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  1 / 3115 MEDLINE  
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[PMID]:29443777
[Au] Autor:Nomura H; Sakamoto K; Sugihara T; Okamoto S; Aoki Y; Tanigawa T; Matoda M; Omatsu K; Kanao H; Kato K; Utsugi K; Sugiyama Y; Takeshima N
[Ad] Endereço:Department of Gynecology, Cancer Institute Hospital.
[Ti] Título:Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment.
[So] Source:Medicine (Baltimore);97(7):e9932, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known precursor of SCCTO, in patients with ovarian cancer and long-term PLD use.After approval of the institutional review board, medical record of 114 patients who were treated with PLD at our institution between January 2010 and December 2016 were retrospectively reviewed. All those patients have been referred for routine monitoring of oral mucositis every time before administration by a dentist. The patient characteristics included in the evaluation were age, smoking and drinking habits, the PLD dose and schedule, and presence or absence of oral leukoplakia and SCCTO at each oral examination. The relationships of the incidence of oral leukoplakia and patient characteristics were analyzed.The median total PLD dose was 160 (range 40-1550) mg/m. Oral leukoplakia was seen in 6 (5.3%) patients. The median PLD dose, at the time of oral leukoplakia diagnosis, was 685 (range 400-800) mg/m. SCCTO was not found. Univariate analysis revealed that age, Brinkman index, and habitual drinking were not considered as risk factors for oral leukoplakia, and only total PLD dose (OR, 1.470; 95% CI, 1.19-1.91; P < .001) remained as a significant independent risk factor for oral leukoplakia. The ROC curve analysis indicated that the optimal cutoff value of the total PLD dose to predict development of oral leukoplakia was 400 mg/m. The sensitivity was 100% and the specificity was 88.8%. No patient discontinued PLD because of oral leukoplakia or SCCTO.The 2 most important clinical observations were the occurrence of oral leukoplakia in patients with long-term PLD use and that the development of oral leukoplakia was related to a total cumulative dose ≥400 mg/m. Routine oral surveillance is recommended, particularly when the cumulative total dose exceeds 400 mg/m.
[Mh] Termos MeSH primário: Antibióticos Antineoplásicos/efeitos adversos
Doxorrubicina/análogos & derivados
Leucoplasia Bucal/induzido quimicamente
Neoplasias Ovarianas/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Doxorrubicina/efeitos adversos
Esquema de Medicação
Feminino
Seres Humanos
Meia-Idade
Polietilenoglicóis/efeitos adversos
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 0 (liposomal doxorubicin); 30IQX730WE (Polyethylene Glycols); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009932


  2 / 3115 MEDLINE  
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[PMID]:28766760
[Au] Autor:Haraguchi K; Yada N; Sato S; Habu M; Hayakawa M; Takahashi O; Sasaguri M; Takenaka S; Yoshioka I; Matsuo K; Tominaga K
[Ad] Endereço:Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University, Kitakyushu, Japan.
[Ti] Título:The methylation status and expression of human telomerase reverse transcriptase is significantly high in oral carcinogenesis.
[So] Source:APMIS;125(9):797-807, 2017 Sep.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Telomerase activity is present in most cancers and is tightly regulated by the expression of human telomerase reverse transcriptase (hTERT). Hypermethylation in the promoter region of hTERT contributes to the regulation of hTERT expression. In this study, we investigated the methylation and expression of hTERT in oral squamous cell carcinoma (OSCC), oral leukoplakia, and normal oral mucosa. Furthermore, we investigated the significance of hTERT to the clinicopathological findings of OSCC. 35 OSCC, 50 oral leukoplakia (epithelial dysplasia n = 25, squamous cell hyperplasia n = 25), and 10 normal oral mucosa samples were investigated through methylation-specific PCR. Immunohistochemistry was analyzed in 35 OSCC, 50 oral leukoplakia, and 4 normal oral mucosa samples. The methylation and expression of hTERT increased from normal oral mucosa to oral leukoplakia to OSCC. In OSCC, all samples were methylated. However, partial methylation (20%) or unmethylation (80%), but never complete methylation, was observed in normal oral mucosa. Additionally, hTERT expression correlated with cervical lymph node metastasis. These results suggested that the methylation and expression of hTERT is high in oral carcinogenesis and may play an important role in oral cancer. hTERT expression may also be predictive of cervical lymph node metastasis.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/genética
Metilação de DNA/genética
Leucoplasia Bucal/genética
Mucosa Bucal/metabolismo
Neoplasias Bucais/genética
Telomerase/biossíntese
Telomerase/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/metabolismo
Carcinogênese/genética
Carcinogênese/patologia
Carcinoma de Células Escamosas/patologia
Feminino
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Antígeno Ki-67/biossíntese
Leucoplasia Bucal/patologia
Metástase Linfática/genética
Masculino
Meia-Idade
Neoplasias Bucais/patologia
Regiões Promotoras Genéticas/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Ki-67 Antigen); EC 2.7.7.49 (TERT protein, human); EC 2.7.7.49 (Telomerase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12723


  3 / 3115 MEDLINE  
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[PMID]:28410381
[Au] Autor:Tadakamadla J; Kumar S; Lalloo R; Johnson NW
[Ad] Endereço:Menzies Health Institute Queensland and School of Dentistry and Oral Health, Griffith University, Gold Coast, Queensland, Australia.
[Ti] Título:Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities.
[So] Source:PLoS One;12(4):e0175531, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the impact of Oral Potentially Malignant Disorders (OPMD) on daily life activities. MATERIALS AND METHODS: Patients diagnosed with Oral Leukoplakia, Oral submucous fibrosis and Oral Lichen Planus attending the Oral Medicine clinic of Panineeya Institute of Dental Sciences & Research Centre, Hyderabad, India were invited to participate. Eighteen interviews and three focus groups were conducted in a non-clinical setting. Voice recordings were transcribed and translated from Telugu to English. Data coding was performed using the NVivo software. RESULTS: Sample size for this qualitative study comprised 32 patients. Four main themes emerged: (1) difficulties with diagnosis and knowledge about the condition, (2) physical impairment and functional limitations, (3) psychological and social wellbeing and (4) effects of treatment on daily life. In a majority of the patients, most of the interview time was spent discussing physical impairment and functional limitations. Patients also reported their mouth condition having a debilitating effect on their psychological well-being and social interactions. CONCLUSIONS: 'Physical impairment and functional limitations' was the most important theme for many of the patients. However, the impacts of OPMD also extended beyond physical impairment and functional limitations to aspects of daily living, notably psychological and social wellbeing.
[Mh] Termos MeSH primário: Atividades Cotidianas
Leucoplasia Bucal/diagnóstico
Líquen Plano Bucal/diagnóstico
Fibrose Oral Submucosa/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Diagnóstico Diferencial
Feminino
Grupos Focais
Seres Humanos
Entrevistas como Assunto
Leucoplasia Bucal/psicologia
Líquen Plano Bucal/psicologia
Masculino
Meia-Idade
Fibrose Oral Submucosa/psicologia
Gravação em Fita
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175531


  4 / 3115 MEDLINE  
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[PMID]:28296547
[Au] Autor:Sowmya GV; Nahar P; Astekar M; Agarwal H; Singh MP
[Ad] Endereço:a Department of Oral Medicine and Radiology , Institute of Dental Sciences , Bareilly , Uttar Pradesh State.
[Ti] Título:Analysis of silver binding nucleolar organizer regions in exfoliative cytology smears of potentially malignant and malignant oral lesions.
[So] Source:Biotech Histochem;92(2):115-121, 2017.
[Is] ISSN:1473-7760
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nucleolar organizer regions are nucleolar components that contain proteins that are stained selectively by silver methods; they can be identified as black dots throughout the nucleolus and are known as silver binding nucleolar organizer regions (AgNOR). The number of AgNOR is related to the cell cycle and the proliferative activity of the cells. We investigated AgNOR using exfoliative cytology smears of potentially malignant oral lesions. Eighty individuals were divided into four equal groups: healthy controls, oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. The mean number of AgNOR in each study group gradually increased from control to oral leukoplakia to oral submucous fibrosis to oral squamous cell carcinoma. The proliferative index was increased in the oral premalignant and malignant patients compared to normal subjects. The mean AgNOR size gradually increased from control to oral leukoplakia to oral submucous fibrosis to oral squamous cell carcinoma. Spherical shaped AgNOR were most common in controls, whereas large, clustered and kidney shapes were most common in oral squamous cell carcinoma. Multiparameter analysis of AgNOR in oral exfoliative smears is a simple, sensitive and cost-effective method for differentiating premalignant from malignant lesions and can be used in conjunction with routine cytomorphological evaluation.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/patologia
Leucoplasia Bucal/patologia
Região Organizadora do Nucléolo/patologia
Lesões Pré-Cancerosas/patologia
Coloração pela Prata
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/diagnóstico
Citodiagnóstico/métodos
Seres Humanos
Fibrose Oral Submucosa/diagnóstico
Fibrose Oral Submucosa/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1080/10520295.2017.1283055


  5 / 3115 MEDLINE  
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Rados, Pantelis Varvaki
Texto completo SciELO Brasil
[PMID]:28273205
[Au] Autor:Silva AD; Maraschin BJ; Laureano NK; Daroit N; Brochier F; Bündrich L; Visioli F; Rados PV
[Ad] Endereço:Universidade Luterana do Brasil, Department of Oral Pathology, Canoas, RS Brazil.
[Ti] Título:Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study.
[So] Source:Braz Oral Res;31:e19, 2017 03 06.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with oral leukoplakia (n = 30) and oral squamous cell carcinoma (n = 22). Cell scrapings and the biopsy were performed at the site of the lesion and histological slides were prepared for the immunocytochemical analysis of exfoliated oral mucosal cells and for the immunohistochemical analysis of biopsy tissues using E-cadherin and involucrin. Spearman's correlation and kappa coefficients were used to assess the correlation and level of agreement between the techniques. Immunostaining for E-cadherin and involucrin by both techniques was similar in the superficial layers of the histological sections compared with cell scrapings. However, there was no statistical correlation and agreement regarding the immunocytochemical and immunohistochemical expression of E-cadherin and involucrin in oral leukoplakia (R = 0.01, p = 0.958) (Kappa = 0.017, p = 0.92) or in oral squamous cell carcinoma (R = 0.26, p = 0.206) (Kappa = 0.36, p = 0.07). The immunoexpression of E-cadherin and involucrin in tissues is consistent with the expression patterns observed in exfoliated oral mucosal cells, despite the lack of a statistically significant correlation. There is an association of the histopathological characteristics of leukoplakia with the expression E-cadherin and of the microscopic aspects of oral squamous cell carcinoma with immunohistochemical expression of involucrin.
[Mh] Termos MeSH primário: Caderinas/metabolismo
Carcinoma de Células Escamosas/metabolismo
Leucoplasia Bucal/metabolismo
Neoplasias Bucais/metabolismo
Precursores de Proteínas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores Tumorais/metabolismo
Biópsia
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Valores de Referência
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CDH1 protein, human); 0 (Cadherins); 0 (Protein Precursors); 60108-77-2 (involucrin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


  6 / 3115 MEDLINE  
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[PMID]:28259083
[Au] Autor:Tsai KY; Su CC; Chiang CT; Tseng YT; Lian IB
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua 500, Taiwan.
[Ti] Título:Environmental heavy metal as a potential risk factor for the progression of oral potentially malignant disorders in central Taiwan.
[So] Source:Cancer Epidemiol;47:118-124, 2017 Apr.
[Is] ISSN:1877-783X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Oral cancer (OC) is a leading cause of death from cancer in men between the ages of 25 and 44 years in Taiwan. The overall 5-year survival rates for the four OC stages (I-IV) in Taiwan are approximately 70%, 30%, 20%, and 10%, respectively, indicating the importance of the early diagnosis of oral potentially malignant disorders (OPMDs). Previous studies indicated an association between the OC incidence and certain environmental heavy metal concentrations. If these associations do exist for OC, they may also be observed for OPMD. The purpose of this study is to explore the association between the development of OPMD to OC and environmental heavy metals. Oral submucous fibrosis (OSF) and oral leukoplakia (OL) are two major types of OPMD in Taiwan. MATERIALS AND METHODS: A retrospective cohort study was conducted by Changhua Christian Hospital, the sole medical center in Changhua County, where 2725 male adult patients diagnosed with either OSF or OL between 2000 and 2014 were recruited. Data were analyzed by Cox regression and adjusted for smoking and betel-quid chewing. RESULTS AND DISCUSSION: OPMD patients who resided in areas with high nickel concentrations (polluted levels) exhibited hazard ratios of 1.8-2 for OC relative to those who lived in areas with low nickel levels (P<0.01). Meanwhile, smokers with OPMDs had a hazard ratio of 2.8-2.9 relative to non-smokers. Betel-quid chewers had a 2.2-2.3 hazard ratio relative to non-chewers. Smoking, betel-quid chewing, and environmental nickel exposure are associated with an increased risk of OC development in OPMD patients. This study provides valuable findings on the environmental effects of heavy metals on human health. Enhanced surveillance of the condition of OPMD patients who have been exposed to high nickel concentrations may be crucial for OC prevention.
[Mh] Termos MeSH primário: Exposição Ambiental/efeitos adversos
Poluição Ambiental/efeitos adversos
Leucoplasia Bucal/etiologia
Metais Pesados/efeitos adversos
Neoplasias Bucais/etiologia
Fibrose Oral Submucosa/etiologia
Lesões Pré-Cancerosas/etiologia
[Mh] Termos MeSH secundário: Adulto
Progressão da Doença
Feminino
Seres Humanos
Leucoplasia Bucal/patologia
Masculino
Meia-Idade
Neoplasias Bucais/patologia
Fibrose Oral Submucosa/patologia
Lesões Pré-Cancerosas/patologia
Estudos Retrospectivos
Fatores de Risco
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


  7 / 3115 MEDLINE  
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[PMID]:28256094
[Au] Autor:Sakata J; Yoshida R; Matsuoka Y; Nagata M; Hirosue A; Kawahara K; Nakamura T; Nakamoto M; Hirayama M; Takahashi N; Nakashima H; Arita H; Ogi H; Hiraki A; Shinohara M; Nakayama H
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
[Ti] Título:Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.
[So] Source:Cancer Med;6(4):730-738, 2017 Apr.
[Is] ISSN:2045-7634
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)-ß signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin-embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event-free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL.
[Mh] Termos MeSH primário: Leucoplasia Bucal/metabolismo
Linfócitos/patologia
Proteína Smad4/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Transformação Celular Neoplásica/metabolismo
Intervalo Livre de Doença
Feminino
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Leucoplasia Bucal/imunologia
Leucoplasia Bucal/patologia
Masculino
Meia-Idade
Células Estromais/metabolismo
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (SMAD4 protein, human); 0 (Smad4 Protein)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1002/cam4.1005


  8 / 3115 MEDLINE  
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[PMID]:28055317
[Au] Autor:Mollen I; Hitz Lindenmüller I; Lambrecht JT
[Ad] Endereço:1 Klinik für Zahnärztliche Chirurgie, -Radiologie, Mund- und Kieferheilkunde, UZB-Universitätszahnkliniken, Basel.
[Ti] Título:Häufige Mundschleimhauterkrankungen..
[So] Source:Praxis (Bern 1994);106(1):21-27, 2017 Jan.
[Is] ISSN:1661-8157
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Candidíase Bucal/diagnóstico
Fibroma/diagnóstico
Leucoplasia Bucal/diagnóstico
Líquen Plano Bucal/diagnóstico
Mucosa Bucal/patologia
Neoplasias Bucais/diagnóstico
[Mh] Termos MeSH secundário: Candidíase Bucal/patologia
Diagnóstico Diferencial
Fibroma/patologia
Seres Humanos
Leucoplasia Bucal/patologia
Líquen Plano Bucal/patologia
Neoplasias Bucais/patologia
Doenças da Língua/diagnóstico
Doenças da Língua/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1024/1661-8157/a002571


  9 / 3115 MEDLINE  
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[PMID]:28055109
[Au] Autor:Chuang SL; Su WW; Chen SL; Yen AM; Wang CP; Fann JC; Chiu SY; Lee YC; Chiu HM; Chang DC; Jou YY; Wu CY; Chen HH; Chen MK; Chiou ST
[Ad] Endereço:Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
[Ti] Título:Population-based screening program for reducing oral cancer mortality in 2,334,299 Taiwanese cigarette smokers and/or betel quid chewers.
[So] Source:Cancer;123(9):1597-1609, 2017 May 01.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To reduce oral cancer mortality, an organized, population-based screening program for the early detection of oral premalignancy and oral cancer was designed for high-risk individuals with habits of betel quid chewing, cigarette smoking, or both. The objective of this report was to evaluate the long-term effectiveness of this program in reducing the incidence of advanced disease and deaths from oral cancer. METHODS: A nationwide, population-based screening program for oral cancer has been conducted in Taiwan since 2004. Residents aged ≥ 18 years with oral habits of cigarette smoking and/or betel quid chewing were invited. The standardized mortality ratio method was used to compare the observed numbers of advanced oral cancers and deaths from oral cancer among screening attendees with the expected numbers derived from mortality among nonattendees. An intention-to-treat analysis of the relative rate of reductions in advanced-stage oral cancers and oral cancer mortality also was conducted. RESULTS: The overall screening rate was 55.1%. The relative risk of death from oral cancer was 0.53 (95% confidence interval [CI], 0.51-0.56) as a result of screening compared with the expected risk of oral cancer deaths in the absence of screening. The corresponding relative risk was 0.74 (95% CI, 0.72-0.77) after adjusting for self-selection bias. The relative risk of advanced oral cancer for the screened group versus the nonscreened group was 0.62 (95% CI, 0.59-0.64), which increased to 0.79 (95% CI, 0.76-0.82) after adjustment for self-selection bias. CONCLUSIONS: An organized, population-based oral cancer screening program targeting more than 2 million Taiwanese cigarette smokers and/or betel quid chewers demonstrated the effectiveness of reducing stage III or IV oral cancers and oral cancer mortality. These evidence-based findings corroborate and support the screening strategy of oral visual inspection for the prevention of oral cancer among high-risk individuals in areas with a high incidence of oral cancer. Cancer 2017;123:1597-1609. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Areca
Leucoplasia Bucal/diagnóstico
Neoplasias Bucais/diagnóstico
Lesões Pré-Cancerosas/diagnóstico
Sistema de Registros
Fumar
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Detecção Precoce de Câncer/métodos
Feminino
Seres Humanos
Armazenamento e Recuperação da Informação
Masculino
Meia-Idade
Neoplasias Bucais/mortalidade
Neoplasias Bucais/patologia
Neoplasias Bucais/prevenção & controle
Taiwan
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30517


  10 / 3115 MEDLINE  
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[PMID]:28004205
[Au] Autor:Rosin FC; Barcessat AR; Borges GG; Ferreira LG; Corrêa L
[Ad] Endereço:General Pathology Department, School of Dentistry, University of São Paulo, Av. Prof Lineu Prestes, 2227 - Cidade Universitária, 05508-000, São Paulo, SP, Brazil.
[Ti] Título:Vascular alterations after photodynamic therapy mediated by 5-aminolevulinic acid in oral leukoplakia.
[So] Source:Lasers Med Sci;32(2):379-387, 2017 Feb.
[Is] ISSN:1435-604X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Impairment of vascular functions after photodynamic therapy (PDT) is frequently associated with tumor remission and is considered one of the main antineoplastic PDT effects. Vascular alterations in oral leukoplakia (OL) treated with PDT have not yet been described. The aim of this study was to evaluate the effect of topical 5-ALA-mediated PDT on the vascular network of 4NQO-induced OL in rats. After applying 4NQO topically on the tongue during 16 weeks, there was induction of dysplastic lesions, which were treated with two PDT sessions (with an interval of 72 h between them), using topical application of 5-ALA and posterior irradiation with a laser (90 J/cm fluency). Histological sections of the tongues were obtained and analyzed concerning plasmatic exudation and microvessel density after immunolabeling with CD31 and CD34 vessel markers. There was intense plasmatic exudation after 6 h of the first PDT session; at 6 h of the second PDT session, there was a significant reduction in the density of CD31- and CD34-positive microvessels in comparison to controls (p < 0.05). In the PDT intervals, there was an increase in the density of CD31 and CD34 microvessels, suggesting angiogenesis. Topical application of 5-ALA-mediated PDT caused an immediate deleterious effect on the vascular network, increasing vessel permeability and reducing vessel density, mainly after two sessions of the treatment. However, secondary angiogenesis emerged in these lesions during intervals of the PDT session. This fact may be considered during the adoption of a PDT protocol, to avoid OL resistance and recurrence after the treatment.
[Mh] Termos MeSH primário: Ácido Aminolevulínico/uso terapêutico
Leucoplasia Bucal/tratamento farmacológico
Microvasos/patologia
Fotoquimioterapia/efeitos adversos
[Mh] Termos MeSH secundário: 4-Nitroquinolina-1-Óxido
Ácido Aminolevulínico/farmacologia
Animais
Seres Humanos
Imuno-Histoquímica
Leucoplasia Bucal/patologia
Masculino
Microvasos/efeitos dos fármacos
Mucosa Bucal/efeitos dos fármacos
Mucosa Bucal/patologia
Tamanho do Órgão
Fármacos Fotossensibilizantes/farmacologia
Quinolonas
Ratos Wistar
Língua/efeitos dos fármacos
Língua/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-nitroquinolone-1-oxide); 0 (Photosensitizing Agents); 0 (Quinolones); 56-57-5 (4-Nitroquinoline-1-oxide); 88755TAZ87 (Aminolevulinic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1007/s10103-016-2127-0



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