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[PMID]:29390408
[Au] Autor:Cormio L; Mancini V; Calò B; Selvaggio O; Mazzilli T; Sanguedolce F; Carrieri G
[Ad] Endereço:Department of Urology and Renal Transplantation.
[Ti] Título:Asymptomatic solitary bladder plasmocytoma: A case report and literature review.
[So] Source:Medicine (Baltimore);96(50):e9347, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Solitary extramedullary plasmocytoma may arise in any organ, either as a primary tumor or as part of a systemic myeloma; if it rarely affects bladder, it presents with urinary symptoms. We describe the first case of asymptomatic BP occasionally diagnosed in a patient with ascites. PATIENT CONCERNS: A 74-year-old woman with hepatitis C virus (HCV)-related liver cirrhosis presented with ascites and no urinary or other symptoms. DIAGNOSES: Routine blood tests were within normal ranges, except for mild elevation of transaminases due to chronic hepatitis. Abdominal ultrasound and computed tomography (CT) scanning showed multiple liver nodules suspected for carcinomas and, incidentally, a 18 mm solid lesion of right bladder wall. OUTCOMES: She underwent transurethral resection of the bladder tumor and percutaneous liver biopsies; final diagnosis was solitary bladder plasmocytoma (BP) and hepatocellular carcinoma (HCC), respectively. She was given chemoembolization of the main HCC nodule but no adjuvant treatment for BP. At 3-month follow-up, total-body CT showed no signs of bladder disease nor distant metastases; unfortunately, she died one month later due to liver failure. LESSONS: This is the first reported case of asymptomatic BP. This rare neoplasm may pose difficulties in differential diagnosis with both bladder metastases and the plasmocytoid variant of bladder transitional cell carcinoma. We also highlighted lack of factors predicting disease outcome as well as response to potential adjuvant treatments.
[Mh] Termos MeSH primário: Plasmocitoma/diagnóstico por imagem
Plasmocitoma/cirurgia
Neoplasias da Bexiga Urinária/diagnóstico por imagem
Neoplasias da Bexiga Urinária/cirurgia
[Mh] Termos MeSH secundário: Idoso
Evolução Fatal
Feminino
Hepatite C/complicações
Seres Humanos
Achados Incidentais
Cirrose Hepática/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009347


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[PMID]:29390503
[Au] Autor:Zhang D; Cao D; Shen D; Mulmi Shrestha S; Yin Y
[Ad] Endereço:Gastroenterology Department, Affiliated Zhongda Hospital of Southeast University, China.
[Ti] Título:Extramedullary plasmacytoma occuring in ileocecum: A case report and literature review.
[So] Source:Medicine (Baltimore);96(51):e9313, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Gastrointestinal solitary extramedullary plasmacytoma (EMP) is rare, just occupies about 5% of all EMPs. The most common site is small intestine followed by stomach. The colorectal incidence is much rare. PATIENT CONCERNS: A 63-year-old female had an episodic pain around the umbilicus for about one week. The hyperemia and edema in the ileocecal mucosa were found in colonoscopy, and the endoscopy could not cross the ileocecal valve. The pathology specimens showed a high index suspicion of plasmacytoma. DIAGNOSES: The patient was diagnosed with extramedullary plasmacytoma. INTERVENTIONS: A right hemicolectomy surgery was performed to treat the disease. OUTCOMES: Post surgery pathologic report showed low grade malignant mucosa associated marginal zone B cell lymphoma. LESSONS: We report a case of an extramedullary plasmacytoma in ileocecum with abdominal pain and a review of extramedullary plasmacytoma.
[Mh] Termos MeSH primário: Neoplasias do Ceco/patologia
Neoplasias do Íleo/patologia
Plasmocitoma/patologia
[Mh] Termos MeSH secundário: Neoplasias do Ceco/cirurgia
Colectomia
Feminino
Seres Humanos
Neoplasias do Íleo/cirurgia
Meia-Idade
Plasmocitoma/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009313


  3 / 7490 MEDLINE  
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[PMID]:29309111
[Au] Autor:Ignjatovic M; Bezmarevic M; Cerovic S
[Ti] Título:Solitary extramedullary plasmacytoma of the duodenum and pancreas: A case report and review of the literature.
[So] Source:Vojnosanit Pregl;73(4):402-7, 2016 Apr.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: The extramedullary plasmacytomas (EMPs) are rare tumors of plasma cell disorders which are rarely found in the duodenum. We presented a case of solitary EMPs involving the duodenum and pancreas successfully treated by surgical resection after failure of chemotherapy. Case Report: A 55-year-old female with previously diagnosed solitary EMP of the duodenum was admitted to our institution after failure of three cycles of vincristine, adriablastine, dexamethasone (VAD) chemotherapy regimen with an upper gastrointestinal obstruction. On admission computed tomography of the abdomen showed tumor in the region of the second part of duodenum and uncinate process of the pancreas with a complete duodenal obstruction. Intraoperatively a tumor formation was in the region of the second duodenal part, originated from the wall of duodenum with the total diameter of 7 x 5 cm, covering the entire circumference of duodenal wall leaded to a narrowing of duodenal lumen to the thigh gap with an upper gastrointestinal obstruction. Infiltration in the head of the pancreas and uncinate process were also found. The Whipple's procedure was performed but postoperative course was complicated by rapidly refilling chylous ascites which was resolved 4 days after the surgery. Conclusion: Each patient with gastrointestinal EMPs should be considered separately and in timely manner, thus adequate treatment could provide local disease control.
[Mh] Termos MeSH primário: Neoplasias Duodenais/patologia
Neoplasias Pancreáticas/patologia
Plasmocitoma/patologia
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias Duodenais/tratamento farmacológico
Neoplasias Duodenais/cirurgia
Feminino
Seres Humanos
Obstrução Intestinal/etiologia
Meia-Idade
Invasividade Neoplásica
Neoplasias Pancreáticas/tratamento farmacológico
Neoplasias Pancreáticas/cirurgia
Plasmocitoma/tratamento farmacológico
Plasmocitoma/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141031142I


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[PMID]:27771291
[Au] Autor:Rosenberg AS; Ruthazer R; Paulus JK; Kent DM; Evens AM; Klein AK
[Ad] Endereço:Division of Hematology/Oncology, Department of Internal Medicine, Tufts University School of Medicine, Boston, MA; Division of Hematology/Oncology, Department of Internal Medicine, Tufts Cancer Center, Boston, MA; Department of Internal Medicine, Tufts Medical Center, Boston, MA. Electronic address:
[Ti] Título:Survival Analyses and Prognosis of Plasma-Cell Myeloma and Plasmacytoma-Like Posttransplantation Lymphoproliferative Disorders.
[So] Source:Clin Lymphoma Myeloma Leuk;16(12):684-692.e3, 2016 Dec.
[Is] ISSN:2152-2669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Multiple myeloma/plasmacytoma-like posttransplantation lymphoproliferative disorder (PTLD-MM) is a rare complication of solid organ transplantation. Case series have shown variable outcomes, and survival data in the modern era are lacking. PATIENTS AND METHODS: A cohort of 212 PTLD-MM patients was identified in the Scientific Registry of Transplant Recipients between 1999 and 2011. Overall survival (OS) was estimated by the Kaplan-Meier method, and the effects of treatment and patient characteristics on OS were evaluated by Cox proportional hazards models. OS in 185 PTLD-MM patients was compared to 4048 matched controls with multiple myeloma (SEER-MM) derived from Surveillance, Epidemiology, and End Results (SEER) data. RESULTS: Men comprised 71% of patients; extramedullary disease was noted in 58%. Novel therapeutic agents were used in 19% of patients (more commonly during 2007-2011 vs. 1999-2006; P = .01), reduced immunosuppression in 55%, and chemotherapy in 32%. Median OS was 2.4 years and improved in the later time period (adjusted hazard ratio [aHR], 0.64, P = .05). Advanced age, creatinine > 2 g/dL, white race, and use of OKT3 were associated with inferior OS in multivariable analysis. OS of PTLD-MM patients is significantly inferior to SEER-MM patients (aHR, 1.6, P < .001). Improvements in OS over time differed between PTLD-MM and SEER-MM. Median OS of patients diagnosed from 2000 to 2005 was shorter for PTLD-MM than SEER-MM patients (18 vs. 47 months, P < .001). There was no difference among those diagnosed from 2006 to 2010 (44 months vs. median not reached, P = .5; interaction P = .08). CONCLUSION: Age at diagnosis, elevated creatinine, white race, and OKT3 were associated with inferior survival in patients with PTLD-MM. Survival of PTLD-MM is inferior to SEER-MM, although significant improvements in survival have been documented.
[Mh] Termos MeSH primário: Transtornos Linfoproliferativos/etiologia
Transtornos Linfoproliferativos/mortalidade
Mieloma Múltiplo/etiologia
Mieloma Múltiplo/mortalidade
Transplante de Órgãos/efeitos adversos
Plasmocitoma/etiologia
Plasmocitoma/mortalidade
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Imunossupressão/efeitos adversos
Estimativa de Kaplan-Meier
Transtornos Linfoproliferativos/diagnóstico
Transtornos Linfoproliferativos/terapia
Masculino
Meia-Idade
Mieloma Múltiplo/diagnóstico
Mieloma Múltiplo/terapia
Plasmocitoma/diagnóstico
Plasmocitoma/terapia
Prognóstico
Modelos de Riscos Proporcionais
Fatores de Risco
Programa de SEER
Análise de Sobrevida
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28973700
[Au] Autor:Alsadi A; Lin D; Alnajar H; Brickman A; Martyn C; Gattuso P
[Ad] Endereço:From the Department of Pathology, Rush University Medical Center, Chicago, Illinois.
[Ti] Título:Hematologic Malignancies Discovered on Investigation of Breast Abnormalities.
[So] Source:South Med J;110(10):614-620, 2017 Oct.
[Is] ISSN:1541-8243
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Hematological malignancies of the breast share a presentation similar to primary breast carcinomas but differ substantially in therapeutic approach and clinical outcomes. In this study, we investigate the frequency of hematological malignancies, their relative primary and secondary occurrences, and further characterize the distinct histopathologies of these malignancies with a special focus on lymphomas. To our knowledge this is one of the largest and most comprehensive studies of breast hematologic malignancies. METHODS: We conducted a retrospective review of our institution's pathology database for hematologic neoplasms diagnosed in breast tissue during a period of 22 years (1992-2014). Clinical characteristics, patient history, histologic subtype, and patient outcomes were analyzed. RESULTS: We identified 52 cases; 46 lymphomas, 4 plasmacytomas, and 2 myeloid sarcomas. The lymphoma cases were 15 diffuse large B-cell lymphomas (DLBCLs), 14 follicular lymphomas (FLs), 8 marginal zone lymphomas (MZLs), 2 anaplastic large T-cell lymphomas, 2 peripheral T-cell lymphomas-not otherwise specified, 1 each of small lymphocytic lymphoma, Burkitt lymphoma, mantle cell lymphoma, B-cell lymphoblastic lymphoma, and T-cell lymphoblastic lymphoma. In total, 30 cases were primary and 22 cases were secondary to the breast. Primary lymphomas accounted for 60% of lymphomas. Most FLs and almost all MZLs were primary. CONCLUSIONS: Primary hematological malignancies of the breast are more common than secondary: 58 % versus 42%. This finding is more evident in lymphomas: 63% versus 37%. The most common hematological malignancy in our study was DLBCL, followed by FL and MZL. Most FLs and almost all MZLs were primary. At the same time, the percentage of primary DLBCLs in our study is lower than the percentage reported in previous studies. We suggest that this could be the result of transformation from low-grade lymphomas. Although rare, hematological malignancies of the breast warrant a higher level of clinical suspicion as they present similarly to breast carcinomas but require a substantially different therapeutic approach.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico
Carcinoma/diagnóstico
Neoplasias Hematológicas/diagnóstico
Linfoma/diagnóstico
Plasmocitoma/diagnóstico
Sarcoma Mieloide/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Neoplasias da Mama/patologia
Neoplasias da Mama/secundário
Linfoma de Burkitt/diagnóstico
Linfoma de Burkitt/patologia
Diagnóstico Diferencial
Feminino
Neoplasias Hematológicas/patologia
Seres Humanos
Leucemia Linfocítica Crônica de Células B/diagnóstico
Leucemia Linfocítica Crônica de Células B/patologia
Linfoma/patologia
Linfoma de Zona Marginal Tipo Células B/diagnóstico
Linfoma de Zona Marginal Tipo Células B/patologia
Linfoma Folicular/diagnóstico
Linfoma Folicular/patologia
Linfoma Difuso de Grandes Células B/diagnóstico
Linfoma Difuso de Grandes Células B/patologia
Linfoma Anaplásico de Células Grandes/diagnóstico
Linfoma Anaplásico de Células Grandes/patologia
Linfoma de Célula do Manto/diagnóstico
Linfoma de Célula do Manto/patologia
Linfoma de Células T/diagnóstico
Linfoma de Células T/patologia
Meia-Idade
Plasmocitoma/patologia
Leucemia-Linfoma Linfoblástico de Células Precursoras B/diagnóstico
Leucemia-Linfoma Linfoblástico de Células Precursoras B/patologia
Leucemia-Linfoma Linfoblástico de Células T Precursoras/diagnóstico
Leucemia-Linfoma Linfoblástico de Células T Precursoras/patologia
Estudos Retrospectivos
Sarcoma Mieloide/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.14423/SMJ.0000000000000710


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[PMID]:28719511
[Au] Autor:Yohe S; Luquette M; Lund TC; Turcotte LM; Dolan M; McKenna RW
[Ad] Endereço:*Department of Laboratory Medicine and Pathology Divisions of †Department of Pediatrics, Pediatric Blood and Marrow Transplant ‡Department of Pediatrics, Pediatric Hematology/Oncology, University of Minnesota, Minneapolis, MN.
[Ti] Título:Plasma Cell Myeloma in Children and Young Adults: A Report of 4 Cases From a Single Institution and a Review of the Literature.
[So] Source:J Pediatr Hematol Oncol;39(6):452-457, 2017 Aug.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plasma cell myeloma (PCM) is rare in children and young adults and therefore may be difficult to diagnose. Here we report the clinicopathologic findings of 4 patients under the age of 30 diagnosed with PCM at our institution and summarize the literature about 48 other cases of PCM in this age group. The male:female ratio was 1.2:1 and the number of cases increased with age. Children and young adults with PCM often present with a plasmacytoma and are less likely to have asymptomatic PCM than their adult counterparts. From the cases that reported ethnicity, the majority (55%) were non-white suggesting a possible ethnic predisposition to PCM in this age group. PCM should be included in the differential diagnosis of mass lesions, especially a destructive bony lesion, after more common causes have been ruled out in this age group. The optimal treatment for PCM in this patient population is unclear and conclusions into this are hampered by the paucity of cases and the lack of standardized follow-up.
[Mh] Termos MeSH primário: Mieloma Múltiplo/diagnóstico
Plasmocitoma/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Mieloma Múltiplo/etnologia
Plasmócitos/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000907


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[PMID]:28677897
[Au] Autor:Chantry A; Kazmi M; Barrington S; Goh V; Mulholland N; Streetly M; Lai M; Pratt G; British Society for Haematology Guidelines
[Ad] Endereço:Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
[Ti] Título:Guidelines for the use of imaging in the management of patients with myeloma.
[So] Source:Br J Haematol;178(3):380-393, 2017 Aug.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of imaging in myeloma has gained increasing importance over the past few years. The recently revised definition of myeloma from the International Myeloma Working Group (IMWG) includes cross sectional imaging as a method to define bone disease and also incorporates its use in the disease definition for patients with suspected smouldering myeloma. The National Institute for Health and Care Excellence myeloma guidelines also recommend cross sectional imaging for patients with suspected myeloma. There is also increasing use of imaging in disease assessments and the International Myeloma Working Group has recently incorporated imaging in defining new response categories of minimal residual disease negativity, with or without imaging-based evidence of disease. Plain X-rays have previously been the standard imaging modality included in a myeloma work up at presentation but evidence is mounting for use of cross-sectional modalities such as computed tomography (CT), magnetic resonance imaging (MRI) and fluoro-deoxyglucose ( F-FDG) positron emission tomography (PET)/CT. Funding and therefore availability of newer imaging techniques remains a barrier. Here, we propose an evidence-based approach to the use and technical application of the latest imaging modalities at diagnosis and in the follow-up of patients with myeloma and plasmacytoma.
[Mh] Termos MeSH primário: Mieloma Múltiplo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Medicina Baseada em Evidências/métodos
Fluordesoxiglucose F18
Seres Humanos
Imagem por Ressonância Magnética/métodos
Mieloma Múltiplo/complicações
Mieloma Múltiplo/terapia
Plasmocitoma/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Tomografia por Emissão de Pósitrons/métodos
Compostos Radiofarmacêuticos
Compressão da Medula Espinal/diagnóstico por imagem
Compressão da Medula Espinal/etiologia
Fraturas da Coluna Vertebral/diagnóstico por imagem
Fraturas da Coluna Vertebral/etiologia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14827


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[PMID]:28640138
[Au] Autor:Wu PW; Lee TJ; Chen JR; Huang CC
[Ad] Endereço:aDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Keelung bDivision of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan cDepartment of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Keelung dGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
[Ti] Título:An unusual presentation of multiple myeloma with unilateral sudden vision loss: A case report.
[So] Source:Medicine (Baltimore);96(25):e7277, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Plasma cell neoplasms are categorized by neoplastic proliferation of a single clone of plasma cells which produce a monoclonal immunoglobulin. Plasma cell neoplasms can present as a solitary plasmacytoma or as multiple myeloma. Both of them can progress to multiple myeloma. Once a diagnosis of plasmacytoma has been made, thorough examinations should be carried out for identifying the disease entity. PATIENT CONCERNS AND DIAGNOSES: Herein, we describe an extraordinary rare case of multiple myeloma with initial presentation of a left sphenoid neoplasm resulting in left-sided headache and rapid deterioration of visual acuity. Histo-pathologic analysis revealed a plasma cell neoplasm with positive immunostaining for cluster of differentiation (CD)138, CD79a, and kappa light chain of immunoglobulin. A bone marrow aspiration was then performed, and the diagnosis of multiple myeloma was then confirmed. INTERVENTIONS AND OUTCOMES: After investigative workup, our patient received chemotherapy, localized radiotherapy, and autologous stem cell transplantation. Her visual acuity recovered to the baseline and she sustained a partial response without subjective discomfort. LESSONS: Extramedullary plasmacytoma is an interesting but infrequent presentation of multiple myeloma. Moreover, involvement of the sphenoid sinus in multiple myeloma resulting in extrinsic optic nerve compression is extremely rare. Clinicians should consider plasmacytoma as a diagnostic possibility when presented with cases of solitary sphenoid neoplasm and rapid progression of clinical course.
[Mh] Termos MeSH primário: Mieloma Múltiplo/diagnóstico
Mieloma Múltiplo/terapia
Transtornos da Visão/diagnóstico
Transtornos da Visão/terapia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Lateralidade Funcional
Cefaleia/diagnóstico
Cefaleia/etiologia
Cefaleia/patologia
Cefaleia/terapia
Seres Humanos
Meia-Idade
Mieloma Múltiplo/complicações
Mieloma Múltiplo/patologia
Plasmocitoma/complicações
Plasmocitoma/diagnóstico
Plasmocitoma/patologia
Plasmocitoma/terapia
Transtornos da Visão/etiologia
Transtornos da Visão/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007277


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[PMID]:28594699
[Au] Autor:Stacey AW; Lavric A; Thaung C; Siddiq S; Sagoo MS
[Ad] Endereço:*Moorfields Eye Hospital, London, United Kingdom;†St. Bartholomew's Hospital, London, United Kingdom;‡Department of Ophthalmology, University of Washington, Seattle, WA;§University College London Institute of Ophthalmology, London, United Kingdom; and¶Department of Haematology, North Bristol NHS Trust, Bristol, United Kingdom.
[Ti] Título:Solitary Iris Plasmacytoma With Anterior Chamber Crystalline Deposits.
[So] Source:Cornea;36(7):875-877, 2017 Jul.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report a case of solitary iris plasmacytoma successfully treated with ruthenium plaque radiotherapy. METHODS: A 44-year-old white woman presented with pain in the right eye and raised intraocular pressure. Her medical history included breast cancer treated 11 years earlier with lumpectomy, lymph node clearance, chemotherapy, and radiotherapy. On examination, the right iris had a tan-colored mass with crystalline deposits visible on the mass surface and on the corneal endothelium. The fundus and left eye were normal. An anterior segment ultrasound scan showed a mass with mixed internal echogenicity and internal blood flow. RESULTS: An iris biopsy showed an infiltrate of plasma cells. Immunohistochemistry for kappa and lambda light chains demonstrated lambda light chain restriction. Systemic hematologic investigations including complete blood count, serum paraproteins, bone marrow biopsy, and full-body magnetic resonance image were normal. The monoclonal plasma cell infiltrate was consistent with a solitary iris plasmacytoma. The mass was treated with ruthenium plaque radiotherapy. After 4 years of follow-up, the mass remained regressed, and no systemic myeloma has developed. CONCLUSIONS: Iris plasmacytoma is rare and should prompt systemic evaluation to rule out multiple myeloma. Solitary iris plasmacytoma can be successfully treated with plaque radiotherapy.
[Mh] Termos MeSH primário: Câmara Anterior/patologia
Neoplasias da Íris/patologia
Plasmocitoma/patologia
[Mh] Termos MeSH secundário: Adulto
Biópsia
Braquiterapia
Feminino
Gonioscopia
Seres Humanos
Neoplasias da Íris/diagnóstico por imagem
Neoplasias da Íris/radioterapia
Imagem por Ressonância Magnética
Plasmocitoma/diagnóstico por imagem
Plasmocitoma/radioterapia
Radioisótopos de Rutênio/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ruthenium Radioisotopes)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001222


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[PMID]:28589896
[Au] Autor:Liapis K; Vlachou S; Markou A; Kakiopoulos G; Kounadi T; Anagnostopoulos NI; Piaditis GP
[Ad] Endereço:Department of Clinical Haematology, Georgios Gennimatas Hospital, Athens, Greece. Electronic address: kosliapis@hotmail.com.
[Ti] Título:As white as ivory: sclerotic vertebra in POEMS syndrome.
[So] Source:Lancet;389(10085):2261-2262, 2017 06 03.
[Is] ISSN:1474-547X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Diagnóstico Diferencial
Síndrome POEMS/complicações
Síndrome POEMS/diagnóstico
Neoplasias da Coluna Vertebral/diagnóstico por imagem
Vértebras Torácicas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Diabetes Mellitus
Estradiol/sangue
Feminino
Seres Humanos
Meia-Idade
Síndrome POEMS/diagnóstico por imagem
Plasmocitoma/patologia
Pigmentação da Pele
Tomografia Computadorizada por Raios X
Fator A de Crescimento do Endotélio Vascular/análise
Fator A de Crescimento do Endotélio Vascular/sangue
Perda de Peso
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vascular Endothelial Growth Factor A); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE



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