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[PMID]:28450657
[Au] Autor:Hendarto H; Pramono LA; Harbuwono DS; Yunir E; Subekti I
[Ad] Endereço:Department of Internal Medicine, Faculty of Medicine and Health Science, Syarif Hidayatullah Islamic State University (UIN), Jakarta, Indonesia. hari.hendarto@uinjkt.ac.id.
[Ti] Título:Parathyroid Adenoma in a Young Female Presenting Multiple Fractures and Postoperative Hungry Bone Syndrome.
[So] Source:Acta Med Indones;49(1):69-73, 2017 Jan.
[Is] ISSN:0125-9326
[Cp] País de publicação:Indonesia
[La] Idioma:eng
[Ab] Resumo:A young 18-year-old female patient with general bone pain and history of multiple fractures brought her to our medical attention. Laboratory work showed hypercalcemia and high parathyroid hormone levels in the blood. Radiograph imaging revealed severe scoliosis with multiple vertebrae fractures with decreased bone mineral density. Sestamibi showed parathyroid adenoma. This case emphasizes the importance of maintaining a primary hyperparathyroidism as a differential diagnosis when a young patient presents with a multiple pathologic fractures history.
[Mh] Termos MeSH primário: Adenoma/diagnóstico por imagem
Hormônio Paratireóideo/sangue
Neoplasias das Paratireoides/diagnóstico por imagem
Escoliose/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenoma/cirurgia
Adolescente
Densidade Óssea
Cálcio/sangue
Diagnóstico Diferencial
Feminino
Fraturas Múltiplas/diagnóstico
Seres Humanos
Hipercalcemia/etiologia
Dor/etiologia
Neoplasias das Paratireoides/cirurgia
Radiografia
Tecnécio Tc 99m Sestamibi
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone); 971Z4W1S09 (Technetium Tc 99m Sestamibi); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29390544
[Au] Autor:Zeng H; Li Z; Zhang X; Wang N; Tian Y; Wang J
[Ad] Endereço:Department of Anesthesiology, Peking University Third Hospital, Beijing, China.
[Ti] Título:Anesthetic management of primary hyperparathyroidism during pregnancy: A case report.
[So] Source:Medicine (Baltimore);96(51):e9390, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary hyperparathyroidism (PHPT) during pregnancy is rare. Nevertheless, hypercalcemia secondary to gestational PHPT may be masked by physiological changes in calcium homeostasis during pregnancy. Gestational PHPT constitutes a serious danger to mother and fetus. Surgery is the only curative treatment when conservative treatment could not control the condition. Due to the lack of guidelines concerning PHPT during pregnancy, the optimal anesthetic management of PHPT during pregnancy needs to be individualized. Patient concerns: We report a case of PHPT with successful surgical treatment under combined cervical plexus block and general anesthesia. DIAGNOSIS: She was diagnosed with hypercalcemia, PHPT, a possible parathyroid adenoma, and a 19-week intrauterine pregnancy. INTERVENTIONS: The patient underwent heparin-free hemodialysis before the surgery in the nephrology department in the presence of a cardiologist. She then received a successful parathyroidectomy under combined bilateral superficial cervical plexus block and general anesthesia in her 19th week of pregnancy. OUTCOMES: She was released from the hospital with no maternal or fetal complications on postoperative day 9. A healthy baby boy was uneventfully born at 37 weeks of gestation. LESSONS: We suggest that surgical removal of the lesion after lowering the blood calcium concentration in mid-pregnancy is currently the optimal treatment option for pregnant patients with PHPT. Furthermore, multidisciplinary perioperative management is particularly important.
[Mh] Termos MeSH primário: Adenoma/cirurgia
Anestesia Geral/métodos
Hiperparatireoidismo Primário/cirurgia
Neoplasias das Paratireoides/cirurgia
Paratireoidectomia
Complicações Neoplásicas na Gravidez/cirurgia
[Mh] Termos MeSH secundário: Adenoma/complicações
Adulto
Feminino
Seres Humanos
Hiperparatireoidismo Primário/etiologia
Neoplasias das Paratireoides/complicações
Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009390


  3 / 7057 MEDLINE  
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[PMID]:29221466
[Au] Autor:Benameur Y; Guerrouj H; Ghfir I; Ben Rais Aouad N
[Ad] Endereço:Department of Nuclear Medicine, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco. Benameur.yassir@gmail.com.
[Ti] Título:Unusual pathological fracture of the clavicle revealing primary hyperparathyroidism: a case report.
[So] Source:J Med Case Rep;11(1):342, 2017 Dec 09.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Primary hyperparathyroidism revealed by a pathological fracture is very uncommon; in the majority of cases the discovery of lytic bone lesions on imaging examinations evokes in the clinician first a neoplastic etiology and a metabolic origin is often omitted. This case report adds to the existing literature as it describes an unusual presentation of primary hyperparathyroidism. CASE PRESENTATION: We report a case of a 50-year-old Moroccan man, without any known tumor, who presented a fracture of his left clavicle with multiple osteolytic lesions on computed tomography suggesting bone metastases. However, bone scintigraphy oriented the diagnosis to a metabolic pathology by showing a metabolic bone "super scan" with increased tracer uptake in the left clavicle; parathyroid scintigraphy was able to localize pathological right parathyroid tissue. CONCLUSIONS: Whenever multiple osteolytic lesions are found in a patient without any known tumor, metabolic bone diseases including hyperparathyroidism should be highly considered.
[Mh] Termos MeSH primário: Adenoma/diagnóstico por imagem
Neoplasias Ósseas/diagnóstico
Clavícula/diagnóstico por imagem
Fraturas Espontâneas/diagnóstico por imagem
Hiperparatireoidismo Primário/diagnóstico
Neoplasias das Paratireoides/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenoma/complicações
Neoplasias Ósseas/secundário
Clavícula/lesões
Diagnóstico Diferencial
Fraturas Espontâneas/etiologia
Seres Humanos
Hiperparatireoidismo Primário/etiologia
Masculino
Meia-Idade
Neoplasias das Paratireoides/complicações
Cintilografia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1509-7


  4 / 7057 MEDLINE  
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[PMID]:29254595
[Au] Autor:Shi Y; Azimzadeh P; Jamingal S; Wentworth S; Ferlitch J; Koh J; Balenga N; Olson JA
[Ad] Endereço:Division of General and Oncologic Surgery, Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD.
[Ti] Título:Polyclonal origin of parathyroid tumors is common and is associated with multiple gland disease in primary hyperparathyroidism.
[So] Source:Surgery;163(1):9-14, 2018 Jan.
[Is] ISSN:1532-7361
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Parathyroid tumors are mostly considered monoclonal neoplasms, the rationale for focused parathyroidectomy in primary hyperparathyroidism. We reported that flow sorting parathyroid tumor cells and methylation-sensitive polymerase chain reaction (me-PCR) of polymorphic human androgen receptor gene and phosphoglycerate kinase gene alleles in deoxyribonucleic acid reveals that ≤35% of parathyroid tumors are polyclonal. We sought to confirm these findings and assess for clinical relevance. METHODS: Parathyroid tumors from 286 female primary hyperparathyroidism patients were analyzed for clonal status. Tumor clonal status was compared with clinical variables and operative findings. Statistical analysis was performed and significance was established at P < .05. RESULTS: In the study, 176 (62%) patients were informative for human androgen receptor gene and/or phosphoglycerate kinase gene. Assignment of clonal status was made in 119 (68%) tumors, of which 64 (54%) were monoclonal and 55 (46%) were polyclonal. Comparison of tumor clonal status to clinical variables in patients with complete operative data (N = 82) showed that while clinical features were the same between tumor types, patients with polyclonal tumors more often had multiple gland disease (risk ratio 4.066, confidence interval, 1.016-16.26; P = .039) potentially missed at unilateral neck exploration. CONCLUSION: This work confirms that primary hyperparathyroidism is often the result of polyclonal tumors and that parathyroid tumor clonal status may be associated with multiple gland disease.
[Mh] Termos MeSH primário: Adenoma/etiologia
Hiperparatireoidismo Primário/etiologia
Neoplasias das Paratireoides/etiologia
[Mh] Termos MeSH secundário: Adenoma/patologia
Adenoma/cirurgia
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Meia-Idade
Glândulas Paratireoides/patologia
Neoplasias das Paratireoides/patologia
Neoplasias das Paratireoides/cirurgia
Paratireoidectomia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  5 / 7057 MEDLINE  
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[PMID]:29189860
[Au] Autor:Paillahueque G; Massardo T; Barberán M; Ocares G; Gallegos I; Toro L; Araya AV
[Ad] Endereço:Sección Medicina Nuclear, Hospital Clínico, Universidad de Chile, Santiago, Chile.
[Ti] Título:[False negative spect parathyroid scintigraphy with sestamibi in patients with primary hyperparathyroidism].
[Ti] Título:Análisis de falsos negativos en la cintigrafía SPECT de paratiroides con sestamibi en pacientes con hiperparatiroidismo primario sometidos a cirugía entre 2008-2015 en hospital universitario..
[So] Source:Rev Med Chil;145(8):1021-1027, 2017 Aug.
[Is] ISSN:0717-6163
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:BACKGROUND: 99mTc-sestamibi parathyroid SPECT scintigraphy is a useful tool in the pre-operative study of hyperparathyroidism. False negatives (FN) have been reported in 5.7-14% of the examinations. AIM: To characterize 99mTc-sestamibi FN in cases referred for primary hyperparathyroidism (PHP) to a university hospital. MATERIAL AND METHODS: Descriptive retrospective analysis. We included patients with PHP, studied with SPECT scintigraphy, operated at our center between 2008 and 2015. Clinical and surgical data were recorded; biopsies of the FN were blindly reviewed by one pathologist. RESULTS: One hundred twenty one scintigraphies fulfilled the inclusion criteria. Seven (5.8%) were negative and 114 positive. There was no difference in age, sex and PTH levels between FN and true positive scintigraphies. At surgery, one FN case had two hyperplasic glands and two cases had ectopic glands. Pathology reported adenoma in three cases, hyperplasia in three and carcinoma in one. The largest diameter of the lesion was lower in FN (1.3 and 2.1 cm respectively, p = 0.02) and the proportion of adenomas was higher in true positive cases (29% and 75% respectively; p < 0.01). The interval between scintigraphy and parathyroidectomy was greater in FN with a median of 92 days (range 20 days-3.2 years, p < 0.01). The percentage of oxyphilic cells observed was similar in both groups. CONCLUSIONS: FN parathyroid SPECT scintigraphies in PHP are uncommon. They corresponded to lesions under the equipment's resolution limit and resulted in longer time lags between scintigraphy and surgery.
[Mh] Termos MeSH primário: Hiperparatireoidismo Primário/diagnóstico por imagem
Glândulas Paratireoides/diagnóstico por imagem
Compostos Radiofarmacêuticos
Tecnécio Tc 99m Sestamibi
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Adenoma/diagnóstico por imagem
Adenoma/patologia
Adulto
Idoso
Carcinoma/diagnóstico por imagem
Carcinoma/patologia
Reações Falso-Negativas
Feminino
Seres Humanos
Hiperparatireoidismo Primário/patologia
Hiperplasia/diagnóstico por imagem
Hiperplasia/patologia
Masculino
Meia-Idade
Glândulas Paratireoides/patologia
Neoplasias das Paratireoides/diagnóstico por imagem
Neoplasias das Paratireoides/patologia
Padrões de Referência
Valores de Referência
Estudos Retrospectivos
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 971Z4W1S09 (Technetium Tc 99m Sestamibi)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:27771850
[Au] Autor:Ward AF; Lee T; Ogilvie JB; Patel KN; Hiotis K; Bizekis C; Zervos M
[Ad] Endereço:Division of Thoracic Surgery, NYU Langone Medical Center, 530 First Avenue, Suite 9V, New York, NY, 10016, USA.
[Ti] Título:Robot-assisted complete thymectomy for mediastinal ectopic parathyroid adenomas in primary hyperparathyroidism.
[So] Source:J Robot Surg;11(2):163-169, 2017 Jun.
[Is] ISSN:1863-2491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One to two percent of ectopic parathyroid adenomas are found in the lower mediastinum and often these are best accessed via a sternotomy or thoracotomy. Video-assisted thoracoscopic surgery (VATS) is an alternative approach with less surgical trauma, decreased morbidity, shorter hospital stays, and superior cosmetic results. Ten years after the first VATS resection of an ectopic mediastinal parathyroid, a robot-assisted thoracoscopic approach was described. Here we describe a series of five robot assisted complete thymectomies in patients with primary hyperparathyroidism due to mediastinal ectopic parathyroid adenomas. A single surgeon, single institution case series of five consecutive robotic-assisted mediastinal parathyroidectomies was performed between March 2013 and September 2015. The patients' ages ranged from 31 to 65, 80 % were female, and all had primary hyperparathyroidism due to an ectopic parathyroid located in the lower mediastinum. Pre-operative imaging workup included Technetium 99-sestimibi parathyroid scan and CT scan of the chest. An ectopic parathyroid adenoma was successfully removed in all five cases, with intraoperative iOPTH decreasing ~50 % from baseline after 10 minutes. A hypercellular parathyroid was confirmed on pathologic exam in all specimens. Post-operative discharge and follow up calcium levels all returned to normal. There were no intraoperative complications, including no recurrent laryngeal nerve injuries, no postoperative morbidity, and no mortalities. This case series demonstrates that a robot-assisted complete thymectomy for mediastinal parathyroid adenomas causing primary hyperparathyroidism provides excellent visualization of the mediastinum, is effective at reducing PTH and calcium levels, and is safe with no morbidity or mortality.
[Mh] Termos MeSH primário: Adenoma/cirurgia
Coristoma/cirurgia
Hiperparatireoidismo Primário/cirurgia
Doenças do Mediastino/cirurgia
Neoplasias das Paratireoides/cirurgia
Procedimentos Cirúrgicos Robóticos/métodos
Timectomia/métodos
[Mh] Termos MeSH secundário: Adenoma/patologia
Adulto
Idoso
Coristoma/patologia
Feminino
Seres Humanos
Laparoscopia/métodos
Masculino
Meia-Idade
Neoplasias das Paratireoides/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1007/s11701-016-0637-1


  7 / 7057 MEDLINE  
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[PMID]:29095277
[Au] Autor:Gao Y; Yu C; Xiang F; Xie M; Fang L
[Ad] Endereço:Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:Acute pancreatitis as an initial manifestation of parathyroid carcinoma: A case report and literature review.
[So] Source:Medicine (Baltimore);96(44):e8420, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Parathyroid carcinoma is a rare endocrine malignancy. Acute pancreatitis as an initial manifestation of parathyroid carcinoma has been rarely reported. PATIENT CONCERNS: A 22-year-old woman was admitted to emergency room with a sudden attack of severe epigastric pain. DIAGNOSES: Acute pancreatitis was diagnosed as elevated levels of serum amylase. During the work-up for acute pancreatitis, patient's abnormally increased serum calcium and bones destruction revealed by abdominal computed tomography (CT) scan raised the suspicion of hyperparathyroidism or malignancy. Elevated serum parathyroid hormone (PTH) levels, parathyroid ultrasound and scintigraphy gave rise to the diagnosis of primary hyperparathyroidism (PHPT) due to a left parathyroid tumor. INTERVENTIONS: The patient was given a complete tumor excision. After the surgery, parathyroid carcinoma with capsular and vascular invasion was confirmed histologically. A second surgery was then performed, including resection of the ipsilateral thyroid lobe and anterior cervical nodes. OUTCOMES: Serum calcium and PTH levels returned to normal postoperatively. LESSONS: Acute pancreatitis accompanied with hypercalcemia should always raise the suspicion of PHPT. The spicule sign, which always suggests the infiltrating pattern growth of tumor, was neglected at first and was observed during a second review of the ultrasound images postoperatively. This specific feature may be predictive for the preoperative diagnosis of parathyroid carcinoma or at least suspicion of malignancy.
[Mh] Termos MeSH primário: Hiperparatireoidismo Primário/etiologia
Pancreatite/etiologia
Neoplasias das Paratireoides/complicações
[Mh] Termos MeSH secundário: Doença Aguda
Amilases/sangue
Cálcio/sangue
Feminino
Seres Humanos
Hiperparatireoidismo Primário/sangue
Hiperparatireoidismo Primário/diagnóstico por imagem
Pancreatite/sangue
Pancreatite/diagnóstico por imagem
Glândulas Paratireoides/diagnóstico por imagem
Hormônio Paratireóideo/sangue
Neoplasias das Paratireoides/sangue
Neoplasias das Paratireoides/diagnóstico por imagem
Cintilografia
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Parathyroid Hormone); EC 3.2.1.- (Amylases); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008420


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[PMID]:28979642
[Au] Autor:Dikmen K; Bostanci H; Gobut H; Yildiz A; Ertunc O; Celik A; Akin M; Taneri F
[Ad] Endereço:Department of General Surgery, Gazi University Medical Faculty, Ankara, Turkey.
[Ti] Título:Nonfunctional double parathyroid carcinoma with incidental thyroid micropapillary carcinoma: a rare case.
[So] Source:Pan Afr Med J;27:241, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Parathyroid carcinomas are rare endocrine tumors which comprise 0.3-5.6% of all causes of hyperparathyroidism. 90% of them are hormonally active, while 10% of them may be non-functional. They mostly occur in a single parathyroid gland. Concurrent involvement of both parathyroid glands is quite rare. A 57-year-old male patient was admitted to emergency department with the complaint of dyspnea. Thorax tomography revealed a retrosternal mass. The mass was thoracoscopically excised by thoracic surgeons. Histopathological examination result of the mass was reported as parathyroid carcinoma. Parathyroid scintigraphy performed and focal activity increase in the lower pole of the left lobe. Parathyroid hormone level was 118 pg/ml and calcium level was measured as 11.4 mg/dl. The patient with these findings was operated and pathological examination of excised left lower parathyroid tissue was reported as carcinoma. In addition, micropapillary carcinoma was detected in left thyroid lobectomy specimen.Our case was also unusual in that double parathyroid carcinoma, which is a rare condition, was hormonally inactive. We aimed to present our case in the light of the literature due to its rare occurrence.
[Mh] Termos MeSH primário: Carcinoma Papilar/diagnóstico
Neoplasias das Paratireoides/diagnóstico
Neoplasias da Glândula Tireoide/diagnóstico
[Mh] Termos MeSH secundário: Carcinoma Papilar/patologia
Carcinoma Papilar/cirurgia
Dispneia/etiologia
Seres Humanos
Achados Incidentais
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Neoplasias das Paratireoides/patologia
Neoplasias das Paratireoides/cirurgia
Neoplasias da Glândula Tireoide/patologia
Neoplasias da Glândula Tireoide/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.241.11503


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[PMID]:28969599
[Au] Autor:Kim BY; Park MH; Woo HM; Jo HY; Kim JH; Choi HJ; Koo SK
[Ad] Endereço:Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeing2-ro, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
[Ti] Título:Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing.
[So] Source:BMC Med Genet;18(1):106, 2017 Oct 02.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant hereditary disorder characterized by the presence of endocrine tumors affecting the parathyroid, pancreas, and pituitary. A heterozygous germline inactivating mutation in the MEN1 gene (first hit) may be followed by somatic loss of the remaining normal copy or somatic mutations in the MEN1 gene (second hit). Whole-exome sequencing has been successfully used to elucidate the mutations associated with the different types of tumors. CASE PRESENTATION: We performed whole-exome sequencing (WES) on three parathyroid tumors, one pancreatic insulinoma, and a blood sample taken from the same patient with MEN1 to study tumor heterogeneity in MEN1 originating from different tumors. We identified a novel frame-shift deletion (c.1382_1383delAG, p.E461GfsX69) in the MEN1 gene using WES, which was confirmed by Sanger sequencing. WES and the SNP array revealed somatic LOH on chromosome 11 in parathyroid tumors (left upper, left lower, and right upper parathyroid). However, we did not detect a somatic MEN1 gene mutation or LOH in the pancreatic insulinoma. WES revealed two somatic functional variants outside the MEN1 gene in the pancreatic insulinoma. CONCLUSIONS: This study revealed heterogeneity among tumors in the same patient with MEN1, suggesting that different tumor-specific tumorigenic mechanisms may contribute to the pathogenesis of MEN1 tumors. The present study supports the clinical applicability of the WES strategy to research on multiple tumor samples and blood.
[Mh] Termos MeSH primário: Testes Genéticos/métodos
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Insulinoma/genética
Neoplasia Endócrina Múltipla Tipo 1/genética
Neoplasias Pancreáticas/genética
Neoplasias das Paratireoides/genética
[Mh] Termos MeSH secundário: Adulto
Exoma/genética
Mutação em Linhagem Germinativa
Seres Humanos
Masculino
Neoplasias Pancreáticas/complicações
Neoplasias das Paratireoides/complicações
Linhagem
Proteínas Proto-Oncogênicas/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MEN1 protein, human); 0 (Proto-Oncogene Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0465-9


  10 / 7057 MEDLINE  
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[PMID]:28855268
[Au] Autor:Haglund F; Hallström BM; Nilsson IL; Höög A; Juhlin CC; Larsson C
[Ad] Endereço:Department of Oncology-PathologyKarolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, Stockholm, Sweden Felix.Haglund@ki.se.
[Ti] Título:Inflammatory infiltrates in parathyroid tumors.
[So] Source:Eur J Endocrinol;177(6):445-453, 2017 Dec.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Inflammatory infiltrates are sometimes present in solid tumors and may be coupled to clinical behavior or etiology. Infectious viruses contribute to tumorigenesis in a significant fraction of human neoplasias. OBJECTIVE: Characterize inflammatory infiltrates and possible viral transcription in primary hyperparathyroidism. DESIGN: From the period 2007 to 2016, a total of 55 parathyroid tumors (51 adenomas and 4 hyperplasias) with prominent inflammatory infiltrates were identified from more than 2000 parathyroid tumors in the pathology archives, and investigated by immunohistochemistry for CD4, CD8, CD20 and CD45 and scored as +0, +1 or +2. Clinicopathological data were compared to 142 parathyroid adenomas without histological evidence of inflammation. Transcriptome sequencing was performed for 13 parathyroid tumors (four inflammatory, 9 non-inflammatory) to identify potential viral transcripts. RESULTS: Tumors had prominent germinal center-like nodular (+2) lymphocytic infiltrates consisting of T and B lymphocytes (31%) and/or diffuse (+1-2) infiltrates of predominantly CD8+ T lymphocytes (84%). In the majority of cases with adjacent normal parathyroid tissue, the normal rim was unaffected by the inflammatory infiltrates (96%). Presence of inflammatory infiltrates was associated with higher levels of serum-PTH ( = 0.007) and oxyphilic differentiation ( = 0.002). Co-existent autoimmune disease was observed in 27% of patients with inflammatory infiltrates, which in turn was associated with oxyphilic differentiation ( = 0.041). Additionally, prescription of anti-inflammatory drugs was associated with lower serum ionized calcium ( = 0.037). CONCLUSIONS: No evidence of virus-like sequences in the parathyroid tumors could be found by transcriptome sequencing, suggesting that other factors may contribute to attract the immune system to the parathyroid tumor tissue.
[Mh] Termos MeSH primário: Adenoma/imunologia
Linfócitos B/imunologia
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Hiperparatireoidismo Primário/imunologia
Glândulas Paratireoides/imunologia
Neoplasias das Paratireoides/imunologia
[Mh] Termos MeSH secundário: Adenoma/metabolismo
Adenoma/patologia
Adenoma/virologia
Antígenos CD20/metabolismo
Linfócitos B/metabolismo
Linfócitos B/patologia
Biomarcadores/metabolismo
Linfócitos T CD4-Positivos/metabolismo
Linfócitos T CD4-Positivos/patologia
Linfócitos T CD8-Positivos/metabolismo
Linfócitos T CD8-Positivos/patologia
Estudos de Coortes
Feminino
Seres Humanos
Hiperparatireoidismo Primário/metabolismo
Hiperparatireoidismo Primário/patologia
Hiperparatireoidismo Primário/virologia
Hiperplasia/imunologia
Hiperplasia/patologia
Imuno-Histoquímica
Antígenos Comuns de Leucócito/metabolismo
Leucócitos/imunologia
Leucócitos/metabolismo
Leucócitos/patologia
Masculino
Meia-Idade
Glândulas Paratireoides/metabolismo
Glândulas Paratireoides/patologia
Glândulas Paratireoides/virologia
Neoplasias das Paratireoides/metabolismo
Neoplasias das Paratireoides/patologia
Neoplasias das Paratireoides/virologia
RNA Viral/metabolismo
Estudos Retrospectivos
Transcrição Genética
Proteínas Virais/genética
Proteínas Virais/metabolismo
Replicação Viral
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD20); 0 (Biomarkers); 0 (RNA, Viral); 0 (Viral Proteins); EC 3.1.3.48 (Leukocyte Common Antigens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0277



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