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[PMID]:29211701
[Au] Autor:Zhong J; Deng Y; Zhang P; Li S; Huang H; Wang B; Zhang H; Peng L; Yang R; Xu J; Yuan J
[Ad] Endereço:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
[Ti] Título:New Grading System for Limbal Dermoid: A Retrospective Analysis of 261 Cases Over a 10-Year Period.
[So] Source:Cornea;37(1):66-71, 2018 Jan.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To establish a new scoring system for limbal dermoid, in order to unify the diagnostic criteria and assess the prognosis. METHODS: A retrospective study was conducted on 261 patients with limbal dermoid. The basic information, clinical features, and pathology of dermoids were recorded, and the prognosis at 1 year after keratoplasty was assessed at follow-up. A new visual scoring system was created for the area of corneal involvement, the area of conjunctival involvement, and the surface shape. RESULTS: There were 154 females and 107 males with mean age of 4 ± 3 years at surgery. After scoring, 59% (136) of patients were classified as grade I, 26% (60) as grade II, and 14% (33) as grade III. The pathological results were 124 dermoid cases, 76 lipodermoid, 5 complex choristoma, and 10 epibulbar osseous choristoma. Moreover, patients with lower clinical scores presented a better prognosis; the mean logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity in grade I patients was 0.38 ± 0.05, which was better than the grade II value of 0.61 ± 0.09 (P < 0.05) and the grade III value of 0.94 ± 0.11 (P < 0.001). CONCLUSIONS: New grading systems for limbal dermoid were useful for clinical diagnosis and may have prognostic value in predicting visual acuity. A lower-grade dermoid exhibited better vision postoperatively.
[Mh] Termos MeSH primário: Doenças da Córnea/diagnóstico
Cisto Dermoide/diagnóstico
Neoplasias Oculares/diagnóstico
Limbo da Córnea/patologia
[Mh] Termos MeSH secundário: Pré-Escolar
Doenças da Córnea/cirurgia
Cisto Dermoide/cirurgia
Neoplasias Oculares/cirurgia
Feminino
Seres Humanos
Lactente
Limbo da Córnea/cirurgia
Masculino
Gradação de Tumores
Procedimentos Cirúrgicos Oftalmológicos
Prognóstico
Estudos Retrospectivos
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001429


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[PMID]:29395041
[Au] Autor:Bertrand A; Favier B; Devaux Y; Goy F; Marcault-Derouard A; Veyet V; Cervos M; Schell M
[Ad] Endereço:Centre Léon-Bérard, hospitalisation à domicile pédiatrique, IHOPe, 1, place du Pr-J.-Renaut, 69373 Lyon cedex 08, France. Electronic address: amandine.bertrand@ihope.fr.
[Ti] Título:[Intravenous chemotherapy at home: A pediatric monocentric experience].
[Ti] Título:Chimiothérapie intraveineuse à domicile en cancérologie pédiatrique : une expérience monocentrique..
[So] Source:Bull Cancer;105(2):155-161, 2018 Feb.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Our home care unit (HCU) developed the administration of IV chemotherapy at home for some pediatric oncologic patients. METHODS: We conducted a retrospective monocentric analysis, leading to identify patients with at least one sequence of chemotherapy at home in 2015. RESULTS: Two hundred and forty four sequences of home chemotherapy have been administered in 2015. We identified two situations for home IV chemotherapy. Pediatric oncologist of day hospital prescribes the sequence. The chemotherapy is delivered at hospital for the first day. HCU takes over for the next days at home. For a sequence replacing a conventional hospitalization, the attending physician examines the patient, and confirm the clinical validation. The pediatric oncologist of HCU checks lab exams, and prescribes the chemotherapy. For both situations, IV chemotherapy is prepared by our hospital pharmacy, delivers at home or at day hospital, and HCU team manages home material and organizes hospitalization. CONCLUSIONS: This kind of organization allows setting up home IV CT for more and more patients. It allows to limit daily hospitalization for some patients living far from the hospital, and whose therapies lead to several hospitalizations.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Serviços Hospitalares de Assistência Domiciliar/organização & administração
Neoplasias/tratamento farmacológico
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Criança
Citarabina/administração & dosagem
Neoplasias Oculares/tratamento farmacológico
Feminino
Glioma/tratamento farmacológico
Acesso aos Serviços de Saúde
Neoplasias Hematológicas/tratamento farmacológico
Seres Humanos
Injeções Intravenosas/estatística & dados numéricos
Masculino
Enfermagem Oncológica
Enfermagem Pediátrica
Pediatras
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
Estudos Retrospectivos
Fatores de Tempo
Vimblastina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 04079A1RDZ (Cytarabine); 5V9KLZ54CY (Vinblastine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE


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[PMID]:28468139
[Au] Autor:Simsek T; Engin MS; Yildirim K; Kodalak EA; Demir A
[Ad] Endereço:Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
[Ti] Título:Reconstruction of Extensive Orbital Exenteration Defects Using an Anterolateral Thigh/Vastus Lateralis Chimeric Flap.
[So] Source:J Craniofac Surg;28(3):638-642, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neglected malignant tumors within the orbital region can invade the eyeball, extraocular muscles, and bone substance surrounding the eye. Such patients require orbital exenteration, which may involve extraocular skeletal structures (even exposing paranasal sinuses), resulting in 3-dimensional defects requiring reconstruction. This study presents our experience with anterolateral thigh vastus lateralis (ALT/VL) chimeric free flaps for the reconstruction of extensive orbital exenteration defects involving various paranasal sinuses.Between 2012 and 2016, 4 patients with extensive 3-dimensional orbital defects with sinus involvement were treated using the ALT/VL chimeric flap. The ALT component (117-170 cm) was used to resurface the cutaneous defect while the VL component (105-243 cm) was used to obliterate the cavitary defect. The flaps were all based on the common descending pedicle, and branches to separate components were individually dissected. Recipient vessels were in the neck region, to which the donor pedicles were passed through a tunnel for anastomosis.All cavitary and surface defects were simultaneously reconstructed via the ALT/VL chimeric flap. Within an average of 17 months, no complications associated with flap surgery were observed. One patient received postoperative adjuvant radiotherapy with no complications. With its separate components supplied by a common vascular pedicle, the ALT/VL chimeric free flap allows the surgeon to conveniently reconstruct separate spatial and volumetric defects resulting from extensive orbital exenteration.
[Mh] Termos MeSH primário: Carcinoma Basocelular/cirurgia
Carcinoma de Células Escamosas/cirurgia
Neoplasias Oculares/cirurgia
Retalhos de Tecido Biológico/transplante
Exenteração Orbitária
Músculo Quadríceps/transplante
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Coxa da Perna/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003430


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[PMID]:28224801
[Au] Autor:Hlavatá L; Dudáková L; Trková M; Soldátová I; Skalická P; Kousal B; Lisková P
[Ti] Título:[Preimplantation genetic diagnosis and monogenic inherited eye diseases].
[Ti] Título:Preimplantacní genetická diagnostika a dedicná onemocnení oka..
[So] Source:Cesk Slov Oftalmol;72(5):167-171, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:OBJECTIVE: Preimplantation genetic diagnosis (PGD) is an established application of genetic testing in the context of in vitro fertilization. PGD is an alternative method to prenatal diagnosis which aims to prevent the transmission of an inherited disorder to the progeny by implanting only embryos that do not carry genetic predisposition for a particular disease. The aim of this study is to provide an overview of eye disorders for which PGD has been carried out. METHODS: The European literature search focused on best practices, ethical issues, risks and results of PGD for inherited eye disorders. RESULTS: PGD is performed for a number of ocular disorders; a prerequisite for its application is however, the knowledge of a disease-causing mutation(s). The main advantage of this method is that the couple is not exposed to a decision of whether or not to undergo an abortion. Qualified counselling must be provided prior to the PGD in order to completely understand the risk of disability in any child conceived, consequences of disease manifestation, and advantages as well as limitations of this method. In the group of non-syndromic eye diseases and diseases in which ocular findings dominate, PGD has been performed in European countries for aniridia, choroideremia, congenital fibrosis of extraocular muscles, Leber congenital amaurosis, ocular albinism, retinitis pigmentosa, X-linked retinoschisis, Stargardt disease, blepharophimosis-ptosis-inverse epicanthus syndrome and retinoblastoma. Sexing for X-linked or mitochondrial diseases has been carried out for blue cone monochromatism, choroideremia, familial exudative vitreoretinopathy, Leber hereditary optic neuropathy, macular dystrophy (not further specified), Norrie disease, X-linked congenital stationary night blindness, X-linked retinoschisis and nystagmus (not further specified). CONCLUSION: In recent years, there has been an increase in potential to use PGD. The spectrum of diseases for this method has widened to include severe inherited eye diseases.Key words: preimplantation genetic diagnosis; monogenic eye diseases; in vitro fertilization.
[Mh] Termos MeSH primário: Oftalmopatias Hereditárias/genética
Neoplasias Oculares/genética
Testes Genéticos
Diagnóstico Pré-Implantação
Diagnóstico Pré-Natal
[Mh] Termos MeSH secundário: Feminino
Fertilização In Vitro
Predisposição Genética para Doença
Seres Humanos
Masculino
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


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[PMID]:27658975
[Au] Autor:Furdová A; Furdová A; Thurzo A; Sramka M; Chorvát M; Králik G
[Ti] Título:[Possibility of 3D Printing in Ophthalmology - First Experiences by Stereotactic Radiosurgery Planning Scheme of Intraocular Tumor].
[Ti] Título:Moznosti 3D tlace v oftalmológii - prvé skúsenosti pri plánovaní stereotaktického rádiochirurgického zákroku u vnútroocného nádoru..
[So] Source:Cesk Slov Oftalmol;72(3):80-84, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:Nowadays 3D printing allows us to create physical objects on the basis of digital data. Thanks to its rapid development the use enormously increased in medicine too. Its creations facilitate surgical planning processes, education and research in context of organ transplantation, individualization prostheses, breast forms, and others.Our article describes the wide range of applied 3D printing technology possibilities in ophthalmology. It is focusing on innovative implementation of eye tumors treatment planning in stereotactic radiosurgery irradiation.We analyze our first experience with 3D printing model of the eye in intraocular tumor planning stereotactic radiosurgery. KEY WORDS: 3D printing, model, Fused Deposition Modelling, stereotactic radiosurgery, prostheses, intraocular tumor.
[Mh] Termos MeSH primário: Neoplasias Oculares/radioterapia
Impressão Tridimensional/utilização
Radiocirurgia/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Imagem por Ressonância Magnética
Modelos Biológicos
Oftalmologia
Planejamento da Radioterapia Assistida por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


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[PMID]:28906322
[Au] Autor:Fischer C; Petriccione M; Vitolano S; Guarini E; Davis ME; Dunkel IJ
[Ad] Endereço:Departments of *Pediatrics †Nursing, Memorial Sloan Kettering Cancer Center ‡Department of Pediatrics, Weill Cornell Medical College, New York, NY.
[Ti] Título:The Effect of Ophthalmic Artery Chemosurgery on Immune Function in Retinoblastoma Patients: A Single Institution Retrospective Analysis.
[So] Source:J Pediatr Hematol Oncol;39(7):555-559, 2017 Oct.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ophthalmic artery chemosurgery (OAC) is associated with grade 3 and 4 neutropenia, however the effect on T-cell number and function is unknown. The purpose of this retrospective review was to confirm that patients treated with OAC do not develop immunosuppression warranting Pneumocystis pneumonia prophylaxis. PROCEDURE: IRB approval was obtained for a single center retrospective review of immune function tests in retinoblastoma patients who received OAC. RESULTS: Twenty-three patients received ≥3 cycles of OAC and had immune function testing (absolute CD4 count) performed at a median of 34 days postcompletion of therapy (range, 15 to 63 d). Only 1 patient had a low absolute CD4 count of 189 cells/µL (normal, 359 to 1570 cells/µL) 2 and a half months after IV carboplatin and 28 days after their third dose of OAC. This patient was found to have coexisting hypogammaglobulinemia. Repeat immune function testing normalized through continued OAC treatment. CONCLUSIONS: Clinically significant immune suppression appears rare following OAC alone, but patients previously treated with IV chemotherapy may be immunosuppressed and may benefit from pneumocystis pneumonia prophylaxis until the CD4 count recovers.
[Mh] Termos MeSH primário: Neoplasias Oculares/imunologia
Artéria Oftálmica/efeitos dos fármacos
Retinoblastoma/imunologia
[Mh] Termos MeSH secundário: Contagem de Linfócito CD4
Carboplatina/uso terapêutico
Criança
Pré-Escolar
Neoplasias Oculares/terapia
Seres Humanos
Tolerância Imunológica/efeitos dos fármacos
Imunidade/efeitos dos fármacos
Lactente
Infusões Intra-Arteriais/efeitos adversos
Neutropenia/induzido quimicamente
Retinoblastoma/terapia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
BG3F62OND5 (Carboplatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000968


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[PMID]:28880986
[Au] Autor:Ahmed AH; Foster CS; Shields CL
[Ad] Endereço:University of New England College of Osteopathic Medicine, Biddeford, Maine.
[Ti] Título:Association of Disease Location and Treatment With Survival in Diffuse Large B-Cell Lymphoma of the Eye and Ocular Adnexal Region.
[So] Source:JAMA Ophthalmol;135(10):1062-1068, 2017 Oct 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Primary diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresolved. Objective: To explore the clinical characteristics and determine factors associated with overall survival in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL. Design, Setting, and Participants: This retrospective analysis included 396 patients with ophthalmic DLBCL from January 1, 1973, through December 31, 2014, using the Surveillance, Epidemiology, and End Results database. The median follow-up was 39.0 months (interquartile range, 5.1-72.9 months). All patients diagnosed with primary DLBCL of the eye or retina (PVRL) or the eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphoma) were included. Patients diagnosed at autopsy or with additional neoplastic disease were excluded. Main Outcomes and Measures: Patient demographic characteristics, disease location, treatment modalities, and overall survival. Results: Forty-seven patients with PVRL (24 women [51.1%] and 23 men [48.9%]) and 349 with OA-uveal DLBCL (192 women [55.0%] and 157 men [45.0%]) had a similar mean (SD) age at diagnosis (69.6 [12.3] vs 66.1 [17.7] years). No difference in the use of surgery or radiation therapy by location was found. For all PVRL and OA-uveal DLBCL, a Cox proportional hazards regression model affirmed that age older than 60 years was associated with increased risk for death (hazard ratio [HR], 2.7; 95% CI, 1.9-4.0; P < .001). Gross total resection was associated with a decreased risk for death (HR, 0.5; 95% CI, 0.3-0.9; P = .04), whereas radiation therapy was not. The 5-year overall survival among patients with PVRL was 41.4% (SE, 8.6%); among those with OA-uveal DLBCL, 59.1% (SE, 2.8%; Mantel-Cox test, P = .007). Median overall survival was lower in PVRL (38.0 months; 95% CI, 14.2-61.8 months) than in OA-uveal DLBCL (96.0 months; 95% CI, 67.3-124.7 months; Mantel-Cox test, P = .007). In addition, median overall survival in ophthalmic-only disease was higher (84.0 months; 95% CI, 63.2-104.8 months) than that in primary DLBCL that occurred outside the central nervous system and ophthalmic regions (46.0 months; 95% CI, 44.4-47.6 months; Mantel-Cox test, P < .001). Conclusions and Relevance: The 5-year survival in PVRL vs OA-uveal DLBCL differed by 17.7%, and overall survival was greater in ophthalmic DLBCL than in DLBCL located outside the central nervous system and ophthalmic regions. Younger age (≤60 years) and gross total resection were associated with increased survival.
[Mh] Termos MeSH primário: Neoplasias Oculares
Linfoma Difuso de Grandes Células B
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Intervalo Livre de Doença
Neoplasias Oculares/mortalidade
Neoplasias Oculares/patologia
Neoplasias Oculares/terapia
Feminino
Seres Humanos
Linfoma Difuso de Grandes Células B/mortalidade
Linfoma Difuso de Grandes Células B/patologia
Linfoma Difuso de Grandes Células B/terapia
Masculino
Meia-Idade
Estadiamento de Neoplasias
Procedimentos Cirúrgicos Oftalmológicos
Prognóstico
Radioterapia
Estudos Retrospectivos
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.3286


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[PMID]:28820917
[Au] Autor:Sant DW; Tao W; Field MG; Pelaez D; Jin K; Capobianco A; Dubovy SR; Tse DT; Wang G
[Ad] Endereço:John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States.
[Ti] Título:Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.
[So] Source:Invest Ophthalmol Vis Sci;58(6):BIO240-BIO246, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To identify genomic mutations in lacrimal gland adenoid cystic carcinoma (LGACC) samples from patients. Methods: Genomic DNA was extracted from LGACC specimens. Whole exome sequencing (exome-seq) was conducted to screen for mutations. Capillary sequencing was performed to verify mutations in genes shared by multiple samples. Luciferase assays were used to evaluate functional consequences of NOTCH1 mutations. Results: The mutation profile of LGACC was complicated. The most frequently mutated gene observed (28.6%) was bromodomain PHD finger transcription factor (BPTF). No mutation was identified in common cancer genes such as TP53, KRAS, and BRAF. However, mutations predicted to be functionally severe were accumulated in the Notch signaling pathway including NOTCH1 and NOTCH2, of which mutations have been reported in head/neck adenoid cystic carcinoma (ACC). Of 14 LGACC samples, five samples carry mutations in Notch pathway genes. Capillary sequencing verified all the mutations in the two NOTCH genes identified by exome-seq. Compared to the wild-type NOTCH1, three frame shifting mutations and two missense mutations (C387W and L1600Q) increased luciferase activity approximately 10- to 25-fold. Conclusions: Major genomic mutation profiles in LGACC were uncovered by exome-seq. Although preliminary in nature, the Notch pathway could be a potential therapeutic target for LGACC.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/genética
Exoma/genética
Neoplasias Oculares/genética
Genes Neoplásicos/genética
Doenças do Aparelho Lacrimal/genética
Receptor Notch1/genética
Receptor Notch2/genética
[Mh] Termos MeSH secundário: Western Blotting
DNA de Neoplasias/genética
Mutação da Fase de Leitura
Genes Reporter
Seres Humanos
Mutação de Sentido Incorreto
Plasmídeos
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Neoplasm); 0 (NOTCH1 protein, human); 0 (NOTCH2 protein, human); 0 (Receptor, Notch1); 0 (Receptor, Notch2)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170826
[Lr] Data última revisão:
170826
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21097


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[PMID]:28767664
[Au] Autor:Bai HX; Mao Y; Shen L; Xu XL; Gao F; Zhang ZB; Li B; Jonas JB
[Ad] Endereço:Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China.
[Ti] Título:Bruch´s membrane thickness in relationship to axial length.
[So] Source:PLoS One;12(8):e0182080, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess a potential role of Bruch´s membrane (BM) in the biomechanics of the eye, we measured its thickness and the density of retinal pigment epithelium (RPE) cells in various ocular regions in eyes of varying axial length. METHODS: Human globes, enucleated because of an ocular tumor or end-stage glaucoma were prepared for histological examination. Using light microscopy, the histological slides were histomorphometrically examined applying a digitized image analysis system. RESULTS: The study included 104 eyes with a mean axial length of 27.9±3.2 mm (range:22.6mm-36.5mm). In eyes without congenital glaucoma, BM was significantly thickest (P<0.001) at the ora serrata, followed by the posterior pole, the midpoint between equator and posterior pole (MBEPP), and finally the equator. BM thickness was not significantly correlated with axial length (ora serrata: P = 0.93; equator:P = 0.31; MBEPP:P = 0.15; posterior pole:P = 0.35). RPE cell density in the pre-equatorial region (P = 0.02; regression coefficient r = -0.24) and in the retro-equatorial region (P = 0.03; r = -0.22) decreased with longer axial length, while RPE cell density at the ora serrata (P = 0.35), the MBEPP (P = 0.06; r = -0.19) and the posterior pole (P = 0.38) was not significantly correlated with axial length. Highly myopic eyes with congenital glaucoma showed a tendency towards lower BM thickness and lower RPE cell density at all locations. CONCLUSIONS: BM thickness, in contrast to scleral and choroidal thickness, was independent of axial length in eyes without congenital glaucoma. In association with an axial elongation associated decrease in the RPE cell density in the midperiphery, the findings support the notion of a biomechanical role BM may play in the process of emmetropization/myopization.
[Mh] Termos MeSH primário: Comprimento Axial do Olho/anatomia & histologia
Lâmina Basilar da Corioide/anatomia & histologia
Neoplasias Oculares/cirurgia
Glaucoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Comprimento Axial do Olho/patologia
Fenômenos Biomecânicos
Lâmina Basilar da Corioide/patologia
Enucleação Ocular
Neoplasias Oculares/patologia
Feminino
Glaucoma/patologia
Seres Humanos
Masculino
Meia-Idade
Miopia/patologia
Epitélio Pigmentado da Retina/anatomia & histologia
Epitélio Pigmentado da Retina/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182080


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[PMID]:28682481
[Au] Autor:Moody S; Escudero-Ibarz L; Wang M; Clipson A; Ochoa Ruiz E; Dunn-Walters D; Xue X; Zeng N; Robson A; Chuang SS; Cogliatti S; Liu H; Goodlad J; Ashton-Key M; Raderer M; Bi Y; Du MQ
[Ad] Endereço:Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.
[Ti] Título:Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma.
[So] Source:J Pathol;243(1):3-8, 2017 Sep.
[Is] ISSN:1096-9896
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends on their cooperation. However, which of these different events concur and how they cooperate in MALT lymphomagenesis is totally unknown. To explore this, we investigated somatic mutations of 17 genes and immunoglobulin heavy chain variable region (IGHV) usage in 179 MALT lymphomas from various sites. We showed that: (1) there was a significant association between the biased usage of IGHV4-34 (binds to the carbohydrate I/i antigens) and inactivating mutation of TNFAIP3 [encoding a global negative regulator of the canonical nuclear factor-κB (NF-κB) pathway] in ocular adnexal MALT lymphoma; (2) IGHV1-69 was significantly overrepresented (54%) in MALT lymphoma of the salivary gland, but was not associated with mutation in any of the 17 genes investigated; and (3) MALT lymphoma lacked mutations that are frequently seen in other B-cell lymphomas characterized by constitutive NF-κB activities, including mutations in CD79B, CARD11, MYD88, TNFRSF11A, and TRAF3. Our findings show, for the first time, a significant association between biased usage of autoreactive IGHV and somatic mutation of NF-κB regulators in MALT lymphoma, arguing for their cooperation in sustaining chronic B-cell receptor signalling and driving oncogenesis in lymphoma development. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Neoplasias Oculares/genética
Rearranjo Gênico
Inativação Gênica
Genes de Cadeia Pesada de Imunoglobulina
Região Variável de Imunoglobulina/genética
Linfoma de Zona Marginal Tipo Células B/genética
Mutação
Neoplasias de Anexos e de Apêndices Cutâneos/genética
Proteína 3 Induzida por Fator de Necrose Tumoral alfa/genética
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/imunologia
Análise Mutacional de DNA
Neoplasias Oculares/imunologia
Neoplasias Oculares/patologia
Predisposição Genética para Doença
Seres Humanos
Região Variável de Imunoglobulina/imunologia
Linfoma de Zona Marginal Tipo Células B/imunologia
Linfoma de Zona Marginal Tipo Células B/patologia
Neoplasias de Anexos e de Apêndices Cutâneos/imunologia
Neoplasias de Anexos e de Apêndices Cutâneos/patologia
Fenótipo
Proteína 3 Induzida por Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Immunoglobulin Variable Region); EC 3.4.19.12 (TNFAIP3 protein, human); EC 3.4.19.12 (Tumor Necrosis Factor alpha-Induced Protein 3)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1002/path.4933



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