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[PMID]:29429175
[Au] Autor:Peng Z; Wang ZX; Xie J; Wang LE; Liu Y; Gong SS
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijng 100050, China.
[Ti] Título:[Middle ear teratoma in infant: report of three cases and review of the literatures].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(2):81-85, 2018 Feb 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To summarize the clinical characteristics and therapeutic experiences of the middle ear teratoma in infants. Three cases of middle ear teratoma, from 2012-2015 in Beijing Friendship Hospital were analyzed. The three cases all developed slowly and presented unilateral otorrhea and hearing loss. Otoscopy showed the granulation tissue in the external ear canal. Audiological changes varied according to the degree of severity. Imaging features showed the pocket-like occupancy lesions in the Eustachian tube area. The temporal bone CT showed mass with soft tissue density usually involved in the mastoid and tympanic cavity. MRI showed mixed signal intense on both T1 and T2 weighted imaging. All the three cases received neoplasm resection of the middle ear. Only one case received tympanoplasty surgery at the same time. And all the pathology results displayed mature teratoma. The follow-up time was 17 to 54 months. MRI showed complete removal of the tumor. Teratoma are rare in the head and neck neoplasm. When the infants suffer from the unilateral otorrhea, hearing loss, and granulation tissue formed in the external ear canal, it should be vigilant for teratoma. The differential diagnosis is middle ear cholesteatoma, congenital first branchial cyst or fistula, and middle ear carcinoma. Temporal bone CT combined with MRI could improve the accuracy of diagnosis. It should be totally resection as soon as possible if there is no contraindication. Postoperative follow-up and imaging examination are necessary to eliminate tumor recurrence.
[Mh] Termos MeSH primário: Neoplasias da Orelha/cirurgia
Orelha Média
Teratoma
[Mh] Termos MeSH secundário: Branquioma
Surdez/etiologia
Diagnóstico Diferencial
Neoplasias da Orelha/complicações
Neoplasias da Orelha/diagnóstico por imagem
Orelha Média/diagnóstico por imagem
Tuba Auditiva/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço
Seres Humanos
Lactente
Imagem por Ressonância Magnética
Processo Mastoide/diagnóstico por imagem
Recidiva Local de Neoplasia
Otoscopia
Osso Temporal/diagnóstico por imagem
Teratoma/complicações
Teratoma/diagnóstico por imagem
Teratoma/cirurgia
Tomografia Computadorizada por Raios X
Timpanoplastia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.02.001


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[PMID]:28468198
[Au] Autor:Kim SB; Lee HH
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea.
[Ti] Título:Capillary Hemangioma of the Tympanic Membrane and External Auditory Canal.
[So] Source:J Craniofac Surg;28(3):e231-e232, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hemangiomas are very common tumors characterized by large numbers of vessels filled with blood. Capillary hemangioma is the most common type of hemangioma, whereas capillary hemangiomas of the tympanic membrane and external auditory canal are extremely rare vascular tumors. The authors present capillary hemangioma of the tympanic membrane and external auditory canal in a 54-year-old woman with right-sided aural fullness for 3 months. Under local anesthesia, the mass was resected by transcanal microscopic surgery. Histologically, the tumor was composed of thin-walled capillaries with scant stroma and diagnosed as capillary hemangioma. After surgery, her symptoms improved and she did not exhibit any signs of recurrence for 1 year. The authors also review the relevant literature related to this report.
[Mh] Termos MeSH primário: Meato Acústico Externo
Neoplasias da Orelha/diagnóstico
Neoplasias da Orelha/terapia
Hemangioma Capilar/diagnóstico
Hemangioma Capilar/terapia
Membrana Timpânica
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003437


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[PMID]:28547535
[Au] Autor:Bell D; El-Naggar AK; Gidley PW
[Ad] Endereço:Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA. Diana.bell@mdanderson.org.
[Ti] Título:Middle ear adenomatous neuroendocrine tumors: a 25-year experience at MD Anderson Cancer Center.
[So] Source:Virchows Arch;471(5):667-672, 2017 Nov.
[Is] ISSN:1432-2307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Neuroendocrine tumors are extremely rare in the middle ear. We reviewed our institutional experience with middle ear adenomatous neuroendocrine tumors (MEANTs). We searched our institution's pathology files to identify patients treated from 1990 to 2015 who had lesions classified as middle ear adenomas, adenomatous tumors, adenomatous tumors with neuroendocrine differentiation, carcinoid tumors of the middle ear, low-grade neuroendocrine tumors of the middle ear, and neuroendocrine carcinomas of the middle ear and identified 14 such patients for whom follow-up information was available. Herein, we review the pathology and differential diagnosis of these patients' tumors and discuss the management and follow-up of these patients. Our report adds to the series cases of MEANTs with recurrences, lymph node involvement, distant metastases, and tumor-related deaths. Our experience suggests that, although these tumors have long been considered to be low-aggression neoplasms, long-term follow-up studies to ascertain this supposed benignity are warranted.
[Mh] Termos MeSH primário: Neoplasias da Orelha/patologia
Orelha Média/patologia
Tumores Neuroendócrinos/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.1007/s00428-017-2155-6


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[PMID]:28545054
[Au] Autor:Beyreuther E; Brüchner K; Krause M; Schmidt M; Szabo R; Pawelke J
[Ad] Endereço:Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.
[Ti] Título:An optimized small animal tumour model for experimentation with low energy protons.
[So] Source:PLoS One;12(5):e0177428, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The long-term aim of developing laser based particle acceleration towards clinical application requires not only substantial technological progress, but also the radiobiological characterization of the resulting ultra-short and ultra-intensive particle beam pulses. After comprehensive cell studies a mouse ear tumour model was established allowing for the penetration of low energy protons (~20 MeV) currently available at laser driven accelerators. The model was successfully applied for a first tumour growth delay study with laser driven electrons, whereby the need of improvements crop out. METHODS: To optimise the mouse ear tumour model with respect to a stable, high take rate and a lower number of secondary tumours, Matrigel was introduced for tumour cell injection. Different concentrations of two human tumour cell lines (FaDu, LN229) and Matrigel were evaluated for stable tumour growth and fulfilling the allocation criteria for irradiation experiments. The originally applied cell injection with PBS was performed for comparison and to assess the long-term stability of the model. Finally, the optimum suspension of cells and Matrigel was applied to determine applicable dose ranges for tumour growth delay studies by 200 kV X-ray irradiation. RESULTS: Both human tumour models showed a high take rate and exponential tumour growth starting at a volume of ~10 mm3. As disclosed by immunofluorescence analysis these small tumours already interact with the surrounding tissue and activate endothelial cells to form vessels. The formation of delimited, solid tumours at irradiation size was shown by standard H&E staining and a realistic dose range for inducing tumour growth delay without permanent tumour control was obtained for both tumour entities. CONCLUSION: The already established mouse ear tumour model was successfully upgraded now providing stable tumour growth with high take rate for two tumour entities (HNSCC, glioblastoma) that are of interest for future irradiation experiments at experimental accelerators.
[Mh] Termos MeSH primário: Neoplasias da Orelha/patologia
Neoplasias da Orelha/radioterapia
Prótons/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Proliferação Celular/efeitos da radiação
Modelos Animais de Doenças
Relação Dose-Resposta à Radiação
Feminino
Seres Humanos
Masculino
Camundongos
Aceleradores de Partículas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protons)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177428


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[PMID]:28329507
[Au] Autor:Coates SJ; Avarbock A; Desman GT
[Ti] Título:Giant benign intradermal melanocytic nevus of rapid onset.
[So] Source:Dermatol Online J;23(2), 2017 Feb 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Benign melanocytic nevi are slowly growing acquiredor congenital tumors with varied morphology,commonly encountered in dermatology clinics. Anytumor with rapid clinical growth must be assessedcarefully in order to exclude malignancy. We report awoman with a histopathologically benign intradermalnevus that presented as a rapidly evolving largecutaneous mass on the ear. Owing to the discrepancybetween the clinical and histopathological findings,an extensive histopathological work-up involvingmany deeper sections, immunohistochemical stains,and fluorescent in situ hybridization (FISH) analysiswas conducted in order to rule out malignancy.
[Mh] Termos MeSH primário: Neoplasias da Orelha/diagnóstico
Nevo Intradérmico/diagnóstico
Nevo Pigmentado/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Neoplasias da Orelha/patologia
Feminino
Seres Humanos
Meia-Idade
Nevo Intradérmico/patologia
Nevo Pigmentado/patologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28296788
[Au] Autor:Galeckas K; Whalen J
[Ad] Endereço:*Department of Dermatology, University of Connecticut, Farmington, Connecticut; †Department of Dermatology, Micrographic Surgery and Dermatologic Oncology Fellowship, University of Connecticut, Farmington, Connecticut.
[Ti] Título:Repair of a Small Antihelical Defect.
[So] Source:Dermatol Surg;43 Suppl 1:S119-S121, 2017 05.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma Basocelular/cirurgia
Procedimentos Cirúrgicos Dermatológicos/métodos
Pavilhão Auricular
Neoplasias da Orelha/cirurgia
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Idoso
Carcinoma Basocelular/patologia
Neoplasias da Orelha/patologia
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001090


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[PMID]:28272087
[Au] Autor:Sklar LR; Tolkachjov SN; Harmon CB
[Ad] Endereço:Department of Dermatology, Wayne State University, Dearborn, Michigan Surgical Dermatology Group, Birmingham, Alabama.
[Ti] Título:Squamous Cell Carcinoma Arising Within an Accessory Tragus.
[So] Source:Dermatol Surg;43(11):1401-1402, 2017 11.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/patologia
Pavilhão Auricular
Neoplasias da Orelha/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Idoso
Carcinoma de Células Escamosas/cirurgia
Neoplasias da Orelha/cirurgia
Seres Humanos
Masculino
Neoplasias Cutâneas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001098


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[PMID]:28263197
[Au] Autor:Pelster MW; Clark MA; Yoo S
[Ad] Endereço:*Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; †Department of Dermatology, Cleveland Clinic, Cleveland, Ohio.
[Ti] Título:Repair of a Multisubunit Defect of the Earlobe, Preauricular Skin, and Superolateral Neck.
[So] Source:Dermatol Surg;43 Suppl 1:S122-S125, 2017 05.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/cirurgia
Procedimentos Cirúrgicos Dermatológicos/métodos
Pavilhão Auricular
Neoplasias da Orelha/cirurgia
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Carcinoma de Células Escamosas/patologia
Neoplasias da Orelha/patologia
Feminino
Seres Humanos
Pescoço/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001081


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[PMID]:28247225
[Au] Autor:Thompson LD
[Ad] Endereço:Department of Pathology, Southern California Kaiser Permanente Group, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA, 91365, USA. lester.d.thompson@kp.org.
[Ti] Título:Update From the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumours of the Ear.
[So] Source:Head Neck Pathol;11(1):78-87, 2017 Mar.
[Is] ISSN:1936-0568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The 2017 fourth edition of the World Health Organization Classification of Tumours, specifically as it relates to the ear (Chap. 9), has several changes. Importantly, the number of entities has been significantly reduced by omitting tumors or lesions if they do not occur exclusively or predominantly at this site or if they are discussed in detail elsewhere in the book. These entities include: embryonal rhabdomyosarcoma, osteoma, exostosis, angiolymphoid hyperplasia with eosinophilia, Schneiderian papilloma, inverted papilloma, lipoma of the internal auditory canal, hemangioma, hematolymphoid tumors, and secondary tumors. Paraganglioma was included in the neck chapter. New entries include otosclerosis and cholesteatoma, while refinements to nomenclature, classification and criteria were incorporated into the ceruminous gland tumors and epithelial tumors of the middle and inner ear. Specifically, the middle and inner ear were combined, as practical limitations of origin and imaging make a definitive separation artificial. The classification reflects the state of current understanding for these uncommon entities, with this update only highlighting selected entities that were the most significantly changed.
[Mh] Termos MeSH primário: Neoplasias da Orelha/classificação
[Mh] Termos MeSH secundário: Neoplasias da Orelha/patologia
Seres Humanos
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1007/s12105-017-0790-5


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[PMID]:28243783
[Au] Autor:Mazzoni A; Zanoletti E; Faccioli C; Martini A
[Ad] Endereço:Department of Neuroscience, Otolaryngology Unit, Padova University, via Giustiniani 2, 35128, Padova, Italy.
[Ti] Título:Acoustic schwannoma with intracochlear extension and primary intracochlear schwannoma: removal through translabyrinthine approach with facial bridge cochleostomy and transcanal approach.
[So] Source:Eur Arch Otorhinolaryngol;274(5):2149-2154, 2017 May.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Intracochlear schwannomas can occur either as an extension of a larger tumor from the internal auditory canal, or as a solitary labyrinthine tumor. They are currently removed via a translabyrinthine approach extended to the basal turn, adding a transotic approach for tumors lying beyond the basal turn. Facial bridge cochleostomy may be associated with the translabyrinthine approach to enable the whole cochlea to be approached without sacrificing the external auditory canal and tympanum. We describe seven cases, five of which underwent cochlear schwannoma resection with facial bridge cochleostomy, one case with the same procedure for a suspect tumor and one, previously subjected to radical tympanomastoidectomy, who underwent schwannoma resection via a transotic approach. Facial bridge cochleostomy involved removing the bone between the labyrinthine and tympanic portions of the fallopian canal, and exposing the cochlea from the basal to the apical turn. Patients' recovery was uneventful, and long-term magnetic resonance imaging showed no residual tumor. Facial bridge cochleostomy can be a flexible extension of the translabyrinthine approach for tumors extending from the internal auditory canal to the cochlea. The transcanal approach is suitable for the primary exclusive intralabyrinthine tumor. The indications for the different approaches are discussed.
[Mh] Termos MeSH primário: Neoplasias da Orelha
Neurilemoma
Neuroma Acústico
Procedimentos Cirúrgicos Otológicos
[Mh] Termos MeSH secundário: Adulto
Dissecação/efeitos adversos
Dissecação/métodos
Meato Acústico Externo/cirurgia
Neoplasias da Orelha/patologia
Neoplasias da Orelha/cirurgia
Orelha Interna/diagnóstico por imagem
Orelha Interna/patologia
Orelha Interna/cirurgia
Feminino
Seres Humanos
Itália
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Invasividade Neoplásica
Neoplasia Residual/diagnóstico
Neoplasia Residual/prevenção & controle
Neurilemoma/patologia
Neurilemoma/cirurgia
Neuroma Acústico/patologia
Neuroma Acústico/cirurgia
Procedimentos Cirúrgicos Otológicos/efeitos adversos
Procedimentos Cirúrgicos Otológicos/métodos
Avaliação de Processos e Resultados (Cuidados de Saúde)
Estudos Retrospectivos
Membrana Timpânica/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-017-4501-3



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