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[PMID]:29373783
[Au] Autor:Lam HP; Addicks BL; Farmer RW; Fancy T
[Ti] Título:Metastatic Renal Cell Carcinoma of the Head and Neck: A Case Series.
[So] Source:W V Med J;113(2):48-51, 2017 Mar-Apr.
[Is] ISSN:0043-3284
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Renal cell carcinoma (RCC) accounts for over 80% of malignant tumors arising from the kidney. However, metastatic RCC to the head and neck is a relatively rare entity. Case Presentation: We describe three patients with metastatic RCC to the head and neck with the involvement of the parapharyngeal space, the level V region of the neck, and the maxillary sinus. Conclusion: Metastatic RCC in the head and neck is uncommon; however, it must be taken into consideration given a patient with a history of RCC. Multiple pathways allow for the spread of RCC to the head and neck region. Treatment options include mastectomy or local radiation and systemic chemotherapy.
[Mh] Termos MeSH primário: Carcinoma de Células Renais/diagnóstico por imagem
Carcinoma de Células Renais/secundário
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/secundário
Neoplasias Renais/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Neoplasias do Seio Maxilar/secundário
Fatores de Tempo
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE


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[PMID]:28493366
[Au] Autor:Dogan S; Chute DJ; Xu B; Ptashkin RN; Chandramohan R; Casanova-Murphy J; Nafa K; Bishop JA; Chiosea SI; Stelow EB; Ganly I; Pfister DG; Katabi N; Ghossein RA; Berger MF
[Ad] Endereço:Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[Ti] Título:Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.
[So] Source:J Pathol;242(4):400-408, 2017 Aug.
[Is] ISSN:1096-9896
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sinonasal undifferentiated carcinoma (SNUC) is a high-grade malignancy with limited treatment options and poor outcome. A morphological spectrum of 47 sinonasal tumours including 17 (36.2%) SNUCs was analysed at genomic level. Thirty carcinomas (cohort 1) were subjected to a hybridization exon-capture next-generation sequencing assay (MSK-IMPACT ) to interrogate somatic variants in 279 or 410 cancer-related genes. Seventeen sinonasal tumours (cohort 2) were examined only for the presence of IDH1/2 exon 4 mutations by Sanger sequencing. IDH2 R172 single nucleotide variants were overall detected in 14 (82.4%) SNUCs, in two (20%) poorly-differentiated carcinomas with glandular/acinar differentiation, and in one of two high-grade neuroendocrine carcinomas, large cell type (HGNECs). No IDH2 mutation was detected in any of five olfactory neuroblastomas or in any of five SMARCB1-deficient carcinomas. Among 12 IDH2-mutated cases in cohort 1, five (41.7%) harboured co-existing TP53 mutations, four (33.3%) CDKN2A/2B loss-of-function alterations, four (33.3%) MYC amplification, and three (25%) had concurrent SETD2 mutations. AKT1 E17K and KIT D816V hotspot variants were each detected in one IDH2-mutated SNUC. The vast majority of SNUCs and variable proportions of other poorly-differentiated sinonasal carcinomas may be amenable to IDH2-targeted therapy. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Carcinoma/genética
Isocitrato Desidrogenase/genética
Neoplasias do Seio Maxilar/genética
Mutação
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/genética
Carcinoma/patologia
Carcinoma Neuroendócrino/genética
Carcinoma de Células Pequenas/genética
Análise Mutacional de DNA/métodos
Feminino
Deleção de Genes
Genes p53/genética
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Seres Humanos
Masculino
Neoplasias do Seio Maxilar/patologia
Meia-Idade
Proteína SMARCB1/deficiência
Proteína SMARCB1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (SMARCB1 Protein); 0 (SMARCB1 protein, human); EC 1.1.1.41 (Isocitrate Dehydrogenase); EC 1.1.1.41 (isocitrate dehydrogenase 2, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1002/path.4915


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[PMID]:28295338
[Au] Autor:Suzuki M; Nakamura Y; Yokota M; Ozaki S; Murakami S
[Ad] Endereço:Department of Otorhinolaryngology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
[Ti] Título:Modified transnasal endoscopic medial maxillectomy through prelacrimal duct approach.
[So] Source:Laryngoscope;127(10):2205-2209, 2017 Oct.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We previously reported a modified endoscopic medial maxillectomy (modified transnasal endoscopic medial maxillectomy through prelacrimal duct approach [MTEMMPDA]) to resect inverted papilloma (IP), for which the inferior turbinate (IT) and nasolacrimal duct (ND) can be preserved. MTEMMPDA is a safe and effective method to obtain wide, straight access to the maxillary sinus (MS). However, there are few reported cases of patients who underwent MTEMMPDA, and even fewer of patients who underwent partial osteotomy of the apertura piriformis and the anterior wall of the MS. In this study, we analyzed the outcomes of 51 patients who underwent MTEMMPDA. STUDY DESIGN: Retrospective review. METHODS: All patients who underwent MTEMMPDA at our hospital between January 2004 and December 2015 were included in this study. RESULTS: Fifty-one patients with sinonasal IP in the MS underwent MTEMMPDA. Recurrence was seen in the MS of one patient (follow-up of 2-138 months). The IT remained unchanged in all 51 patients without atrophy. We have not observed epiphora, eye discharge, dry nose, or persistent crusting after this surgery. Although seven patients had numbness around the upper lip after surgery, this had disappeared by 1 year after surgery. Additional partial osteotomy of the apertura piriformis and the anterior wall of the MS were done in eight patients. Deformation of the external nose was not seen. CONCLUSION: This approach appears to be a safe and effective method to resect IP in the MS, even if there is additional partial osteotomy of the apertura piriformis and the anterior wall of the MS. LEVEL OF EVIDENCE: 4. Laryngoscope, 127:2205-2209, 2017.
[Mh] Termos MeSH primário: Aparelho Lacrimal/cirurgia
Neoplasias do Seio Maxilar/cirurgia
Seio Maxilar/cirurgia
Cirurgia Endoscópica por Orifício Natural/métodos
Papiloma Invertido/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Ossos Faciais/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Recidiva Local de Neoplasia
Nariz/cirurgia
Osteotomia/métodos
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26529


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[PMID]:28291122
[Au] Autor:Agaimy A; Hartmann A; Antonescu CR; Chiosea SI; El-Mofty SK; Geddert H; Iro H; Lewis JS; Märkl B; Mills SE; Riener MO; Robertson T; Sandison A; Semrau S; Simpson RH; Stelow E; Westra WH; Bishop JA
[Ad] Endereço:*Institute of Pathology Departments of ¶Otorhinolaryngology Head and Neck Surgery ¶¶Radiation Therapy, University Hospital of Erlangen, Erlangen ∥Institute of Pathology, St Vincent's Hospital, Karlsruhe **Institute of Pathology, Klinikum Augsburg, Augsburg ‡‡Pathology Laboratory, Frankfurt am Main, Germany †Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ‡Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA §Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St Louis, MO #Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN ††Department of Pathology, University of Virginia, Charlottesville, VA §§Department of Neuropathology, Pathology Queensland, Royal Brisbane Hospitals Campus, Herston, Qld, Australia ∥∥Department of Histopathology, Charing Cross Hospital & Imperial College Healthcare NHS Trust, London, UK ##Department of Anatomical Pathology, University of Calgary, Calgary, AB, Canada ***Departments of Pathology, Otolaryngology-Head and Neck Surgery, and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD.
[Ti] Título:SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity.
[So] Source:Am J Surg Pathol;41(4):458-471, 2017 Apr.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To more fully characterize the clinical and pathologic spectrum of a recently described tumor entity of the sinonasal tract characterized by loss of nuclear expression of SMARCB1 (INI1), we analyzed 39 SMARCB1-deficient sinonasal carcinomas collected from multiple medical centers. The tumors affected 23 males and 16 females with an age range of 19 to 89 years (median, 52). All patients presented with locally advanced disease (T3, n=5; T4, n=27) involving the sinuses (mainly ethmoid) with variable involvement of the nasal cavity. Thirty patients received surgery and/or radiochemotherapy with curative intent. At last follow-up, 56% of patients died of disease 0 to 102 months after diagnosis (median, 15), 2 were alive with disease, and 1 died of an unrelated cause. Only 9 patients (30%) were alive without disease at last follow-up (range, 11 to 115 mo; median, 26). The original diagnosis of retrospectively identified cases was most often sinonasal undifferentiated carcinoma (n=14) and nonkeratinizing/basaloid squamous cell carcinoma (n=5). Histologically, most tumors displayed either a predominantly basaloid (61%) or plasmacytoid/rhabdoid morphology (36%). The plasmacytoid/rhabdoid form consisted of sheets of tumor cells with abundant, eccentrically placed eosinophilic cytoplasm, whereas similar cells were typically rare and singly distributed in the basaloid variant. Glandular differentiation was seen in a few tumors. None of the cases showed squamous differentiation or surface dysplasia. By immunohistochemistry, the tumors were positive for pancytokeratin (97%), CK5 (64%), p63 (55%), and CK7 (48%); and they were negative for NUT (0%). Epstein-Barr virus and high-risk human papillomavirus was not detected by in situ hybridization. Immunohistochemical loss of SMARCB1 (INI1) expression was confirmed for all 39 tumors. Investigation of other proteins in the SWI/SNF complex revealed co-loss of SMARCA2 in 4 cases, but none were SMARCA4 deficient or ARID1A deficient. Of 27 tumors with SMARCB1 fluorescence in situ hybridization analysis, 14 showed homozygous (biallelic) deletions and 7 showed heterozygous (monoallelic) deletions. SMARCB1-deficient sinonasal carcinoma represents an emerging poorly differentiated/undifferentiated sinonasal carcinoma that (1) cannot be better classified as another specific tumor type, (2) has consistent histopathologic findings (albeit with some variability) with varying proportions of plasmacytoid/rhabdoid cells, and (3) demonstrates an aggressive clinical course. This entity should be considered in any difficult-to-classify sinonasal carcinoma, as correct diagnosis will be mandatory for optimizing therapy and for further delineation of this likely underdiagnosed disease.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/deficiência
Carcinoma de Células Escamosas/química
Carcinoma/química
Neoplasias do Seio Maxilar/química
Neoplasias Nasais/química
Seios Paranasais/química
Proteína SMARCB1/deficiência
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/genética
Biópsia
Carcinoma/genética
Carcinoma/patologia
Carcinoma/terapia
Carcinoma de Células Escamosas/genética
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/terapia
Diferenciação Celular
Quimiorradioterapia Adjuvante
Feminino
Alemanha
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Imagem por Ressonância Magnética
Masculino
Neoplasias do Seio Maxilar/genética
Neoplasias do Seio Maxilar/patologia
Neoplasias do Seio Maxilar/terapia
Meia-Idade
Procedimentos Cirúrgicos Nasais
Estadiamento de Neoplasias
Neoplasias Nasais/genética
Neoplasias Nasais/patologia
Neoplasias Nasais/terapia
Seios Paranasais/patologia
Reação em Cadeia da Polimerase
Valor Preditivo dos Testes
Estudos Retrospectivos
Proteína SMARCB1/genética
Fatores de Tempo
Resultado do Tratamento
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (SMARCB1 Protein); 0 (SMARCB1 protein, human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000797


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[PMID]:28069272
[Au] Autor:Laco J; Chmelarová M; Vosmiková H; Sieglová K; Bubancová I; Dundr P; Nemejcová K; Michálek J; Celakovský P; Mottl R; Sirák I; Vosmik M; Ryska A
[Ad] Endereço:The Fingerland Department of Pathology, Charles University, Faculty of Medicine and University Hospital in Hradec Kralove, Czechia. Electronic address: lacoj@lfhk.cuni.cz.
[Ti] Título:SMARCB1/INI1-deficient sinonasal carcinoma shows methylation of RASSF1 gene: A clinicopathological, immunohistochemical and molecular genetic study of a recently described entity.
[So] Source:Pathol Res Pract;213(2):133-142, 2017 Feb.
[Is] ISSN:1618-0631
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of the study was detailed clinicopathological investigation of SMARCB1/INI1-deficient sinonasal carcinomas, including molecular genetic analysis of mutational status and DNA methylation of selected protooncogenes and tumor suppressor genes by means of next generation sequencing (NGS) and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA). A total of 4/56 (7%) cases of SMARCB1/INI1-deficient carcinomas were detected among 56 sinonasal carcinomas diagnosed over a 19year period using immunohistochemical screening. The series comprised 3 males and 1 female, aged 27-76 years (median 64 years). All tumors arose in the nasal cavity. Three neoplasms were diagnosed in advanced stage pT4. During the follow-up period (range 14-111 months (median 72 months)), three tumors recurred locally, but none of the patients developed regional or distant metastases. Ultimately, two patients died due to the tumor. Microscopically, all tumors consisted of infiltrating nests of polygonal basaloid cells with a variable component of rhabdoid cells with eosinophilic cytoplasm. Immunohistochemically, there was almost diffuse expression of cytokeratins (CK), p16, p40 and p63 in all cases, while expression of CK5/6, CK7 and vimentin was only focal or absent. The detection of NUT gave negative results. In three cases, the absence of SMARCB1/INI1 expression was due to deletion of SMARCB1/INI1 gene. Methylation of SMARCB1/INI1 gene was not found. One tumor harbored HPV18 E6/E7 mRNA. All 12 genes (BRAF, BRCA1, BRCA2, KIT, EGFR, KRAS, NRAS, PDGFRA, PIK3CA, PTEN, RET, and ROS1) tested for mutations using NGS were wild-type. Regarding DNA methylation, all four SMARCB1/INI1-deficient tumors showed methylation of RASSF1 gene by means of MS-MLPA. There was a statistically significant difference in RASSF1 gene methylation between SMARCB1/INI1-deficient and SMARCB1/INI1-positive tumors (p=0.0095). All other examined genes (ATM, BRCA1, BRCA2, CADM1, CASP8, CD44, CDKN1B, CDKN2A, CDKN2B, CHFR, DAPK1, ESR1, FHIT, GSTP1, HIC1, KLLN, MLH1a, MLH1b, RARB, and VLH) were unmethylated. In summary, we described four cases of SMARCB1/INI1-deficient sinonasal carcinoma with detailed clinicopathological data indicating that these tumors can be regarded as a distinct entity with aggressive behaviour. For the first time, we performed analysis of DNA methylation in SMARCB1/INI1-deficient sinonasal carcinomas, reporting on significantly higher methylation of RASSF1 gene in this neoplasm.
[Mh] Termos MeSH primário: Carcinoma/genética
Metilação de DNA
Neoplasias do Seio Maxilar/genética
Proteína SMARCB1/genética
Proteínas Supressoras de Tumor/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores Tumorais/genética
Biomarcadores Tumorais/metabolismo
Carcinoma/metabolismo
Carcinoma/patologia
Feminino
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Imuno-Histoquímica
Masculino
Neoplasias do Seio Maxilar/metabolismo
Neoplasias do Seio Maxilar/patologia
Meia-Idade
Estadiamento de Neoplasias
Proteína SMARCB1/metabolismo
Proteínas Supressoras de Tumor/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (RASSF1 protein, human); 0 (SMARCB1 Protein); 0 (Tumor Suppressor Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


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[PMID]:27938440
[Au] Autor:Bhasker S; Mallick S; Benson R; Bhanuprasad V; Sharma A; Thakar A
[Ad] Endereço:Department of Radiation Oncology,All India Institute of Medical Sciences,New Delhi,India.
[Ti] Título:A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience.
[So] Source:J Laryngol Otol;131(1):19-25, 2017 Jan.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sinonasal undifferentiated carcinoma is a rare aggressive tumour arising from the Schneiderian epithelium lining the sinonasal tract. Although considered the cornerstone of therapy, surgical resection can only be performed in a limited number of patients. This report describes the experience of treating sinonasal undifferentiated carcinoma with a multimodality approach. METHOD: The treatment charts of sinonasal undifferentiated carcinoma patients treated at a tertiary care centre from 2004 to 2012 were retrospectively reviewed. RESULTS: A total of 16 sinonasal undifferentiated carcinoma patients with a median age at diagnosis of 47.5 years (range 8-65 years) were included: 19 per cent had neck nodal metastasis at presentation. Four patients (25 per cent) underwent surgery: of these, two had post-operative radiotherapy, one had pre-operative radiotherapy and one had adjuvant chemotherapy alone. Six patients (38 per cent) received definitive radiotherapy: five had received neoadjuvant chemotherapy to reduce tumour size and help in radiotherapy planning, while four (25 per cent) received palliative radiotherapy. The median follow up was 10.4 months (range 1-42.5 months). The estimated median progression-free survival time was 29.3 months. One- and three-year progression-free survival rates were 77 per cent and 41 per cent, respectively. CONCLUSION: Surgery is the best treatment option for sinonasal undifferentiated carcinoma, although most patients require post-operative radiotherapy for advanced disease and close tumour margins. Definitive radiotherapy with or without chemotherapy may be suitable for patients with inoperable locally advanced disease. Elective nodal irradiation to address the high nodal involvement rates should be considered to improve the survival rate.
[Mh] Termos MeSH primário: Carcinoma/terapia
Terapia Combinada/métodos
Neoplasias do Seio Maxilar/terapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Carcinoma/mortalidade
Carcinoma/cirurgia
Quimioterapia Adjuvante
Criança
Feminino
Seres Humanos
Masculino
Neoplasias do Seio Maxilar/mortalidade
Neoplasias do Seio Maxilar/cirurgia
Meia-Idade
Radioterapia Adjuvante
Estudos Retrospectivos
Análise de Sobrevida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27916624
[Au] Autor:Lan J; Huang SC; Chen YH; Chen WC; Jin YT; Lu YC; Chien CY; Huang HY
[Ad] Endereço:Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Niao-Sung, Kaohsiung 833, Taiwan.
[Ti] Título:Primary paranasal sinus clear cell carcinoma with EWSR1-ATF1 fusion: report of 2 molecularly confirmed cases exhibiting unique histopathology.
[So] Source:Hum Pathol;63:139-143, 2017 May.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumor of the salivary glands made up of clear cells that form cords and nests in hyalinized stroma. To date, primary HCCCs of the paranasal sinus have not been described. This article presents 2 cases of HCCC of the maxillary sinus with unusual glandular formation and lymphoplasmacytic stroma in case 1 and a characteristic solid nest pattern and fibrocellular and hyalinized stroma in case 2. Immunohistochemical studies excluded myoepithelial origin and sinonasal renal cell-like adenocarcinomas. Negativity for p63 and p40 in case 1 ruled out a squamous cell origin. Both cases showed a rearranged EWSR1 gene. Reverse-transcription polymerase chain reaction detected EWSR1-ATF1 fusion gene transcripts, and Sanger sequencing confirmed an EWSR1 exon 11 fused in-frame to ATF exon 3.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Carcinoma/genética
Fusão Gênica
Neoplasias do Seio Maxilar/genética
Proteínas de Fusão Oncogênicas/genética
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Biópsia
Carcinoma/química
Carcinoma/patologia
Carcinoma/terapia
Endoscopia
Éxons
Predisposição Genética para Doença
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Masculino
Neoplasias do Seio Maxilar/química
Neoplasias do Seio Maxilar/patologia
Neoplasias do Seio Maxilar/terapia
Meia-Idade
Fenótipo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Análise de Sequência de DNA
Células Estromais/química
Células Estromais/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (EWSR1-ATF1 fusion protein, human); 0 (Oncogene Proteins, Fusion)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27853061
[Au] Autor:Kitahara T; Taoda K; Shibata E; Mori I
[Ad] Endereço:Division of Occupational and Environmental Health, Department of Social Medicine, Shiga University of Medical Science.
[Ti] Título:A Case of Maxillary Cancer Possibly Related to Exposure to Wood Dust and Formaldehyde.
[So] Source:Sangyo Eiseigaku Zasshi;59(1):23-28, 2017 01 31.
[Is] ISSN:1349-533X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/etiologia
Poeira
Formaldeído/efeitos adversos
Neoplasias do Seio Maxilar/etiologia
Doenças Profissionais/etiologia
Exposição Ocupacional/efeitos adversos
Madeira/efeitos adversos
Local de Trabalho
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/diagnóstico
Carcinoma de Células Escamosas/diagnóstico por imagem
Evolução Fatal
Seres Humanos
Masculino
Neoplasias do Seio Maxilar/diagnóstico
Neoplasias do Seio Maxilar/diagnóstico por imagem
Meia-Idade
Doenças Profissionais/diagnóstico
Doenças Profissionais/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dust); 1HG84L3525 (Formaldehyde)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.1539/sangyoeisei.16-008-D


  9 / 1666 MEDLINE  
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[PMID]:27842216
[Au] Autor:Kamochi H; Sarukawa S; Uda H; Nishino H; Yoshimura K
[Ad] Endereço:Research Associate and Attending Physician, Department of Plastic Surgery, Jichi Medical University, Tochigi, Japan. Electronic address: hkamochi@me.com.
[Ti] Título:Orbitomaxillary Reconstruction Using a Combined Latissimus Dorsi Musculocutaneous and Scapular Angle Osseous Flap.
[So] Source:J Oral Maxillofac Surg;75(2):439.e1-439.e6, 2017 Feb.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Immediate reconstruction of orbitomaxillary defects is challenging for head and neck reconstructive surgeons. The primary goals of orbitomaxillary reconstruction are to cover the skin and mucosal defects, fill the defect space, and reconstruct the natural facial contour. This report describes 2 patients who underwent extended orbitomaxillectomy and immediate reconstruction using a combined latissimus dorsi musculocutaneous and scapular angle osseous free flap (LD-SA flap). The LD-SA flap has substantial advantages, such as providing structural support to the malar prominence, filling the large soft tissue defect, and preventing postoperative drooping of the cheek. The surgical technique is relatively straightforward, requires a shorter operative time, and produces less blood loss compared with other reconstruction approaches. The LD-SA flap is a useful option for extended orbitomaxillary defect reconstruction.
[Mh] Termos MeSH primário: Maxila/cirurgia
Retalho Miocutâneo/cirurgia
Órbita/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Escápula/cirurgia
Músculos Superficiais do Dorso/transplante
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/cirurgia
Seres Humanos
Masculino
Neoplasias do Seio Maxilar/cirurgia
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


  10 / 1666 MEDLINE  
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[PMID]:27816363
[Au] Autor:Wu RY; Liu K; Wang WH; Jin J; Song YW; Wang SL; Liu YP; Ren H; Fang H; Liu QF; Yang Y; Chen B; Qi SN; Lu NN; Tang Y; Tang Y; Li N; Ouyang H; Li YX
[Ad] Endereço:Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
[Ti] Título:Patterns of Primary Tumor Invasion and Regional Lymph Node Spread Based on Magnetic Resonance Imaging in Early-Stage Nasal NK/T-cell Lymphoma: Implications for Clinical Target Volume Definition and Prognostic Significance.
[So] Source:Int J Radiat Oncol Biol Phys;97(1):50-59, 2017 Jan 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study aimed to determine the pathways of primary tumor invasion (PTI) and regional lymph node (LN) spread based on magnetic resonance imaging (MRI) in early-stage nasal NK/T-cell lymphoma (NKTCL), to improve clinical target volume (CTV) delineation and evaluate the prognostic value of locoregional extension patterns. METHODS AND MATERIALS: A total of 105 patients with newly diagnosed early-stage nasal NKTCL who underwent pretreatment MRI were retrospectively reviewed. All patients received radiation therapy with or without chemotherapy. RESULTS: The incidences of PTI and regional LN involvement were 64.7% and 25.7%, respectively. Based on the incidence of PTI, involved sites surrounding the nasal cavity were classified into 3 risk subgroups: high-risk (>20%), intermediate-risk (5%-20%), and low-risk (<5%). The most frequently involved site was the nasopharynx (35.2%), followed by the maxillary (21.9%) and ethmoid (21.9%) sinuses. Local disease and regional LN spread followed an orderly pattern without LN skipping. The retropharyngeal nodes (RPNs) were most frequently involved (19.0%), followed by level II (11.4%). The 5-year overall survival (OS), progression-free survival (PFS), and locoregional control (LRC) rates for all patients were 72.8%, 65.2%, and 90.0%, respectively. The presence of PTI and regional LN involvement based on MRI significantly and negatively affected PFS and OS. CONCLUSIONS: Early-stage nasal NKTCL presents with a high incidence of PTI but a relatively low incidence of regional LN spread. Locoregional spread followed an orderly pattern, and PTI and regional LN spread are powerful prognostic factors for poorer survival outcomes. CTV reduction may be feasible for selected patients.
[Mh] Termos MeSH primário: Linfoma Extranodal de Células T-NK/patologia
Imagem por Ressonância Magnética
Neoplasias Nasais/patologia
[Mh] Termos MeSH secundário: Adulto
Intervalo Livre de Doença
Seio Etmoidal/diagnóstico por imagem
Seio Etmoidal/patologia
Feminino
Seres Humanos
Metástase Linfática
Linfoma Extranodal de Células T-NK/diagnóstico por imagem
Linfoma Extranodal de Células T-NK/mortalidade
Masculino
Neoplasias do Seio Maxilar/diagnóstico por imagem
Neoplasias do Seio Maxilar/patologia
Meia-Idade
Neoplasias Nasofaríngeas/diagnóstico por imagem
Neoplasias Nasofaríngeas/patologia
Invasividade Neoplásica
Recidiva Local de Neoplasia
Neoplasias Nasais/diagnóstico por imagem
Neoplasias dos Seios Paranasais/diagnóstico por imagem
Neoplasias dos Seios Paranasais/patologia
Prognóstico
Radioterapia Conformacional
Radioterapia de Intensidade Modulada
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE



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