Base de dados : MEDLINE
Pesquisa : C04.588.443.392.500 [Categoria DeCS]
Referências encontradas : 4046 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 405 ir para página                         

  1 / 4046 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29310408
[Au] Autor:Fan B; Liu JJ; Wang BF; Sun YJ; Li GY
[Ad] Endereço:Department of Ophthalmology, Second Hospital of JiLin University, ChangChun.
[Ti] Título:Case report repairing orbital skin defects using composite flaps after giant eyelid-derived tumor excision and orbital exenteration.
[So] Source:Medicine (Baltimore);96(48):e8978, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy. PATIENT CONCERNS: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Clinical examination revealed a huge pigmented, nonhealing ulcerated lesion, approximately 52×44×40 mm in size. Case 2 was a 52-year old rural male complaining of a huge tumor in the right eyelid. Patient medical history revealed that the mass was initially the size of a soybean and gradually grew over 3 years to the size of a fist. DIAGNOSES: Histopathological examination of the tumors revealed that one was a basal cell carcinoma and the other a sebaceous gland carcinoma. INTERVENTIONS: The two cases of giant malignant eyelid tumors were surgically excised using rapid frozen section margin control. Different pedicle myocutaneous flaps were used to repair the orbital skin defects. OUTCOMES: Postoperative follow-up showed perfect healing of the pedicle flaps and good patient compliance. The results of these cases indicate that covering exposed orbital cavities with composite pedicle mycuaneous flaps is a simple and practical strategy for orbital reconstruction. Not only does this help maintain orbital stability, but it also provides opportunities for patients to return to normal lives. LESSONS: Although surgical management is often the first option for treatment of giant eyelid tumors, recurrence and mortality due to the tumors is still high after long-term follow-up. Therefore, early discovery and treatment is the best way to control the progression of giant eyelid tumors and enhance survivability.
[Mh] Termos MeSH primário: Carcinoma Basocelular/cirurgia
Neoplasias Palpebrais/cirurgia
Pálpebras/cirurgia
Neoplasias das Glândulas Sebáceas/cirurgia
Neoplasias Cutâneas/cirurgia
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Idoso
Carcinoma Basocelular/diagnóstico por imagem
Carcinoma Basocelular/patologia
Neoplasias Palpebrais/diagnóstico por imagem
Neoplasias Palpebrais/patologia
Pálpebras/diagnóstico por imagem
Pálpebras/patologia
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Reconstrutivos
Neoplasias das Glândulas Sebáceas/diagnóstico por imagem
Neoplasias das Glândulas Sebáceas/patologia
Neoplasias Cutâneas/diagnóstico por imagem
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008978


  2 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28741159
[Au] Autor:Schmitz EJ; Herwig-Carl MC; Holz FG; Loeffler KU
[Ad] Endereço:Department of Ophthalmology, University Eye Hospital Bonn, University of Bonn, Ernst-Abbe Str. 2, 53127, Bonn, Germany. eva.schmitz@ukb.uni-bonn.de.
[Ti] Título:Sebaceous gland carcinoma of the ocular adnexa - variability in clinical and histological appearance with analysis of immunohistochemical staining patterns.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(11):2277-2285, 2017 Nov.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of the study was to evaluate the characteristics of sebaceous gland carcinoma (SGC) of the ocular adnexae, which is due to a high variability in clinical, histological and immunohistochemical characteristics often challenging to diagnose. METHODS: Records of six patients with SGC were reviewed, who underwent surgical excision and who were histologically diagnosed with SGC. For comparison, there were specimens from four patients with basal cell carcinoma (BCC) and four patients with squamous cell carcinoma (SCC). Histological and immunohistochemical analysis included stains for HE, cytokeratins (CKpan, Cam5.2), epithelial membrane antigen (EMA), androgen receptor (AR441), perforin and adipophilin. RESULTS: SGC's were located in the upper (n = 2) or lower (n = 4) eyelid and were associated with various presenting clinical signs including chalazion-like lesions with pyogenic granuloma (n = 1), papillomatous conjunctival tumors (n = 3), a hyperkeratotic exophytic neoplasm (n = 1) and an ulcerating crusted lesion resembling chronic blepharitis (n = 1). The treatment was tumor resection, followed (if necessary) by adjuvant therapy with topical Mitomycin C (n = 2). Histologic characteristics included basophilic pleomorphic cells with vacuolated cytoplasm, prominent nucleoli, mitotic figures and in some cases pagetoid spread (n = 2). CKpan, EMA and Cam5.2 showed strong positive immunoreactivity in all specimens (SGC, BCC, SCC). Perforin immunostaining showed a varying, but overall weak, non-specific cytoplasmatic staining reaction in all lesions. AR441 positivity was noted with variable intensity in almost all lesions and in particular in pagetoid spread in contrast to non-tumor cells. Adipophilin showed an annular staining of lipid granules in immature sebaceous cells in SGC in contrast to a more granular staining pattern in BCC and SCC. CONCLUSION: SGCs display a variety of clinical signs and may mimic many other lesions. Tumor resection, followed by histological and immunohistochemical analysis, leads to the diagnosis and initiation of the proper treatment regimen. Herein, immunohistochemistry showed an unequivocal profile in SGC and did not allow for an exact differentiation from BCC and SCC by immunohistochemical means only. An extended evaluation of HE stains remains essential. However, immunohistochemistry can make relevant contributions to the diagnosis of SGC, especially in cases of inconclusive histology, by positive staining for adipophilin in immature sebaceous cells or by AR441 labeling in cases of pagetoid spread.
[Mh] Termos MeSH primário: Adenocarcinoma Sebáceo/patologia
Biomarcadores Tumorais/metabolismo
Neoplasias Palpebrais/patologia
Estadiamento de Neoplasias
Neoplasias das Glândulas Sebáceas/patologia
Glândulas Sebáceas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/metabolismo
Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Palpebrais/metabolismo
Feminino
Seguimentos
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Perilipina-2/metabolismo
Estudos Retrospectivos
Neoplasias das Glândulas Sebáceas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Perilipin-2)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3738-2


  3 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27775232
[Au] Autor:Pfeiffer ML; Ozgur OK; Myers JN; Peng A; Ning J; Zafereo ME; Thakar S; Thuro B; Prieto VG; Ross MI; Esmaeli B
[Ad] Endereço:Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
[Ti] Título:Sentinel lymph node biopsy for ocular adnexal melanoma.
[So] Source:Acta Ophthalmol;95(4):e323-e328, 2017 Jun.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We sought to update our prior report of findings on sentinel lymph node biopsy (SLNB) and predictors of a positive SLN in patients with conjunctival or eyelid melanoma. METHODS: We reviewed the records of all patients with ocular adnexal melanoma who underwent SLNB at one institution during 2000-2015. We determined rates of positive and false-negative findings on SLNB, primary tumour features correlated with positive findings and rate of nodal recurrence (false-negative event) after negative findings. RESULTS: The study included 51 patients, 31 with conjunctival and 20 with eyelid melanoma. These patients include 30 patients who underwent SLNB during 2000-2008, described in our previous report, and 21 additional patients who underwent SLNB during 2008-2015. There were 30 women and 21 men with median age at SLNB of 62 years (range, 24-83). The nodal basins most commonly sampled were intraparotid (27 patients) and level II (14 patients). Ten patients had positive SLNB findings. Compared to tumours with negative findings, tumours with positive findings had greater median thickness (3.5 mm versus 2.2 mm, p = 0.04), greater median number of mitotic figures (6 versus 2, p = 0.03) and greater incidence of ulceration (80% versus 26%, p = 0.003). Perineural and vascular invasion were not significantly associated with positive findings. There were three false-negative events. Three patients (6%) had temporary marginal mandibular weakness which resolved spontaneously. CONCLUSION: SLNB in patients with ocular adnexal melanoma is safe and identifies nodal micrometastasis in approximately 20% of cases. Histologic features associated with a positive SLN included greater tumour thickness, greater number of mitotic figures and ulceration.
[Mh] Termos MeSH primário: Neoplasias da Túnica Conjuntiva/patologia
Neoplasias Palpebrais/patologia
Melanoma/secundário
Biópsia de Linfonodo Sentinela/métodos
Linfonodo Sentinela/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Reações Falso-Negativas
Feminino
Seres Humanos
Metástase Linfática
Masculino
Melanoma/diagnóstico
Meia-Idade
Valor Preditivo dos Testes
Prognóstico
Reprodutibilidade dos Testes
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13252


  4 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:26782918
[Au] Autor:Furdová A; Horkovicová K; Babál P; Kobzová D; Ondrusová M
[Ti] Título:[Non-melanotic Tumors of the Eyelids Skin and Inner Corner - Basocellular Carcinoma].
[Ti] Título:Nemelanómové nádory koze mihalníc a vnútorného kútika - bazocelulárny karcinóm..
[So] Source:Cesk Slov Oftalmol;71(6):293-301, 2015.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:AIM: Non-melanoma skin cancer cases in the European population are increasing. Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer of the eyelids and in the inner corner of the eyelid. Due to the latest statistics compiled and published in 2008 in the Slovak Republic (SR) there were registered 5,173 cases of non-melanoma skin cancer (C44 according to ICD-10) in both sexes together (of which women accounted for 51.2 %). The proportion of non-melanoma skin cancer accounted for 17.2 % (16.3 % of men and 18 % of women) of the total number of all reported cancer cases (n = 30,144). The aim of this study is to evaluate the number of clinical relapses in a group of patients. MATERIAL: Retrospectively analyzed data from the medical records of patients with newly detected basal cell carcinoma in period between Jan. 1 2008 to Dec. 31 2013 who underwent surgery and outpatient follow-up at the Department of Ophthalmology and the University Hospital in Bratislava. METHODS: The incidence of relapse was evaluated up to date Dec. 31 2014. We followed the following parameters: location and tumor size, TNM classification, histopathological degree of differentiation, the edges of excised tissue and evaluated recurrence rate separately for each parameter. Statistics were analyzed by chi2 test, which was found to be significant for P < 0.05. The results of continuous parameters were expressed as arithmetic mean ± standard deviation. RESULTS: At the Department of Ophthalmology Faculty of Medicine and UNB, Ruzinov Hospital, in Bratislava, in the period 2008 - 2013 were treated 219 basal cell carcinomas in 217 patients and basal cell carcinoma was histologically confirmed. Basal cell carcinomas were divided into groups according to the stage: G1 (n = 139), G 1-2 (n = 41) and G 2 (n = 39). Localization was more frequent on left side (n = 112) compared to the right one (n = 107). We recorded significantly lower incidence (n = 5) in the area - angulus externus, prevalent occurrence was in the inner area - angulus internus (n = 65). The incidence in the lower eyelid (palpebra inferior) was recorded more frequently (n = 127) as in the upper eyelid (palpebra superior) - (n = 24). During these six years period we have seen 11 recurrences (5.02 %). Exenteration of the orbit was indicated in 5 cases (2.7 %). CONCLUSION: When monitoring patients with newly detected eyelid basal cell carcinoma, operated at the Department of Ophthalmology Faculty of Medicine and UNB in period 2008-2013, incidence of recurrence was recorded in 11 cases, accounting for 5.02 %, which is about one percentage point lower share than in the previous reporting period from period 2005 -2007 from the same Department. The occurrence of relapses corresponds to those in the literature. None of the clinical parameters statistically did affect significantly the incidence of relapses. KEY WORDS: eyelid basal cell carcinoma, non-melanoma skin cancer, tumors eyelashes.
[Mh] Termos MeSH primário: Carcinoma Basocelular/patologia
Neoplasias Palpebrais/patologia
Recidiva Local de Neoplasia/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma Basocelular/epidemiologia
Carcinoma Basocelular/cirurgia
Neoplasias Palpebrais/epidemiologia
Neoplasias Palpebrais/cirurgia
Feminino
Seres Humanos
Incidência
Meia-Idade
Recidiva Local de Neoplasia/epidemiologia
Recidiva Local de Neoplasia/cirurgia
Prevalência
Estudos Retrospectivos
Neoplasias Cutâneas/epidemiologia
Neoplasias Cutâneas/cirurgia
Eslováquia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160120
[St] Status:MEDLINE


  5 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27658974
[Au] Autor:Zikmund L
[Ti] Título:[Local Rotating Flaps in Oculoplastic Surgery].
[Ti] Título:Místní otocné laloky v okuloplastice..
[So] Source:Cesk Slov Oftalmol;72(3):72-79, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:AIM: In the contemporary medicine, strong emphasis is put on early closing of body surface defects, which contributes to good and early healing, but, of course, closes the entrance gate for possible infection as well. The easiest closing of the defect is the direct suture of the emerged wound. But some defects are of such an extent, so their closure is necessary to handle other way than simple suture, e.g. by rotating flap plastic surgery. In the paper are evaluated results of flap surgery technique in 56 patients. MATERIAL AND METHODS: It is a retrospective overview of 56 patients operated on by the author in the years 2011-2012, in whom the rotating flap plastic surgery was used as surgery technique. In 46 patients, the reason of flap plastic surgery technique was tumor of the eyelids. In 35 patients, it was due to the basalioma of the lower eyelid, in 8 patients due to the basalioma of the upper eyelid, and in three patients due to the basalioma of the medial cantus region. In 10 patients, the reason of the surgery was ectropion of the lower eyelid, and in two of them bilaterally. The paper is supplemented by surgical procedures photographs, and by a table, with detailed analysis of the sizes of tumors and corresponding flaps as well. RESULTS: According to the experience with 56 rotating flap plastic surgeries, performed by author during the period of two years at the Department of Ophthalmology, Masaryk Hospital in Ústí nad Labem, Czech Republic. E.U., the results of the use of rotating skin flaps in 46 eyelids basalioma, of correcting 12 ectropions of the lower eyelid, and reliability of the tumors excision with 2 mm surrounding healthy tissue rim were followed-up. Using the mentioned surgery technique, it was possible in all patients to secure the closing of the eyelid defect, or to return to normal and correct anatomical position of the eyelids in ectropions. In two patients with basalioma of the lower eyelid, the additional technique of lateral cantotomy was used to relieve the tension in the wound. Statistical results of recurrences number in tumors excisions with 2 mm safety margin in to the healthy tissue confirm the relative safety of such wide excision, and our results (4.34 %) differ only slightly from the results published in the literature (4.0 %). KEY WORDS: flap plastic surgery, basalioma, ectropion.
[Mh] Termos MeSH primário: Blefaroplastia/métodos
Carcinoma Basocelular/cirurgia
Ectrópio/cirurgia
Neoplasias Palpebrais/cirurgia
Pálpebras/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


  6 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28936056
[Au] Autor:Raj A; Nagpal RC; Harsh M; Bahadur H
[Ad] Endereço:Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.
[Ti] Título:Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report.
[So] Source:Middle East Afr J Ophthalmol;24(2):103-105, 2017 Apr-Jun.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Syringocystadenoma papilliferum (SP) is a rare benign hamartomatous malformation of skin which arises from apocrine or eccrine sweat glands. Skin of the head and neck is the usual site for this but rarely involves the eyelids. It is also called as a childhood tumor since it usually appears at birth or during puberty. The diagnosis is confirmed on histopathological examination after surgical excision. We are first to report a case of SP involving the caruncle in an elderly female.
[Mh] Termos MeSH primário: Cistadenoma/diagnóstico
Neoplasias Palpebrais/diagnóstico
Pálpebras/patologia
Neoplasias das Glândulas Sudoríparas/diagnóstico
Siringoma/diagnóstico
[Mh] Termos MeSH secundário: Biópsia
Diagnóstico Diferencial
Neoplasias Palpebrais/cirurgia
Pálpebras/cirurgia
Feminino
Seres Humanos
Meia-Idade
Procedimentos Cirúrgicos Oftalmológicos/métodos
Neoplasias das Glândulas Sudoríparas/cirurgia
Siringoma/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_195_15


  7 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28654937
[Au] Autor:Cinotti E; Singer A; Labeille B; Grivet D; Rubegni P; Douchet C; Cambazard F; Thuret G; Gain P; Perrot JL
[Ad] Endereço:Department of Medical, Surgical, and Neurological Science, Dermatology Section, University of Siena, S Maria alle Scotte Hospital, Siena, Italy.
[Ti] Título:Handheld In Vivo Reflectance Confocal Microscopy for the Diagnosis of Eyelid Margin and Conjunctival Tumors.
[So] Source:JAMA Ophthalmol;135(8):845-851, 2017 Aug 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: The clinical diagnosis of conjunctival and eyelid margin tumors is challenging, and new noninvasive imaging techniques could be valuable in this field. Objective: To assess the diagnostic accuracy of handheld in vivo reflectance confocal microscopy (IVCM) for the diagnosis of eyelid margin and conjunctival tumors. Design: A prospective observational study was conducted at University Hospital of Saint-Etienne from January 2, 2011, to December 31, 2016 (inclusion of patients until December 31, 2015, and follow-up until December 31, 2016). A total of 278 consecutive patients with eyelid margin or conjunctival lesions were included. Conjunctival lesions were diagnosed with a conventional clinical examination using a slitlamp and by handheld IVCM. Final diagnoses were established by histopathologic examination for 155 neoformations suspicious for being malignant through clinical and/or IVCM examination that were excised and on follow-up of 12 months or longer for the remaining 140 lesions. Main Outcomes and Measures: Sensitivity, specificity, and positive and negative predictive values for malignant tumors of the conjunctiva and eyelid margin were calculated using clinical examination with slitlamp and handheld IVCM. Results: In the 278 patients (136 [48.9%] females; mean [SD] age, 59 [21] years), a total of 166 eyelid margin and 129 conjunctival lesions were included in the analysis. Of the 155 excised neoformations with a histopathologic diagnosis, IVCM showed higher sensitivity compared with clinical examination conducted with the slitlamp for malignant tumors of the eyelid margin (98% vs 92%) and conjunctiva (100% vs 88%). The specificity for malignant eyelid margin tumors was higher for IVCM than for slitlamp examination (74% vs 46%), but slightly less for malignant conjunctival tumors (78% vs 88%). Analysis of all neoformations (155 excised and 140 in follow-up) confirmed these differences in the diagnostic accuracy of the clinical examination and IVCM. The presence of hyperreflective Langerhans cells mimicking malignant melanocytes was the main cause for misdiagnosis of malignant conjunctival tumors with IVCM. Conclusions and Relevance: Handheld IVCM could be a useful tool for the identification of malignant conjunctival tumors. Further studies are required to confirm the usefulness of this device and identify possible features that can differentiate Langerhans cells from malignant melanocytes to prevent the misdiagnosis of melanoma using IVCM.
[Mh] Termos MeSH primário: Neoplasias da Túnica Conjuntiva/diagnóstico por imagem
Neoplasias Palpebrais/diagnóstico por imagem
Microscopia Confocal/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma Basocelular/diagnóstico por imagem
Carcinoma de Células Escamosas/diagnóstico por imagem
Criança
Diagnóstico Diferencial
Erros de Diagnóstico
Reações Falso-Positivas
Feminino
Granuloma de Corpo Estranho/diagnóstico por imagem
Seres Humanos
Células de Langerhans/patologia
Masculino
Melanoma/diagnóstico por imagem
Microscopia Confocal/instrumentação
Meia-Idade
Nevo/diagnóstico por imagem
Valor Preditivo dos Testes
Estudos Prospectivos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.2019


  8 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28399341
[Au] Autor:Verdijk RM
[Ad] Endereço:Department of Pathology, section Ophthalmic Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam; and Rotterdam Eye Hospital, Rotterdam, Netherlands.
[Ti] Título:Lymphoproliferative Tumors of the Ocular Adnexa.
[So] Source:Asia Pac J Ophthalmol (Phila);6(2):132-142, 2017 Mar-Apr.
[Is] ISSN:2162-0989
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The ocular adnexa include the eyelids, conjunctiva, lacrimal apparatus, and orbital soft tissue. One percent of all lymphomas and approximately 8% of all extranodal lymphomas arise in the ocular adnexa and their incidence is increasing. Reactive lymphoid hyperplasia comprises 16% of all lymphoproliferative tumors of the ocular adnexa. The relative frequencies of ocular adnexal lymphoma presentation are in the orbit, 37%; conjunctiva, 29%; lacrimal apparatus, 20%; and eyelid, 14%. The most frequent primary lymphoma types of the ocular adnexa are extranodal marginal zone lymphoma, 62%; follicular lymphoma, 17%; and diffuse large B-cell lymphoma, 10%. The eyelids show the highest proportion of secondary lymphoma involvement, 49% of all eyelid lymphoproliferative lesions, compared with 24% in all ocular adnexa. The specific aspects of the site, histologic, immunohistochemical, cytogenetic, and molecular findings of the most relevant lymphoma types occurring in the various parts of the ocular adnexa will be discussed in relation to clinical parameters and relevance for therapy choice. Furthermore, the implications of the updated version of the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues in relation to ocular adnexal lymphoma are reviewed.
[Mh] Termos MeSH primário: Neoplasias da Túnica Conjuntiva
Neoplasias Palpebrais
Linfoma
Estadiamento de Neoplasias
[Mh] Termos MeSH secundário: Terapia Combinada
Neoplasias da Túnica Conjuntiva/diagnóstico
Neoplasias da Túnica Conjuntiva/epidemiologia
Neoplasias da Túnica Conjuntiva/terapia
Neoplasias Palpebrais/diagnóstico
Neoplasias Palpebrais/epidemiologia
Neoplasias Palpebrais/terapia
Seres Humanos
Incidência
Linfoma/diagnóstico
Linfoma/epidemiologia
Linfoma/terapia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.22608/APO.2016209


  9 / 4046 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28399340
[Au] Autor:Silverman N; Shinder R
[Ad] Endereço:Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.
[Ti] Título:What's New in Eyelid Tumors.
[So] Source:Asia Pac J Ophthalmol (Phila);6(2):143-152, 2017 Mar-Apr.
[Is] ISSN:2162-0989
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Given the constraints of the anatomy and function of the eyelids, excision with negative margins and reconstruction can be challenging. In cases of significant tissue invasion or metastasis, complete tumor removal may not be possible. This review examines the management of periocular skin cancer from diagnosis and staging, including the role of sentinel lymph node biopsy, to both surgical and nonsurgical treatment. The development of targeted drug therapy against specific genetic mutations in cutaneous malignancies has allowed for the treatment of specific cancer cells with less systemic toxicity than more traditional treatments.
[Mh] Termos MeSH primário: Neoplasias Palpebrais
Estadiamento de Neoplasias
[Mh] Termos MeSH secundário: Terapia Combinada
Neoplasias Palpebrais/epidemiologia
Neoplasias Palpebrais/patologia
Neoplasias Palpebrais/terapia
Saúde Global
Seres Humanos
Incidência
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.22608/APO.201701


  10 / 4046 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:28373462
[Au] Autor:Yunoki T; Tabuchi Y; Hayashi A
[Ad] Endereço:Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan yunokiki@med.u-toyama.ac.jp.
[Ti] Título:Expression of Anti-apoptotic Protein BAG3 in Human Sebaceous Gland Carcinoma of the Eyelid.
[So] Source:Anticancer Res;37(4):1931-1934, 2017 04.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play a role in anti-apoptosis of various malignant tumors. In this study, the expression of BAG3 was examined in human sebaceous gland carcinoma of the eyelid. MATERIALS AND METHODS: The expression of BAG3 was evaluated by immunohistochemistry of surgical samples from 5 patients with sebaceous gland carcinoma in the eyelid. RESULTS: BAG3 was positive diffusely in the cytoplasm in all patients. The average positive rate of BAG3 was 73.0±26.0% in tumor cells of all patients. CONCLUSION: BAG3 was highly expressed in sebaceous gland carcinoma of the eyelid. BAG3 may play an important role in the pathogenesis and progression of sebaceous gland carcinoma of the eyelid.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Proteínas Reguladoras de Apoptose/metabolismo
Apoptose
Biomarcadores Tumorais/metabolismo
Neoplasias Palpebrais/metabolismo
Neoplasias das Glândulas Sebáceas/metabolismo
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Neoplasias Palpebrais/patologia
Neoplasias Palpebrais/cirurgia
Feminino
Seres Humanos
Técnicas Imunoenzimáticas
Metástase Linfática
Masculino
Recidiva Local de Neoplasia/tratamento farmacológico
Recidiva Local de Neoplasia/patologia
Estadiamento de Neoplasias
Prognóstico
Neoplasias das Glândulas Sebáceas/secundário
Neoplasias das Glândulas Sebáceas/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Apoptosis Regulatory Proteins); 0 (BAG3 protein, human); 0 (Biomarkers, Tumor)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE



página 1 de 405 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde