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[PMID]:27818351
[Au] Autor:Yang C; Zhao D; Zhang P; Fei K; Jiang G
[Ad] Endereço:Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Medical School of Tongji University, Zhengmin Road 507, Shanghai, 200433, China.
[Ti] Título:Intrathoracic neurogenic tumor with malignant transition-20 years operation experience in a medical center of China.
[So] Source:Neurosci Lett;637:195-200, 2017 01 10.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Malignant peripheral neurogenic tumor is always found in large peripheral nerve of the extremities, however, benign peripheral neurogenic tumors of chest is an uncommon disorder, furthermore, malignant transition is even rare. So far, few cases have been reported. We studied 45 neurogenic thoracic tumors patients with malignant transition. METHODS: We retrospectively reviewed clinical data of 45 malignant neurogenic thoracic tumors from 1992 to 2012, including 11 (24.44%) cases of borderline tumors (group X), 13 cases of (28.88%) low-grade malignant tumor (group L), and 21 cases (46.66%) of malignant tumors (group M). Specifically, we reviewed the clinical characteristics, surgical approach, postoperative outcome, complications and prognosis of these patients. RESULTS: All tumors are located in the thoracic cavity, and arising from sympathetic or spinal nerve or their branches from the lung or posterior mediastinum. The patients from groups X and L had more complete resection than group M. Unfortunately, one patient was dead intra operatively in Group M. Group M had more recurrence than groups X and L. Our results indicates that, the survival rate may be correlated with tumor size, malignant degree (P=0.018), tumor recurrence and incomplete resection (P<0.05). CONCLUSION: The most effective treatment method for these tumors is early identification and resection by minimally invasive surgery during benign stage. In addition, regarding low-grade malignant tumor, non-radical surgery could also be responsible for the low survival rate.
[Mh] Termos MeSH primário: Recidiva Local de Neoplasia/diagnóstico
Neoplasias de Tecido Nervoso/diagnóstico
Neoplasias Torácicas/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
China
Feminino
Seres Humanos
Masculino
Meia-Idade
Recidiva Local de Neoplasia/patologia
Recidiva Local de Neoplasia/cirurgia
Neoplasias de Tecido Nervoso/patologia
Neoplasias de Tecido Nervoso/cirurgia
Prognóstico
Estudos Retrospectivos
Taxa de Sobrevida
Neoplasias Torácicas/patologia
Neoplasias Torácicas/cirurgia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  2 / 960 MEDLINE  
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[PMID]:27236779
[Au] Autor:Wellner UF; Shen Y; Keck T; Jin W; Xu Z
[Ad] Endereço:Clinic for Surgery, UKSH Campus Lübeck, Lübeck, Germany.
[Ti] Título:The survival outcome and prognostic factors for distal cholangiocarcinoma following surgical resection: a meta-analysis for the 5-year survival.
[So] Source:Surg Today;47(3):271-279, 2017 Mar.
[Is] ISSN:1436-2813
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the available evidence on the prognostic factors for the 5-year survival for patients with distal cholangiocarcinoma (DCC) following surgical resection. METHODS: We performed a comprehensive search of abstracts included in databases where relevant studies were published between January 2000 and August 2015. Risk ratios (RRs), 95 % confidence intervals (95 % CIs), and random-effects model were calculated using RevMan 5.3 software. RESULTS: A total of 23 observational studies involving 2063 patients with DCC were analyzed. The meta-analysis showed that postoperative adjuvant chemotherapy was not confirmed as a prognostic factor, with similar 5-year survival rates between those receiving and not receiving chemotherapy (RR 0.71; 95 % CI 0.21-2.36; P = 0.57). Perineural invasion (RR 0.51; 95 % CI 0.40-0.64; P < 0.00001), lymph node metastasis (RR 0.51; 95 % CI 0.38-0.70; P < 0.0001), positive resection margin status (RR 2.11; 95 % CI 1.36-3.30; P = 0.001), and not-well-differentiated adenocarcinoma (RR 1.77; 95 % CI 1.39-2.25; P < 0.00001) were associated with shorter survival. CONCLUSIONS: Perineural invasion, lymph node metastasis, resection margin status, and tumor differentiation were the significant prognostic factors for the 5-year survival.
[Mh] Termos MeSH primário: Neoplasias dos Ductos Biliares/mortalidade
Neoplasias dos Ductos Biliares/cirurgia
Colangiocarcinoma/mortalidade
Colangiocarcinoma/cirurgia
[Mh] Termos MeSH secundário: Idoso
Neoplasias dos Ductos Biliares/patologia
Quimioterapia Adjuvante
Colangiocarcinoma/patologia
Feminino
Seres Humanos
Metástase Linfática
Masculino
Margens de Excisão
Meia-Idade
Invasividade Neoplásica
Neoplasias de Tecido Nervoso/patologia
Prognóstico
Taxa de Sobrevida
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160530
[St] Status:MEDLINE
[do] DOI:10.1007/s00595-016-1362-0


  3 / 960 MEDLINE  
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[PMID]:27532530
[Au] Autor:Ben Gamra O; Romdhane N; Khamassi K; Nacef I; Abid W; Chammakhi C; Hariga I; Mbarek C
[Ti] Título:Extracranial head and neck neurogenic tumors: report of 47 cases.
[So] Source:Tunis Med;94(2):135-9, 2016 Feb.
[Is] ISSN:0041-4131
[Cp] País de publicação:Tunisia
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Extracranial head and neck neurogenic tumors are rare and usually revealed by histological examination. The aim of this study was to review the clinical, radiological and therapeutic particularities of these tumors. METHODS: This retrospective study concerns 47 patients with neurogenic tumors of the head and neck, operated on between 1989 and 2011 (22 years period). All patients had complete physical examination and ultrasonography was performed when a cervical extension was found. CT scan and MRI were performed in 16 cases. Minimum follow up was 4 years. RESULTS:   A sinusonasal tumor was found in 9 cases and a cervical mass was seen in 28 cases. Parapharyngeal extension was observed in two cases. Two patients had tympano-jugular glomic tumors and 8 of them had a cervical soft tissue tumor. Complete surgical resection was performed in 46 patients. Histological examination revealed a benign tumor in 91% of cases (n=43), 24 of them were schwannomas. Malignant tumors were seen in 4 cases: esthesioneuroblastoma (3 cases) and malignant schwannoma (1 case). These patients received post operative radiotherapy. After surgery, two patients had Claude Bernard Horner syndrome and one had a definitive facial nerve palsy. CONCLUSION: Extracranial head and neck neurogenic tumors may have several aspects depending on their localisation and their histological type. Surgery, when performed, should be complete with minimum complications.
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Tecido Nervoso/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Seguimentos
Neoplasias de Cabeça e Pescoço/terapia
Seres Humanos
Meia-Idade
Neoplasias de Tecido Nervoso/terapia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160818
[St] Status:MEDLINE


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[PMID]:27178695
[Au] Autor:Strowd RE; Strowd LC; Blakeley JO
[Ad] Endereço:Department of Neurology, Wake Forest School of Medicine, Winston Salem, NC; Department of Neurology and Oncology, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address: rstrowd@wakehealth.edu.
[Ti] Título:Cutaneous manifestations in neuro-oncology: clinically relevant tumor and treatment associated dermatologic findings.
[So] Source:Semin Oncol;43(3):401-7, 2016 Jun.
[Is] ISSN:1532-8708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. The skin may also manifest findings in paraneoplastic conditions that affect the nervous system, providing an early indication of underlying neoplasm, including dermatomyosistis, neuropathic itch, and brachioradial pruritus. In this article, we review the major cutaneous findings in patients with tumors of the brain, spine, and peripheral nervous system focusing on (1) cutaneous manifestations of genetic and sporadic primary nervous system tumor syndromes, and (2) paraneoplastic neurological syndromes with prominent cutaneous features.
[Mh] Termos MeSH primário: Neoplasias de Tecido Nervoso/patologia
Síndromes Paraneoplásicas/patologia
Esclerose Tuberosa/patologia
[Mh] Termos MeSH secundário: Dermatomiosite/etiologia
Dermatomiosite/patologia
Seres Humanos
Neoplasias de Tecido Nervoso/terapia
Neurofibromatose 1/patologia
Neurofibromatose 1/terapia
Neurofibromatose 2/patologia
Neurofibromatose 2/terapia
Esclerose Tuberosa/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160515
[St] Status:MEDLINE


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[PMID]:25973926
[Au] Autor:Liu C; Hu J; Liu R; Liu W; Zhang T; Ma Z
[Ad] Endereço:a Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai , China.
[Ti] Título:Migration of Transformed Bone Marrow-Derived Cells with Peripheral Neural Tumor Traits In Vivo.
[So] Source:Cancer Invest;33(8):361-8, 2015.
[Is] ISSN:1532-4192
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The identification of the original cells in tumors may allow for measures that protect the original cells and prevent tumor formation. In the present study, we isolated a subpopulation of cells with the features of neural tumor cells from transformed BMDCs in vitro. These neural tumor cells expressed the markers of neural tumor progenitor cells and differentiated neural tumor cells in vitro. Moreover, the subcloned cells from transformed BMDCs could migrate to distant tissues and drive peripheral neural tumors in vivo. Therefore, our results further verify that transformed mouse BMDCs are a potential source of peripheral neural tumors.
[Mh] Termos MeSH primário: Células da Medula Óssea/patologia
Células-Tronco Neoplásicas/patologia
[Mh] Termos MeSH secundário: Animais
Movimento Celular
Transformação Celular Neoplásica
Células Cultivadas
Feminino
Masculino
Camundongos Nus
Neoplasias de Tecido Nervoso/patologia
Neurofibromatoses/patologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150930
[Lr] Data última revisão:
150930
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150515
[St] Status:MEDLINE
[do] DOI:10.3109/07357907.2014.933233


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[PMID]:25966500
[Au] Autor:Setsu N
[Ad] Endereço:Division of musculoskeletal oncology, National cancer center hospital
[Ti] Título:[An update of classification and new molecular insights-2013 world health organization classification of tumors of soft tissue and bone].
[So] Source:Gan To Kagaku Ryoho;42(3):291-5, 2015 Mar.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Neoplasias Ósseas/classificação
Sarcoma/classificação
Neoplasias de Tecidos Moles/classificação
[Mh] Termos MeSH secundário: Neoplasias Ósseas/patologia
Seres Humanos
Gradação de Tumores
Neoplasias de Tecido Nervoso/classificação
Neoplasias de Tecido Nervoso/patologia
Sarcoma/patologia
Neoplasias de Tecidos Moles/patologia
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1505
[Cu] Atualização por classe:150512
[Lr] Data última revisão:
150512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150514
[St] Status:MEDLINE


  7 / 960 MEDLINE  
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[PMID]:25840574
[Au] Autor:Ilias I; Meristoudis G; Notopoulos A
[Ad] Endereço:Department of Nuclear Medicine, Hippokration General Hospital, Konstantinoupoleos St. 49, P.C. 546 42, Thessaloniki, Macedonia, Greece. meristoudis@yahoo.gr.
[Ti] Título:A probabilistic assessment of the diagnosis of paraganglioma/pheochromocytoma based on clinical criteria and biochemical/imaging findings.
[So] Source:Hell J Nucl Med;18(1):63-5, 2015 Jan-Apr.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Paragangliomas (PGL) and pheochromocytomas (P) are rare neural-crest-derived neoplasms. Very recently guidelines on diagnosis and treatment of PGL/P have been presented by the US Endocrine Society. In the following overview we assessed the implementation of these guidelines with probabilistic reasoning (calculating with Fagan nomograms the post-test probability of PGL/P for a given pre-test probability). CONCLUSION: Biochemical evaluation of PGL/P showed excellent diagnostic characteristics with post-test probabilities that are very different from the pre-test probabilities, thus a positive biochemical test is usually indicative of disease whereas a negative one usually rules out disease. The post-test probabilities of anatomical and functional imaging modalities (i.e. in nuclear medicine) were different from the pre-test probabilities but to a lesser degree than the biochemical tests; furthermore in biochemically-proven PGL/P a negative imaging modality is not useful, while a positive one may indicate only one of multiple foci of metastatic/extra-adrenal disease. Thus, regarding imaging modalities, they should be combined in order to get the most of their characteristics for the localization of PGL/P.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Suprarrenais/diagnóstico
Neoplasias de Tecido Nervoso/diagnóstico
Crista Neural/patologia
Paraganglioma/diagnóstico
Feocromocitoma/diagnóstico
[Mh] Termos MeSH secundário: Fluordesoxiglucose F18
Seres Humanos
Metástase Neoplásica
Neoplasias de Tecido Nervoso/diagnóstico por imagem
Nomogramas
Medicina Nuclear/métodos
Paraganglioma/diagnóstico por imagem
Feocromocitoma/diagnóstico por imagem
Tomografia por Emissão de Pósitrons/métodos
Guias de Prática Clínica como Assunto
Probabilidade
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150405
[St] Status:MEDLINE


  8 / 960 MEDLINE  
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[PMID]:25525087
[Au] Autor:Cubuk S; Yucel O
[Ad] Endereço:GATA Medical Faculty, Department of Thoracic Surgery, Ankara, Turkey.
[Ti] Título:eComment. Muscle sparing thoracotomy for the apical posterior mediastinal lesions.
[So] Source:Interact Cardiovasc Thorac Surg;20(1):40, 2015 Jan.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias de Tecido Nervoso/cirurgia
Neoplasias Torácicas/cirurgia
Cirurgia Torácica Vídeoassistida
Toracotomia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141219
[Lr] Data última revisão:
141219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141220
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivu377


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[PMID]:25525086
[Au] Autor:Hudorovic N; Vicic-Hudorovic V
[Ad] Endereço:University Hospital Centre "Sestre milosrdnice", Zagreb, Croatia.
[Ti] Título:eComment. The supraclavicular approach for removal of neurogenic tumours at the thoracic apex.
[So] Source:Interact Cardiovasc Thorac Surg;20(1):39, 2015 Jan.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias de Tecido Nervoso/cirurgia
Neoplasias Torácicas/cirurgia
Cirurgia Torácica Vídeoassistida
Toracotomia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141219
[Lr] Data última revisão:
141219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141220
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivu373


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[PMID]:25525085
[Au] Autor:Leuzzi G; Forcella D; Rapicetta C; Lococo F
[Ad] Endereço:Department of Surgical Oncology, Thoracic Surgery Unit, Regina Elena National Cancer Institute - IFO, Rome, Italy.
[Ti] Título:eComment. Is video-assisted thoracoscopic surgery resection really superior to the thoracotomic approach in mediastinal neurogenic tumours?
[So] Source:Interact Cardiovasc Thorac Surg;20(1):39, 2015 Jan.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias de Tecido Nervoso/cirurgia
Neoplasias Torácicas/cirurgia
Cirurgia Torácica Vídeoassistida
Toracotomia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141219
[Lr] Data última revisão:
141219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141220
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivu365



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