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[PMID]:29480846
[Au] Autor:Cai J; Li W; Du J; Xu N; Gao P; Zhou J; Li X
[Ad] Endereço:Department of Radiology, Beijing Tiantan Hospital affiliated to Capital Medical University.
[Ti] Título:Supratentorial intracerebral cerebellar liponeurocytoma: A case report and literature review.
[So] Source:Medicine (Baltimore);97(2):e9556, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cerebellar liponeurocytoma is a rare tumor of the central nervous system (CNS) characterized by low proliferation but high likelihood of recurrence. Because of its rarity and the paucity of systematic follow-up, the biological behaviors and clinical features of this tumor are still poorly understood. We herein reported a case of cerebellar liponeurocytoma originating in the cerebral hemisphere. PATIENT CONCERNS: A 11-year-old male with intermittent headache, nausea, and vomiting. The first computed tomography revealed a large mass in the right cerebral hemisphere. He was transferred to our institution for neurosurgical treatment. DIAGNOSIS: Magnetic resonance imaging showed a large cystic-solid mass in the right frontal lobe with obvious contrast enhancement. Histopathological examinations showed sheets of isomorphic small neoplastic cells with clear cytoplasm and focal lipomatous differentiation. On immunohistochemistry, tumor cells were positive for synaptophysin, microtubule-associated protein 2, and neuronal nuclei antigen. INTERVENTIONS: The patient was performed a right fronto-parietal craniotomy, and gross total resection of the tumor was achieved without adjuvant therapy. OUTCOMES: No clinical or neuroradiological evidence of recurrence or residual of the tumor was found 6 years and 2 months after initial surgery. LESSONS: Cerebellar liponeurocytoma developing in supratentorial cerebral hemisphere was first reported in the present study. The radiological and histopathological features may be useful in differentiating this rare tumor from other tumors at similar locations. A change in the nomenclature of cerebellar liponeurocytomas should be considered in future World Health Organization (WHO) classifications.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/diagnóstico por imagem
Neoplasias Cerebelares/cirurgia
Neurocitoma/diagnóstico por imagem
Neurocitoma/cirurgia
Neoplasias Supratentoriais/diagnóstico por imagem
Neoplasias Supratentoriais/cirurgia
[Mh] Termos MeSH secundário: Neoplasias Cerebelares/patologia
Criança
Diagnóstico Diferencial
Seres Humanos
Masculino
Neurocitoma/patologia
Neoplasias Supratentoriais/patologia
Terminologia como Assunto
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009556


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[PMID]:28559066
[Au] Autor:Nasi D; Servadei F; Romano A
[Ad] Endereço:Department of Neurosurgery, Institute for Scientific and Care Research, Main Hospital of Santa Maria Nuova, Reggio Emilia, Italy. Electronic address: davidenasi83@gmail.com.
[Ti] Título:Status Epilepticus Secondary to Pseudonodular Hemorragic Occipital Lesion with Edema: "Non Semper Ea Sunt, Quae Videntur, Decipit Frons Prima Multos" (Things Are Not Always What They Seem; The First Appearance Deceives Many).
[So] Source:World Neurosurg;104:1044.e1-1044.e3, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a case in which common radiologic images masked a rare case of supratentorial hemangioblastoma (HBL). Other peculiarities of this case are the clinical presentation with status epilepticus and the occurrence of a supratentorial HBL unrelated to von Hippel-Lindau syndrome. Based on clinical and radiologic findings, including massive cerebral edema and hemorrhagic presentation, our preoperative diagnosis was a cerebral metastasis. In this scenario, physicians must take into account the words of the Roman fabulist Phaedrus: "Non semper ea sunt, quae videntur, decipit frons prima multos" (things are not always what they seem; the first appearance deceives many).
[Mh] Termos MeSH primário: Edema Encefálico/diagnóstico por imagem
Hemorragia Cerebral/diagnóstico por imagem
Erros de Diagnóstico
Hemangioblastoma/diagnóstico
Lobo Occipital/diagnóstico por imagem
Estado Epiléptico/etiologia
Neoplasias Supratentoriais/diagnóstico
[Mh] Termos MeSH secundário: Hemangioblastoma/complicações
Hemangioblastoma/cirurgia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Procedimentos Neurocirúrgicos
Neoplasias Supratentoriais/complicações
Neoplasias Supratentoriais/cirurgia
Tomografia Computadorizada por Raios X
Doença de von Hippel-Lindau/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE


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[PMID]:28512049
[Au] Autor:Beez T; Burgula S; Kamp M; Rapp M; Steiger HJ; Sabel M
[Ad] Endereço:Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. Electronic address: thomas.beez@med.uni-duesseldorf.de.
[Ti] Título:Space-Occupying Tumor Bed Cysts as a Complication of Modern Treatment for High-Grade Glioma.
[So] Source:World Neurosurg;104:509-515, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The management of high-grade glioma (HGG) has been affected by recent landmark trials and is now more proactive. More aggressive treatment leads to hospitalization due to side effects, however. Space-occupying tumor bed cysts have been described, but not systematically assessed. We sought to analyze this complication in a contemporary HGG cohort. METHODS: We performed a retrospective review of patients with HGG treated between 2007 and 2013, identified patients with space-occupying tumor bed cysts, and reviewed their hospital notes for relevant variables. Statistical analyses were performed, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. RESULTS: Tumor bed cysts were found in 12 of 282 patients (4%). The main symptoms were increased intracranial pressure (n = 11), new focal deficits (n = 6), and pseudomeningocele (n = 3), presenting at a median of 19 days since the last resection. Cysts were treated with cystoperitoneal (n = 7) and ventriculoperitoneal (n = 5) shunts, resulting in clinical benefit in 75% of those treated. Intraoperative opening of ventricles is a risk factor, with an OR of 39.339. We propose a classification system comprising 3 cyst types: isolated cyst, cyst with local cerebrospinal fluid (CSF) disturbance, and cyst with global CSF disturbance. CONCLUSIONS: In modern neuro-oncology, the rate of tumor bed cysts complicating HGG management appears stable compared with historical data. Shunt implantation is feasible and effective. We propose a classification system as a common data element for comparison across future studies.
[Mh] Termos MeSH primário: Cistos do Sistema Nervoso Central/patologia
Cistos do Sistema Nervoso Central/cirurgia
Glioma/patologia
Glioma/cirurgia
Neoplasias Supratentoriais/patologia
Neoplasias Supratentoriais/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Edema Encefálico/classificação
Edema Encefálico/diagnóstico
Edema Encefálico/patologia
Edema Encefálico/cirurgia
Carmustina/administração & dosagem
Cistos do Sistema Nervoso Central/classificação
Cistos do Sistema Nervoso Central/diagnóstico
Ventrículos Cerebrais/patologia
Ventrículos Cerebrais/cirurgia
Quimiorradioterapia Adjuvante
Terapia Combinada
Irradiação Craniana
Craniotomia
Feminino
Glioblastoma/classificação
Glioblastoma/diagnóstico
Glioblastoma/patologia
Glioblastoma/cirurgia
Glioma/classificação
Glioma/diagnóstico
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Gradação de Tumores/classificação
Estudos Retrospectivos
Neoplasias Supratentoriais/classificação
Neoplasias Supratentoriais/diagnóstico
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
U68WG3173Y (Carmustine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


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[PMID]:28319448
[Au] Autor:Waters AM; Johnston JM; Reddy AT; Fiveash J; Madan-Swain A; Kachurak K; Bag AK; Gillespie GY; Markert JM; Friedman GK
[Ad] Endereço:1 Department of Surgery, Division of Pediatric Surgery, University of Alabama at Birmingham , Birmingham, Alabama.
[Ti] Título:Rationale and Design of a Phase 1 Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors.
[So] Source:Hum Gene Ther Clin Dev;28(1):7-16, 2017 Mar.
[Is] ISSN:2324-8645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary central nervous system tumors are the most common solid neoplasm of childhood and the leading cause of cancer-related death in pediatric patients. Survival rates for children with malignant supratentorial brain tumors are poor despite aggressive treatment with combinations of surgery, radiation, and chemotherapy, and survivors often suffer from damaging lifelong sequelae from current therapies. Novel innovative treatments are greatly needed. One promising new approach is the use of a genetically engineered, conditionally replicating herpes simplex virus (HSV) that has shown tumor-specific tropism and potential efficacy in the treatment of malignant brain tumors. G207 is a genetically engineered HSV-1 lacking genes essential for replication in normal brain cells. Safety has been established in preclinical investigations involving intracranial inoculation in the highly HSV-sensitive owl monkey (Aotus nancymai), and in three adult phase 1 trials in recurrent/progressive high-grade gliomas. No dose-limiting toxicities were seen in the adult studies and a maximum tolerated dose was not reached. Approximately half of the 35 treated adults had radiographic or neuropathologic evidence of response at a minimum of one time point. Preclinical studies in pediatric brain tumor models indicate that a variety of pediatric tumor types are highly sensitive to killing by G207. This clinical protocol outlines a first in human children study of intratumoral inoculation of an oncolytic virus via catheters placed directly into recurrent or progressive supratentorial malignant tumors.
[Mh] Termos MeSH primário: Vetores Genéticos/administração & dosagem
Herpesvirus Humano 1/genética
Terapia Viral Oncolítica
Projetos de Pesquisa
Neoplasias Supratentoriais/genética
Neoplasias Supratentoriais/radioterapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Neoplasias Encefálicas/genética
Neoplasias Encefálicas/radioterapia
Neoplasias Encefálicas/virologia
Criança
Pré-Escolar
Feminino
Terapia Genética
Seres Humanos
Masculino
Recidiva Local de Neoplasia/genética
Recidiva Local de Neoplasia/radioterapia
Recidiva Local de Neoplasia/virologia
Vírus Oncolíticos/genética
Segurança
Neoplasias Supratentoriais/virologia
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1089/humc.2017.002


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[PMID]:28213194
[Au] Autor:Roth J; Korn A; Bitan-Talmor Y; Kaufman R; Ekstein M; Constantini S
[Ad] Endereço:Departments of Pediatric Neurosurgery and Anesthesiology, Dana Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: jonaroth@gmail.com.
[Ti] Título:Subcortical Mapping Using an Electrified Cavitron UltraSonic Aspirator in Pediatric Supratentorial Surgery.
[So] Source:World Neurosurg;101:357-364, 2017 May.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intraoperative electrophysiology is increasingly used for various lesion resections, both in adult and pediatric brain surgery. Subcortical mapping is often used in adult surgery when lesions lie in proximity to the corticospinal tract (CST). We describe a novel technique of continuous subcortical mapping using an electrified Cavitron UltraSonic Aspirator (CUSA) in children with supratentorial lesions. METHODS: We evaluated the method of subcortical mapping using a CUSA as a stimulation probe. Included in this study were children (<18 years of age) with supratentorial lesions in proximity to the CST in which the CUSA stimulator was applied. Data were collected retrospectively. RESULTS: Eleven children were included. Lesions were located in the thalamus (3), basal-ganglia (2), lateral ventricle (1), and convexity (5). Lesions included low-grade gliomas (6), arteriovenous malformation (1), cavernoma (1), cortical dysplasia (1), ependymoma grade II (1), and high-grade glioma (1). Seven patients had positive mapping responses to CUSA-based stimulation at various stimulation intensities. These responses led to a more limited resection in 5 cases. There were no complications related to the mapping technique. CONCLUSION: Continuous CUSA-based subcortical stimulation is a feasible mapping technique for assessing proximity to the CST during resection of supratentorial lesions in children. Future studies should be performed to better correlate the current threshold for eliciting a motor response with the distance from the CST, as well as the effect of age on this technique.
[Mh] Termos MeSH primário: Mapeamento Encefálico/métodos
Estimulação Encefálica Profunda/métodos
Eletrocoagulação/métodos
Procedimentos Neurocirúrgicos/métodos
Neoplasias Supratentoriais/diagnóstico por imagem
Neoplasias Supratentoriais/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Potencial Evocado Motor/fisiologia
Feminino
Seres Humanos
Lactente
Masculino
Córtex Motor/diagnóstico por imagem
Córtex Motor/fisiologia
Paracentese/métodos
Tratos Piramidais/diagnóstico por imagem
Tratos Piramidais/cirurgia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28115362
[Au] Autor:Sreedharan S; Maturi NP; Xie Y; Sundström A; Jarvius M; Libard S; Alafuzoff I; Weishaupt H; Fryknäs M; Larsson R; Swartling FJ; Uhrbom L
[Ad] Endereço:Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden.
[Ti] Título:Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.
[So] Source:Cancer Res;77(3):802-812, 2017 Feb 01.
[Is] ISSN:1538-7445
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High-grade glioma (HGG) is a group of primary malignant brain tumors with dismal prognosis. Whereas adult HGG has been studied extensively, childhood HGG, a relatively rare disease, is less well-characterized. Here, we present two novel platelet-derived growth factor (PDGF)-driven mouse models of pediatric supratentorial HGG. Tumors developed from two different cells of origin reminiscent of neural stem cells (NSC) or oligodendrocyte precursor cells (OPC). Cross-species transcriptomics showed that both models are closely related to human pediatric HGG as compared with adult HGG. Furthermore, an NSC-like cell-of-origin enhanced tumor incidence, malignancy, and the ability of mouse glioma cells (GC) to be cultured under stem cell conditions as compared with an OPC-like cell. Functional analyses of cultured GC from these tumors showed that cells of NSC-like origin were more tumorigenic, had a higher rate of self-renewal and proliferation, and were more sensitive to a panel of cancer drugs compared with GC of a more differentiated origin. These two mouse models relevant to human pediatric supratentorial HGG propose an important role of the cell-of-origin for clinicopathologic features of this disease. Cancer Res; 77(3); 802-12. ©2016 AACR.
[Mh] Termos MeSH primário: Glioma/patologia
Células-Tronco Neurais/patologia
Neurônios/patologia
Oligodendroglia/patologia
Neoplasias Supratentoriais/patologia
[Mh] Termos MeSH secundário: Adulto
Animais
Linhagem da Célula
Criança
Modelos Animais de Doenças
Perfilação da Expressão Gênica
Seres Humanos
Camundongos
Camundongos Transgênicos
Análise de Sequência com Séries de Oligonucleotídeos
Fenótipo
Análise de Componente Principal
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1158/0008-5472.CAN-16-2482


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[PMID]:28089418
[Au] Autor:Ravindran K; Gaillard F; Lasocki A
[Ad] Endereço:Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia.
[Ti] Título:Distant spread of a supratentorial glioblastoma to the spinal cord.
[So] Source:J Clin Neurosci;38:56-57, 2017 Apr.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Extracranial spread from a glioblastoma is rare. We present a case of a 48year-old man with a previously radiologically-stable left temporal lobe glioblastoma presenting with symptoms referrable to the spinal cord. MRI revealed a spinal cord lesion, with the differential including transverse myelitis and tumour. Open surgical biopsy revealed high-grade astrocytoma. Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour.
[Mh] Termos MeSH primário: Glioblastoma/diagnóstico
Neoplasias da Medula Espinal/diagnóstico
Neoplasias Supratentoriais/diagnóstico
[Mh] Termos MeSH secundário: Glioblastoma/patologia
Seres Humanos
Masculino
Meia-Idade
Neoplasias da Medula Espinal/patologia
Neoplasias da Medula Espinal/secundário
Neoplasias Supratentoriais/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


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[PMID]:28017177
[Au] Autor:Güçlü ÇY; Meço BC; Karamustafa M; Keçik Y
[Ad] Endereço:Ankara University School of Medicine, Department of Anesthesiology and ICU, Ankara, Turkey. Electronic address: drcigdemyldrm@yahoo.com.tr.
[Ti] Título:Maintenance of balance between airway pressure and intracranial pressure in a patient with tracheal stenosis undergoing craniotomy: a case report.
[So] Source:Braz J Anesthesiol;67(1):92-94, 2017 Jan - Feb.
[Is] ISSN:0104-0014
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Tracheal stenosis is a rare but a life-threatening condition and anesthesia of a patient with tracheal stenosis is challenging for anesthesiologists. Maintaining stable hemodynamics and ventilation parameters are important issues in neuroanesthesia. Any increase in airway peak pressure and ETCO will result in increase in intracranial pressure which must be avoided during craniotomies. Tracheal stenosis could be a reason for increased airway pressure. CASE REPORT: We described a patient undergoing craniotomy with tracheal stenosis. CONCLUSION: Detailed preparation for intubation, to stabilize airway dynamics and to make the right decision for the surgery were important points. To maintain of a good balance between cerebral dynamics and airway dynamics were the pearls of this case.
[Mh] Termos MeSH primário: Craniotomia
Pressão Intracraniana/fisiologia
Estenose Traqueal/complicações
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Monitorização Intraoperatória/métodos
Mecânica Respiratória/fisiologia
Neoplasias Supratentoriais/fisiopatologia
Neoplasias Supratentoriais/cirurgia
Estenose Traqueal/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


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[PMID]:28012127
[Au] Autor:Höhne J; Hohenberger C; Proescholdt M; Riemenschneider MJ; Wendl C; Brawanski A; Schebesch KM
[Ad] Endereço:Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany. julius.hoehne@ukr.de.
[Ti] Título:Fluorescein sodium-guided resection of cerebral metastases-an update.
[So] Source:Acta Neurochir (Wien);159(2):363-367, 2017 Feb.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cerebral metastasis (CM) is the most common malignancy affecting the brain. In patients eligible for surgery, complete tumor removal is the most important predictor of overall survival and neurological outcome. The emergence of surgical microscopes fitted with a fluorescein-specific filter have facilitated fluorescein-guided microsurgery and identification of tumor tissue. In 2012, we started evaluating fluorescein (FL) with the dedicated microscope filter in cerebral metastases (CM). After describing the treatment results of our first 30 patients, we now retrospectively report on 95 patients. METHODS: Ninety-five patients with CM of different primary cancers were included (47 women, 48 men, mean age, 60 years, range, 25-85 years); 5 mg/kg bodyweight of FL was intravenously injected at induction of anesthesia. A YELLOW 560-nm filter (Pentero 900, ZEISS Meditec, Germany) was used for microsurgical tumor resection and resection control. The extent of resection (EOR) was assessed by means of early postoperative contrast-enhanced MRI and the grade of fluorescent staining as described in the surgical reports. Furthermore, we evaluated information on neurological outcome and surgical complications as well as any adverse events. RESULTS: Ninety patients (95%) showed bright fluorescent staining that markedly enhanced tumor visibility. Five patients (5%); three with adenocarcinoma of the lung, one with melanoma of the skin, and one with renal cell carcinoma) showed insufficient FL staining. Thirteen patients (14%) showed residual tumor tissue on the postoperative MRI. Additionally, the MRI of three patients did not confirm complete resection beyond doubt. Thus, gross-total resection had been achieved in 83% (n = 79) of patients. No adverse events were registered during the postoperative course. CONCLUSIONS: FL and the YELLOW 560-nm filter are safe and feasible tools for increasing the EOR in patients with CM. Further prospective evaluation of the FL-guided technique in CM-surgery is in planning.
[Mh] Termos MeSH primário: Fluoresceína
Corantes Fluorescentes
Imagem por Ressonância Magnética/métodos
Procedimentos Neurocirúrgicos/métodos
Complicações Pós-Operatórias/diagnóstico por imagem
Neoplasias Supratentoriais/cirurgia
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma de Células Renais/patologia
Feminino
Seres Humanos
Masculino
Melanoma/patologia
Meia-Idade
Neoplasia Residual
Procedimentos Neurocirúrgicos/efeitos adversos
Neoplasias Supratentoriais/diagnóstico por imagem
Neoplasias Supratentoriais/secundário
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes); TPY09G7XIR (Fluorescein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-016-3054-3


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[PMID]:27989974
[Au] Autor:Fukui A; Muragaki Y; Saito T; Maruyama T; Nitta M; Ikuta S; Kawamata T
[Ad] Endereço:Faculty of Advanced Techno-Surgery, Institute of Advanced Biomedical Engineering and Science, Graduate School of Medicine, Tokyo Women's Medical University, Tokyo, Japan; Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
[Ti] Título:Volumetric Analysis Using Low-Field Intraoperative Magnetic Resonance Imaging for 168 Newly Diagnosed Supratentorial Glioblastomas: Effects of Extent of Resection and Residual Tumor Volume on Survival and Recurrence.
[So] Source:World Neurosurg;98:73-80, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Extent of resection (EOR) remains controversial in therapy for glioblastoma (GBM). However, an increasing number of studies favor maximum EOR as being associated with longer patient survival. Residual tumor volume (RTV) has also recently emerged as a prognostic factor. Low-field intraoperative magnetic resonance imaging (iMRI) has contributed to improve the EOR of GBM. The purpose of this study was to analyze the relationships between EOR/RTV and overall survival (OS)/progression-free survival (PFS) in patients with newly diagnosed GBM using low-field iMRI. METHODS: Adult patients who underwent surgery for newly diagnosed supratentorial GBM between 2000 and 2012 were retrospectively reviewed. Three-dimensional volumetric tumor measurements were made. Multivariate analysis was used to evaluate the relationships between EOR/RTV and OS/PFS. RESULTS: Of 168 patients, 126 (75%) died and 154 (91%) showed tumor recurrence. Median OS and PFS for patients with iMRI were 19.3 months (95% confidence interval, 15.4-23.7 months) and 9.5 months (95% confidence interval, 7.8-10.8 months). Median preoperative tumor volume was 37.0 cm (interquartile range [IQR], 19.9-59.8 cm ). Median RTV was 0 cm (IQR, 0-1.6 cm ). Median EOR was 100% (IQR, 96.2%-100%). In multivariate analysis, after controlling for age and Karnofsky Performance Status, EOR and RTV remained significantly associated with survival (hazard ratio, 1.56; P = 0.018) and recurrence (hazard ratio, 1.53; P = 0.013). Maximum RTV for survival was 3 cm . CONCLUSIONS: This volumetric analysis for low-field iMRI showed that both EOR and RTV were significantly associated with survival and recurrence. We determined a threshold RTV of 3 cm as the maximum RTV associated with survival.
[Mh] Termos MeSH primário: Glioblastoma
Imagem por Ressonância Magnética
Monitorização Intraoperatória/métodos
Procedimentos Neurocirúrgicos/métodos
Neoplasias Supratentoriais
[Mh] Termos MeSH secundário: Adulto
Idoso
Análise de Variância
Intervalo Livre de Doença
Feminino
Glioblastoma/diagnóstico por imagem
Glioblastoma/mortalidade
Glioblastoma/cirurgia
Seres Humanos
Masculino
Meia-Idade
Recidiva Local de Neoplasia/cirurgia
Neoplasia Residual/cirurgia
Neoplasias Supratentoriais/diagnóstico por imagem
Neoplasias Supratentoriais/mortalidade
Neoplasias Supratentoriais/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE



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