
Estadiamento de Neoplasias
Papiloma/sangue
Papiloma/patologia
Infecções por Papillomavirus/sangue
Infecções por Papillomavirus/patologia
Neoplasias da Bexiga Urinária/sangue
Neoplasias da Bexiga Urinária/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


  7 / 9357 MEDLINE  
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[PMID]:28807115
[Au] Autor:Duvall MJ; Maxon JA; Lehman JS
[Ad] Endereço:Department of Family Medicine, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:Correlation between HPV status via in situ hybridization testing on genital squamous papillomas and risk for cervical dysplasia or other anogenital HPV-related complications: A case-control study.
[So] Source:J Am Acad Dermatol;77(3):579-580, 2017 09.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças do Ânus/virologia
Neoplasia Intraepitelial Cervical/virologia
Condiloma Acuminado/virologia
Neoplasias dos Genitais Femininos/virologia
Papiloma/virologia
Infecções por Papillomavirus/virologia
[Mh] Termos MeSH secundário: Células Escamosas Atípicas do Colo do Útero/virologia
Estudos de Casos e Controles
Feminino
Neoplasias dos Genitais Femininos/patologia
Seres Humanos
Hibridização In Situ
Meia-Idade
Teste de Papanicolaou
Papiloma/patologia
Infecções por Papillomavirus/genética
Estudos Retrospectivos
Lesões Intraepiteliais Escamosas Cervicais/virologia
Esfregaço Vaginal
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


  8 / 9357 MEDLINE  
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[PMID]:28720294
[Au] Autor:Munday JS; Thomson NA; Luff JA
[Ad] Endereço:Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand. Electronic address: j.munday@massey.ac.nz.
[Ti] Título:Papillomaviruses in dogs and cats.
[So] Source:Vet J;225:23-31, 2017 Jul.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Papillomaviruses (PVs) cause disease in both dogs and cats. In dogs, PVs are thought to cause oral papillomatosis, cutaneous papillomas and canine viral pigmented plaques, whereas PVs have been rarely associated with the development of oral and cutaneous squamous cell carcinomas in this species. In cats, PVs are currently thought to cause oral papillomas, feline viral plaques, Bowenoid in situ carcinomas and feline sarcoids. Furthermore, there is increasing evidence that PVs may also be a cause of cutaneous squamous cell carcinomas and basal cell carcinomas in cats. These diseases are discussed in this review. Additionally, there is a brief overview of PV biology, including how these viruses cause disease. Diagnostic techniques and possible methods to prevent PV infection are also discussed.
[Mh] Termos MeSH primário: Doenças do Gato/virologia
Doenças do Cão/virologia
Infecções por Papillomavirus/veterinária
[Mh] Termos MeSH secundário: Animais
Doença de Bowen/veterinária
Carcinoma Basocelular/veterinária
Carcinoma Basocelular/virologia
Carcinoma de Células Escamosas/veterinária
Gatos
Cães
Neoplasias Bucais/veterinária
Neoplasias Bucais/virologia
Papiloma/veterinária
Papiloma/virologia
Papillomaviridae/classificação
Papillomaviridae/genética
Papillomaviridae/patogenicidade
Infecções por Papillomavirus/diagnóstico
Infecções por Papillomavirus/prevenção & controle
Neoplasias Cutâneas/veterinária
Neoplasias Cutâneas/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE


  9 / 9357 MEDLINE  
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[PMID]:28615209
[Au] Autor:Work TM; Dagenais J; Weatherby TM; Balazs GH; Ackermann M
[Ad] Endereço:U.S. Geological Survey, National Wildlife Health Center, Honolulu Field Station, Honolulu, Hawaii, USA Thierry_work@usgs.gov.
[Ti] Título: Replication of Chelonid Herpesvirus 5 in Organotypic Skin Cultures from Hawaiian Green Turtles (Chelonia mydas).
[So] Source:J Virol;91(17), 2017 Sep 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fibropapillomatosis (FP) is a tumor disease of marine turtles associated with chelonid herpesvirus 5 (ChHV5), which has historically been refractory to growth in tissue culture. Here we show, for the first time, formation of ChHV5-positive intranuclear inclusions in cultured green turtle cells, which is indicative of active lytic replication of the virus. The minimal requirements to achieve lytic replication in cultured cells included (i) either cultures of ChHV5-positive tumor biopsy specimens (plugs) or organotypic cultures (rafts) consisting of ChHV5-positive turtle fibroblasts in collagen rafts seeded with turtle keratinocytes and (ii) keratinocyte maturation induced by raising raft or biopsy cultures to the air-liquid interface. Virus growth was confirmed by detailed electron microscopic studies that revealed intranuclear sun-shaped capsid factories, tubules, various stages of capsid formation, nuclear export by budding into the perinuclear space, tegument formation, and envelopment to complete virus production. Membrane synthesis was also observed as a sign of active viral replication. Interestingly, cytoplasmic particles became associated with keratin filaments, a feature not seen in conventional monolayer cell cultures, in which most studies of herpesvirus replication have been performed. Our findings draw a rich and realistic picture of ChHV5 replication in cells derived from its natural host and may be crucial not only to better understand ChHV5 circulation but also to eventually complete Koch's postulates for FP. Moreover, the principles described here may serve as a model for culture of other viruses that are resistant to replication in conventional cell culture. A major challenge in virology is the study of viruses that cannot be grown in the laboratory. One example is chelonid herpesvirus 5 (ChHV5), which is associated with fibropapillomatosis, a globally distributed, debilitating, and fatal tumor disease of endangered marine turtles. Pathological examination shows that ChHV5 is shed in skin. Here we show that ChHV5 will grow if we replicate the complex three-dimensional structure of turtle skin. Moreover, lytic virus growth requires a close interplay between fibroblasts and keratinocytes. Finally, the morphogenesis of herpesviral growth in three-dimensional cultures reveals a far richer, and likely more realistic, array of capsid morphologies than that encountered in traditional monolayer cell cultures. Our findings have applications to other viruses, including those of humans.
[Mh] Termos MeSH primário: Herpesviridae/fisiologia
Queratinócitos/ultraestrutura
Pele/patologia
Tartarugas/virologia
[Mh] Termos MeSH secundário: Animais
Núcleo Celular/ultraestrutura
Núcleo Celular/virologia
Citoplasma/ultraestrutura
Citoplasma/virologia
Replicação do DNA
Hawaii
Herpesviridae/ultraestrutura
Infecções por Herpesviridae/veterinária
Corpos de Inclusão Intranuclear/virologia
Microscopia Eletrônica
Técnicas de Cultura de Órgãos
Papiloma/veterinária
Papiloma/virologia
Pele/virologia
Neoplasias Cutâneas/veterinária
Neoplasias Cutâneas/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE


  10 / 9357 MEDLINE  
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[PMID]:28476808
[Au] Autor:Ciesielska U; Zatonski T; Nowinska K; Ratajczak-Wielgomas K; Grzegrzolka J; Piotrowska A; Olbromski M; Pula B; Podhorska-Okolow M; Dziegiel P
[Ad] Endereço:Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland urszula.ciesielska@umed.wroc.pl.
[Ti] Título:Expression of Cell Cycle-related Proteins p16, p27 and Ki-67 Proliferating Marker in Laryngeal Squamous Cell Carcinomas and in Laryngeal Papillomas.
[So] Source:Anticancer Res;37(5):2407-2415, 2017 05.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The deregulation of the cell cycle is crucial for the processes of carcinogenesis and tumor progression. The cell cycle is under the control of cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs). Proteins p16 and p27 are CDKIs, and their altered expression has been noticed in many types of cancers. The aim of this study has been to compare the expression levels of these proteins in laryngeal papillomas and carcinomas in order to confirm their predictive value in cancer development. MATERIALS AND METHODS: Eighty-three cases of laryngeal lesions were analyzed: cancers (51) and papillomas (32). Immunohistochemical (IHC) reactions were performed in order to detect the expression levels of p16, p27 and Ki-67. Immunofluorescence (IF) and western blot were performed on HEp-2 cell line. RESULTS: The expression of p16 and p27 was decreased in cancer cells in comparison to papillomas. Additionally, we observed cytoplasmic expression of p16 in cancers and lack of such expression in papillomas. The same pattern of expression of p16 was also detected by IF and western blot analysis in HEp-2 cell line. The expression of Ki-67 protein revealed no significant differences in the case of papilloma compared with cancer, however a significant correlation between tumor grade and the nuclear expression of Ki-67 was observed. CONCLUSION: There is a necessity in finding biomarkers, which would predict the risk level of malignant transformation. Our study has confirmed that altered expressions of the p16 and p27 proteins might be useful biomarkers in the progression of laryngeal squamous cell carcinomas (LSCC).
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/metabolismo
Inibidor p16 de Quinase Dependente de Ciclina/metabolismo
Inibidor de Quinase Dependente de Ciclina p27/metabolismo
Antígeno Ki-67/metabolismo
Neoplasias Laríngeas/metabolismo
Papiloma/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/metabolismo
Linhagem Celular Tumoral
Núcleo Celular/metabolismo
Criança
Pré-Escolar
Citoplasma/metabolismo
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cyclin-Dependent Kinase Inhibitor p16); 0 (Ki-67 Antigen); 0 (P16 protein, human); 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE



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