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  1 / 12228 MEDLINE  
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[PMID]:29480860
[Au] Autor:Zhu H; Zhao Y; Wang X
[Ad] Endereço:Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
[Ti] Título:The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report.
[So] Source:Medicine (Baltimore);97(2):e9598, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with great mortality rates. The prognosis of advanced HCC is very poor. PATIENT CONCERNS: Here, we report a HCC patient with a big paraspinal metastasis with 10 cm in diameter who failed the treatment of sorafenib. DIAGNOSES: Sorafenib refractory HCC with big paraspinal metastasis. INTERVENTIONS: The concurrent treatment of apatinib with stereotactic body radiotherapy (SBRT). OUTCOMES: The paraspinal metastasis with 10 cm in diameter showed nearly complete response. LESSONS: We think that the apatinib may be a good choice for HCC and it may function as a radiosensitizer of HCC. However, it warrants further investigation in the future prospective clinical studies.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/terapia
Neoplasias Hepáticas/terapia
Piridinas/uso terapêutico
Radiossensibilizantes/uso terapêutico
Neoplasias da Coluna Vertebral/secundário
Neoplasias da Coluna Vertebral/terapia
[Mh] Termos MeSH secundário: Adulto
Antineoplásicos/uso terapêutico
Carcinoma Hepatocelular/diagnóstico por imagem
Carcinoma Hepatocelular/patologia
Evolução Fatal
Seres Humanos
Neoplasias Hepáticas/diagnóstico por imagem
Neoplasias Hepáticas/patologia
Masculino
Neoplasias da Coluna Vertebral/diagnóstico por imagem
Carga Tumoral
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Pyridines); 0 (Radiation-Sensitizing Agents); 5S371K6132 (apatinib)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009598


  2 / 12228 MEDLINE  
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[PMID]:29177265
[Au] Autor:Sachpekidis C; Hassel JC; Dimitrakopoulou-Strauss A
[Ad] Endereço:Medical PET Group-Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, D-69210, Heidelberg, Germany. christosâ‚‹saxpe @yahoo.gr, c. sachpekidis@dkfz.de.
[Ti] Título:Metastatic melanoma response to combination therapy with ipilimumab and vemurafenib.
[So] Source:Hell J Nucl Med;20(3):251-253, 2017 Sep-Dec.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Combination therapies for the treatment of metastatic melanoma are a matter of debate nowadays. We report on a stage IV metastatic melanoma patient with the BRAF V600 mutation and a large tumor burden initially treated with two cycles of ipilimumab. Due to dramatic disease progression, demonstrated on interim F-FDG PET/CT, vemurafenib was added in the patient's therapeutical scheme. After completion of the concurrent ipilimumab and vemurafenib administration, a third F-FDG PET/CT showed an impressive metabolic remission of the metastatic disease, reflecting the potential role of the modality in treatment response evaluation of melanoma patients receiving combination therapies.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Indóis/administração & dosagem
Ipilimumab/administração & dosagem
Melanoma/tratamento farmacológico
Melanoma/secundário
Neoplasias da Coluna Vertebral/tratamento farmacológico
Neoplasias da Coluna Vertebral/secundário
Sulfonamidas/administração & dosagem
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Fluordesoxiglucose F18
Seres Humanos
Melanoma/diagnóstico por imagem
Meia-Idade
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Compostos Radiofarmacêuticos
Neoplasias Cutâneas/diagnóstico por imagem
Neoplasias Cutâneas/tratamento farmacológico
Neoplasias Cutâneas/patologia
Neoplasias da Coluna Vertebral/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 0 (Ipilimumab); 0 (Radiopharmaceuticals); 0 (Sulfonamides); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 207SMY3FQT (vemurafenib)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910611


  3 / 12228 MEDLINE  
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[PMID]:29252651
[Au] Autor:Zhang Y; Ilaslan H; Krishnaney AA; Bauer TW
[Ad] Endereço:Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute (Y.Z. and T.W.B.), Department of Diagnostic Radiology (H.I.), Department of Neurosurgery and Center for Spine Health (A.A.K. and T.W.B.), and Department of Orthopaedic Surgery (T.W.B.), Cleveland Clinic, Clevela
[Ti] Título:Morphological Transformation of Giant-Cell Tumor of Bone After Treatment with Denosumab: A Case Report.
[So] Source:JBJS Case Connect;6(3):e74, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: Denosumab, an inhibitor of RANKL (receptor activator of nuclear factor κ-B ligand), was recently introduced for the treatment of giant-cell tumor of bone (GCTB). We describe the clinical, radiographic, and histological features of a GCTB of the spine in a 24-year-old woman that progressed after neoadjuvant treatment with denosumab. Disappearance of the multinuclear osteoclastic giant cells was accompanied by newly formed woven bone, which was deposited in interconnected strands with a prominent fibrovascular stroma that was histologically and radiographically similar to that of an osteoblastoma. CONCLUSION: Pathologists, radiologists, and surgeons should be aware of this post-treatment transformation to avoid misdiagnosis.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/uso terapêutico
Denosumab/uso terapêutico
Tumor de Células Gigantes do Osso/patologia
Neoplasias da Coluna Vertebral/patologia
Vértebras Torácicas/patologia
[Mh] Termos MeSH secundário: Conservadores da Densidade Óssea/farmacologia
Denosumab/farmacologia
Feminino
Tumor de Células Gigantes do Osso/diagnóstico por imagem
Tumor de Células Gigantes do Osso/tratamento farmacológico
Tumor de Células Gigantes do Osso/cirurgia
Seres Humanos
Laminectomia
Neoplasias da Coluna Vertebral/diagnóstico por imagem
Neoplasias da Coluna Vertebral/tratamento farmacológico
Neoplasias da Coluna Vertebral/cirurgia
Vértebras Torácicas/diagnóstico por imagem
Vértebras Torácicas/efeitos dos fármacos
Vértebras Torácicas/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 4EQZ6YO2HI (Denosumab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00015


  4 / 12228 MEDLINE  
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[PMID]:29381931
[Au] Autor:Zheng Y; Wang J; Liao S; Zhang D; Zhang J; Ma L; Xia H
[Ad] Endereço:Southern Medical University, Guangzhou.
[Ti] Título:Biomechanical evaluation of a novel integrated artificial axis: A finite element study.
[So] Source:Medicine (Baltimore);96(47):e8597, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Various modified instruments are used for the anterior reconstruction of the tumor lesion affecting the second cervical vertebra, but there have been no reports regarding individual integrated artificial axis (IAA) prosthesis fabricated by selective laser melting. In the present work, a new type of IAA prosthesis has been designed with a 3-dimensional (3D) finite element model of normal occiput-the fourth cervical vertebra being established to assess its biomechanics. For easy comparison, another 3D finite element model is also established for the T-shaped Harms cage and an additional posterior fixation was performed on each model. The models are tested under a preliminary loading of 40 N to simulate cervical physical action including flexion, extension, lateral bending, and rotation. Under various loads from 4 different directions, the maximum stress and displacement of the IAA are less than those of the modified T-shaped Harms cage. Except for flexion, the maximum stress of the third cervical vertebra endplate of the IAA is smaller than that of the modified T-shaped Harms cage. The new prosthesis with axis is a good choice for upper cervical operation, which not only can greatly increase the operation stability of the upper cervical segment but also could significantly reduce the risk of fixation failure due to Harms cage subsidence.
[Mh] Termos MeSH primário: Vértebra Cervical Áxis/cirurgia
Desenho de Prótese/métodos
Neoplasias da Coluna Vertebral/cirurgia
Substituição Total de Disco/instrumentação
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Simulação por Computador
Análise de Elementos Finitos
Seres Humanos
Imagem Tridimensional
Terapia a Laser/métodos
Teste de Materiais
Melhoria de Qualidade
Substituição Total de Disco/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008597


  5 / 12228 MEDLINE  
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[PMID]:29374734
[Au] Autor:Rades D; Conde-Moreno AJ; Cacicedo J; Segedin B; Stanic K; Metz M; Rudat V; Schild SE
[Ad] Endereço:Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
[Ti] Título:Comparison of Two Radiotherapy Regimens for Metastatic Spinal Cord Compression: Subgroup Analyses from a Randomized Trial.
[So] Source:Anticancer Res;38(2):1009-1015, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: According to our randomized trial, 5×4Gy was comparable to 10×3Gy for metastatic spinal cord compression. Since it remained unclear whether findings applied to poor and intermediate prognoses patients, subgroup analyses were performed. PATIENTS AND METHODS: In patients with poor prognoses, 58 received 5×4Gy, 53 received 10×3Gy. In intermediate-prognoses patients, numbers were 43 and 49. RESULTS: In patients with poor prognoses, 1-month overall response (OR) was 85% after 5×4Gy and 10×3Gy (p=0.99), improvement 38% vs. 42%, ambulatory status 60% vs. 64% (p=0.83), 6-month local progression-free survival (LPFS) 75% vs. 69% (p=0.74) and 6-month overall survival (OS) 26% vs. 19% (p=0.43). In patients with intermediate prognoses, 1-month OR was 89% after 5×4Gy and 93% after 10×3Gy (p=0.85), improvement 39% vs. 45%, ambulatory status 84% vs. 82% (p=0.90), 6-month LPFS 79% vs. 92% (p=0.17) and 6-months OS 65% vs. 58% (p=0.65). CONCLUSION: 5×4Gy was not significantly inferior to 10x3Gy in both subgroups.
[Mh] Termos MeSH primário: Fracionamento de Dose
Neoplasias/radioterapia
Compressão da Medula Espinal/radioterapia
Neoplasias da Coluna Vertebral/radioterapia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seguimentos
Seres Humanos
Masculino
Neoplasias/complicações
Neoplasias/patologia
Prognóstico
Estudos Retrospectivos
Compressão da Medula Espinal/etiologia
Neoplasias da Coluna Vertebral/secundário
Taxa de Sobrevida
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


  6 / 12228 MEDLINE  
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[PMID]:29369169
[Au] Autor:Dong R; Ji J; Liu H; Wang J; He X
[Ad] Endereço:Department of Medical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine.
[Ti] Título:Primary spinal mucosa-associated lymphoid tissue lymphoma: A case report.
[So] Source:Medicine (Baltimore);97(4):e9329, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent B-cell lymphoma which occurs mainly in the organs having mucosal layer and owns a fairly good prognosis. To date, 7 cases of spinal primary MALT has been reported before. However, there is no consensus on the optimal adjuvant treatment modalities for primary spinal MALT. The aim of this study was to add a new case of MALT which responded well to systemic therapy to the literature and to review the current literature. PATIENT CONCERNS: A 68-year-old woman visited to our hospital due to back pain and progressive bilateral lower extremity weakness for 2 months. Magnetic resonance imaging (MRI) of the spine revealed a diffusely contrast-enhancing epidural mass extending from vertebral body T6 to T8 with compression of the spinal cord. Due to the spinal cord compression, patient underwent surgical resection. Histological examination indicated monocytoid small B-cells. Immunochemical study demonstrates that most tumor cells were positive for CD20, CD21, CD45, CD79a, CD43, bcl-2 with Ki-67 labing index was 15%, but were negative for CD3, CD5 cyclin D1, BCL6, and CD23. The positron emission tomography/computer tomography (PET/CT) revealed that right iliac wing and right liver were metastases for the standard uptake value (SUV) were 9.05 and 8.35, respectively. DIAGNOSES: Based on these findings, final diagnosis of spinal MALT lymphoma was made. INTERVENTIONS: After the diagnosis, the patient received 6 cycles of immuno-chemotherapy and repeated intrathecal methotrexate and intrathecal cytarabine. OUTCOMES: At 1 year follow up, no recurrence or other dissemination was detected. LESSONS: Chemotherapy and/or radiation have been employed in larger case series. While there is no defined treatment guideline for this rare disease entity, our reported case suggests a favorable prognosis when combining both surgical and adjuvant systemic approach.
[Mh] Termos MeSH primário: Linfoma de Zona Marginal Tipo Células B/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Neoplasias da Coluna Vertebral/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Antineoplásicos/uso terapêutico
Citarabina/uso terapêutico
Feminino
Seres Humanos
Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico
Linfoma de Zona Marginal Tipo Células B/patologia
Metotrexato/uso terapêutico
Neoplasias da Coluna Vertebral/tratamento farmacológico
Neoplasias da Coluna Vertebral/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 04079A1RDZ (Cytarabine); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009329


  7 / 12228 MEDLINE  
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[PMID]:28462790
[Au] Autor:Yao A; Sarkiss CA; Ladner TR; Jenkins AL
[Ad] Endereço:Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, 1 Gustave L. Levy Place, New York, NY 10029, USA.
[Ti] Título:Contemporary spinal oncology treatment paradigms and outcomes for metastatic tumors to the spine: A systematic review of breast, prostate, renal, and lung metastases.
[So] Source:J Clin Neurosci;41:11-23, 2017 Jul.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Metastatic spinal disease most frequently arises from carcinomas of the breast, lung, prostate, and kidney. Management of spinal metastases (SpM) is controversial in the literature. Recent studies advocate more aggressive surgical resection than older studies which called for radiation therapy alone, challenging previously held beliefs in conservative therapy. A literature search of the PubMed database was performed for spinal oncology outcome studies published in the English language between 2006 and 2016. Data concerning study characteristics, patient demographics, tumor origin and spinal location, treatment paradigm, and median survival were collected. The search retrieved 220 articles, 24 of which were eligible to be included. There were overall 3457 patients. Nine studies of 1723 patients discussed parameters affecting median survival time with comparison of different primary cancers. All studies found that primary cancer significantly predicted survival. Median survival time was highest for primary breast and renal cancers and lowest for prostate and lung cancers, respectively. Multiple spinal metastases, a cervical location of metastasis, and pathologic fracture each had no significant influence on survival. Survival in metastatic spinal tumors is largely driven by primary tumor type, and this should influence palliative management decisions. Surgery has been shown to greatly increase quality of life in patients who can tolerate the procedure, even in those previously treated with radiotherapy. Surgery for SpM can be used as first-line therapy for preservation of function and symptom relief. Future studies of management of SpM are warranted and primary tumor diagnosis should be studied to determine contribution to survival.
[Mh] Termos MeSH primário: Neoplasias da Coluna Vertebral/secundário
Neoplasias da Coluna Vertebral/terapia
[Mh] Termos MeSH secundário: Neoplasias da Mama/secundário
Feminino
Seres Humanos
Neoplasias Renais/secundário
Neoplasias Pulmonares/secundário
Masculino
Neoplasias da Próstata/secundário
Neoplasias da Coluna Vertebral/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  8 / 12228 MEDLINE  
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[PMID]:29255564
[Au] Autor:Kapetanakis S; Chourmouzi D; Gkasdaris G; Katsaridis V; Eleftheriadis E; Givissis P
[Ad] Endereço:Spine Department and Deformities, Interbalkan European Medical Center, Thessaloniki, Greece.
[Ti] Título:Functional extra-adrenal paraganglioma of the retroperitoneum giving thoracolumbar spine metastases after a five-year disease-free follow-up: a rare malignant condition with challenging management.
[So] Source:Pan Afr Med J;28:94, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Paragangliomas are benign neoplasms that arise from the autonomic nervous system and the associated paraganglia. Although benign, they have been shown to possess metastatic potential. Extra-adrenal retroperitoneal paraganglioma with vertebral metastasis is considered very uncommon. Here, we present a case of a functional extra-adrenal paraganglioma of the retroperitoneum giving metastasis to T4 vertebra after five years of follow-up in a 48-year-old man who had been initially treated with complete resection of the primary tumor. The condition of the patient improved significantly after radiosurgery and somatostatin analogs treatment, until lumbar spine lesions appeared six months later. Our case demonstrates that retroperitoneal paraganglioma is a rare condition which should be considered in the differential diagnosis of a retroperitoneal mass combined with vertebral lesions. Additionally, increased physician awareness and long-term follow-up is mandatory for all patients with history of retroperitoneal paraganglioma since metastases may occur after long latent intervals from the initial diagnosis.
[Mh] Termos MeSH primário: Paraganglioma Extrassuprarrenal/patologia
Neoplasias Retroperitoneais/patologia
Neoplasias da Coluna Vertebral/secundário
[Mh] Termos MeSH secundário: Seguimentos
Seres Humanos
Vértebras Lombares
Masculino
Meia-Idade
Paraganglioma Extrassuprarrenal/cirurgia
Neoplasias Retroperitoneais/cirurgia
Neoplasias da Coluna Vertebral/patologia
Neoplasias da Coluna Vertebral/terapia
Vértebras Torácicas
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.94.13783


  9 / 12228 MEDLINE  
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[PMID]:29208438
[Au] Autor:Spratt DE; Beeler WH; de Moraes FY; Rhines LD; Gemmete JJ; Chaudhary N; Shultz DB; Smith SR; Berlin A; Dahele M; Slotman BJ; Younge KC; Bilsky M; Park P; Szerlip NJ
[Ad] Endereço:Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. Electronic address: sprattda@med.umich.edu.
[Ti] Título:An integrated multidisciplinary algorithm for the management of spinal metastases: an International Spine Oncology Consortium report.
[So] Source:Lancet Oncol;18(12):e720-e730, 2017 Dec.
[Is] ISSN:1474-5488
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Spinal metastases are becoming increasingly common because patients with metastatic disease are living longer. The close proximity of the spinal cord to the vertebral column limits many conventional therapeutic options that can otherwise be used to treat cancer. In response to this problem, an innovative multidisciplinary approach has been developed for the management of spinal metastases, leveraging the capabilities of image-guided stereotactic radiosurgery, separation surgery, vertebroplasty, and minimally invasive local ablative approaches. In this Review, we discuss the variables that should be considered during the management of these patients and review the role of each discipline and their respective management options to provide optimal care. This work is synthesised into a practical algorithm to aid clinicians in the management of patients with spinal metastasis.
[Mh] Termos MeSH primário: Radiocirurgia/métodos
Radioterapia Conformacional/métodos
Compressão da Medula Espinal/cirurgia
Neoplasias da Coluna Vertebral/secundário
Neoplasias da Coluna Vertebral/terapia
[Mh] Termos MeSH secundário: Algoritmos
Terapia Combinada
Congressos como Assunto
Descompressão Cirúrgica/métodos
Eletromiografia/métodos
Feminino
Seres Humanos
Comunicação Interdisciplinar
Internacionalidade
Imagem por Ressonância Magnética/métodos
Masculino
Compressão da Medula Espinal/diagnóstico por imagem
Neoplasias da Coluna Vertebral/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  10 / 12228 MEDLINE  
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[PMID]:29095319
[Au] Autor:Liu S; Song A; Zhou X; Kong X; Li WA; Wang Y; Liu Y
[Ad] Endereço:aDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences bDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College cDepartment of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China dDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI.
[Ti] Título:Malignant pheochromocytoma with multiple vertebral metastases causing acute incomplete paralysis during pregnancy: Literature review with one case report.
[So] Source:Medicine (Baltimore);96(44):e8535, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We present a rare case of malignant pheochromocytoma with thoracic metastases during pregnancy that presented with symptoms of myelopathy and was treated with circumferential decompression, stabilization, and radiation. The management of this unique case is not well documented. The clinical manifestations, imaging results, pathological characteristics, treatment and prognosis of the case were analyzed. PATIENT CONCERNS: A 26-year-old pregnant woman with a history of paroxysmal hypertension during the second trimester presented with lower extremity weakness, numbness, urinary incontinence, and back pain. Imaging studies revealed a right adrenal pheochromocytoma, multiple metastases at T8, T11, T12, and the pelvis girdle causing significant multilevel cord compression and significant osteolytic lesions at T11 and T12. DIAGNOSES: We believe this is the first reported case of metastatic pheochromocytoma of the thoracic spine presenting with symptoms of myelopathy during pregnancy. INTERVENTIONS: A healthy neonate was delivered by emergency caesarean section at 34 weeks. Subsequently, the patient underwent a circumferential spinal cord decompression and a stabilization procedure. OUTCOMES: The patient's neurological deficits improved significantly after the surgery, and the postoperative period was uneventful at the 6-month follow-up visit. LESSONS: This article emphasizes that metastatic pheochromocytoma of the spine, although rare, should be part of the differential when a patient presents with elevated blood pressure, weakness, and urinary incontinence.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Suprarrenais/patologia
Feocromocitoma/secundário
Complicações Neoplásicas na Gravidez/patologia
Neoplasias da Coluna Vertebral/secundário
Vértebras Torácicas
[Mh] Termos MeSH secundário: Neoplasias das Glândulas Suprarrenais/complicações
Neoplasias das Glândulas Suprarrenais/cirurgia
Adulto
Cesárea/métodos
Descompressão Cirúrgica/métodos
Feminino
Seres Humanos
Nascimento Vivo
Paresia/etiologia
Paresia/cirurgia
Feocromocitoma/complicações
Feocromocitoma/cirurgia
Gravidez
Complicações Neoplásicas na Gravidez/cirurgia
Compressão da Medula Espinal/etiologia
Compressão da Medula Espinal/cirurgia
Neoplasias da Coluna Vertebral/complicações
Neoplasias da Coluna Vertebral/cirurgia
Vértebras Torácicas/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008535



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