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[PMID]:29384975
[Au] Autor:Kim JS; Kwon SH
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery.
[Ti] Título:Different characteristics of a single sinonasal inverted papilloma from sequential PET-CT: A case report.
[So] Source:Medicine (Baltimore);96(52):e9557, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Inverted papilloma (IP) is a benign tumor that should be monitored carefully because it frequently recurs and has the potential to become malignant. PATIENT CONCERNS: We report a case of a 59-year-old woman who presented with a mass which had been found incidentally on positron emission tomography computed tomography (PET CT). DIAGNOSES: Using endoscopy and CT, the preoperative diagnosis was inverted papilloma. PET CT showed a mass with hot uptake in the left ethmoid and frontal sinus (maximum standardized uptake value (SUVmax) = 7.80). INTERVENTIONS: We performed endoscopic sinus surgery (ESS) using 4 mm 0° and 70° endoscopes under general anesthesia. After 15 months of follow-up, remnant masses existed in the left frontal and supraorbital ethmoid cells. In the second PET CT taken at this time, a mass with lower SUV compared to the preoperative PET was observed in the lateral side of the left frontal sinus (SUVmax= 1.71). Revision ESS was performed using the "above and below" technique. OUTCOMES: Two years after initial surgery, follow-up CT showed there was no tumor recurrence in the frontal sinus or supraorbital ethmoid cell. There were no complications such as numbness in the forehead area after the operations. CONCLUSION: If the tumor is located at a site that is difficult to reach with an endoscope alone, it is faster and less painful to choose a more convenient approach for the patientand it can avoid unnecessary cost burden. It should also be noted that the SUV of PET is not a tool to distinguish IP from other inflammatory polyps or cancer.
[Mh] Termos MeSH primário: Papiloma Invertido/patologia
Neoplasias dos Seios Paranasais/patologia
[Mh] Termos MeSH secundário: Endoscopia/métodos
Feminino
Seres Humanos
Meia-Idade
Papiloma Invertido/diagnóstico
Papiloma Invertido/diagnóstico por imagem
Papiloma Invertido/cirurgia
Neoplasias dos Seios Paranasais/diagnóstico por imagem
Neoplasias dos Seios Paranasais/cirurgia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009557


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[PMID]:29381961
[Au] Autor:Xiong J; Chen J; Zheng L; Yang S; Zhao G; Cheng J
[Ad] Endereço:Cancer Center.
[Ti] Título:Rare metastasis to paranasal sinuses from triple-negative breast cancer: A case report and literature review.
[So] Source:Medicine (Baltimore);96(47):e8718, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Breast cancer, the most common form of cancer among women, rarely metastases to the head and neck region. To date, there have been only 6 similar cases in the literature, and most patients in these reports had very poor prognosis. PATIENTS CONCERNS: We report a 61-year-old female presented pain and numbness on the right side of the face 5 years after being diagnosed with triple-negative breast cancer. DIAGNOSIS: Magnetic resonance imaging (MRI) revealed a tissue mass in the sphenoid sinus. The tissue biopsy confirmed metastasis of breast cancer. INTERVENTION: The patient received initial chemotherapy and radiotherapy plus 10 cycles of maintenance chemotherapy OUTCOMES:: The patient got long-term progression-free survival time. The total time to progression was 32 months. LESSONS: Although breast cancer rarely metastasizes to the head and neck region, awareness should be raised when breast cancer patients experience headache or have sinus-related symptoms. Chemotherapy and radiotherapy may be effective to treat paranasal sinus metastasis of triple-negative breast cancer, and patients may achieve long-term survival.
[Mh] Termos MeSH primário: Neoplasias dos Seios Paranasais/secundário
Neoplasias de Mama Triplo Negativas/patologia
[Mh] Termos MeSH secundário: Quimiorradioterapia/métodos
Intervalo Livre de Doença
Feminino
Seres Humanos
Meia-Idade
Neoplasias dos Seios Paranasais/terapia
Neoplasias de Mama Triplo Negativas/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008718


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[PMID]:28468156
[Au] Autor:Arslan HH; Tasli H; Cebeci S; Gerek M
[Ad] Endereço:*Department of Otolaryngology, Head and Neck Surgery, Gulhane Military Medical School †Etlik Zübeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.
[Ti] Título:The Management of the Paranasal Sinus Osteomas.
[So] Source:J Craniofac Surg;28(3):741-745, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Osteoma is the most common benign tumor of the paranasal sinuses. The clinical characteristics and treatment of this disease remain controversial. The aim of this study is to determine the appropriate method of treatment approach according to the features of osteomas. METHODS: Forty-one patients with paranasal sinus osteomas were included in the study. According to the location and the size of tumors, patients were followed up or operated. Surgical treatment was performed via external, endoscopic, or combined approaches for symptomatic patients. Routine physical and radiological evaluations were performed for follow-up in asymptomatic patients. RESULTS: Paranasal sinus osteomas were found most common in frontal sinus (n = 26, 63.4%) followed by ethmoid sinus (n = 10, 24.3%), maxillary sinus (n = 4, 9.7%), and sphenoid sinus (n = 1, 2.4%). Of the patients with frontal sinus osteomas, the endoscopic approach was performed in 11 patients, external approach (osteoplastic flap) in 9, and combined (external + endoscopic) approach in 5 patients. Endoscopic approach was preferred in all patients with ethmoid osteoma. The combination of Caldwell-Luc procedure and endoscopic approach was performed in 1 patient with maxillary sinus osteoma. In 3 patients, who underwent osteoplastic flap technique, mucocele developed in the postoperative period. Partial loss of vision developed postoperatively in 1 patient with a giant ethmoid osteoma. There were no other complications and recurrence in an average of 29 months follow-up. CONCLUSION: Paranasal sinus osteomas are rare, slow-growing benign lesions, with potentially serious complications. Main treatment option for sphenoid and ethmoid sinus and other symptomatic osteomas are surgical resection. Radiographic follow-up is necessary for asymptomatic lesions. Selection of surgical resection method depends on tumor location and size. Patients should be observed for recurrence with periodic examination and imaging techniques. Follow-up should be performed at least in 1-year intervals after the surgery. LEVEL OF EVIDENCE: 1c.
[Mh] Termos MeSH primário: Endoscopia/métodos
Seio Etmoidal
Seio Frontal
Seio Maxilar
Osteoma/cirurgia
Neoplasias dos Seios Paranasais/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Osteoma/diagnóstico
Neoplasias dos Seios Paranasais/diagnóstico
Período Pós-Operatório
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003397


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[PMID]:29224278
[Au] Autor:Zhao M; LaoI QY; Zhao DH; Ma J; Ru GQ; He XL; Wang Z; Wang J
[Ad] Endereço:Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
[Ti] Título:[Clinicopathologic and molecular genetic characterizations of biphenotypic sinonasal sarcoma].
[So] Source:Zhonghua Bing Li Xue Za Zhi;46(12):841-846, 2017 Dec 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinicopathologic characteristics, immunophenotypes, molecular genetics, and diagnostic and differential diagnostic features of biphenotypic sinonasal sarcoma (BSNS). Three cases of BSNS were retrieved, the histomorphology, immunophenotype and molecular genetics were analyzed with review of literature. There were 2 male and 1 female patient aged 45, 29 and 40 years, respectively.Computed tomography and magnetic resonance imaging examinations showed a large polypoid mass occupying the sinonasal cavity in all 3 patients. Microscopically, these tumors were un-circumscribed and composed of cellular spindle-shaped cells arranged in long and interlaced fascicles. A hemangiopericytoma-like growth pattern was frequently identified. The overlying hyperplastic respiratory epithelium invaginated down into the tumor forming a cystic (2 cases), glandular (1 case) structures and inverted in a papilloma-like (1 case)pattern, and foci of eosinophilic metaplasia were also noted in 2 of the three cases. The tumor nuclei were bland-appearing, mitoses were scarce and necrosis was absent. Immunohistochemically, the tumor cells showed co-expression of neural and myogenic markers in all the 3 cases, including that 3/3 showed diffuse and strong positivity of S-100 protein, 3/3 positivity of smooth muscle actin (1 diffuse and 2 focal), 1/2 diffuse positivity of calponin, 1/3 focal positivity of desmin, and 1/1 focal positivity of MyoD1.In addition, 1 detected for ß-catenin showed focal nuclear positivity. None of the 3 showed positivity to cytokeratin, CD34 or SOX10 in the tumor cells.Ki-67 showed an index <5%, 10% and <2%, respectively. Fluorescence in situ hybridization analysis showed rearrangements of PAX3 gene in all 3 cases. In case 3, reverse transcription polymerase chain reaction, followed by Sanger sequencing, demonstrated an in-frame fusion between PAX3 and FOXO1.Follow-up information (range 3-15 months)showed no evidence of local recurrence or distant metastasis in three cases. BSNS is a newly described entity which can be readily confused with a variety of benign and malignant spindle cell tumors encountered in the sinonasal cavity; immunohistochemistry co-expression of neural and myogenic markers and PAX3 gene rearrangement can help distinguish this tumor from its many mimickers.
[Mh] Termos MeSH primário: Neoplasias dos Seios Paranasais/genética
Neoplasias dos Seios Paranasais/patologia
Sarcoma/genética
Sarcoma/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
Núcleo Celular
Desmina/análise
Diagnóstico Diferencial
Feminino
Rearranjo Gênico
Hemangiopericitoma/patologia
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Hibridização in Situ Fluorescente
Queratinas/análise
Masculino
Meia-Idade
Recidiva Local de Neoplasia
Fator de Transcrição PAX3/genética
Neoplasias dos Seios Paranasais/química
Neoplasias dos Seios Paranasais/imunologia
Proteínas S100/análise
Fatores de Transcrição SOXE/análise
Sarcoma/química
Sarcoma/imunologia
beta Catenina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CTNNB1 protein, human); 0 (Desmin); 0 (PAX3 Transcription Factor); 0 (PAX3 protein, human); 0 (S100 Proteins); 0 (SOXE Transcription Factors); 0 (beta Catenin); 68238-35-7 (Keratins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2017.12.006


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[PMID]:28468210
[Au] Autor:Çelik M; Sahin B; Enver N; Orhan KS
[Ad] Endereço:*Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul Medical Faculty, University of Istanbul †Department of Otorhinolaryngology and Head and Neck Surgery, University of Marmara, Istanbul, Turkey.
[Ti] Título:Nasopharyngeal Extension of Giant Meningioma.
[So] Source:J Craniofac Surg;28(3):e254-e255, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Meningiomas are common intracranial neoplasms but extracranial meningioma of the paranasal sinus is extremely rare. The recommended treatment of these meningothelial tumors is complete surgical excision. The authors report a 79-year-old woman presenting with facial pain and nasal obstruction for several months. Endoscopic nasopharyngeal examination showed a right nasal mass that arose from the nasopharynx and reached around the middle meatus. Gadolinium-enhanced magnetic resonance imaging showed a well-circumscribed nasopharyngeal mass, which originates from the right rosenmuller fossa and extends to the right nasal cavity. A biopsy was made with nasal endoscopy under local anesthesia for definitive diagnosis. Histopathologic examination was reported as benign meningothelial meningioma.In conclusion, physicians should keep in mind uncommon tumors in the nasal cavity and paranasal sinuses. Surgical resection is the primary treatment choice; however, close follow-up could be an option in patients with comorbidities.
[Mh] Termos MeSH primário: Neoplasias Meníngeas/diagnóstico
Meningioma/diagnóstico
Neoplasias Nasofaríngeas/diagnóstico
Neoplasias dos Seios Paranasais/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Neoplasias Meníngeas/patologia
Meningioma/patologia
Cavidade Nasal/patologia
Neoplasias Nasofaríngeas/patologia
Invasividade Neoplásica
Neoplasias dos Seios Paranasais/patologia
Seios Paranasais/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003475


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[PMID]:27860481
[Au] Autor:Jordáková J
[Ti] Título:[Ocular Motility Disorders with Diplopia Like the first Symptoms of Paranasal Tumours with Orbital Invasion - a Case Report].
[Ti] Título:Porucha motility bulbu s diplopií jako první príznak tumoru prorustajícího do orbity z vedlejsích dutin nosních..
[So] Source:Cesk Slov Oftalmol;72(4):157-163, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:Presentation of two case reports about our experiences with diagnostics of paranasal tumours in patients with diplopia or ocular motility disorders which were the first symptoms of these tumours. Furthermore, the following diagnostic and therapeutic procedure which has been conducted in cooperation with other hospital departments is presented. The first case report is an example of primary paranasal tumour, the second case report represents secondary infiltration of maxillary sinus and orbital invasion. METHODS: A case reports.Key words: diplopia, paranasal tumours, orbital invasion, spinocellulary carcinoma.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/diagnóstico
Diplopia/diagnóstico
Transtornos da Motilidade Ocular/diagnóstico
Neoplasias Orbitárias/diagnóstico
Neoplasias dos Seios Paranasais/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Evisceração do Olho
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Invasividade Neoplásica
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


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[PMID]:28767609
[Au] Autor:Kim NI; Yang JI; Kim SS; Lee JS; Lim SC; Jung S; Lee JH; Moon KS; Lee KH
[Ad] Endereço:aDepartment of Pathology bDepartment of Otolaryngology-Head and Neck Surgery cDepartment of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, Jeollanamdo, South Korea.
[Ti] Título:Sinonasal renal cell-like adenocarcinoma, a unique variant of primary clear cell carcinoma of the head and neck: The first reported case in Korea.
[So] Source:Medicine (Baltimore);96(31):e7711, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm. PATIENT CONCERNS: A 63-year-old man presented with repeated epistaxis, nasal obstruction and hyposmia of 2-month duration. Radiological studies revealed a mass of the left ethmoid sinus involving anterior skull base. DIAGNOSIS: The patient was treated with craniofacial resection, bifrontal craniotomy combined with an endonasal endoscopic approach. Intraoperatively, a hypervascular paranasal mass invading the dura mater was removed en block. Histologically, the tumor resembled a clear cell renal cell carcinoma, with cuboidal shaped cells having clear cytoplasm. The tumor cells were positive for CK7, S100, vimentin and PAX-8 and negative for CD10 and PAX-2 by immunohistochemistry. No evidence of renal malignancy was found by radiological and clinical examinations. INTERVENTIONS AND OUTCOMES: Following local radiation therapy, the patient was in good health without recurrence for 15 months after the operation. LESSONS: To the best of the authors' knowledge, this is the first reported case of SNRCLA in Korea. Because of its histological feature of clear cytoplasm, SNRCLA needs to be differentiated from clear cell renal cell carcinoma and other salivary clear cell carcinomas. The prognosis of SNRCLA is generally favorable as shown in the previously reported cases. Considering the limited number and follow-up periods of the cases, however, delayed recurrence should be kept in mind for clinicians.
[Mh] Termos MeSH primário: Adenocarcinoma de Células Claras/diagnóstico
Carcinoma de Células Renais/diagnóstico
Seio Etmoidal
Neoplasias dos Seios Paranasais/diagnóstico
Neoplasias da Base do Crânio/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma de Células Claras/patologia
Adenocarcinoma de Células Claras/cirurgia
Adenocarcinoma de Células Claras/terapia
Diagnóstico Diferencial
Seres Humanos
Masculino
Meia-Idade
Neoplasias dos Seios Paranasais/patologia
Neoplasias dos Seios Paranasais/terapia
Neoplasias da Base do Crânio/diagnóstico
Neoplasias da Base do Crânio/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007711


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[PMID]:28734993
[Au] Autor:Vass G; Bella Z; Tóbiás Z; Nagy A; Iván L; Rovó L
[Ad] Endereço:Assistant Lecturer, Department of Otorhinolaryngology, Head and Neck Surgery, University of Szeged, Szeged, Hungary. Electronic address: vassgabor@hotmail.com.
[Ti] Título:Esthetically Favorable Surgical Alternative for the Removal of Sinonasal Malignant Tumors-The Modified Facial Degloving Technique.
[So] Source:J Oral Maxillofac Surg;75(10):2272.e1-2272.e10, 2017 Oct.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The widely used external approach (Weber-Fergusson incision) for the removal of maxillary ethmoid tumors leaves stigmatizing scars and deformities on the patient's face. As an alternative technique, the scarless facial degloving approach was first described in the 1970s; since then, several modifications have been developed. PATIENTS AND METHODS: The authors have been using a modified facial degloving technique for 7 years to remove maxillary ethmoid tumors. This article is a retrospective methodologic review. The inclusion criteria for this retrospective study were patients who underwent the modified facial degloving technique for management of malignant maxillary ethmoid tumors. The exclusion criteria were patients who did not undergo a surgical procedure (who received primary chemoradiation therapy) and patients who underwent an endoscopic surgical procedure for an early-stage localized tumor. The authors describe their method, which provides for a wide surgical approach using an osteoplastic flap for the entire nasal and paranasal region, with good cosmetic results. They present the adaptability of their method for 3 malignant maxillary ethmoid tumors in different locations. RESULTS: From 2012 through 2016, 23 consecutive patients underwent surgery with the modified facial degloving approach at the Department of Otorhinolaryngology, Head and Neck Surgery at the University of Szeged (Szeged, Hungary). The authors evaluated their results with acoustic rhinometry and photographic documentation of postoperative facial expressions. Neither narrowing of the nasal cavity on the operated side (loss of nasal breathing function) nor facial movement dysfunction was visible in these patients. CONCLUSION: Although several modifications of the original facial degloving approach have been published, in the present technique, the novel osteoplastic flap and the intact soft tissue of the nasal and midfacial region result in shorter hospitalization time and fewer complications. No functional or esthetic distortion was visible. No severe complications were observed; the patients' only complaint was the dryness of the nasal mucosa and temporary crusting of the nose. The present modified facial degloving technique offers proper and safe surgical resection for tumors of the maxillary ethmoid region. It can be routinely combined with endoscopic techniques and, if necessary, can be converted to an open approach.
[Mh] Termos MeSH primário: Osso Etmoide
Neoplasias Maxilares/cirurgia
Neoplasias dos Seios Paranasais/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Neoplasias Cranianas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estética
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


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[PMID]:28719468
[Au] Autor:Andreasen S; Skálová A; Agaimy A; Bishop JA; Laco J; Leivo I; Franchi A; Larsen SR; Erentaite D; Ulhøi BP; von Buchwald C; Melchior LC; Michal M; Kiss K
[Ad] Endereço:Departments of *Otorhinolaryngology Head & Neck Surgery and Audiology ∥∥Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen †Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge ††Department of Pathology, Odense University Hospital, Odense ‡‡Department of Pathology, Aalborg University Hospital, Aalborg §§Department of Pathology, Aarhus University Hospital, Aarhus, Denmark ‡Department of Pathology, Faculty of Medicine, Charles University, Pilsen ¶The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic §Institute of Pathology, University Hospital of Erlangen, Erlangen, Germany ∥Departments of Pathology, Otolaryngology, and Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD #Department of Pathology and Forensic Medicine, University of Turku, Turku, Finland **Department of Surgery and Translational Medicine, Division of Anatomic Pathology, University of Florence, Florence, Italy.
[Ti] Título:ETV6 Gene Rearrangements Characterize a Morphologically Distinct Subset of Sinonasal Low-grade Non-intestinal-type Adenocarcinoma: A Novel Translocation-associated Carcinoma Restricted to the Sinonasal Tract.
[So] Source:Am J Surg Pathol;41(11):1552-1560, 2017 Nov.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Low-grade sinonasal adenocarcinomas (low-grade SNACs) of the sinonasal tract comprise a poorly characterized and histologically heterogeneous group of tumors. We describe three cases of a histologically distinct variant of low-grade SNAC characterized by ETV6 gene rearrangements. The patients included 2 women (aged 32 and 88 y) and a man (aged 75 y); all were initially treated with surgery alone. Follow-up ranged from 9 to 170 months with one patient having 2 local recurrences and none experiencing distant or regional metastases. Tumors were composed of cytologically bland columnar and cuboidal eosinophilic tumor cells with basally located nuclei arranged in tubular and tubulotrabecular patterns. Immunohistochemically, CK7, DOG1, GCDFP-15, and SOX10 were positive in all cases, and vimentin was positive in 2 cases. Scattered single cells or small groups of tumor cells were S-100 positive. Only one case had weak, focal expression of GATA3, and mammaglobin was consistently negative. Two cases had ETV6-NTRK3 gene fusions, whereas ETV6 had an unknown fusion partner gene in one case. The highly similar morphology, immunohistochemical profile, and genetics of the presented cases are suggestive of a specific disease. Although translocation-associated adenocarcinomas in the sinonasal tract have previously been described exclusively as salivary-type carcinomas, we present the first type of carcinoma characterized by recurrent genetic rearrangements and distinct phenotype occurring exclusively in the sinonasal tract with no known major salivary gland counterpart. We provisionally designate this tumor ETV6-rearranged low-grade SNAC. Identification of additional cases is necessary to fully appreciate the morphologic and biological spectrum of this disease.
[Mh] Termos MeSH primário: Adenocarcinoma/genética
Biomarcadores Tumorais/genética
Rearranjo Gênico
Neoplasias dos Seios Paranasais/genética
Proteínas Proto-Oncogênicas c-ets/genética
Proteínas Repressoras/genética
[Mh] Termos MeSH secundário: Adenocarcinoma/química
Adenocarcinoma/patologia
Adenocarcinoma/cirurgia
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Biópsia
Feminino
Fusão Gênica
Predisposição Genética para Doença
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Imagem por Ressonância Magnética
Masculino
Gradação de Tumores
Recidiva Local de Neoplasia
Neoplasias dos Seios Paranasais/química
Neoplasias dos Seios Paranasais/patologia
Neoplasias dos Seios Paranasais/cirurgia
Fenótipo
Reação em Cadeia da Polimerase em Tempo Real
Receptor trkC/genética
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (ETS translocation variant 6 protein); 0 (Proto-Oncogene Proteins c-ets); 0 (Repressor Proteins); EC 2.7.10.1 (Receptor, trkC)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000912


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Fotocópia
[PMID]:28685551
[Au] Autor:Yang JP; Hu CM; Zhong W; Wang ZG
[Ad] Endereço:Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, China.
[Ti] Título:Primary diffuse large B-cell lymphoma of the frontal sinus.
[So] Source:J Biol Regul Homeost Agents;31(2):447-451, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Primary frontal sinus lymphoma is a rare disease, with the presenting symptoms that are secondary to the tumor mass effect and often misleading. Here we describe the case of a 43-year-old male patient who presented with a 4-week history of a gradually enlarging painful diffuse swelling over the right frontal sinus region. We report the clinical presentation, differential diagnosis and treatment of the case. We also reviewed the available literature on the diffuse large B-cell lymphoma in the frontal sinus region. The article emphasizes the importance of early recognition of this rare disease.
[Mh] Termos MeSH primário: Seio Frontal
Linfoma Difuso de Grandes Células B
Neoplasias dos Seios Paranasais
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Linfoma Difuso de Grandes Células B/diagnóstico
Linfoma Difuso de Grandes Células B/terapia
Masculino
Neoplasias dos Seios Paranasais/diagnóstico
Neoplasias dos Seios Paranasais/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE



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