[PMID]: | 28655412 |
[Au] Autor: | Viau M; Renaud MC; Grégoire J; Sebastianelli A; Plante M |
[Ad] Endereço: | Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Université Laval 2705 boulevard Laurier, Québec City, Québec G1V 4G2, Canada. Electronic address: Mathieu.Viau.1@ULaval.ca. |
[Ti] Título: | Paraneoplastic syndromes associated with gynecological cancers: A systematic review. |
[So] Source: | Gynecol Oncol;146(3):661-671, 2017 Sep. |
[Is] ISSN: | 1095-6859 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | A number of paraneoplastic syndromes have been described with gynecological cancers. These syndromes are induced by substances secreted by the tumor or by an immune response triggered by the cancer. Each system of the human body can be affected by different syndromes. Indeed, paraneoplastic syndromes occurring from tumors of the gynecologic tract were found to involve the nervous, ophthalmologic, dermatologic, rheumatologic, endocrine, hematologic and renal systems. These syndromes can manifest before, at the time, or after the diagnosis of cancer. They can also occur at the time of a recurrence. Knowledge about these syndromes is important for physicians caring for patients with cancers, as they can result in severe morbidity and must be treated appropriately. Literature regarding paraneoplastic syndromes associated with tumors of the female genital tract is scattered and the subject has not been reviewed recently. A systematic literature search was thus conducted to identify paraneoplastic syndromes associated with gynecologic cancers. This review focuses on the cancers involved with each paraneoplastic syndrome, and on their pathophysiology, clinical manifestations, possible complications, outcomes, and treatments. As the mainstay of treatment in these conditions is often to address the underlying tumor, it is of upmost importance that physicians be aware of these rare cancer manifestations. |
[Mh] Termos MeSH primário: |
Neoplasias dos Genitais Femininos/complicações Doenças Hematológicas/etiologia Síndromes Paraneoplásicas/etiologia Dermatopatias/etiologia
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[Mh] Termos MeSH secundário: |
Feminino Seres Humanos Nefropatias/etiologia Síndromes Endócrinas Paraneoplásicas/etiologia Síndromes Paraneoplásicas do Sistema Nervoso/etiologia Síndromes Paraneoplásicas Oculares/etiologia Doenças Reumáticas/etiologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; REVIEW |
[Em] Mês de entrada: | 1709 |
[Cu] Atualização por classe: | 170919 |
[Lr] Data última revisão:
| 170919 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170629 |
[St] Status: | MEDLINE |
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