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  1 / 621 MEDLINE  
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[PMID]:28982854
[Au] Autor:Park CK; Kim HS
[Ad] Endereço:Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Clinicopathological Characteristics of Ovarian Sclerosing Stromal Tumor with an Emphasis on TFE3 Overexpression.
[So] Source:Anticancer Res;37(10):5441-5447, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:A sclerosing stromal tumor is a very rare benign sex cord-stromal tumor of the ovary. Because its clinical presentation and imaging findings are similar to those of borderline or malignant epithelial tumors and other sex cord-stromal tumors, accurate preoperative clinical diagnosis can be difficult. The aim of this study was to analyze the clinicopathological characteristics of SSTs and examine the immunohistochemical expression TFE3, which has not been studied in SSTs. Our study cohort consisted of 9 patients diagnosed as having SST; the median age was 36 years. Radiologically, SSTs presented as multiseptated cystic masses, mixed echoic masses, pseudolobular masses, solid pelvic masses, or uterine subserosal nodules. In 4 of the 9 cases, the preoperative clinical impression was a borderline or malignant ovarian tumor. SSTs displayed the following histopathological features: 1) relatively well-circumscribed cellular nodules that were randomly distributed in the fibrous or edematous stroma; 2) a characteristic alternating pattern of hypercellular and hypocellular areas; 3) a hemangiopericytoma-like vascular growth pattern in the cellular nodules; 4) bland-looking spindle-shaped cells and round or polygonal cells densely clustered around blood vessels; and 5) red blood cell-containing intracytoplasmic vacuole-like spaces in the tumor cell cytoplasm, possibly indicating epithelioid hemangioendothelioma. Immunohistochemically, the tumor cells exhibited diffuse and moderate-to-strong TFE3 expression in 7 of the 9 SSTs. TFE3 was strongly expressed in the nuclei of round or polygonal cells and lutein cells. In contrast, neither luteinized thecomas nor fibromas appreciably expressed TFE3. In summary, our study describes characteristic histopathological features that may be useful for differentiating SSTs from other sex-cord stromal tumors and demonstrates for the first time that SSTs show strong TFE3 expression. Further investigations are necessary to clarify the role of TFE3 in the development of SSTs.
[Mh] Termos MeSH primário: Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/análise
Biomarcadores Tumorais/análise
Neoplasias Ovarianas/química
Tumores do Estroma Gonadal e dos Cordões Sexuais/química
Células Estromais/química
[Mh] Termos MeSH secundário: Adulto
Biópsia
Feminino
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Neoplasias Ovarianas/patologia
Esclerose
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Células Estromais/patologia
Carga Tumoral
Regulação para Cima
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Biomarkers, Tumor); 0 (TFE3 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  2 / 621 MEDLINE  
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[PMID]:28906379
[Au] Autor:Zang L; Ye M; Yang G; Li J; Liu M; Du J; Gu W; Jin N; Yang L; Ba J; Dou J; Fan W; Mu Y; Meng Y; Lyu Z
[Ad] Endereço:aDepartment of Endocrinology bDepartment of Gynecology cDepartment of Pathology, Chinese PLA General Hospital, Beijing, China.
[Ti] Título:Accessory ovarian steroid cell tumor producing testosterone and cortisol: A case report.
[So] Source:Medicine (Baltimore);96(37):e7998, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: An accessory ovary is a rare structure containing normal ovarian tissue, which has a direct or ligamentous connection with a normal and eutopic ovary. PATIENT CONCERNS: In the study, we reported a 46-year-old woman presented with secondary amenorrhea and virilization symptoms for 1 year. DIAGNOSES: Endocrine evaluation revealed slightly elevated serum cortisol, extremely elevated 24-hour urinary-free cortisol and serum testosterone. Clinical assessment exhibited a large solid mass with heterogeneous enhancement in the left adnexauteri compounded with hypercortisolism and hyperandrogenemia. An accessory ovarian tumor attached to the infundibulum of the left fallopian tube was found, and a separate normal ovary was present on the same side. INTERVENTIONS: The patient underwent a left adnexectomy. OUTCOMES: During surgery, a 12 cm × 8 cm, gray-red, and well-circumscribed solid mass was be identified. The tumor had ligamentous attachment with the infundibulum of left fallopian tube. The sectioned surface was gray-brown, lobulated and did not exhibit either significant necrosis or hemorrhage. Pathological findings demonstrated that tumor cells had small round nuclei, mild atypia, no mitosis were arranged in a diffuse pattern of columns or nests separated by a rich vascular network and no crystals of Reinke were found. It was diagnosis ovarian steroid cell tumor (NOS) without malignant behavior by immunohistochemical staining. The patient was finally diagnosed as accessory ovarian steroid. The patient was discharged from the hospital on the seventeenth day after surgery. During postoperative follow-up, the first postoperative menstrual flow recovered and blood pressure regained 1 month after surgery. Furthermore, her Cushing syndrome regressed and hirsutism disappeared completely 4 months after surgery cell tumor. LESSONS: It is vitally important to establish a final diagnosis according to the clinical manifestations and laboratory values in addition to imaging studies and laparoscopic examination of a rare coexistence of hyperandrogenemia and Cushing syndrome based on the accessory ovarian pathology.
[Mh] Termos MeSH primário: Hidrocortisona/biossíntese
Neoplasias Ovarianas/metabolismo
Ovário/anormalidades
Tumores do Estroma Gonadal e dos Cordões Sexuais/metabolismo
Testosterona/biossíntese
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Neoplasias Ovarianas/complicações
Tumores do Estroma Gonadal e dos Cordões Sexuais/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007998


  3 / 621 MEDLINE  
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[PMID]:28819473
[Au] Autor:Tahaineh S; Mughli RA; Fallatah M
[Ad] Endereço:Urology Department, Security Forces Hospital, Makkah, Saudi Arabia.
[Ti] Título:Giant mixed Sertoli-Leydig-Granulosa sex cord tumor of the testis; clinical, histopathological, and radiological features: a case report.
[So] Source:Pan Afr Med J;27:51, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Sex cord tumors of the testis in post pubertal men are rare. Mixed leydig-Sertoli-Granulosa sex cord tumors are exceptionally rare. To the best of our knowledge there are only three reported similar cases in the literature. We reported a case of a 27-year-old male who presented with huge left scrotal mass of 6-years duration. The gross tumor specimen after resection measured 11 cm in diameter. Histological examination revealed mixed sex cord stromal tumor. This case demonstrates the limited ability of accurate diagnostic determination preoperatively, with pathologic examination and immune-histochemical staining post-orchiectomy representing the only definitive means of diagnosis. It also highlights the unique radiological appearances of this tumor, which were not previously reported in literature.
[Mh] Termos MeSH primário: Orquiectomia/métodos
Tumor de Células de Sertoli-Leydig/diagnóstico
Tumores do Estroma Gonadal e dos Cordões Sexuais/diagnóstico
Neoplasias Testiculares/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Tumor de Células de Sertoli-Leydig/patologia
Tumor de Células de Sertoli-Leydig/cirurgia
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Tumores do Estroma Gonadal e dos Cordões Sexuais/cirurgia
Neoplasias Testiculares/patologia
Neoplasias Testiculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.51.10571


  4 / 621 MEDLINE  
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[PMID]:28739499
[Au] Autor:Michalova K; Michal M; Kazakov DV; Sedivcova M; Hes O; Hadravsky L; Agaimy A; Tretiakova M; Bacchi C; Hartmann A; Kuroda N; Bulimbasic S; Coric M; Antic T; Michal M
[Ad] Endereço:Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic. Electronic address: kveta.michalova@biopticka.cz.
[Ti] Título:Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm.
[So] Source:Hum Pathol;67:85-93, 2017 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT to better characterize this entity. We studied 13 cases of PSRSTTs using histological, immunohistochemical (IHC), and molecular genetic methods and compared the results with pancreatic SPN. Grossly, the size of PSRSTTs ranged from 0.5 to 2 cm (mean 1.1). Microscopically, PSRSTTs predominantly showed a proliferation of low-grade epithelioid cells containing characteristic cytoplasmic vacuole dislodging the nucleus (signet ring cells) separated by fibrous septa into trabeculae and nests. The immunoprofile was characterized by immunoreactivity for ß-catenin, cyclin D1 (nuclear positivity for both antibodies), CD10, vimentin, galectin-3, claudin 7, α-1-antitrypsin, CD56, and neuron-specific enolase and negativity for chromogranin, inhibin, calretinin, SF-1, NANOG, OCT3/4, and SALL4. In some cases, the IHC panel was restricted because of a limited amount of tissue. Molecular genetic analysis revealed mutations within exon 3 of the CTNNB1 encoding ß-catenin in all analyzable cases. Based on histological similarities between pancreatic SPN and PSRSTT and their identical IHC and molecular genetic features, we assume that both neoplasms share the same pathogenesis, and thus, PSRSTT can be considered as a testicular analogue of pancreatic SPN.
[Mh] Termos MeSH primário: Carcinoma de Células em Anel de Sinete
Neoplasias Pancreáticas
Tumores do Estroma Gonadal e dos Cordões Sexuais
Neoplasias Testiculares
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Carcinoma de Células em Anel de Sinete/química
Carcinoma de Células em Anel de Sinete/genética
Carcinoma de Células em Anel de Sinete/imunologia
Carcinoma de Células em Anel de Sinete/patologia
Diferenciação Celular
Linhagem da Célula
Proliferação Celular
Análise Mutacional de DNA
Predisposição Genética para Doença
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Mutação
Gradação de Tumores
Neoplasias Pancreáticas/química
Neoplasias Pancreáticas/genética
Neoplasias Pancreáticas/imunologia
Neoplasias Pancreáticas/patologia
Fenótipo
Tumores do Estroma Gonadal e dos Cordões Sexuais/química
Tumores do Estroma Gonadal e dos Cordões Sexuais/genética
Tumores do Estroma Gonadal e dos Cordões Sexuais/imunologia
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Neoplasias Testiculares/química
Neoplasias Testiculares/genética
Neoplasias Testiculares/imunologia
Neoplasias Testiculares/patologia
Adulto Jovem
beta Catenina/análise
beta Catenina/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CTNNB1 protein, human); 0 (beta Catenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  5 / 621 MEDLINE  
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[PMID]:28551672
[Au] Autor:Na K; Kim EK; Jang W; Kim HS
[Ad] Endereço:Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título: Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation.
[So] Source:Anticancer Res;37(6):3249-3258, 2017 06.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Microcystic stromal tumor (MCST) is a rare stromal tumor of the ovary. In this study, we describe clinicopathological characteristics and results of mutational analyses of the CTNNB1gene in two cases of ovarian MCST and we provide a thorough review of previously published cases alongside our current cases and clarify the clinicopathological characteristics of ovarian MCST. PATIENTS AND METHODS: Patients' age was 33 and 31 years, respectively. One patient presented with fever and low abdominal pain, whereas a pelvic mass was incidentally detected in another patient. Grossly, the cut surface of the tumors was mixed solid and cystic. RESULTS: Histologically, the tumor characteristically displayed numerous microcysts, solid cellular areas, and intervening hyalinized stroma. Areas of moderate-to-severe nuclear pleomorphism with occasional multinucleated giant cells and bizarre nuclei were noted in one of the two cases. Immunohistochemically, both cases demonstrated diffuse and strong ß-catenin expression in the nuclei and the cytoplasm. The tumor cells were also diffusely positive for CD10, vimentin, Wilms tumor 1, and cyclin D1. The tumor cells were consistently negative for E-cadherin, inhibin-α, calretinin, estrogen receptor, and progesterone receptor. Mutational analyses using direct sequencing and pyrosequencing methods exhibited a single nucleotide mutation in CTNNB1 exon 3 (c.122C>T) in one case. We also found a novel deletion mutation in the same exon (c.88_99delTACCTGGACTCT) in another case. CONCLUSION: We demonstrated a previously reported CTNNB1 point-mutation using pyrosequencing and a novel deletion mutation in ovarian MCSTs. The review of the literature of previously published cases in combination with our current cases clarifies the clinicopathological characteristics of ovarian MCST and the comprehensive analysis of these cases would expand our knowledge regarding ovarian MCST.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Análise Mutacional de DNA/métodos
Neoplasias Císticas, Mucinosas e Serosas/genética
Neoplasias Ovarianas/genética
Mutação Puntual
Deleção de Sequência
Tumores do Estroma Gonadal e dos Cordões Sexuais/genética
beta Catenina/genética
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
Feminino
Predisposição Genética para Doença
Seres Humanos
Imuno-Histoquímica
Neoplasias Císticas, Mucinosas e Serosas/química
Neoplasias Císticas, Mucinosas e Serosas/patologia
Neoplasias Císticas, Mucinosas e Serosas/cirurgia
Neoplasias Ovarianas/química
Neoplasias Ovarianas/patologia
Neoplasias Ovarianas/cirurgia
Fenótipo
Tumores do Estroma Gonadal e dos Cordões Sexuais/química
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Tumores do Estroma Gonadal e dos Cordões Sexuais/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CTNNB1 protein, human); 0 (beta Catenin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


  6 / 621 MEDLINE  
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[PMID]:28476811
[Au] Autor:Na K; Sung JY; Kim HS
[Ad] Endereço:Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary.
[So] Source:Anticancer Res;37(5):2437-2444, 2017 05.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Adult granulosa cell tumor of the ovary is usually diagnosed at an early stage. However, most patients with advanced or recurrent disease will die of the disease due to limited treatment options. Data on the stromal p16 expression of ovarian adult granulosa cell tumors are limited. The aim of this study was to analyze the immunohistochemical p16 expression in the peritumoral stroma of primary and recurrent adult granulosa cell tumors and investigate whether there were significant differences in stromal p16 expression among nonpathological ovaries, benign sex cord-stromal tumors, and adult granulosa cell tumors. MATERIALS AND METHODS: This study included 13 and 11 cases of primary and recurrent adult granulosa cell tumors, respectively. Non-pathological ovaries and benign sex cord-stromal tumors showed negative or weak positive expression, whereas most of the adult granulosa cell tumors showed diffuse and moderate-to-strong immunostaining. RESULTS: Primary adult granulosa cell tumors had significantly higher stromal p16 expression levels than nonpathological ovaries and benign sex cord-stromal tumors (p<0.001). Moreover, recurrent adult granulosa cell tumors showed significantly elevated levels of stromal p16 expression compared to primary adult granulosa cell tumors (p=0.032). In contrast, the difference in stromal p16 expression between non-pathological ovaries and benign sex cord-stromal tumors was not statistically significant (p=0.522). CONCLUSION: Our observations suggest that stromal p16 expression may be involved in the development and progression of ovarian adult granulosa cell tumors.
[Mh] Termos MeSH primário: Inibidor p16 de Quinase Dependente de Ciclina/metabolismo
Tumor de Células da Granulosa/metabolismo
Neoplasias Ovarianas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores Tumorais/metabolismo
Feminino
Tumor de Células da Granulosa/patologia
Seres Humanos
Meia-Idade
Recidiva Local de Neoplasia/metabolismo
Neoplasias Ovarianas/patologia
Ovário/metabolismo
Tumores do Estroma Gonadal e dos Cordões Sexuais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cyclin-Dependent Kinase Inhibitor p16); 0 (P16 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


  7 / 621 MEDLINE  
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[PMID]:28445692
[Au] Autor:Roth LM; Lyu B; Cheng L
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202. Electronic address: lroth@iupui.edu.
[Ti] Título:Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms.
[So] Source:Hum Pathol;65:1-14, 2017 Jul.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2% to 5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between testicular and ovarian SCSTs. For example, large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia occur in the testis but have not been described in the ovary. In this article, we discuss recently described diagnostic entities as well as inconsistencies in nomenclature used in the recent World Health Organization classifications of SCSTs in the testis and ovary. We also thoroughly review the topic of neoplasms composed of both germ cells and sex cord derivatives with an emphasis on controversial aspects. These include "dissecting gonadoblastoma" and testicular mixed germ cell-sex cord stromal tumor (MGC-SCST). The former is a recently described variant of gonadoblastoma that sometimes is an immediate precursor of germinoma in the dysgenetic gonads of patients with a disorder of sex development. Although the relationship of dissecting gonadoblastoma to the previously described undifferentiated gonadal tissue is complex and not entirely resolved, we believe that it is preferable to continue to use the term undifferentiated gonadal tissue for those cases that are not neoplastic and are considered to be the precursor of classical gonadoblastoma. Although the existence of testicular MGC-SCST has been challenged, the most recent evidence supports its existence; however, testicular MGC-SCST differs significantly from ovarian examples due to both genetic and epigenetic factors.
[Mh] Termos MeSH primário: Neoplasias Complexas Mistas/patologia
Neoplasias Embrionárias de Células Germinativas/patologia
Neoplasias Ovarianas/patologia
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Diferenciação Celular
Linhagem da Célula
Epigênese Genética
Feminino
Regulação Neoplásica da Expressão Gênica
Predisposição Genética para Doença
Seres Humanos
Masculino
Neoplasias Complexas Mistas/química
Neoplasias Complexas Mistas/classificação
Neoplasias Complexas Mistas/genética
Neoplasias Embrionárias de Células Germinativas/química
Neoplasias Embrionárias de Células Germinativas/classificação
Neoplasias Embrionárias de Células Germinativas/genética
Neoplasias Ovarianas/química
Neoplasias Ovarianas/classificação
Neoplasias Ovarianas/genética
Fenótipo
Tumores do Estroma Gonadal e dos Cordões Sexuais/química
Tumores do Estroma Gonadal e dos Cordões Sexuais/classificação
Tumores do Estroma Gonadal e dos Cordões Sexuais/genética
Neoplasias Testiculares/química
Neoplasias Testiculares/classificação
Neoplasias Testiculares/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


  8 / 621 MEDLINE  
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[PMID]:28376598
[Au] Autor:Li JL; Ma YQ; Li JH; Song X; Liu AJ
[Ti] Título:[Steroid cell tumors,NOS of mesosalpinx : report of a case].
[So] Source:Zhonghua Bing Li Xue Za Zhi;46(4):267-268, 2017 Apr 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Tubas Uterinas/patologia
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2017.04.014


  9 / 621 MEDLINE  
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[PMID]:28292524
[Au] Autor:Nasioudis D; Kanninen TT; Holcomb K; Sisti G; Witkin SS
[Ad] Endereço:Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA. Electronic address: din2004@med.cornell.edu.
[Ti] Título:Prevalence of lymph node metastasis and prognostic significance of lymphadenectomy in apparent early-stage malignant ovarian sex cord-stromal tumors.
[So] Source:Gynecol Oncol;145(2):243-247, 2017 05.
[Is] ISSN:1095-6859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this retrospective population-based study was to investigate the prevalence of lymph node metastasis in patients with apparent early stage malignant sex cord-stromal tumors (SCSTs) and the effect of regional lymph node sampling/lymphadenectomy (LND) on their survival. METHODS: A cohort of patients diagnosed with malignant SCSTs between 1988 and 2012 was drawn from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Overall and Cancer Specific Survival, stratified by performance of LND, were calculated following generation of Kaplan-Meier curves. Comparisons were made using the log-rank and Breslow tests. A multivariate Cox proportional analysis was performed to determine the effect of LND on overall mortality. RESULTS: A total of 1156 patients with SCST met the inclusion criteria; 1000 (86.5%) and 156 (13.5%) patients had apparent stage I and II disease, respectively. LND was performed in 572 (49.5%) patients. Lymph node metastases were pathologically confirmed in 19 patients (3.3%). Five-year cancer specific survival (CSS) was similar, 92.7% and 94.7%, for patients who did or did not undergo LND, respectively. According to multivariate analysis overall mortality did not differ between the two groups after controlling for age, histology and apparent stage. CONCLUSIONS: Regional lymphatic mode metastasis in patients with apparent early stage SCSTs is uncommon and lymphadenectomy did not confer a survival benefit in this cohort.
[Mh] Termos MeSH primário: Linfonodos/patologia
Linfonodos/cirurgia
Neoplasias Ovarianas/patologia
Neoplasias Ovarianas/cirurgia
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Tumores do Estroma Gonadal e dos Cordões Sexuais/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Excisão de Linfonodo/estatística & dados numéricos
Metástase Linfática
Meia-Idade
Estadiamento de Neoplasias
Neoplasias Ovarianas/epidemiologia
Prevalência
Prognóstico
Estudos Retrospectivos
Programa de SEER
Tumores do Estroma Gonadal e dos Cordões Sexuais/epidemiologia
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE


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[PMID]:28204871
[Au] Autor:Bremmer F; Behnes CL; Schildhaus HU; Gaisa NT; Reis H; Jarry H; Radzun HJ; Stroebel P; Schweyer S
[Ad] Endereço:Institute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany. felix.bremmer@med.uni-goettingen.de.
[Ti] Título:The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis.
[So] Source:Virchows Arch;470(4):421-428, 2017 Apr.
[Is] ISSN:1432-2307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The WHO classification of testis tumours includes the group of sex cord-stromal tumours. They are divided into several histological types, i.e. Leydig cell (LCT) and Sertoli cell tumours (SCT). Based on the physiological expression of ß-catenin in normal testis/Sertoli cells, it was previously shown that SCT can carry a ß-catenin mutation, causing a nuclear positivity for ß-catenin and cyclin D1. Furthermore, it could be shown that the stabilization of ß-catenin in Sertoli cells causes the loss of the Sertoli cell marker SOX9. We wanted to know whether the stabilization of ß-catenin in sex cord-stromal tumours influences SOX-9 expression and thus could be used in the diagnosis of sex cord-stromal tumours. Therefore, 53 cases of sex cord-stromal tumours and tumour-like lesions were investigated for their immunohistochemical expressions of ß-catenin, cyclin D1 and SOX9. In addition, mutation analyses of the ß-catenin gene (exon 3; CTNNB1) were performed. ß-catenin mutation in SCT results in nuclear ß-catenin and cyclin-D1 expressions on immunohistochemical analysis. The nuclear expression/stabilization of ß-catenin causes the loss of SOX9 in these tumours. In contrast, SOX9 is considerably expressed in non-mutated SCT as well as in Sertoli cells of non-neoplastic testes. In summary, immunohistochemical analyses of ß-catenin and SOX9 are useful to distinguish SCT from other sex cord-stromal tumours of the testis. Furthermore, the presence of SOX9 indicates that the cells of origin may be Sertoli cells.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Fatores de Transcrição SOX9/biossíntese
Tumores do Estroma Gonadal e dos Cordões Sexuais/diagnóstico
Neoplasias Testiculares/diagnóstico
beta Catenina/biossíntese
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Análise Mutacional de DNA
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Mutação
Fatores de Transcrição SOX9/análise
Tumores do Estroma Gonadal e dos Cordões Sexuais/genética
Tumores do Estroma Gonadal e dos Cordões Sexuais/metabolismo
Neoplasias Testiculares/genética
Neoplasias Testiculares/metabolismo
beta Catenina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CTNNB1 protein, human); 0 (SOX9 Transcription Factor); 0 (SOX9 protein, human); 0 (beta Catenin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1007/s00428-017-2090-6



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