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[PMID]:29400039
[Au] Autor:Plantier D; Gusmão de Araújo J; Portmann D; Guindi S
[Ti] Título:Cholesteatoma and osteoradionecrosis after radio­therapy of the temporal bone: Surgical aspects.
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(4):163-5, 2015.
[Is] ISSN:0035-1334
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Introduction: The treatment for head and neck cancer with radiotherapy can cause different alterations of the auditory system. We report two cases of chronic otitis of the external and middle ear secondary to osteoradionecrosis of the temporal bone. This article aims to report the experience of the surgical approach in such condition. Cases report: The first patient was treated with radiotherapy in his childhood for a cerebellar tumor. He developed years later a cholesteatoma which invaded the mastoid cavities through a destruction of the external auditory canal. The second was treated for a malignant parotid tumour 15 years before by surgery and radiotherapy. She developed a chronic otorrhea with a partial destruction of the bony external auditory canal. Both patients were treated by surgery with reconstruction including bone, cartilage, fascia and skin grafts. The outcome was good in both cases. Osteo­radio­necrosis of the temporal bone is a rare but serious complication of radiotherapy for head and neck cancer. This complication can occur even many years after the treatment. Our two cases demonstrate a way to solve this pathology. A long term supervision with regular cares is essential in order to get a good healing. Due to the improvement of the radiation therapy we could expect less complications of this type in the future.
[Mh] Termos MeSH primário: Colesteatoma da Orelha Média/etiologia
Osteorradionecrose/etiologia
Radioterapia/efeitos adversos
Osso Temporal/patologia
[Mh] Termos MeSH secundário: Adulto
Neoplasias Cerebelares/radioterapia
Colesteatoma da Orelha Média/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Osteorradionecrose/cirurgia
Neoplasias Parotídeas/radioterapia
Osso Temporal/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


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[PMID]:29480846
[Au] Autor:Cai J; Li W; Du J; Xu N; Gao P; Zhou J; Li X
[Ad] Endereço:Department of Radiology, Beijing Tiantan Hospital affiliated to Capital Medical University.
[Ti] Título:Supratentorial intracerebral cerebellar liponeurocytoma: A case report and literature review.
[So] Source:Medicine (Baltimore);97(2):e9556, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cerebellar liponeurocytoma is a rare tumor of the central nervous system (CNS) characterized by low proliferation but high likelihood of recurrence. Because of its rarity and the paucity of systematic follow-up, the biological behaviors and clinical features of this tumor are still poorly understood. We herein reported a case of cerebellar liponeurocytoma originating in the cerebral hemisphere. PATIENT CONCERNS: A 11-year-old male with intermittent headache, nausea, and vomiting. The first computed tomography revealed a large mass in the right cerebral hemisphere. He was transferred to our institution for neurosurgical treatment. DIAGNOSIS: Magnetic resonance imaging showed a large cystic-solid mass in the right frontal lobe with obvious contrast enhancement. Histopathological examinations showed sheets of isomorphic small neoplastic cells with clear cytoplasm and focal lipomatous differentiation. On immunohistochemistry, tumor cells were positive for synaptophysin, microtubule-associated protein 2, and neuronal nuclei antigen. INTERVENTIONS: The patient was performed a right fronto-parietal craniotomy, and gross total resection of the tumor was achieved without adjuvant therapy. OUTCOMES: No clinical or neuroradiological evidence of recurrence or residual of the tumor was found 6 years and 2 months after initial surgery. LESSONS: Cerebellar liponeurocytoma developing in supratentorial cerebral hemisphere was first reported in the present study. The radiological and histopathological features may be useful in differentiating this rare tumor from other tumors at similar locations. A change in the nomenclature of cerebellar liponeurocytomas should be considered in future World Health Organization (WHO) classifications.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/diagnóstico por imagem
Neoplasias Cerebelares/cirurgia
Neurocitoma/diagnóstico por imagem
Neurocitoma/cirurgia
Neoplasias Supratentoriais/diagnóstico por imagem
Neoplasias Supratentoriais/cirurgia
[Mh] Termos MeSH secundário: Neoplasias Cerebelares/patologia
Criança
Diagnóstico Diferencial
Seres Humanos
Masculino
Neurocitoma/patologia
Neoplasias Supratentoriais/patologia
Terminologia como Assunto
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009556


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[PMID]:28463155
[Au] Autor:Nanda RH; Ganju RG; Schreibmann E; Chen Z; Zhang C; Jegadeesh N; Cassidy R; Deng C; Eaton BR; Esiashvili N
[Ad] Endereço:Department of Radiation Oncology, Winship Cancer Institute, Emory University College of Medicine, Atlanta, Georgia. Electronic address: rhazari@emory.edu.
[Ti] Título:Correlation of Acute and Late Brainstem Toxicities With Dose-Volume Data for Pediatric Patients With Posterior Fossa Malignancies.
[So] Source:Int J Radiat Oncol Biol Phys;98(2):360-366, 2017 06 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Radiation-induced brainstem toxicity after treatment of pediatric posterior fossa malignancies is incompletely understood, especially in the era of intensity modulated radiation therapy (IMRT). The rates of, and predictive factors for, brainstem toxicity after photon RT for posterior fossa tumors were examined. METHODS AND MATERIALS: After institutional review board approval, 60 pediatric patients treated at our institution for nonmetastatic infratentorial ependymoma and medulloblastoma with IMRT were included in the present analysis. Dosimetric variables, including the mean and maximum dose to the brainstem, the dose to 10% to 90% of the brainstem (in 10% increments), and the volume of the brainstem receiving 40, 45, 50, and 55 Gy were recorded for each patient. Acute (onset within 3 months) and late (>3 months of RT completion) RT-induced brainstem toxicities with clinical and radiographic correlates were scored using Common Terminology Criteria for Adverse Events, version 4.0. RESULTS: Patients aged 1.4 to 21.8 years underwent IMRT or volumetric arc therapy postoperatively to the posterior fossa or tumor bed. At a median clinical follow-up period of 2.8 years, 14 patients had developed symptomatic brainstem toxicity (crude incidence 23.3%). No correlation was found between the dosimetric variables examined and brainstem toxicity. Vascular injury or ischemia showed a strong trend toward predicting brainstem toxicity (P=.054). Patients with grade 3 to 5 brainstem toxicity had undergone treatment to significant volumes of the posterior fossa. CONCLUSION: The results of the present series demonstrate a low, but not negligible, risk of brainstem radiation necrosis for pediatric patients with posterior fossa malignancies treated with IMRT. No specific dose-volume correlations were identified; however, modern treatment volumes might help limit the incidence of severe toxicity. Additional work investigating inherent biologic sensitivity might also provide further insight into this clinical problem.
[Mh] Termos MeSH primário: Tronco Encefálico/efeitos da radiação
Neoplasias Cerebelares/radioterapia
Ependimoma/radioterapia
Neoplasias Infratentoriais/radioterapia
Meduloblastoma/radioterapia
Lesões por Radiação/patologia
Radioterapia de Intensidade Modulada/efeitos adversos
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Tronco Encefálico/patologia
Neoplasias Cerebelares/patologia
Neoplasias Cerebelares/cirurgia
Criança
Pré-Escolar
Ependimoma/patologia
Ependimoma/cirurgia
Feminino
Seguimentos
Seres Humanos
Lactente
Neoplasias Infratentoriais/patologia
Neoplasias Infratentoriais/cirurgia
Masculino
Meduloblastoma/patologia
Meduloblastoma/cirurgia
Necrose/etiologia
Dosagem Radioterapêutica
Radioterapia de Intensidade Modulada/métodos
Fatores de Tempo
Carga Tumoral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29390569
[Au] Autor:Roh TH; Park YS; Park YG; Kim SH; Chang JH
[Ad] Endereço:Yonsei University Graduate School.
[Ti] Título:Intracranial squamous cell carcinoma arising in a cerebellopontine angle epidermoid cyst: A case report and literature review.
[So] Source:Medicine (Baltimore);96(51):e9423, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Most of the intracranial epidermoid cysts are benign, but malignant lesions are occasionally reported. These lesions appear as squamous cell carcinoma and carry a dismal prognosis. Here, we report a case of a primary intracranial squamous cell carcinoma arising in a cerebellopontine epidermoid cyst. The relevant literatures were also reviewed. PATIENT CONCERNS: A 53-year-old woman presented with dizziness and diplopia 9 months in duration. Magnetic resonance imaging revealed an epidermoid cyst in the left cerebellopontine angle and prepontine region with a focal enhancing lesion on T1-weighted gadolinium-enhanced images. DIAGNOSES: Histopathologic diagnosis revealed squamous cell carcinoma on a background of epidermoid cyst. Imaging studies excluded metastases. INTERVENTIONS: The tumor was removed subtotally through a lateral suboccipital approach. The patient received intensity modulated radiation therapy (6720 cGy total) postoperatively. OUTCOMES: The patient was free from recurrence of the tumor until 3 years after surgery, at which point she was lost to follow-up. The patient died 4 years after the surgery. LESSONS: The epidermoid cyst may occasionally become malignant. Finding an area of enhancement through preoperative magnetic resonance imaging can help to make a correct diagnosis. Based on the review of previous reports, surgical removal followed by radiotherapy shows the best result to treat malignant epidermoid cysts.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/etiologia
Neoplasias Cerebelares/etiologia
Ângulo Cerebelopontino
Cisto Epidérmico/complicações
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/diagnóstico
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/terapia
Neoplasias Cerebelares/diagnóstico
Neoplasias Cerebelares/patologia
Neoplasias Cerebelares/terapia
Ângulo Cerebelopontino/patologia
Terapia Combinada
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009423


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[PMID]:29381948
[Au] Autor:Qin Y; Zhang HB; Ke CS; Huang J; Wu B; Wan C; Yang CS; Yang KY
[Ad] Endereço:Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei.
[Ti] Título:Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review.
[So] Source:Medicine (Baltimore);96(47):e8684, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant neoplasm of which intracranial EMC is the rarest. PATIENT CONCERNS: We present an unusual case report of a 41-year-old woman who was sent to the emergency department for a sudden headache and other symptoms related to increased intracranial pressure. INTERVENTIONS: Emergent CT revealed an occupying lesion in the left cerebellum with surrounding edema. A complete surgical excision of the lesion through a transcortical approach was performed. After the operation, this patient received adjuvant radiotherapy and temozolomide treatment. DIAGNOSES: Pathology diagnosis was an intracranial EMC. OUTCOMES: The patient survives with no tumor recurrence as of the last follow-up. Progression-free survival exceeded 20 months. LESSONS: We have reviewed the literature and here summarize the diagnosis and treatment options for intracranial EMC. Diagnosis and treatment options of this rare disease are discussed.
[Mh] Termos MeSH primário: Neoplasias Cerebelares
Cerebelo
Condrossarcoma
Dacarbazina/análogos & derivados
Neoplasias de Tecido Conjuntivo e de Tecidos Moles
Procedimentos Neurocirúrgicos/métodos
[Mh] Termos MeSH secundário: Adulto
Antineoplásicos Alquilantes/administração & dosagem
Neoplasias Cerebelares/complicações
Neoplasias Cerebelares/patologia
Neoplasias Cerebelares/fisiopatologia
Neoplasias Cerebelares/cirurgia
Cerebelo/diagnóstico por imagem
Cerebelo/cirurgia
Quimiorradioterapia Adjuvante/métodos
Condrossarcoma/complicações
Condrossarcoma/patologia
Condrossarcoma/fisiopatologia
Condrossarcoma/cirurgia
Dacarbazina/administração & dosagem
Feminino
Seres Humanos
Hipertensão Intracraniana/diagnóstico
Hipertensão Intracraniana/etiologia
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/complicações
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/patologia
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/fisiopatologia
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/cirurgia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 7GR28W0FJI (Dacarbazine); YF1K15M17Y (temozolomide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008684


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[PMID]:28742274
[Au] Autor:Ma D; Yang J; Wang Y; Huang X; Du G; Zhou L
[Ad] Endereço:Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
[Ti] Título:Whole exome sequencing identified genetic variations in Chinese hemangioblastoma patients.
[So] Source:Am J Med Genet A;173(10):2605-2613, 2017 Oct.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hemangioblastomas (HBs) are uncommon tumors characterized by the presence of inactivating alterations in the von Hippel-Lindau (VHL) gene in inherited cases and by infrequent somatic mutation in sporadic entities. We performed whole exome sequencing on 11 HB patients to further elucidate the genetics of HBs. A total of 270 somatic variations in 219 genes, of which there were 86 mutations in 67 genes, were found in sporadic HBs, and 184 mutations were found in 154 genes in familial HBs. C: G>T: A and T: A>C: G mutations are relatively common in most HB patients. Genes harboring the most significant mutations include PCDH9, KLHL12, DCAF4L1, and VHL in sporadic HBs, and ZNF814, DLG2, RIMS1, PNN, and MUC7 in familial HBs. The frequency of CNV varied considerably within sporadic HBs but was relatively similar within familial HBs. Five genes, including OTOGL, PLCB4, SCEL, THSD4, and WWOX, have CNVs in the six patients with sporadic HBs, and three genes, including ABCA6, CWC27, and LAMA2, have CNVs in the five patients with familial HBs. We found new genetic mutations and CNVs that might be involved in HBs; these findings highlight the complexity of the tumorigenesis of HBs and pinpoint potential therapeutic targets for the treatment of HBs.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Biomarcadores Tumorais/genética
Neoplasias Cerebelares/genética
Exoma/genética
Hemangioblastoma/genética
Mutação
Sequenciamento Completo do Exoma/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Predisposição Genética para Doença
Seres Humanos
Masculino
Meia-Idade
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.38350


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[PMID]:28940863
[Au] Autor:Kramer K; Pandit-Taskar N; Humm JL; Zanzonico PB; Haque S; Dunkel IJ; Wolden SL; Donzelli M; Goldman DA; Lewis JS; Lyashchenko SK; Khakoo Y; Carrasquillo JA; Souweidane MM; Greenfield JP; Lyden D; De Braganca KD; Gilheeney SW; Larson SM; Cheung NV
[Ad] Endereço:Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York.
[Ti] Título:A phase II study of radioimmunotherapy with intraventricular I-3F8 for medulloblastoma.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: High-risk and recurrent medulloblastoma (MB) is associated with significant mortality. The murine monoclonal antibody 3F8 targets the cell-surface disialoganglioside GD2 on MB. We tested the efficacy, toxicity, and dosimetry of compartmental radioimmunotherapy (cRIT) with intraventricular I-labeled 3F8 in patients with MB on a phase II clinical trial. METHODS: Patients with histopathologically confirmed high-risk or recurrent MB were eligible for cRIT. After determining adequate cerebrospinal fluid (CSF) flow, patients received 2 mCi (where Ci is Curie) I-3F8 or I-3F8 with nuclear imaging for dosimetry, followed by up to four therapeutic (10 mCi/dose) I-3F8 injections. Dosimetry estimates were based on serial CSF and blood samplings over 48 hr plus region-of-interest analyses on serial imaging scans. Disease evaluation included pre- and posttherapy brain/spine magnetic resonance imaging approximately every 3 months for the first year after treatment, and every 6-12 months thereafter. RESULTS: Forty-three patients received a total of 167 injections; 42 patients were evaluable for outcome. No treatment-related deaths occurred. Toxicities related to drug administration included acute bradycardia with somnolence, headache, fatigue, and CSF pleocytosis consistent with chemical meningitis and dystonic reaction. Total CSF absorbed dose was 1,453 cGy (where Gy is Gray; 350.0-2,784). Median overall survival from first dose of cRIT was 24.9 months (95% confidence interval [CI]:16.3-55.8). Patients treated in radiographic and cytologic remission were at a lower risk of death compared to patients with radiographically measurable disease (hazard ratio: 0.40, 95% CI: 0.18-0.88, P = 0.024). CONCLUSIONS: cRIT with I-3F8 is safe, has favorable dosimetry to CSF, and when added to salvage therapy using conventional modalities, may have clinical utility in maintaining remission in high-risk or recurrent MB.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Murinos/administração & dosagem
Antineoplásicos Imunológicos/administração & dosagem
Neoplasias Cerebelares/radioterapia
Radioisótopos do Iodo/administração & dosagem
Meduloblastoma/radioterapia
Radioimunoterapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Neoplasias Cerebelares/líquido cefalorraquidiano
Neoplasias Cerebelares/diagnóstico por imagem
Neoplasias Cerebelares/mortalidade
Criança
Pré-Escolar
Intervalo Livre de Doença
Feminino
Seres Humanos
Lactente
Injeções Intraventriculares
Masculino
Meduloblastoma/líquido cefalorraquidiano
Meduloblastoma/diagnóstico por imagem
Meduloblastoma/mortalidade
Taxa de Sobrevida
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Murine-Derived); 0 (Antineoplastic Agents, Immunological); 0 (Iodine Radioisotopes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26754


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[PMID]:28792655
[Au] Autor:Bendelsmith CR; Skrypek MM; Patel SR; Pond DA; Linabery AM; Bendel AE
[Ad] Endereço:Department of Hematology-Oncology, Children's Minnesota, Minneapolis, Minnesota.
[Ti] Título:Multiple pilomatrixomas in a survivor of WNT-activated medulloblastoma leading to the discovery of a germline APC mutation and the diagnosis of familial adenomatous polyposis.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Because children diagnosed with WNT-activated medulloblastoma have a 10-year overall survival rate of 95%, active long-term follow-up is critically important in reducing mortality from other causes. Here, we describe an 11-year-old adopted female who developed multiple pilomatrixomas 3 years after diagnosis of WNT-activated medulloblastoma, an unusual finding that prompted deeper clinical investigation. A heterozygous germline APC gene mutation was discovered, consistent with familial adenomatous polyposis. Screening endoscopy revealed numerous precancerous polyps that were excised. This case highlights the importance of long-term follow-up of pediatric cancer survivors, including attention to unexpected symptoms, which might unveil an underlying cancer predisposition syndrome.
[Mh] Termos MeSH primário: Proteína da Polipose Adenomatosa do Colo
Polipose Adenomatosa do Colo
Sobreviventes de Câncer
Neoplasias Cerebelares
Mutação em Linhagem Germinativa
Doenças do Cabelo
Meduloblastoma
Segunda Neoplasia Primária
Pilomatrixoma
Neoplasias Cutâneas
Proteínas Wnt
[Mh] Termos MeSH secundário: Polipose Adenomatosa do Colo/diagnóstico
Polipose Adenomatosa do Colo/genética
Polipose Adenomatosa do Colo/metabolismo
Polipose Adenomatosa do Colo/patologia
Proteína da Polipose Adenomatosa do Colo/genética
Proteína da Polipose Adenomatosa do Colo/metabolismo
Neoplasias Cerebelares/diagnóstico
Neoplasias Cerebelares/genética
Neoplasias Cerebelares/metabolismo
Neoplasias Cerebelares/patologia
Criança
Feminino
Doenças do Cabelo/diagnóstico
Doenças do Cabelo/genética
Doenças do Cabelo/metabolismo
Doenças do Cabelo/patologia
Seres Humanos
Meduloblastoma/diagnóstico
Meduloblastoma/genética
Meduloblastoma/metabolismo
Meduloblastoma/patologia
Segunda Neoplasia Primária/diagnóstico
Segunda Neoplasia Primária/genética
Segunda Neoplasia Primária/metabolismo
Segunda Neoplasia Primária/patologia
Pilomatrixoma/diagnóstico
Pilomatrixoma/genética
Pilomatrixoma/metabolismo
Pilomatrixoma/patologia
Neoplasias Cutâneas/diagnóstico
Neoplasias Cutâneas/genética
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
Proteínas Wnt/genética
Proteínas Wnt/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (APC protein, human); 0 (Adenomatous Polyposis Coli Protein); 0 (Wnt Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26756


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[PMID]:28887665
[Au] Autor:Scobioala S; Parfitt R; Matulat P; Kittel C; Ebrahimi F; Wolters H; Am Zehnhoff-Dinnesen A; Eich HT
[Ad] Endereço:Department of Radiotherapy and Radiooncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Muenster, Germany. Sergiu.Scobioala@ukmuenster.de.
[Ti] Título:Impact of radiation technique, radiation fraction dose, and total cisplatin dose on hearing : Retrospective analysis of 29 medulloblastoma patients.
[Ti] Título:Effekte von Bestrahlungstechnik, Fraktionierung und Cisplatin-Gesamtdosis auf das Hörvermögen : Retrospektive Analyse von 29 Patienten mit Medulloblastom..
[So] Source:Strahlenther Onkol;193(11):910-920, 2017 Nov.
[Is] ISSN:1439-099X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To analyze the incidence and degree of sensorineural hearing loss (SNHL) resulting from different radiation techniques, fractionation dose, mean cochlear radiation dose (D ), and total cisplatin dose. MATERIAL AND METHODS: In all, 29 children with medulloblastoma (58 ears) with subclinical pretreatment hearing thresholds participated. Radiotherapy (RT) and cisplatin had been applied sequentially according to the HIT MED Guidance. Audiological outcomes up to the latest follow-up (median 2.6 years) were compared. RESULTS: Bilateral high-frequency SNHL was observed in 26 patients (90%). No significant differences were found in mean hearing threshold between left and right ears at any frequency. A significantly better audiological outcome (p < 0.05) was found after tomotherapy at the 6 kHz bone-conduction threshold (BCT) and left-sided 8 kHz air-conduction threshold (ACT) than after a combined radiotherapy technique (CT). Fraction dose was not found to have any impact on the incidence, degree, and time-to-onset of SNHL. Patients treated with CT had a greater risk of SNHL at high frequencies than tomotherapy patients even though D was similar. Increase in severity of SNHL was seen when the total cisplatin dose reached above 210 mg/m , with the highest abnormal level found 8-12 months after RT regardless of radiation technique or fraction dose. CONCLUSION: The cochlear radiation dose should be kept as low as possible in patients who receive simultaneous cisplatin-based chemotherapy. The risk of clinically relevant HL was shown when D exceeds 45 Gy independent of radiation technique or radiation regime. Cisplatin ototoxicity was shown to have a dose-dependent effect on bilateral SNHL, which was more pronounced in higher frequencies.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/terapia
Quimiorradioterapia/efeitos adversos
Quimiorradioterapia/métodos
Cisplatino/administração & dosagem
Cisplatino/efeitos adversos
Fracionamento de Dose
Perda Auditiva Bilateral/etiologia
Perda Auditiva Neurossensorial/etiologia
Meduloblastoma/terapia
Lesões por Radiação/etiologia
Radioterapia de Intensidade Modulada/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Limiar Auditivo/efeitos dos fármacos
Limiar Auditivo/efeitos da radiação
Criança
Pré-Escolar
Terapia Combinada
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE
[do] DOI:10.1007/s00066-017-1205-y


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[PMID]:28844716
[Au] Autor:Hortal AM; Vermeulen JF; Van Hecke W; Bovenschen N
[Ad] Endereço:Department of Pathology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
[Ti] Título:Oncogenic role of cytomegalovirus in medulloblastoma?
[So] Source:Cancer Lett;408:55-59, 2017 Nov 01.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Medulloblastoma is the most common solid tumor among children. Current therapeutic strategies for this malignancy include surgical resection, radiation therapy and chemotherapy. However, these treatments are accompanied with serious side effects such as neurological complications and psychosocial problems, due to the severity of treatment on the developing nervous system. To solve this problem, novel therapeutic approaches are currently being investigated. One of them is targeting human cytomegalovirus in medulloblastoma cancer cells. However, this approach is still under debate, since the presence of cytomegalovirus in medulloblastomas remains controversial. In this review, we discuss the current controversies on the role of cytomegalovirus in medulloblastoma oncogenesis and the potential of cytomegalovirus as a novel (immuno)therapeutic target.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/terapia
Citomegalovirus/isolamento & purificação
Imunoterapia
Meduloblastoma/terapia
Oncogenes
[Mh] Termos MeSH secundário: Animais
Neoplasias Cerebelares/imunologia
Neoplasias Cerebelares/virologia
Seres Humanos
Meduloblastoma/imunologia
Meduloblastoma/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE



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