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[PMID]:28468169
[Au] Autor:Cha JA; Kim B; Lee KA
[Ad] Endereço:*Department of Plastic and Reconstructive Surgery †Department of Pathology, Haeundae Paik Hospital, College of Medicine, The Inje University, Busan, Republic of Korea.
[Ti] Título:B Cell Lymphoma Underlying Paraffinoma of Glabella.
[So] Source:J Craniofac Surg;28(3):798-800, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soft tissue reactions to paraffin include inflammation, fibrosis, disfigurement, and granulomatous inflammation with foreign body giant cell reaction. The authors report the case of a 77-year-old woman with cutaneous marginal zone B cell lymphoma located on glabella, arising in association with underlying paraffinoma. While it is unclear whether the implant directly contributed to the development of lymphoma, this association has not been previously documented, prompting this report.
[Mh] Termos MeSH primário: Neoplasias Faciais/complicações
Granuloma de Corpo Estranho/complicações
Linfoma de Zona Marginal Tipo Células B/complicações
Parafina/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Terapia Combinada
Neoplasias Faciais/diagnóstico
Neoplasias Faciais/terapia
Feminino
Granuloma de Corpo Estranho/induzido quimicamente
Granuloma de Corpo Estranho/diagnóstico
Granuloma de Corpo Estranho/terapia
Seres Humanos
Linfoma de Zona Marginal Tipo Células B/diagnóstico
Linfoma de Zona Marginal Tipo Células B/terapia
Imagem por Ressonância Magnética
Tomografia por Emissão de Pósitrons
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
8002-74-2 (Paraffin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003551


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[PMID]:28468216
[Au] Autor:Sigua-Rodriguez ÉA; Goulart DR; Manzano ACM; Asprino L
[Ad] Endereço:*Department of Oral and Maxillofacial Surgery, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba †Department of Head and Neck Surgery, Santa Casa of Limeira Hospital, Limeira, Brazil.
[Ti] Título:A Rare Case of Malignant Fibrous Histiocytoma (Undifferentiated High-Grade Pleomorphic Sarcoma) of Malar Region.
[So] Source:J Craniofac Surg;28(3):e267-e269, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malignant fibrous histiocytoma is a sarcoma with rare occurrence in the oral and maxillofacial region; surgery is the most reliable treatment. Inadequate resection of the sarcoma on the oral and maxillofacial region is associated with a high incidence of local recurrence and a poor prognosis. Only few patients of malignant fibrous histiocytoma of the malar region have been previously reported in the literature. The authors report a new patient of malignant fibrous histiocytoma on the right malar region that treated a complete tumor surgical excision without lymph node dissection. Examination of the resected specimen revealed that the tumor was completely removed.
[Mh] Termos MeSH primário: Neoplasias Faciais/diagnóstico
Histiocitoma Fibroso Maligno/diagnóstico
Procedimentos Cirúrgicos Bucais/métodos
Doenças Raras
[Mh] Termos MeSH secundário: Idoso
Bochecha
Diagnóstico Diferencial
Neoplasias Faciais/cirurgia
Feminino
Histiocitoma Fibroso Maligno/cirurgia
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003566


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[PMID]:28468144
[Au] Autor:Aksu AE; Uzun H; Bitik O; Tunçbilek G; Safak T
[Ad] Endereço:Department of Plastic, Reconstructive and Aesthetic Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
[Ti] Título:Microvascular Tissue Transfers for Midfacial and Anterior Cranial Base Reconstruction.
[So] Source:J Craniofac Surg;28(3):659-663, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reconstruction of a midfacial defect can represent a difficult challenge for the plastic surgeon. Although many midfacial deformities have traumatic or congenital origins, the vast majority of head and neck defects occur after resection of malignant head and neck neoplasms. Autogenous reconstruction is now routinely performed for larger, complex defects resulting from surgical resection or trauma. In this study, the authors present 27 patients with midfacial defects reconstructed with free flaps. Twenty-two of the defects were created by surgical ablation of cancer (maxillectomy) and the others were traumatic. The maxillectomy defects were classified into 4 according to the classification proposed by Cordeiro. Eighteen of the patients were male and 9 were female. Twenty-nine free flaps were performed. Six different types of flaps including radial forearm flap, vertical rectus abdominis (VRAM) flap, anterolateral thigh (ALT) flap, tensor fasciae latae (TFL) flap, fibula osteocutaneous flap, and iliac osteocutaneous flap were accomplished. Types I and II defects were reconstructed with radial forearm flap. Type III defects were reconstructed with VRAM and ALT. Type IV defects were reconstructed with VRAM and TFL. Two patients underwent a second flap reconstruction due to recurrent disease (9.1%). Average patient age was 53.1 years. Free-flap survival was 100%. Free tissue transfer is the method of choice in midfacial reconstruction. Following a reconstructive algorithm is useful in the decision-making process for patient evaluation and treatment. Every reconstructive microsurgeon might have different experiences with different flaps. Therefore, the algorithm for flap choices is not universal among surgeons.
[Mh] Termos MeSH primário: Fossa Craniana Anterior/cirurgia
Traumatismos Faciais/cirurgia
Neoplasias Faciais/cirurgia
Retalhos de Tecido Biológico/irrigação sanguínea
Maxila/cirurgia
Microcirurgia/métodos
Procedimentos Cirúrgicos Reconstrutivos/métodos
Retalhos Cirúrgicos/irrigação sanguínea
Retalhos Cirúrgicos/cirurgia
Transplantes/irrigação sanguínea
Transplantes/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Ossos Faciais/cirurgia
Feminino
Seguimentos
Neoplasias de Cabeça e Pescoço/cirurgia
Seres Humanos
Ílio/cirurgia
Masculino
Meia-Idade
Reto do Abdome/transplante
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003448


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[PMID]:29157549
[Au] Autor:White SM
[Ad] Endereço:Private Practice, 8 Brenda Lane, Merrimack, NH 03054, USA. Electronic address: susanwhite@ucla.edu.
[Ti] Título:Malignant Lesions in the Dentomaxillofacial Complex.
[So] Source:Radiol Clin North Am;56(1):63-76, 2018 Jan.
[Is] ISSN:1557-8275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malignancies in the maxillofacial region are rare but comprise a broad spectrum of lesions. Given the potential for malignancies to mimic dental/sinus/temporomandibular joint pathology or remain asymptomatic, the judicious radiologist will be familiar with the initial and unique malignant changes affecting the dentition, periodontium, and supporting osseous structures on conventional film, dental, and sinus imaging. This article is meant to serve as a complement to the many excellent texts dedicated to advanced imaging techniques for the staging of known malignancies. The lesions discussed are a representative sample of malignancies involving hard tissues of the maxillofacial complex but are far from complete.
[Mh] Termos MeSH primário: Neoplasias Faciais/diagnóstico por imagem
Neoplasias Faciais/patologia
Neoplasias Maxilomandibulares/diagnóstico por imagem
Neoplasias Maxilomandibulares/patologia
Radiografia Dentária/métodos
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Estadiamento de Neoplasias/métodos
Intensificação de Imagem Radiográfica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171122
[St] Status:MEDLINE


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[PMID]:28932344
[Au] Autor:Kissou A; Hassam B
[Ad] Endereço:Service de Dermatologie, Centre Hospitalier Universitaire Ibn Sina, Rabat, Maroc.
[Ti] Título:[A pink nodule on the face].
[Ti] Título:Un nodule rose du visage..
[So] Source:Pan Afr Med J;27:205, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:We report the case of a 32-year old female patient, with no notable medical history, requiring dermatology consultation for evaluation of a nodule on her right cheek which had evolved over the past 10 years. Clinical examination showed a reddish dermal-based nodule with a smooth surface. The lesion measured 1cm in diameter and was located at the level of the right cheek (A). There was no adenopathy and the remainder of the clinical examination was normal. The patient underwent skin biopsy which showed tumor proliferation composed of fusiform cells with poorly limited eosinophilic cytoplasm and lightly atypical elongated nuclei without mitosis and with mononuclear inflammatory cell infiltrate at the level of the dermis. The epidermis was thinner. Anti-CD68 antibody was positive, while anti-CD34 antibody, PS100 and anti-AML were negative. The diagnosis of benign cellular histiocytofibroma was retained. The patient underwent total resection with a healthy resection margin of 5mm. The patient had a median 2-year follow-up with no recurrences identified. Benign histiocytofibroma mainly occurs in middle-aged women. It more often appears as an erythematous nodular, bluish, brownish or achromique dermal-based little painful but sometimes embarrassing lesion characterized by firm consistency and commonly located at the level of the lower limbs. Racial histiocytofibroma is rarely reported in the literature. Differential diagnosis includes Darier-Ferrand dermatofibrosarcoma, leiomyoma, Kaposi nodule and solitary fibrous tumor of the skin. Histologically, benign cellular histiocytofibroma is composed of pure intradermal disordered proliferation of fusiform cells arranged in bundles or in eddies and circumscribed by lymphocytic inflammatory reaction with presence of foamy histiocytes. The lesion is often highly vascularized with possibile hemorrhagic foci and especially, with angiogenesis images. In a minority of cases, especially in the case of huge histiocytofibromas, the epidermis is thinner and may even ulcerate. The immunohistochemistry shows the expression of CD68 and F XIIIa + positive cells while a lack of CD34, PS100 and Anti-AML expression. It is characterized by a chronic, benign evolution with possible spontaneous regression. The treatment is based on surgical resection.
[Mh] Termos MeSH primário: Neoplasias Faciais/diagnóstico
Histiocitoma Fibroso Benigno/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biópsia
Neoplasias Faciais/patologia
Feminino
Seguimentos
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.205.13273


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[PMID]:28858104
[Au] Autor:Deng D; Wang Y; Liu W; Qian Y
[Ad] Endereço:aDepartment of Head Neck Surgery, Hainan Cancer Hospital, Haikou, Hainan bDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
[Ti] Título:Oral and maxillofacial non-Hodgkin lymphomas: Case report with review of literature.
[So] Source:Medicine (Baltimore);96(35):e7890, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Lymphomas take up about 14% of all head-neck malignancies, out of which 97% are non-Hodgkin lymphomas (NHL). The clinical courses, treatment responses, and prognoses of NHLs vary with different subtypes and anatomic sites. In the Chinese population (including the Taiwanese), head-neck NHLs are often seen with the tonsils, nasal cavity, nasal sinus, and the nasopharynx. However, oral NHLs are relatively rare. Delay of diagnosis is also often seen in clinical practice. Thus, we present 4 cases with delayed diagnosis of oral maxillofacial NHLs and discuss their clinical manifestations so as to draw a clue that can remind the doctors to take biopsies in time. PATIENT CONCERNS: Four cases, including 3 males and 1 female aged between 43 and 70 years old with oral lesions (ulcerations and/or masses) and accompanying cervical lymphadenopathies and/or skin erythemas presented to the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China from January 2010 to January 2015. DIAGNOSES: The diagnoses of non-Hodgkin lymphomas were made by pathology, including nasal type extranodal NK/T-cell lymphoma, mycosis fungoides, subcutaneous panniculitis-like T-cell lymphoma, and extranodal marginal B-cell lymphoma of mucosa-associated lymphatic tissue. Their clinical courses until confirmed diagnosis varied between 2 months and 1 year and the follow-up/survival time from diagnosis ranged between 2 and 24 months. None of the biopsies was taken at the patients' initial medical consultations. INTERVENTIONS: Cyclophosphamide, hydroxydaunorubicin, vincristine and prednisone (CHOP) and Rituximab, CHOP (R-CHOP) regimens were given to 2 (Cases 1 and 4) and 1 patient (Case 3), respectively. One patient refused further treatment. OUTCOMES: Two patients, including the one who refused treatment, died at 2-2.5 months from diagnosis. The other two patients survived until their last follow-ups at 13 and 24 months from diagnosis, respectively. LESSONS: Oral lesions with aggressive growth patterns, multiple lymphadenopathies, and comorbid systemic skin lesions, elevated serum lactate dehydrogenase and poor response to medical therapies should warn the doctors of the possibility of malignancy and the necessity of biopsy. Excisional biopsy without sacrificing organs or functions should be preserved for patients whose pathological diagnoses cannot be established through aspiration or punch biopsy.
[Mh] Termos MeSH primário: Neoplasias Faciais/fisiopatologia
Linfoma não Hodgkin/fisiopatologia
Neoplasias Bucais/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias Faciais/diagnóstico
Neoplasias Faciais/tratamento farmacológico
Feminino
Seres Humanos
Linfoma não Hodgkin/diagnóstico
Linfoma não Hodgkin/tratamento farmacológico
Linfoma não Hodgkin/mortalidade
Masculino
Meia-Idade
Neoplasias Bucais/diagnóstico
Neoplasias Bucais/tratamento farmacológico
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007890


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[PMID]:28816793
[Au] Autor:Shilpakar R; Lemperle G; Mentzel T; Shakya J; Bhandari SB
[Ad] Endereço:*Sushma Koirala Memorial Hospital, Sakhu-Kathmandu, Nepal †Division of Plastic Surgery, San Diego School of Medicine, University of California, Frankfurt am Main ‡Institute for Dermatopathology, Friedrichshafen, Germany.
[Ti] Título:Unexpected Effect of Propranolol and Prednisolone on Infantile Facial Rhabdomyosarcoma.
[So] Source:J Pediatr Hematol Oncol;39(8):e460-e462, 2017 Nov.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 14-month-old Nepalese infant had developed a rapidly growing facial tumor originating from a dark spot on her upper eyelid. A cavernous hemangioma was suspected and treated with high doses of propranolol and prednisolone. Remission was dramatic. Histology confirmed alveolar rhabdomyosarcoma. Chemotherapy was planned but not carried out due to complicated logistics. The girl died at the age of 3. We present this case for discussion as to whether propranolol and prednisolone might be effective in rapidly growing rhabdomyosarcomas.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias Faciais/tratamento farmacológico
Rabdomiossarcoma/tratamento farmacológico
[Mh] Termos MeSH secundário: Biópsia
Diagnóstico Diferencial
Neoplasias Faciais/diagnóstico
Feminino
Hemangioma/diagnóstico
Seres Humanos
Lactente
Exame Físico
Prednisolona/administração & dosagem
Propranolol/administração & dosagem
Rabdomiossarcoma/diagnóstico
Tomografia Computadorizada por Raios X
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9PHQ9Y1OLM (Prednisolone); 9Y8NXQ24VQ (Propranolol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000925


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[PMID]:28654578
[Au] Autor:Gordon S; Fischer C; Martin A; Rosman IS; Council ML
[Ad] Endereço:*Division of Dermatology, Department of Internal Medicine, Washington University, St. Louis, Missouri; †Department of Pathology and Immunology, Washington University, St. Louis, Missouri.
[Ti] Título:Microcystic Adnexal Carcinoma: A Review of the Literature.
[So] Source:Dermatol Surg;43(8):1012-1016, 2017 Aug.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive cutaneous neoplasm that commonly occurs on the face. OBJECTIVE: The purpose of this article is to comprehensively review the current literature on MAC pertaining to epidemiology, pathogenesis, clinical presentation, histology, immunohistochemistry, prognosis, follow-up, and treatment. MATERIALS AND METHODS: An extensive literature review was conducted using OVID MEDLINE and PubMed to identify articles relating to MAC. RESULTS: Microcystic adnexal carcinoma typically presents as a skin-colored nodule on the face. The pathogenesis is mostly related to pilar and eccrine differentiation. Histologically, MAC can mimic syringoma, desmoplastic trichoepithelioma, and infiltrative basal cell carcinoma. Diagnosis is challenging because superficial shave biopsies may reveal only benign findings that do not warrant further management. A deep biopsy is mandatory for the correct diagnosis, and Mohs micrographic surgery provides the highest cure rate. CONCLUSION: Microcystic adnexal carcinoma is a locally aggressive disease with histological margins that often far surpass what is clinically suspected. Mohs micrographic surgery is the standard of care for removal of these lesions. Patients with a history of MAC should be examined at least every 6 months for recurrence, metastasis, and development of additional skin cancers.
[Mh] Termos MeSH primário: Neoplasias Faciais
Neoplasias Cutâneas
Siringoma
[Mh] Termos MeSH secundário: Neoplasias Faciais/epidemiologia
Neoplasias Faciais/metabolismo
Neoplasias Faciais/patologia
Neoplasias Faciais/cirurgia
Seres Humanos
Imuno-Histoquímica
Prognóstico
Neoplasias Cutâneas/epidemiologia
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/cirurgia
Siringoma/epidemiologia
Siringoma/metabolismo
Siringoma/patologia
Siringoma/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001142


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[PMID]:28628727
[Au] Autor:Brunner M; Ch'ng S; Shannon K; Clifford A; Ashford B; Elliott M; Clark JR
[Ad] Endereço:Sydney Head and Neck Cancer Institute, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.
[Ti] Título:Bone resection for facial cutaneous malignancies.
[So] Source:J Surg Oncol;116(4):545-549, 2017 Sep.
[Is] ISSN:1096-9098
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: The aim of this study is to analyze the clinical outcomes of patients who underwent bone resection for cutaneous malignancy of the face and scalp. METHODS: We retrospectively collected patient data from 62 patients who underwent bone resection for craniofacial cutaneous malignancy of the face and scalp over the last 10 years. We investigated risk factors for disease progression and assessed the utility of pre-operative imaging to predict bone, dura, and brain infiltration. RESULTS: Out of all factors analyzed, brain invasion, surgical margin involvement, and dural margin involvement were found to significantly reduce survival. CT and MRI correctly predicted bone infiltration in 88% and 89% of cases. MRI correctly predicted dura invasion in 89% but grossly underestimated the amount of dural invasion in 23% of reports. CONCLUSIONS: Our data indicate that the resection of bone is a reasonable surgical option in the treatment of patients with advanced cutaneous malignancies of the face and scalp. Brain invasion and positive margins reduced the probability of survival.
[Mh] Termos MeSH primário: Ossos Faciais/cirurgia
Neoplasias Faciais/cirurgia
Neoplasias Cutâneas/patologia
Neoplasias Cranianas/cirurgia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Encéfalo/patologia
Ossos Faciais/patologia
Neoplasias Faciais/patologia
Feminino
Seres Humanos
Masculino
Margens de Excisão
Meia-Idade
Invasividade Neoplásica
Estudos Retrospectivos
Couro Cabeludo/patologia
Neoplasias Cutâneas/mortalidade
Neoplasias Cranianas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1002/jso.24693


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[PMID]:28591206
[Au] Autor:Hayes DA; Kunde DA; Taylor RL; Pyecroft SB; Sohal SS; Snow ET
[Ad] Endereço:Department of Primary Industries, Parks Water and Environment, Animal Health Laboratory, Launceston, Tasmania, Australia.
[Ti] Título:ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1).
[So] Source:PLoS One;12(6):e0177919, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Devil Facial Tumour 1 (DFT1) is one of two transmissible neoplasms of Tasmanian devils (Sarcophilus harrisii) predominantly affecting their facial regions. DFT1's cellular origin is that of Schwann cell lineage where lesions are evident macroscopically late in the disease. Conversely, the pre-clinical timeframe from cellular transmission to appearance of DFT1 remains uncertain demonstrating the importance of an effective pre-clinical biomarker. We show that ERBB3, a marker expressed normally by the developing neural crest and Schwann cells, is immunohistohemically expressed by DFT1, therefore the potential of ERBB3 as a biomarker was explored. Under the hypothesis that serum ERBB3 levels may increase as DFT1 invades local and distant tissues our pilot study determined serum ERBB3 levels in normal Tasmanian devils and Tasmanian devils with DFT1. Compared to the baseline serum ERBB3 levels in unaffected Tasmanian devils, Tasmanian devils with DFT1 showed significant elevation of serum ERBB3 levels. Interestingly Tasmanian devils with cutaneous lymphoma (CL) also showed elevation of serum ERBB3 levels when compared to the baseline serum levels of Tasmanian devils without DFT1. Thus, elevated serum ERBB3 levels in otherwise healthy looking devils could predict possible DFT1 or CL in captive or wild devil populations and would have implications on the management, welfare and survival of Tasmanian devils. ERBB3 is also a therapeutic target and therefore the potential exists to consider modes of administration that may eradicate DFT1 from the wild.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/sangue
Neoplasias Faciais/sangue
Receptor ErbB-3/sangue
Neoplasias Cutâneas/sangue
[Mh] Termos MeSH secundário: Animais
Biomarcadores Tumorais/genética
Linhagem da Célula/genética
Detecção Precoce de Câncer
Neoplasias Faciais/genética
Neoplasias Faciais/patologia
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Linfoma/sangue
Linfoma/genética
Linfoma/patologia
Marsupiais/sangue
Projetos Piloto
Receptor ErbB-3/genética
Células de Schwann/patologia
Neoplasias Cutâneas/genética
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 2.7.10.1 (Receptor, ErbB-3)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177919



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