[PMID]: | 28727518 |
[Au] Autor: | Lassaletta A; Zapotocky M; Mistry M; Ramaswamy V; Honnorat M; Krishnatry R; Guerreiro Stucklin A; Zhukova N; Arnoldo A; Ryall S; Ling C; McKeown T; Loukides J; Cruz O; de Torres C; Ho CY; Packer RJ; Tatevossian R; Qaddoumi I; Harreld JH; Dalton JD; Mulcahy-Levy J; Foreman N; Karajannis MA; Wang S; Snuderl M; Nageswara Rao A; Giannini C; Kieran M; Ligon KL; Garre ML; Nozza P; Mascelli S; Raso A; Mueller S; Nicolaides T; Silva K; Perbet R; Vasiljevic A; Faure Conter C; Frappaz D; Leary S; Crane C; Chan A; Ng HK; Shi ZF; Mao Y; Finch E; Eisenstat D; Wilson B |
[Ad] Endereço: | Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie H |
[Ti] Título: | Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas. |
[So] Source: | J Clin Oncol;35(25):2934-2941, 2017 Sep 01. |
[Is] ISSN: | 1527-7755 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown. Patients and Methods A combined clinical and genetic institutional study of patients with PLGGs with long-term follow-up was performed (N = 510). Clinical and treatment data of patients with BRAF V600E mutated PLGG (n = 99) were compared with a large international independent cohort of patients with BRAF V600E mutated-PLGG (n = 180). Results BRAF V600E mutation was detected in 69 of 405 patients (17%) with PLGG across a broad spectrum of histologies and sites, including midline locations, which are not often routinely biopsied in clinical practice. Patients with BRAF V600E PLGG exhibited poor outcomes after chemotherapy and radiation therapies that resulted in a 10-year progression-free survival of 27% (95% CI, 12.1% to 41.9%) and 60.2% (95% CI, 53.3% to 67.1%) for BRAF V600E and wild-type PLGG, respectively ( P < .001). Additional multivariable clinical and molecular stratification revealed that the extent of resection and CDKN2A deletion contributed independently to poor outcome in BRAF V600E PLGG. A similar independent role for CDKN2A and resection on outcome were observed in the independent cohort. Quantitative imaging analysis revealed progressive disease and a lack of response to conventional chemotherapy in most patients with BRAF V600E PLGG. Conclusion BRAF V600E PLGG constitutes a distinct entity with poor prognosis when treated with current adjuvant therapy. |
[Mh] Termos MeSH primário: |
Neoplasias Encefálicas/enzimologia Glioma/enzimologia Proteínas Proto-Oncogênicas B-raf/genética
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[Mh] Termos MeSH secundário: |
Adolescente Neoplasias Encefálicas/genética Neoplasias Encefálicas/patologia Neoplasias Encefálicas/terapia Neoplasias do Tronco Encefálico/enzimologia Neoplasias do Tronco Encefálico/genética Neoplasias do Tronco Encefálico/patologia Neoplasias do Tronco Encefálico/terapia Criança Pré-Escolar Estudos de Coortes Diencéfalo/enzimologia Diencéfalo/patologia Feminino Glioma/genética Glioma/patologia Glioma/terapia Seres Humanos Lactente Masculino Mutação Gradação de Tumores Prognóstico
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| EC 2.7.11.1 (BRAF protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf) |
[Em] Mês de entrada: | 1709 |
[Cu] Atualização por classe: | 170915 |
[Lr] Data última revisão:
| 170915 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170721 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1200/JCO.2016.71.8726 |
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