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[PMID]:29390545
[Au] Autor:Duan SJ; Gao ZM; Wang PL; Gong BC; Huang HW; Luo L; Wang X; Xing YN; Xu HM; Liu FN
[Ad] Endereço:Department of Surgical Oncology, The First Affiliated Hospital of China Medical University.
[Ti] Título:Rare upper gastrointestinal hemorrhage of cetuximab: A case report.
[So] Source:Medicine (Baltimore);96(51):e9391, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: cetuximab, an epidermal growth factor receptor inhibitor, is a targeted therapeutic regimen of colorectal cancers. Several common adverse effects have been found, such as cutaneous or gastrointestinal toxicity. However, according to the articles had been published, upper gastrointestinal bleeding (UGIB) is considered to be rare and its mechanism remains unclear. PATIENT CONCERNS: In this report, we presented a 42-year-old male patient with advanced recto-sigmoid cancer. After palliative operation, the patient suffered from complete upper gastrointestinal (GI) obstruction, which was induced by extensive abdominal metastasis of the tumor. Considering his poor condition, we chose the targeted drug, cetuximab, as his further treatment. But after the application of cetuximab, the UGIB immediately happened twice in this patient. DIAGNOSIS: UGIB, as a rare complication of cetuximab, occured to the patient. INTERVENTIONS: We stopped the bleeding with thrombin, hemocoagulase and somatostatin and suspended the subsequent treatment plan of cetuximab. At the same time, anti-shock treatment was given immediately. OUTCOMES: He was died of respiratory and circulatory failure caused by UGIB and advanced tumor eventually. LESSONS: UGIB should be considered as a rare but severe complication of cetuximab. When cetuximab is applied for patients with advanced colon tumors, more cautions should be required if the patients are accompanied by upper gastrointestinal obstruction. In addition, for those patients who suffered from UGIB recently, cetuximab should be prohibited if the Rockall score ranged > 5 points.
[Mh] Termos MeSH primário: Adenocarcinoma/tratamento farmacológico
Antineoplásicos Imunológicos/efeitos adversos
Cetuximab/efeitos adversos
Hemorragia Gastrointestinal/induzido quimicamente
Hematemese/induzido quimicamente
Neoplasias Retais/tratamento farmacológico
Neoplasias do Colo Sigmoide/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Antineoplásicos Imunológicos/uso terapêutico
Cetuximab/uso terapêutico
Evolução Fatal
Hemorragia Gastrointestinal/diagnóstico
Hematemese/diagnóstico
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Immunological); PQX0D8J21J (Cetuximab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009391


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[PMID]:29381999
[Au] Autor:Zhu Y; Jiang H; Chen Z; Lu B; Wu J
[Ti] Título:Abdominal surgery in patients with essential thrombocythemia: A case report and systematic review of literature.
[So] Source:Medicine (Baltimore);96(47):e8856, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Essential thrombocythemia/thrombocytosis (ET) is characterized by increased bleeding and thrombosis risk during the perioperative period. We report the case of a woman with ET and sigmoid colon cancer, in whom the postoperative course was complicated by anastomotic bleeding. A systematic review was conducted to seek guidance for the management of such patient in the perioperative period. METHODS: A systematic literature review was conducted using EMBASE, Medline, and PubMed databases to detect relevant English language articles. Published studies with full-text articles were included. Two authors independently searched and extracted the data. Any differences were resolved by consensus. Studies on abdominal surgery were manually retrieved. RESULTS: Four case reports (including our case report) that described abdominal surgery in patients with ET were included. All patients were females, with a mean age of 47 years. Laparoscopic surgery was performed in 2 patients, and open surgery was performed in the other 2 patients. Two patients had postoperative bleeding that occurred on the first postoperative day. There was one case of pseudohyperkalemia after surgery and one case of Budd-Chiari syndrome caused by hepatic vein thrombosis. No guidelines for patients with ET undergoing abdominal surgery were found. CONCLUSION: In conclusion, there are currently no definitive guidelines for the perioperative management of patients with ET. Furthermore, there are few reports of ET in patients with malignancy undergoing surgery. Further studies in this unique group of patients are required.
[Mh] Termos MeSH primário: Anastomose Cirúrgica/efeitos adversos
Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos
Hemorragia Pós-Operatória/etiologia
Neoplasias do Colo Sigmoide/cirurgia
Trombocitemia Essencial/cirurgia
[Mh] Termos MeSH secundário: Abdome/cirurgia
Procedimentos Cirúrgicos do Sistema Digestório/métodos
Feminino
Seres Humanos
Meia-Idade
Trombocitemia Essencial/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008856


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[PMID]:28738953
[Au] Autor:Belkin N; Bordeianou LG; Shellito PC; Hawkins AT
[Ti] Título:Morbidity Associated with Diverting Loop Ileostomies: Weighing Diversion in Rectosigmoid Resection.
[So] Source:Am Surg;83(7):786-792, 2017 Jul 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anterior resection with primary anastomosis is the procedure of choice for patients with rectosigmoid cancers with good sphincter function. Surgeons may perform an associated diverting loop ileostomy (DLI) to minimize the likelihood and/or the severity of an anastomotic leak. To examine the morbidity of DLIs, we performed a review of a prospectively maintained database. Participants included all patients at the Massachusetts General Hospital who underwent anterior resection from January 2013 to July 2015 for rectosigmoid cancers and who subsequently underwent adjuvant chemotherapy. The primary outcome was time to start of adjuvant chemotherapy. Secondary outcomes included length of hospitalization, perioperative complications, and 60-day postoperative complications. Inclusion criteria were met in 57 patients and DLI was performed in 21 (37%). The DLI group had higher estimated blood loss (431.7 vs 192.1 mL, P = 0.03) and a longer operation time (3.7 vs 2.3 hours, P = 0.0007). The DLI group took over a week longer to start adjuvant chemotherapy than the non-DLI group (median time to chemo: 43 vs 34 days, P = 0.002). Postoperatively, DLI was associated with a longer hospitalization (6.7 vs 3.1 days, P = 0.0003), more perioperative complications (57.1% vs 13.9%, P = 0.0006), and more 60-day readmissions or emergency department visits (38.1% vs 5.6%, P = 0.002). Ostomies are associated with appreciable morbidity. In turn, they do not eliminate postoperative complications. Surgeons should closely consider ostomy morbidity in rectosigmoid resection and institute a proactive approach toward identification and prevention of complications.
[Mh] Termos MeSH primário: Neoplasias Colorretais/cirurgia
Ileostomia/efeitos adversos
Ileostomia/métodos
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/etiologia
Neoplasias Retais/cirurgia
Neoplasias do Colo Sigmoide/cirurgia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Meia-Idade
Morbidade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28422825
[Au] Autor:Zhu J; Su S; Zhou J; Li H
[Ad] Endereço:Department of Radiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
[Ti] Título:Interdigitating dendritic cell sarcoma presenting in the sigmoid colon mesentery: A case report and literature review.
[So] Source:Medicine (Baltimore);96(16):e6210, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare disease. It commonly occurs in middle-aged males and mainly involves the lymph nodes. Pathological examination plays an important role in differentiating from other tumors, but far less published literature focuses on the imaging characteristics of IDCS. PATIENT CONCERNS: Here, we reported a case of IDCS in a 52-year-old male involving the pelvis with medical imaging and pathologic findings. DIAGNOSES: Preoperative unenhanced CT scan revealed a 6.0 × 6.3 × 8.0 cm mass with density equal to that of adjacent muscle, located in the pelvis. On contrast-enhanced CT images, the tumor presented apparent homogeneous enhancement. CT angiography showed that the tumor was supplied by the branches of inferior mesenteric artery. Pelvic magnetic resonance imaging manifested a lobulated solid mass with low signal on T1-weighted and intermediate to high signal on T2-weighted images. Simultaneously, significantly high signal intensity was exhibited on the diffusion-weighted images. This patient underwent operative resection of the tumor. The pathologic diagnosis was IDCS. INTERVENTIONS: This patient underwent operative resection of the tumor. The resection margins were negative for the neoplastic proliferation and no distant metastases were found. The patient did not receive advanced radiotherapy or chemotherapy. OUTCOMES: Three months after surgery, the follow-up CT scan did not reveal any recurrence or metastases. LESSONS: This case adds to the experience with IDCS by summarizing its characteristics as well as reviewing the literature.
[Mh] Termos MeSH primário: Sarcoma de Células Dendríticas Interdigitantes/diagnóstico por imagem
Sarcoma de Células Dendríticas Interdigitantes/cirurgia
Neoplasias do Colo Sigmoide/diagnóstico por imagem
Neoplasias do Colo Sigmoide/cirurgia
[Mh] Termos MeSH secundário: Colo Sigmoide/diagnóstico por imagem
Colo Sigmoide/patologia
Colo Sigmoide/cirurgia
Sarcoma de Células Dendríticas Interdigitantes/patologia
Diagnóstico Diferencial
Seres Humanos
Masculino
Mesentério/diagnóstico por imagem
Mesentério/patologia
Mesentério/cirurgia
Meia-Idade
Neoplasias do Colo Sigmoide/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006210


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[PMID]:28294676
[Au] Autor:Banai Z; Lestár B; Berczi L; Földi J; Harkai Z; Karácsony T
[Ad] Endereço:Sebészeti Osztály, Toldy Ferenc Kórház és Rendelointézet 2700 Cegléd, Törteli út 1-3.
[Ti] Título:[Treatment results of patients with rectum tumor in a city hospital].
[Ti] Título:Rectum daganatos betegek kezelésének eredményei egy városi kórházban..
[So] Source:Magy Seb;70(1):56-63, 2017 03.
[Is] ISSN:0025-0295
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:INTRODUCTION: Two hundred and three patients were operated on with rectal malignancy between 2007 and 2014 in our surgical department. METHODS: Of these, patients who had cancer within 16 cm of the anal verge were included. 73 patients received neoadjuvant treatment and 130 patients were treated with primary resection. The specimens were graded by the Dworak and the Rödel regression score system. RESULTS: We found strong response in 45 patients and pathologic complete remission in three patients. 5-years survival was compared in the two groups operated between 2007 and 2009. While the overall survival rates were just the same, we can report that response to neoadjuvant therapy is a strong predictor of disease free survival. The incidence of loco-regional recurrence was lower in patients who received neoadjuvant treatment compared to the ones who underwent primary resection. Postoperative complications, incidence of anastomotic leakage were also analysed. We did not find increase in the postoperative complications in the group of patients with neoadjuvant treatment.
[Mh] Termos MeSH primário: Canal Anal/cirurgia
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Terapia Neoadjuvante
Neoplasias Retais/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Canal Anal/patologia
Fístula Anastomótica/epidemiologia
Fístula Anastomótica/etiologia
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Intervalo Livre de Doença
Feminino
Hospitais Urbanos
Seres Humanos
Masculino
Meia-Idade
Terapia Neoadjuvante/efeitos adversos
Terapia Neoadjuvante/mortalidade
Recidiva Local de Neoplasia
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/etiologia
Neoplasias Retais/mortalidade
Neoplasias Retais/patologia
Reto/cirurgia
Neoplasias do Colo Sigmoide/complicações
Taxa de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1556/1046.70.2017.1.8


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[PMID]:28292997
[Au] Autor:Kamitani N; Ishii Y; Mizumoto K
[Ad] Endereço:Dept. of Surgery, Shodoshima Central Hospital.
[Ti] Título:[A Case of Trousseau Syndrome Associated with Advanced Rectal Cancer].
[So] Source:Gan To Kagaku Ryoho;44(3):251-253, 2017 Mar.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We report a case of Trousseau syndrome associated with advanced rectalcancer. A 67-year-old man visited our hospital for right hemiparesis and gait disturbance. Head magnetic resonance imaging showed multiple cerebral infarctions. Abdominal computed tomography showed wallthickening of the rectum and colonoscopy showed type 2 circumferentialrectalcancer. Therefore, he was diagnosed with Trousseau syndrome. After anticoagulation therapy with heparin, an operation was performed. Thereafter, chemotherapy was continued and he has experienced no recurrence of cerebralinfarction.
[Mh] Termos MeSH primário: Infarto Cerebral/etiologia
Neoplasias do Colo Sigmoide/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Infarto Cerebral/diagnóstico por imagem
Seres Humanos
Metástase Linfática
Imagem por Ressonância Magnética
Masculino
Neoplasias do Colo Sigmoide/complicações
Neoplasias do Colo Sigmoide/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE


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[PMID]:28271688
[Au] Autor:Chen T; Yu L; Li B; Zhang F; Wang Y; Wang X; Liu S; Yang C; Qi H; Yu M; Meng S; Chen T
[Ti] Título:Elevated Preoperative Carcinoembryonic Antigen and Vascular Endothelial Growth Factor Predict Shorter Survival in Patients with Sigmoid Colon Carcinoma.
[So] Source:Clin Lab;63(3):445-451, 2017 Mar 01.
[Is] ISSN:1433-6510
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We investigated the prognostic significance of carcinoembryonic antigen (CEA) and vascular endothelial growth factor (VEGF) and their associations with clinicopathological features in patients with sigmoid colon carcinoma (SCC). METHODS: We retrospectively reviewed patients with SCC treated with curative surgery from January 2001 to June 2010 at our hospital. Patients' general, clinical, histopathologic, and serum biomarkers were analyzed. We measured VEGF in 176 sets of SCC tissues and adjacent noncancerous tissue samples with immunohistochemical and Elivison staining. CEA was measured with a tumor biomarker chip. Their correlations with clinicopathologic factors were analyzed by chi-square test. Univariate and multivariate analyses were used to identify factors associated with overall survival (OS). RESULTS: Of the 176 patients, 69.3% were alive and 30.7% had died. In univariate analysis, serum CEA level (p = 0.002, OR = 2.394, 1.392 - 4.116), tumor VEGF (p = 0.04, OR = 1.968, 1.032 - 3.752), lymph node metastasis (N, p = 0.000, OR = 3.712, 2.064 - 6.675), T stage (T, p = 0.016, OR = 5.706, 1.382 - 23.552) and differentiation (p = 0.000) were the prognostic factors for OS. In stratified analysis, combined elevated serum CEA and tumor VEGF levels were associated with poorer prognosis. CONCLUSIONS: Elevated preoperative serum CEA and tumor VEGF were predictors of poor prognosis for patients with SCC.
[Mh] Termos MeSH primário: Neoplasias do Colo Sigmoide
[Mh] Termos MeSH secundário: Biomarcadores Tumorais
Antígeno Carcinoembrionário
Colo Sigmoide
Seres Humanos
Metástase Linfática
Estadiamento de Neoplasias
Prognóstico
Estudos Retrospectivos
Fator A de Crescimento do Endotélio Vascular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Carcinoembryonic Antigen); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.7754/Clin.Lab.2016.160720


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[PMID]:28221694
[Au] Autor:Gluskin AB; Singh NA
[Ad] Endereço:Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
[Ti] Título:Gastrointestinal: A sigmoid lipoma as the cause of intussusception.
[So] Source:J Gastroenterol Hepatol;32(2):292, 2017 Feb.
[Is] ISSN:1440-1746
[Cp] País de publicação:Australia
[La] Idioma:eng
[Mh] Termos MeSH primário: Intussuscepção/diagnóstico por imagem
Intussuscepção/etiologia
Lipoma/complicações
Lipoma/diagnóstico por imagem
Neoplasias do Colo Sigmoide/complicações
Neoplasias do Colo Sigmoide/diagnóstico por imagem
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Intussuscepção/patologia
Intussuscepção/cirurgia
Lipoma/patologia
Lipoma/cirurgia
Meia-Idade
Neoplasias do Colo Sigmoide/patologia
Neoplasias do Colo Sigmoide/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1111/jgh.13487


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[PMID]:28210093
[Au] Autor:Zhang NS; Shi F; Kong L; Zhu H
[Ad] Endereço:Na-Sha Zhang, Fang Shi, Li Kong, Hui Zhu, Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China.
[Ti] Título:Mucosa-associated lymphoid tissue lymphoma with unusual F-FDG hypermetabolism arising at the colorectal anastomosis.
[So] Source:World J Gastroenterol;23(3):551-559, 2017 Jan 21.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mucosa-associated lymphoid tissue (MALT) lymphoma usually originates from the stomach and presents with low F-fluorodeoxyglucose (FDG) avidity with average maximum standard uptake value of 3.6. Colorectal MALT lymphoma is a rare entity that contributes to 1.6% of all MALT lymphomas and < 0.2% of large intestinal malignancies. The case reported herein firstly revealed stage IIE MALT lymphoma with unexpected higher F-FDG avidity of 18.9 arising at the colorectal anastomosis in a patient with a surgical history for sigmoid adenocarcinoma, which was strongly suspected as local recurrence before histopathological and immunohistochemical examinations. After accurate diagnosis, the patient received four cycles of standard R-CVP regimen (rituximab, cyclophosphamide, vincristine and prednisone), combined target therapy and chemotherapy, instead of radiotherapy recommended by National Comprehensive Cancer Network guidelines. He tolerated the treatment well and reached complete remission.
[Mh] Termos MeSH primário: Adenocarcinoma/terapia
Antineoplásicos/uso terapêutico
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias Colorretais/metabolismo
Linfoma de Zona Marginal Tipo Células B/diagnóstico por imagem
Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico
Recidiva Local de Neoplasia/diagnóstico por imagem
Rituximab/uso terapêutico
Neoplasias do Colo Sigmoide/terapia
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Idoso
Antineoplásicos/administração & dosagem
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Quimiorradioterapia Adjuvante
Colectomia
Colo Sigmoide/patologia
Colo Sigmoide/cirurgia
Colonoscopia
Neoplasias Colorretais/diagnóstico por imagem
Neoplasias Colorretais/patologia
Ciclofosfamida/administração & dosagem
Ciclofosfamida/uso terapêutico
Fluordesoxiglucose F18/administração & dosagem
Seres Humanos
Linfoma de Zona Marginal Tipo Células B/metabolismo
Linfoma de Zona Marginal Tipo Células B/patologia
Masculino
Estadiamento de Neoplasias
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Prednisona/administração & dosagem
Prednisona/uso terapêutico
Indução de Remissão/métodos
Rituximab/administração & dosagem
Neoplasias do Colo Sigmoide/patologia
Vincristina/administração & dosagem
Vincristina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 4F4X42SYQ6 (Rituximab); 5J49Q6B70F (Vincristine); 8N3DW7272P (Cyclophosphamide); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i3.551


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[PMID]:28174387
[Au] Autor:Ono R; Ise N; Yoshioka H; Iwasaki W; Sato K; Niwa M
[Ad] Endereço:Division of Surgery, Yokote Municipal Hospital.
[Ti] Título:[A Case of Heterochronic Ovarian Metastasis from Sigmoid Colon Cancer after Sigmoidectomy Treated with CapeOX That Included Bevacizumab].
[So] Source:Gan To Kagaku Ryoho;44(1):83-85, 2017 Jan.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The patient was a 41-year-old woman. When she was 39 years old, she had undergone laparoscopic high anterior resection for sigmoid colon cancer without adjuvant chemotherapy. Histologically, the surgical specimen was type 2, tub2, pT4a (SE), pN0, int, INF b, ly1, v1, and pStage II. Nine months after the operation, she suffered from abdominal fullness. Laborato- rydata showed elevation of tumor markers: the CEA level was 6.48 ng/mL, the CA19-9 level was 89.70 U/mL, and the CA125 level was 662 U/mL. Computed tomographyrevealed bilateral ovarian tumors and lung and peritoneal nodules with massive ascites. Chemotherapywas started with a regimen consisting of capecitabine plus oxaliplatin(CapeOX)that included bevacizumab. After 4 courses, the sizes of the lung and peritoneal nodules had decreased and the amount of ascites was almost zero. However, the ovarian tumors had increased in size and her sense of abdominal fullness had not improved. Bilateral oophorectomy with hysterectomy was performed to alleviate her symptom. Immunohistochemically, the resected ovarian tumors were negative for cytokeratin 7 and positive for cytokeratin 20. CapeOX with bevacizumab was then resumed. However, the lung tumor had graduallyincreased in size, and therefore, she underwent partial resection of the lung for the metastatic lung tumor.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias Ovarianas/tratamento farmacológico
Neoplasias do Colo Sigmoide/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Bevacizumab/administração & dosagem
Capecitabina/administração & dosagem
Colectomia
Feminino
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/secundário
Neoplasias Pulmonares/cirurgia
Compostos Organoplatínicos/administração & dosagem
Neoplasias Ovarianas/secundário
Pneumonectomia
Neoplasias do Colo Sigmoide/patologia
Neoplasias do Colo Sigmoide/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organoplatinum Compounds); 04ZR38536J (oxaliplatin); 2S9ZZM9Q9V (Bevacizumab); 6804DJ8Z9U (Capecitabine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE



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