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  1 / 2264 MEDLINE  
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[PMID]:29443738
[Au] Autor:Qin Y; Lu L; Lu Y; Yang K
[Ad] Endereço:Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
[Ti] Título:Hodgkin lymphoma involving the tonsil misdiagnosed as tonsillar carcinoma: A case report and review of the literature.
[So] Source:Medicine (Baltimore);97(7):e9761, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary Hodgkin lymphoma (HL) involving the tonsil is extremely rare. Only about 20 such cases with verification of biopsy and immunohistochemistry have been reported. Because of its rarity and unremarkable clinical presentation, a timely correct diagnosis is very challenging. PATIENT CONCERNS: A 43-year-old man complained left tonsillar enlargement and painless masses in left neck, with night sweat. The clinical examination found a marked tonsillar asymmetry, with an enlarged left tonsil and ipsilateral cervical lymphadenopathy and a normal right tonsil. DIAGNOSIS: The patient was initially regarded as tonsillar lymphoepithelial carcinoma. INTERVENTIONS: The patient received a resection of left tonsil and left cervical masses and then was definitively diagnosed as HL (IIEB). He was managed by 6 cycles of chemotherapy (adriamycin, bleomycin, vinblastine, and dacarbazine) and radiotherapy to the Waldeyer ring. OUTCOMES: The patient has been disease free for more than 3 years after diagnosis. LESSONS: As the reason of an extreme rare occurrence of HL involving the tonsil, doctors can easily misdiagnose the disease as tonsillar lymphoepithelial carcinoma. This case serves as a reminder important role of biopsy.
[Mh] Termos MeSH primário: Carcinoma/diagnóstico
Erros de Diagnóstico
Doença de Hodgkin/diagnóstico
Neoplasias Tonsilares/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Doença de Hodgkin/tratamento farmacológico
Seres Humanos
Masculino
Tonsila Palatina/patologia
Tonsila Palatina/cirurgia
Neoplasias Tonsilares/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009761


  2 / 2264 MEDLINE  
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[PMID]:29338018
[Au] Autor:Marcussen M; Sønderkær M; Bødker JS; Andersen M; Nielsen S; Vesteghem C; Christiansen I; Bergmann OJ; Bøgsted M; Dybkær K; Vyberg M; Johnsen HE
[Ad] Endereço:Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
[Ti] Título:Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma.
[So] Source:PLoS One;13(1):e0190709, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Radiation-therapy (RT) induces mucositis, a clinically challenging condition with limited prophylactic interventions and no predictive tests. In this pilot study, we applied global gene-expression analysis on serial human oral mucosa tissue and blood cells from patients with tonsil squamous cell cancer (TSCC) to identify genes involved in mucositis pathogenesis. METHODS AND FINDINGS: Eight patients with TSCC each provided consecutive buccal biopsies and blood cells before, after 7 days of RT treatment, and 20 days following RT. We monitored clinical mucositis and performed gene-expression analysis on tissue samples. We obtained control tissue from nine healthy individuals. After RT, expression was upregulated in apoptosis inducer and inhibitor genes, EDA2R and MDM2, and in POLH, a DNA-repair polymerase. Expression was downregulated in six members of the histone cluster family, e.g., HIST1H3B. Gene expression related to proliferation and differentiation was altered, including MKI67 (downregulated), which encodes the Ki-67-proliferation marker, and KRT16 (upregulated), which encodes keratin16. These alterations were not associated with the clinical mucositis grade. However, the expression of LY6G6C, which encodes a surface immunoregulatory protein, was upregulated before treatment in three cases of clinical none/mild mucositis, but not in four cases of ulcerative mucositis. CONCLUSION: RT caused molecular changes related to apoptosis, DNA-damage, DNA-repair, and proliferation without a correlation to the severity of clinical mucositis. LY6G6C may be a potential protective biomarker for ulcerative mucositis. Based on these results, our study model of consecutive human biopsies will be useful in designing a prospective clinical validation trial to characterize molecular mucositis and identify predictive biomarkers.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/genética
Perfilação da Expressão Gênica
Mucosa Bucal/metabolismo
Neoplasias Tonsilares/genética
[Mh] Termos MeSH secundário: Idoso
Carcinoma de Células Escamosas/radioterapia
Dano ao DNA
Reparo do DNA
Feminino
Seres Humanos
Meia-Idade
Neoplasias Tonsilares/radioterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190709


  3 / 2264 MEDLINE  
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[PMID]:27776338
[Au] Autor:Hong AM; Vilain RE; Romanes S; Yang J; Smith E; Jones D; Scolyer RA; Lee CS; Zhang M; Rose B
[Ad] Endereço:Sydney Medical School, The University of Sydney, NSW, Australia.
[Ti] Título:PD-L1 expression in tonsillar cancer is associated with human papillomavirus positivity and improved survival: implications for anti-PD1 clinical trials.
[So] Source:Oncotarget;7(47):77010-77020, 2016 Nov 22.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, we examined PD-L1 expression by immunohistochemistry in 99 patients with tonsillar cancer and known human papillomavirus (HPV) status to assess its clinical significance. We showed that the pattern of PD-L1 expression is strongly related to HPV status. The PD-L1 positivity rate was 83.3% in HPV-positive cases and 56.9% in HPV-negative cases (p < 0.05). Patients with HPV-positive/PD-L1-positive cancer had significantly better event free survival and overall survival compared with patients with HPV-negative/PD-L1-negative cancer. Relative to those patients with HPV-negative/PD-L1-negative disease who had the highest risk of death, patients with HPV-positive/PD-L1-positive cancers had a 2.85 fold lower risk of developing an event (HR 0.35, 95% CI: 0.16-0.79) and a 4.5 fold lower risk of death (HR =0.22, 95% CI: 0.09-0.53). Our findings will help to guide future clinical trial design in immunotherapy based on PD-L1 expression in tonsillar cancer.
[Mh] Termos MeSH primário: Antígeno B7-H1/metabolismo
Infecções por Papillomavirus/metabolismo
Neoplasias Tonsilares/metabolismo
Neoplasias Tonsilares/virologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Linfócitos do Interstício Tumoral
Masculino
Meia-Idade
Infecções por Papillomavirus/patologia
Prognóstico
Fumar/metabolismo
Análise de Sobrevida
Neoplasias Tonsilares/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-H1 Antigen); 0 (CD274 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.12776


  4 / 2264 MEDLINE  
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[PMID]:29277098
[Au] Autor:Pham TA; Berkowitz RG
[Ad] Endereço:1 Department of Otolaryngology, Royal Children's Hospital, Melbourne, VIC, Australia.
[Ti] Título:Targeted Tonsillar Biopsy for Unilateral Tonsillar Enlargement.
[So] Source:Ann Otol Rhinol Laryngol;127(2):113-117, 2018 Feb.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Unilateral tonsillar enlargement (UTE) is not an uncommon incidental finding. Lymphoma is the most common malignancy of the tonsils in children and presents with tonsillar enlargement. METHODS: This is a retrospective case series of all cases of histopathological analysis of tonsillectomy specimens at a single pediatric tertiary hospital between 1996 and 2015. Patients either had a preoperative indication (n = 53) for pathological testing or indications based on intraoperative findings (n = 88). Of the preoperative group, 17 patients had tonsillectomy for UTE alone. In 72% of cases, the side of perceived unilateral enlargement was confirmed at histopathological assessment. RESULTS: Zero cases of suspected malignancy were identified on testing. CONCLUSION: There is a very low prevalence of unsuspected and suspected malignancy in routine and targeted examination of tonsillar specimens. It is reasonable to test based on other clinical findings and risk factors such as immunosuppression.
[Mh] Termos MeSH primário: Biópsia/métodos
Tonsila Palatina/patologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Diagnóstico Diferencial
Feminino
Seres Humanos
Hipertrofia/patologia
Hipertrofia/cirurgia
Achados Incidentais
Lactente
Linfoma/patologia
Masculino
Estudos Retrospectivos
Neoplasias Tonsilares/patologia
Tonsilectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417749252


  5 / 2264 MEDLINE  
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[PMID]:29245278
[Au] Autor:Wu Y; Zhu Z; Chen Y; Chai Y
[Ad] Endereço:Department of Thoracic Surgery, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
[Ti] Título:Tonsillar metastasis of nonsmall cell lung cancer with G719S mutation in exon 18: A case report.
[So] Source:Medicine (Baltimore);96(49):e9003, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Lung cancer has the highest mortality of all malignant tumors and is becoming the leading cause of death in China. Surgical resection is the best treatment for early non-small-cell lung carcinoma. But postoperative tumor recurrence is very common. Brain, bone and liver are the most common metastatic sites of lung cancer. PATIENT CONCERNS: A 59-year-old woman was admitted to our hospital finding a lung nodule in physical examination. No other obvious symptoms were obsessed in this patient. No remarkable abnormality was detected in preoperative laboratory tests and physical examination. DIAGNOSES: A ground-glass nodule was detected on the left inferior lobe in the imaging examination. No metastases were detected before the surgery and early-stage lung cancer was supposed. INTERVENTION: This patient underwent a radical resection of lung cancer successfully and enjoyed a peaceful postoperative rehabilitation. OUTCOMES: Although pathological diagnosed confirmed early stage lung adenocarcinoma (T1N0M0). The patient had tumor recurrence 7 months after operation. Gene sequencing confirmed the G719S mutation in exon 18 of the EGFR gene and target therapy, chemotherapy and radiotherapy were all given to this patient successively, but they were all unresponsive. The patient died 26 months after surgery. LESSONS: We herein first report G719S mutation in lung adenocarcinoma with tonsillar metastasis. Generally, the tumor responded poorly to treatment and progressed quickly, which didn't achieve the desired effect. G719S mutant is supposed to be the cause of poor responsive to treatment.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/patologia
Genes erbB-1/genética
Neoplasias Pulmonares/patologia
Neoplasias Tonsilares/secundário
[Mh] Termos MeSH secundário: Carcinoma Pulmonar de Células não Pequenas/genética
Carcinoma Pulmonar de Células não Pequenas/terapia
China
Feminino
Seres Humanos
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/terapia
Meia-Idade
Neoplasias Tonsilares/genética
Neoplasias Tonsilares/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009003


  6 / 2264 MEDLINE  
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[PMID]:29100961
[Au] Autor:Hoffmann M; Quabius ES; Tribius S; Gebhardt S; Görögh T; Hedderich J; Huber K; Dunst J; Ambrosch P
[Ad] Endereço:Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel, D-24105 Kiel, Germany. Electronic address: markus.hoffmann@uksh.de.
[Ti] Título:Influence of HPV-status on survival of patients with tonsillar carcinomas (TSCC) treated by CO -laser surgery plus risk adapted therapy - A 10 year retrospective single centre study.
[So] Source:Cancer Lett;413:59-68, 2018 Jan 28.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The positive prognostic value of HPV-infections in oropharyngeal squamous cell cancer (OSCC) patients has led to the initiation of prospective clinical trials testing the value of treatment de-escalation. It is unclear how to define patients potentially benefiting from de-escalated treatment, whether a positive smoking history impacts survival data and what kind of de-escalation might be best. Here, we investigate the effect of HPV-status, smoking habit and treatment design on overall survival (OS) and progression free survival (PFS) of 126 patients with tonsillar SCC (TSCC) who underwent CO -laser-surgery and risk adapted adjuvant treatment. HPV-DNA-, HPV-mRNA-, and p16 -expression were analysed and results were correlated to OS and PFS. Factors tested for prognostic value included HPV-status, p16 -protein expression, therapy and smoking habit. Log rank test and p-values ≤0.05 defined significant differences between groups. The highest accuracy of data with highest significance in this study is given when the HPV-RNA-status is considered. Using p16 -expression alone or in combination with HPV-DNA-status, would have misclassified 23 and 7 patients, respectively. Smoking fully abrogates the positive impact of HPV-infection in TSCC on survival. Non-smoking HPV-positive TSCC patients show 10-year OS of 100% and 90.9% PFS when treated with adjuvant RCT. The presented data show that high-precision HPV-detection methods are needed, specifically when treatment decisions are based on the results. Furthermore, smoking habit should be included in all studies and clinical trials testing HPV-associated survival. Adjuvant RCT especially for HPV-positive non-smokers may help to avoid distant failure.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/cirurgia
Neoplasias de Cabeça e Pescoço/cirurgia
Terapia a Laser/instrumentação
Lasers de Gás/uso terapêutico
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/virologia
Neoplasias Tonsilares/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Carcinoma de Células Escamosas/química
Carcinoma de Células Escamosas/mortalidade
Carcinoma de Células Escamosas/virologia
Quimiorradioterapia Adjuvante
Inibidor p16 de Quinase Dependente de Ciclina/análise
DNA Viral/genética
Progressão da Doença
Intervalo Livre de Doença
Feminino
Neoplasias de Cabeça e Pescoço/química
Neoplasias de Cabeça e Pescoço/mortalidade
Neoplasias de Cabeça e Pescoço/virologia
Testes de DNA para Papilomavírus Humano
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Terapia a Laser/efeitos adversos
Terapia a Laser/mortalidade
Lasers de Gás/efeitos adversos
Masculino
Meia-Idade
Esvaziamento Cervical
Papillomaviridae/genética
Infecções por Papillomavirus/diagnóstico
Valor Preditivo dos Testes
Modelos de Riscos Proporcionais
RNA Mensageiro/genética
RNA Viral/genética
Radioterapia Adjuvante
Estudos Retrospectivos
Fatores de Risco
Fumar/efeitos adversos
Fumar/mortalidade
Fatores de Tempo
Neoplasias Tonsilares/química
Neoplasias Tonsilares/mortalidade
Neoplasias Tonsilares/virologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cyclin-Dependent Kinase Inhibitor p16); 0 (DNA, Viral); 0 (P16 protein, human); 0 (RNA, Messenger); 0 (RNA, Viral)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171105
[St] Status:MEDLINE


  7 / 2264 MEDLINE  
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[PMID]:28982840
[Au] Autor:Näsman A; Bersani C; Lindquist D; Du J; Ramqvist T; Dalianis T
[Ad] Endereço:Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
[Ti] Título:Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma.
[So] Source:Anticancer Res;37(10):5319-5328, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Human papillomavirus (HPV)-positive tonsillar- and base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negative cancer and most other head and neck cancers with around 80% 3-year disease free survival with conventional radiotherapy and surgery. Consequently, most HPV-positive cancer patients may not require the intensified chemoradiotherapy given to many head and neck cancer patients and would, with tapered treatment, avoid several severe side-effects. Moreover, intensified therapy has not improved survival and treatment alternatives are needed. To identify patients eligible for tapered or targeted therapy, additional biomarkers are required. Several studies have, therefore, focused on finding predictive markers, some of which are also potentially targetable. To conclude, better-tailored therapy, either as tapered or targeted, is important for increasing numbers of patients with HPV-positive tonsillar- and base of tongue cancer. This review deals with some of these issues and presents some promising markers.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Carcinoma de Células Escamosas/metabolismo
Neoplasias de Cabeça e Pescoço/metabolismo
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/complicações
Neoplasias da Língua/metabolismo
Neoplasias Tonsilares/metabolismo
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/genética
Carcinoma de Células Escamosas/genética
Carcinoma de Células Escamosas/terapia
Carcinoma de Células Escamosas/virologia
Neoplasias de Cabeça e Pescoço/genética
Neoplasias de Cabeça e Pescoço/terapia
Neoplasias de Cabeça e Pescoço/virologia
Testes de DNA para Papilomavírus Humano
Seres Humanos
Estadiamento de Neoplasias
Células-Tronco Neoplásicas/metabolismo
Células-Tronco Neoplásicas/virologia
Papillomaviridae/classificação
Papillomaviridae/genética
Infecções por Papillomavirus/terapia
Infecções por Papillomavirus/virologia
Seleção de Pacientes
Valor Preditivo dos Testes
Neoplasias da Língua/genética
Neoplasias da Língua/terapia
Neoplasias da Língua/virologia
Neoplasias Tonsilares/genética
Neoplasias Tonsilares/terapia
Neoplasias Tonsilares/virologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  8 / 2264 MEDLINE  
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[PMID]:28926591
[Au] Autor:Wilms T; Khan G; Coates PJ; Sgaramella N; Fåhraeus R; Hassani A; Philip PS; Norberg Spaak L; Califano L; Colella G; Olofsson K; Loizou C; Franco R; Nylander K
[Ad] Endereço:Department of Clinical Sciences/ENT, Umeå University, Umeå, Sweden.
[Ti] Título:No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue.
[So] Source:PLoS One;12(9):e0184201, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongue is the most common site for tumour development. The incidence of tongue squamous cell carcinoma (TSCC) is increasing in younger people, which has been suggested to associate with a viral aetiology. Two common human oncogenic viruses, human papilloma virus (HPV) and Epstein-Barr virus (EBV) are known causes of certain types of SCCHN, namely the oropharynx and nasopharynx, respectively. EBV infects most adults worldwide through oral transmission and establishes a latent infection, with sporadic productive viral replication and release of virus in the oral cavity throughout life. In view of the prevalence of EBV in the oral cavity and recent data indicating that it infects tongue epithelial cells and establishes latency, we examined 98 cases of primary squamous cell carcinoma of the mobile tongue and 15 cases of tonsillar squamous cell carcinoma for the presence of EBV-encoded RNAs (EBERs), EBV DNA and an EBV-encoded protein, EBNA-1. A commercially available in situ hybridisation kit targeting EBER transcripts (EBER-ISH) showed a positive signal in the cytoplasm and/or nuclei of tumour cells in 43% of TSCCs. However, application of control probes and RNase A digestion using in-house developed EBER-ISH showed identical EBER staining patterns, indicating non-specific signals. PCR analysis of the BamH1 W repeat sequences did not identify EBV genomes in tumour samples. Immunohistochemistry for EBNA-1 was also negative. These data exclude EBV as a potential player in TSCC in both old and young patients and highlight the importance of appropriate controls for EBER-ISH in investigating EBV in human diseases.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/virologia
Herpesvirus Humano 4/genética
Neoplasias da Língua/virologia
Neoplasias Tonsilares/virologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma de Células Escamosas/patologia
DNA Viral/análise
DNA Viral/metabolismo
Antígenos Nucleares do Vírus Epstein-Barr/genética
Antígenos Nucleares do Vírus Epstein-Barr/metabolismo
Herpesvirus Humano 4/isolamento & purificação
Seres Humanos
Imuno-Histoquímica
Hibridização In Situ
Meia-Idade
Reação em Cadeia da Polimerase
Neoplasias da Língua/patologia
Neoplasias Tonsilares/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (EBV-encoded nuclear antigen 1); 0 (Epstein-Barr Virus Nuclear Antigens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184201


  9 / 2264 MEDLINE  
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[PMID]:28669307
[Au] Autor:Roden DF; Schreiber D; Givi B
[Ad] Endereço:1 Department of Otolaryngology-Head and Neck Surgery, New York University, New York, NY, USA.
[Ti] Título:Multimodality Treatment of Early-Stage Tonsil Cancer.
[So] Source:Otolaryngol Head Neck Surg;157(1):62-68, 2017 Jul.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective Compare survival outcomes between unimodality and multimodality treatments for early-stage tonsil squamous cell carcinoma (SCC). Study Design and Setting Review of the National Cancer Database. Subjects and Methods Patients were selected if they were <70 years old with clinical stage I-II SCC of the tonsil, as documented in the National Cancer Database from 1998 to 2011. Palliative and nonstandard treatments were excluded. Propensity score matching was performed, controlling for tumor stage, age, race, comorbidity, insurance status, and year of diagnosis. Overall survival (OS) was compared with the Kaplan-Meier method and log-rank test. Results We identified 3247 patients. Radiotherapy (RT) was delivered in 1295 patients (39.9%), surgery in 824 (25.4%), and surgery + RT in 1128 (34.7%). Patients treated with surgery + RT had the highest 5-year OS (81.1%), followed by surgery (67.4%) and RT (63.4%; P < .001). In a propensity score-matched subpopulation of 2378 patients, the 5-year OS was 78.8% for surgery + RT, 66.7% for surgery, and 64.5% for RT ( P < .001). Among patients who underwent surgical tonsillectomy plus elective neck dissection and/or adjuvant RT, the 5-year OS was equal ( P = .29), and all were superior to RT alone ( P < .001). Conclusion Multimodality treatment is associated with the greatest survival in early-stage tonsil cancer. The addition of tonsillectomy to RT confers a 20% increase in survival. The current guidelines might not offer the most effective treatment. An up-front surgical approach, followed by appropriately selected adjuvant therapy, may result in improved survival for early-stage tonsil SCC. These findings merit investigation in a prospective clinical trial.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/terapia
Terapia Combinada
Neoplasias Tonsilares/terapia
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Esvaziamento Cervical
Estadiamento de Neoplasias
Pontuação de Propensão
Radiocirurgia
Radioterapia Adjuvante
Taxa de Sobrevida
Neoplasias Tonsilares/patologia
Tonsilectomia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817696290


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[PMID]:28644855
[Au] Autor:Vojtechova Z; Zavadil J; Klozar J; Grega M; Tachezy R
[Ad] Endereço:Department of Genetics and Microbiology, Faculty of Science, Charles University, Prague, Czech Republic.
[Ti] Título:Comparison of the miRNA expression profiles in fresh frozen and formalin-fixed paraffin-embedded tonsillar tumors.
[So] Source:PLoS One;12(6):e0179645, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:MicroRNAs are considered as promising prognostic and diagnostic biomarkers of human cancer since their profiles differ between tumor types. Most of the tumor profiling studies were performed on rarely available fresh frozen (FF) samples. Alternatively, archived formalin-fixed paraffin-embedded (FFPE) tissue samples are also well applicable to larger-scale retrospective miRNA profiling studies. The aim of this study was to perform systematic comparison of the miRNA expression profiles between FF and macrodissected FFPE tonsillar tumors using the TaqMan Low Density Array system, with the data processed by different software programs and two types of normalization methods. We observed a marked correlation between the miRNA expression profiles of paired FF and FFPE samples; however, only 27-38% of the differentially deregulated miRNAs overlapped between the two source systems. The comparison of the results with regard to the distinct modes of data normalization revealed an overlap in 58-67% of differentially expressed miRNAs, with no influence of the choice of software platform. Our study highlights the fact that for an accurate comparison of the miRNA expression profiles from published studies, it is important to use the same type of clinical material and to test and select the best-performing normalization method for data analysis.
[Mh] Termos MeSH primário: Criopreservação
MicroRNAs/metabolismo
Inclusão em Parafina
Neoplasias Tonsilares/metabolismo
[Mh] Termos MeSH secundário: Fixadores
Formaldeído
Perfilação da Expressão Gênica
Seres Humanos
Análise em Microsséries
Tonsila Palatina/metabolismo
Análise de Componente Principal
Processamento de Sinais Assistido por Computador
Software
Fixação de Tecidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fixatives); 0 (MicroRNAs); 1HG84L3525 (Formaldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179645



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