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  1 / 7284 MEDLINE  
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[PMID]:29400040
[Au] Autor:Lechien JR; Doyen J; Deleuze M; Khalife M; Saussez S
[Ti] Título:Giant metastasis invading pharyngeal wall, pterygo­maxillary space, submaxillary and parotid glands.
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(4):167-8, 2015.
[Is] ISSN:0035-1334
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/patologia
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias Primárias Desconhecidas/patologia
Faringe/patologia
Neoplasias das Glândulas Salivares/secundário
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Invasividade Neoplásica
Glândula Parótida/patologia
Glândula Submandibular/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


  2 / 7284 MEDLINE  
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[PMID]:29187728
[Au] Autor:Uz U; Celik O
[Ad] Endereço:Department of Otorhinolaryngology, Bayindir Government Hospital, Bayindir, Izmir, Turkey.
[Ti] Título:Pleomorphic Adenoma of the Posterior Surface of the Soft Palate Causing Sleep Disturbance: A Case Report.
[So] Source:Am J Case Rep;18:1266-1270, 2017 Nov 30.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Pleomorphic adenoma is the most common benign tumor arising in the salivary gland. The signs and symptoms of pleomorphic adenoma of the minor salivary glands vary, depending on the anatomical site involved. A rare case of pleomorphic adenoma of the posterior surface of the soft palate is reported that caused sleep disturbance, which was resolved with endoscopic surgical treatment. CASE REPORT A 32-year-old woman experienced snoring and mouth-breathing during sleep. Flexible fiberoptic nasopharyngoscopy imaging of the oropharyngeal passage showed obstruction by a tumor the soft palate, which obstructed the oropharyngeal passage. The tumor was excised using endoscopic-assisted transoral surgery and measure 3×2 cm in diameter. Histopathology showed a benign pleomorphic adenoma of the minor salivary gland. Following surgical excision of the tumor, the patient's sleep improved. CONCLUSIONS To our knowledge, this is the first case of a pleomorphic adenoma of the posterior surface of the soft palate, causing sleep disturbance, removed by endoscopic-assisted transoral surgery following pre-operative flexible fiberoptic nasopharyngoscopy imaging of the oropharyngeal passage.
[Mh] Termos MeSH primário: Adenoma Pleomorfo/patologia
Respiração Bucal/etiologia
Palato Mole/patologia
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores/patologia
Ronco/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  3 / 7284 MEDLINE  
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[PMID]:29277772
[Au] Autor:Ishibashi K; Ishii K; Sugiyama G; Sumida T; Sugiura T; Kamata YU; Seki K; Fujinaga T; Kumamaru W; Kobayashi Y; Hiyake N; Nakano H; Yamada T; Mori Y
[Ad] Endereço:Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
[Ti] Título:Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.
[So] Source:Anticancer Res;38(1):187-197, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Adenoid cystic carcinoma (AdCC) is a malignant tumor that occurs in the salivary glands and frequently metastasizes. The aim of this study was to identify factors mediating AdCC metastasis. MATERIALS AND METHODS: We established three AdCC cell lines by orthotropic transplantation and in vivo selection: parental, highly metastatic (ACCS-M-GFP), and lymph node metastatic (ACCS-LN-GFP) cells. RESULTS: We examined the three cell lines. DNA microarray indicated significantly altered processes in ACCS-LN-GFP cells: particularly, the expression of nicotinamide N-methyltransferase (NNMT) was enhanced the most. NNMT is associated with tumorigenesis and is a potential tumor biomarker. Concomitantly, we found-significant down-regulation of gap junction protein alpha-1. We suggest that ACCS-LN-GFP cells acquire cancer stem cell features involving the up-regulation of NNMT and the loss of gap junction protein alpha-1, leading to epithelial-mesenchymal transition and consequent AdCC metastasis. CONCLUSION: NNMT is a potential biomarker of AdCC.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/patologia
Conexina 43/metabolismo
Nicotinamida N-Metiltransferase/metabolismo
Neoplasias das Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Animais
Carcinoma Adenoide Cístico/metabolismo
Linhagem Celular Tumoral
Movimento Celular
Proliferação Celular
Feminino
Seres Humanos
Camundongos Nus
Neoplasias das Glândulas Salivares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexin 43); 0 (GJA1 protein, mouse); EC 2.1.1.1 (Nicotinamide N-Methyltransferase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  4 / 7284 MEDLINE  
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[PMID]:29187488
[Au] Autor:Rades D; Bajrovic A; Bartscht T
[Ad] Endereço:Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
[Ti] Título:Predictive Factors and a Survival Score for Patients Irradiated for Metastatic Spinal Cord Compression from Carcinoma of the Salivary Glands.
[So] Source:Anticancer Res;37(12):7011-7015, 2017 12.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:AIM: To our knowledge, this is the first study focusing on metastatic spinal cord compression (MSCC) from carcinoma of the salivary glands. PATIENTS AND METHODS: Nine patients receiving radiation alone were evaluated for improvement of motor deficits, post-radiation gait function and survival. RESULTS: Of nine characteristics (radiation program, age, sex, additional metastases to bone or to other organs, dynamic of motor deficits, pre-radiation gait function, number of vertebrae affected by MSCC, general condition), strong trends were found for associations between improved motor deficits and their dynamic (p=0.05), post-radiation gait function and pre-treatment ambulatory status (p=0.08) and between survival and additional metastases to other organs (p=0.07), dynamic of motor deficits (p=0.07) and general condition (p=0.07). In addition, a survival score was created. Patients with 2-3 points had a significantly better 6-month survival than those with 0-1 points (100% vs. 0%, p=0.027). CONCLUSION: Characteristics predicting outcomes identified in this study and the new survival score can guide physicians when making treatment decisions.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Salivares/complicações
Compressão da Medula Espinal/radioterapia
[Mh] Termos MeSH secundário: Feminino
Marcha/fisiologia
Seres Humanos
Masculino
Meia-Idade
Transtornos Motores/etiologia
Transtornos Motores/fisiopatologia
Prognóstico
Estudos Retrospectivos
Compressão da Medula Espinal/etiologia
Compressão da Medula Espinal/fisiopatologia
Análise de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:28914715
[Au] Autor:Sajed DP; Faquin WC; Carey C; Severson EA; H Afrogheh A; A Johnson C; Blacklow SC; Chau NG; Lin DT; Krane JF; Jo VY; Garcia JJ; Sholl LM; Aster JC
[Ad] Endereço:*Department of Pathology, Massachusetts General Hospital ¶Department of Surgery, Massachusetts General Hospital ‡Department of Pathology, Brigham and Women's Hospital §Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School ∥Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA #Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN †Northern Institute for Cancer Research, University of Newcastle, Newcastle on Tyne, UK.
[Ti] Título:Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.
[So] Source:Am J Surg Pathol;41(11):1473-1482, 2017 Nov.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:NOTCH1 is frequently mutated in adenoid cystic carcinoma (ACC). To test the idea that immunohistochemical (IHC) staining can identify ACCs with NOTCH1 mutations, we performed IHC for activated NOTCH1 (NICD1) in 197 cases diagnosed as ACC from 173 patients. NICD1 staining was positive in 194 cases (98%) in 2 major patterns: subset positivity, which correlated with tubular/cribriform histology; and diffuse positivity, which correlated with a solid histology. To determine the relationship between NICD1 staining and NOTCH1 mutational status, targeted exome sequencing data were obtained on 14 diffusely NICD1-positive ACC specimens from 11 patients and 15 subset NICD1-positive ACC specimens from 15 patients. This revealed NOTCH1 gain-of-function mutations in 11 of 14 diffusely NICD1-positive ACC specimens, whereas all subset-positive tumors had wild-type NOTCH1 alleles. Notably, tumors with diffuse NICD1 positivity were associated with significantly worse outcomes (P=0.003). To determine whether NOTCH1 activation is unique among tumors included in the differential diagnosis with ACC, we performed NICD1 IHC on a cohort of diverse salivary gland and head and neck tumors. High fractions of each of these tumor types were positive for NICD1 in a subset of cells, particularly in basaloid squamous cell carcinomas; however, sequencing of basaloid squamous cell carcinomas failed to identify NOTCH1 mutations. These findings indicate that diffuse NICD1 positivity in ACC correlates with solid growth pattern, the presence of NOTCH1 gain-of-function mutations, and unfavorable outcome, and suggest that staining for NICD1 can be helpful in distinguishing ACC with solid growth patterns from other salivary gland and head and neck tumors.
[Mh] Termos MeSH primário: Biomarcadores Tumorais
Carcinoma Adenoide Cístico/química
Carcinoma Adenoide Cístico/genética
Neoplasias de Cabeça e Pescoço/química
Neoplasias de Cabeça e Pescoço/genética
Mutação
Receptor Notch1
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Carcinoma Adenoide Cístico/patologia
Carcinoma Adenoide Cístico/terapia
Proliferação Celular
Criança
Análise Mutacional de DNA
Diagnóstico Diferencial
Feminino
Predisposição Genética para Doença
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Cabeça e Pescoço/terapia
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Fenótipo
Valor Preditivo dos Testes
Receptor Notch1/análise
Receptor Notch1/genética
Neoplasias das Glândulas Salivares/química
Neoplasias das Glândulas Salivares/genética
Neoplasias das Glândulas Salivares/patologia
Neoplasias das Glândulas Salivares/terapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (NOTCH1 protein, human); 0 (Receptor, Notch1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000945


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[PMID]:28870928
[Au] Autor:Gutschenritter T; Machiorlatti M; Vesely S; Ahmad B; Razaq W; Razaq M
[Ad] Endereço:College of Medicine, Department of Medicine - Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.
[Ti] Título:Outcomes and Prognostic Factors of Resected Salivary Gland Malignancies: Examining a Single Institution's 12-year Experience.
[So] Source:Anticancer Res;37(9):5019-5025, 2017 09.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite adjuvant radiotherapy, survival outcomes remain poor in patients with salivary gland malignancies who have multiple poor prognostic factors. This study aimed to determine which patients may benefit from treatment intensification. PATIENTS AND METHODS: Patients who underwent curative resection with or without adjuvant radiotherapy between 2002 and 2014 were identified and a retrospective chart review was performed. Overall survival (OS) and disease-free survival (DFS) were the main outcomes measured. RESULTS: A total of 95 patients met the inclusion criteria. The median follow-up was 46.8 months. The median age was 60 years. Radiotherapy was given to 78 patients. Multivariate analysis revealed that male sex and perineural invasion significantly reduced overall and disease-free survival. Distant metastases comprised of 67% of recurrences and 33% were locoregional. CONCLUSION: Adjuvant chemoradiotherapy should be considered for patients with tumors with perineural invasion, especially in males with high-risk histopathology or high-grade, late-stage disease. To our knowledge, this is the first study to assess the impact of pack-year smoking history on survival outcomes.
[Mh] Termos MeSH primário: Adenocarcinoma/secundário
Carcinoma Adenoide Cístico/secundário
Carcinoma Mucoepidermoide/secundário
Carcinoma de Células Escamosas/secundário
Recidiva Local de Neoplasia/patologia
Neoplasias das Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/cirurgia
Idoso
Carcinoma Adenoide Cístico/cirurgia
Carcinoma Mucoepidermoide/cirurgia
Carcinoma de Células Escamosas/cirurgia
Feminino
Seguimentos
Seres Humanos
Metástase Linfática
Masculino
Meia-Idade
Gradação de Tumores
Recidiva Local de Neoplasia/cirurgia
Prognóstico
Estudos Retrospectivos
Neoplasias das Glândulas Salivares/cirurgia
Taxa de Sobrevida
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE


  7 / 7284 MEDLINE  
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[PMID]:28834233
[Au] Autor:Griffith CC; Schmitt AC; Pantanowitz L; Monaco SE
[Ad] Endereço:Department of Pathology, Emory University, Atlanta, Georgia.
[Ti] Título:A pattern-based risk-stratification scheme for salivary gland cytology: A multi-institutional, interobserver variability study to determine applicability.
[So] Source:Cancer;125(10):776-785, 2017 Oct.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Salivary gland aspiration cytology is useful in the preoperative management of patients but remains challenging, because of the extensive morphologic overlap of some tumors limits the ability to always determine the presence of malignancy. In response to this challenge, there has been increasing drive to develop a risk-based categorization scheme for salivary gland aspirates. Herein, the authors examine the interobserver variability of 1 such pattern and risk-based system. METHODS: Select smears and cell-block sections of 50 salivary gland aspirates from 2 large academic centers were digitally imaged. These scanned slides were independently and blindly reviewed by 4 cytopathologists, and each aspirate was assigned to 1 of the proposed pattern-based categories if it was considered neoplastic by the observer. Interobserver agreement was scored and aggregated risks of malignancy were calculated for cases with available surgical follow-up. RESULTS: In total, 42 samples (84%) were considered neoplastic by at least 2 observers and were scored for interobserver agreement: 10 of 42 (23.8%) had uniform agreement, 14 of 42 (33.3%) had majority agreement, and 5 of 42 (11.9%) had divided agreement. Only 9 of 42 samples (21.4%) had minimal agreement, and 4 of 42 (9.5%) had no agreement. Condensation of similar categories was able to improve interobserver agreement and still maintain stratified risk of malignancy. CONCLUSIONS: The proposed pattern-based risk-stratification scheme, which could be implemented with the forthcoming Milan System, has good overall interobserver agreement and successfully stratifies the risk of malignancy. Some simplification is possible to make the system easier to use and improve interobserver agreement while maintaining stratification of risk. Cancer Cytopathol 2017;125:776-85. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Biópsia por Agulha Fina
Seres Humanos
Variações Dependentes do Observador
Patologia Clínica/normas
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21906


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[PMID]:28828496
[Au] Autor:Haderlein M; Scherl C; Semrau S; Lettmaier S; Hecht M; Erber R; Iro H; Fietkau R; Agaimy A
[Ad] Endereço:Department of Radiation Oncology, University Hospital of Erlangen, Universitätsstraße 27, 91054, Erlangen, Germany. marlen.haderlein@uk-erlangen.de.
[Ti] Título:Impact of postoperative radiotherapy and HER2/new overexpression in salivary duct carcinoma : A monocentric clinicopathologic analysis.
[Ti] Título:Der Einfluss postoperativer Strahlentherapie und HER2/neu-Überexpression auf Speichelgangkarzinome : Eine monozentrische klinisch-pathologische Analyse..
[So] Source:Strahlenther Onkol;193(11):961-970, 2017 Nov.
[Is] ISSN:1439-099X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:AIM: Retrospective Investigation of the prognostic relevance of clinicopathologic parameters in patients with salivary duct carcinoma (SDC). METHODS: An experienced pathologist reviewed 67 patients with de novo SDC or SDC ex pleomorphic adenoma. Paraffin-embedded tumor samples were examined by immunohistochemistry for expression of HER2/neu, androgen (AR), progesterone (PR), estrogen (ER), epidermal growth factor (EGFR) and programmed death ligand 1 (PD-L1-R) receptor. In 45 patients who had cM0 and follow-up data available, survival rates were calculated (Kaplan-Meier method) and prognostic variables were analyzed (univariate analysis: log-rank test; multivariate analysis: Cox-regression analysis). RESULTS: Overexpression of HER2/neu, AR, ER, PR, EGFR, PD-L1-R was found in 25.4%, 84%, 0%, 0%, 17.9%, 16.4% of patients. Overall (OS), disease-free (DFS), distant-metastases-free survival (DMFS) and locoregional control (LRC) were 92.3/72.4/56.9%, 78.2/58.1/58.1%, 85.4/65.2/65.2% and 89.7/81.9/81.9% after 1/3/5 years (medial follow-up 26 months). In univariate analysis a positive resection margin (p = 0.008) and no postoperative radiotherapy (p = 0.001) predict an increased locoregional recurrence rate. In multivariate analysis only postoperative radiotherapy is statistically significant (p = 0.004). Presence of lymph node metastases, a lymph node density >4 and HER2/neu overexpression predict decreased DFS and DMFS. In multivariate HER2/neu overexpression was the only significant predictor for reduced DFS (p = 0.04) and DMFS (p = 0.02). CONCLUSION: Postoperative radiotherapy is the only significant predictor for LRC. HER2/neu receptor expression is an independent prognostic factor for decreased DFS and DMFS in patients with SDC. In addition to radio(chemo)therapy, intensified first-line treatment regimens should also be evaluated in the future.
[Mh] Termos MeSH primário: Adenoma Pleomorfo/radioterapia
Adenoma Pleomorfo/cirurgia
Radioterapia Adjuvante
Receptor ErbB-2/metabolismo
Ductos Salivares/efeitos da radiação
Ductos Salivares/cirurgia
Neoplasias das Glândulas Salivares/radioterapia
Neoplasias das Glândulas Salivares/cirurgia
[Mh] Termos MeSH secundário: Adenoma Pleomorfo/patologia
Idoso
Terapia Combinada
Intervalo Livre de Doença
Feminino
Seres Humanos
Masculino
Metástase Neoplásica
Estadiamento de Neoplasias
Prognóstico
Receptor do Fator de Crescimento Epidérmico/metabolismo
Receptores Androgênicos/metabolismo
Ductos Salivares/patologia
Neoplasias das Glândulas Salivares/mortalidade
Neoplasias das Glândulas Salivares/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Androgen); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.10.1 (Receptor, ErbB-2)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1007/s00066-017-1196-8


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[PMID]:28802370
[Au] Autor:Ngouajio AL; Drejet SM; Phillips DR; Summerlin DJ; Dahl JP
[Ad] Endereço:Department of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
[Ti] Título:A systematic review including an additional pediatric case report: Pediatric cases of mammary analogue secretory carcinoma.
[So] Source:Int J Pediatr Otorhinolaryngol;100:187-193, 2017 Sep.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:IMPORTANCE: Mammary Analogue Secretory Carcinoma (MASC) is a newly characterized salivary gland carcinoma resembling secretory carcinoma of the breast. Prior to being described, MASC was most commonly misdiagnosed as Acinic Cell Carcinoma. Though MASC is predominantly an adult neoplasm, cases have been reported in the pediatric population. Reporting and summarizing of known cases is imperative to understand the prognosis and clinical behavior of MASC. OBJECTIVE: EVIDENCE REVIEW: Web of Science, Medline, EMBASE, and The Cochrane Library were searched for studies that included pediatric cases of MASC. Data on clinical presentation, diagnosis and management, and pathology were collected from all pediatric cases. FINDINGS: CONCLUSIONS AND RELEVANCE: Since the first case of MASC in the pediatric population was described in 2011, only 12 cases, including this one, have been described in the literature. With this paucity of information, much remains unknown regarding this new pathologic diagnosis. The collection of clinical outcomes data of children with MASC is needed to better understand the behavior of this malignancy as well as determine optimal treatment regimens.
[Mh] Termos MeSH primário: Carcinoma Secretor Análogo ao Mamário/diagnóstico
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Carcinoma Secretor Análogo ao Mamário/terapia
Prognóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


  10 / 7284 MEDLINE  
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[PMID]:28786207
[Au] Autor:Rohilla M; Singh P; Rajwanshi A; Gupta N; Srinivasan R; Dey P; Vashishta RK
[Ad] Endereço:Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
[Ti] Título:Three-year cytohistological correlation of salivary gland FNA cytology at a tertiary center with the application of the Milan system for risk stratification.
[So] Source:Cancer;125(10):767-775, 2017 Oct.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fine-needle aspiration (FNA) cytology of salivary glands is a well-established technique that plays a critical role in the preoperative diagnosis of lesions. A risk stratification of FNA diagnostic categories has been recently proposed to be useful in reporting. The aims of this study were to evaluate the diagnostic accuracy of salivary gland FNA and to apply the proposed Milan system for reporting salivary gland lesions. METHODS: A retrospective audit of FNA specimens of salivary gland lesions reported from 2014 to 2016 was performed. A correlation with the follow-up histopathology, wherever it was available, was performed. The aspirates were then categorized according to the Milan system as follows: nondiagnostic, nonneoplastic, atypical, benign neoplasm, neoplasm of uncertain malignant potential (NUMP), suspicious for malignancy, or positive for malignancy. Furthermore, the risk of malignancy and the risk of high-grade malignancy were calculated for all diagnostic categories. RESULTS: A total of 631 salivary gland aspirates were evaluated: 2.2% were nondiagnostic, 55.8% indicated nonneoplastic lesions, and 40.4% indicated neoplastic lesions. Histopathology was available for 94 cases (14.9%). FNA had a sensitivity of 79.4% and a specificity of 98.3% with an overall diagnostic accuracy of 91.4% for differentiating malignant tumors from benign tumors. The overall risk of malignancy was 17.4% for the nonneoplastic category, 100% for the atypical category, 7.3% for the benign neoplasm category, 50% for the NUMP category, and 96% for the positive-for-malignancy category. CONCLUSIONS: Salivary gland FNA continues to have high diagnostic accuracy and is thus helpful for guiding management. Neoplasms with classic cytomorphology are easily diagnosed; however, in difficult cases showing overlapping features, the use of the Milan system could be beneficial. Cancer Cytopathol 2017;125:767-75. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biópsia por Agulha Fina/classificação
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Meia-Idade
Patologia Clínica/normas
Lesões Pré-Cancerosas/patologia
Estudos Retrospectivos
Medição de Risco
Doenças das Glândulas Salivares/patologia
Sensibilidade e Especificidade
Centros de Atenção Terciária
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21900



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