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[PMID]:29480880
[Au] Autor:Hong S; Jiang J; Zhou F; Liu J
[Ad] Endereço:Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
[Ti] Título:Computed tomography findings of primary pulmonary meningioma: A case report.
[So] Source:Medicine (Baltimore);97(2):e9651, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary pulmonary meningiomas are extremely rare, and only a few cases have been reported in the medical literature. Imaging findings of primary pulmonary meningiomas have been reported even more rarely. PATIENT CONCERNS: We present the case of a 54-year-old male patient with cough and sputum lasting for 20 years. This was a case of primary pulmonary meningioma with initial suspicion of a chest wall intercostal neurinoma. DIAGNOSES: A lung lesion was detected on chest computed tomography (CT) imaging 4 years ago. This case appeared as a solitary well-defined round nodule close to the left chest wall, with heterogeneous enhancement on CT, which inaccurately led to the suspicion of a chest wall intercostal neurinoma. INTERVENTIONS: A thoracoscopic wedge resection was performed. OUTCOMES: The postoperative histological diagnosis was primary pulmonary meningioma. After 2 years of follow-up, the patient is still alive without evidence of metastasis or recurrence. LESSONS: Increased awareness of the CT characteristics of this rare tumor may broaden the radiologist's knowledge base.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/diagnóstico por imagem
Pulmão/diagnóstico por imagem
Neoplasias Meníngeas/diagnóstico por imagem
Meningioma/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Pulmão/patologia
Pulmão/cirurgia
Neoplasias Pulmonares/patologia
Neoplasias Pulmonares/cirurgia
Masculino
Neoplasias Meníngeas/patologia
Neoplasias Meníngeas/cirurgia
Meningioma/patologia
Meningioma/cirurgia
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009651


  2 / 13545 MEDLINE  
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[PMID]:29361626
[Au] Autor:Asai M; Tanaka H; Goto Y; Yamada T; Yuasa N; Takeuchi E; Miyake H; Nagai H; Yoshioka Y; Okuno M; Kawai N; Minami T; Nagao T; Maeda S; Mouri K; Fukata K; Mizuno H; Iwase T; Miyata K
[Ad] Endereço:Dept. of Surgery, Japanese Red Cross Nagoya Daiichi Hospital.
[Ti] Título:[Secondary Dementia Due to Leptomeningeal Metastasis of Breast Cancer Improved by Whole Brain Radiation].
[So] Source:Gan To Kagaku Ryoho;44(13):2101-2103, 2017 Dec.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 62-year-old woman received chemotherapy for breast cancer with bone metastasis and malignant pleural and pericardial effusion. She was examined by imaging for progressive cognitive impairment and headache. Enhanced MRI findings showed multiple solid tumors on brain surface, and brain perfusion scintigraphy showed blood flow decrease in both parietal lobes. She was diagnosed with secondary dementia due to leptomeningeal metastases of breast cancer, and whole brain external irradiation was performed(30 Gy/15 Fr). After treatment, multiple tumors were decreased in size and her cognitive impair- ment was improved.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/radioterapia
Neoplasias da Mama/patologia
Demência/etiologia
Neoplasias Meníngeas/radioterapia
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/secundário
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Neoplasias Meníngeas/diagnóstico por imagem
Neoplasias Meníngeas/secundário
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE


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[PMID]:29390316
[Au] Autor:Zhao Y; Zhang H; Lian W; Xing B; Feng M; Liu X; Wang R
[Ad] Endereço:Department of Neurosurgery, Peking Union Medical College Hospital.
[Ti] Título:Collision tumors composed of meningioma and growth hormone-secreting pituitary adenoma in the sellar region: Case reports and a literature review.
[So] Source:Medicine (Baltimore);96(50):e9139, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Collision tumor is a rare disease that represents the coexistence of two histologically distinct neoplasms in the same area without histological admixture or an intermediate cell population zone. To our best knowledge, 13 cases besides our 2 cases have been reported till now, and our report represents the first publication regarding a collision tumor composed of growth hormone (GH)-secreting pituitary adenoma and sellar meningioma. PATIENT CONCERNS: We collected two cases of collision tumors composed of meningioma and GH-secreting adenoma in the sellar region from 2014 to 2015 at Peking Union Medical College Hospital (PUMCH). DIAGNOSIS: Two cases were diagnosed with solid sellar tumors, and two tumor types were suspected with magnetic resonance imaging (MRI). Blood hormone tests revealed increased insulin-like growth factor 1 (IGF-1) and GH levels. INTERVENTIONS: Both cases underwent transsphenoidal microsurgical resection of pituitary adenoma. OUTCOMES: The tumor was completely resected, and the pathological examination after the operation revealed meningioma and GH-secreting pituitary adenoma. LESSONS: Collision tumors consisting of pituitary adenomas with other sellar neoplasms are rare. Histological examination is necessary because preoperative studies cannot guarantee an accurate diagnosis. If a collision tumor is suspected prior to operation, a craniotomy may need to be considered before other operation methods to avoid reoperation.
[Mh] Termos MeSH primário: Adenoma Hipofisário Secretor de Hormônio do Crescimento/patologia
Neoplasias Meníngeas/patologia
Meningioma/patologia
Neoplasias Primárias Múltiplas/patologia
Sela Túrcica/patologia
[Mh] Termos MeSH secundário: Feminino
Adenoma Hipofisário Secretor de Hormônio do Crescimento/diagnóstico por imagem
Adenoma Hipofisário Secretor de Hormônio do Crescimento/cirurgia
Seres Humanos
Imagem por Ressonância Magnética
Neoplasias Meníngeas/diagnóstico por imagem
Neoplasias Meníngeas/cirurgia
Meningioma/diagnóstico por imagem
Meningioma/cirurgia
Meia-Idade
Neoplasias Primárias Múltiplas/diagnóstico por imagem
Neoplasias Primárias Múltiplas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009139


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[PMID]:29390304
[Au] Autor:Liu Y; Song DP; Wang T
[Ad] Endereço:Department of Neurosurgery.
[Ti] Título:Meningiomas with different histological grade in the same patient: Case report.
[So] Source:Medicine (Baltimore);96(50):e9086, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Meningiomas are mostly regarded as benign tumors histologically,accounting for 13% to 26% of all primary intracranial tumors.It is testified that multiple meningiomas occur in <10% of cases.A case of concurrent grades I and II in the same patient in our hospital was described. PATIENT CONCERN: A 66-year-old man who was experiencing headache and weakening in the left limbs, which gradually improved.Then, the myodynamia of left limb was weakening to level 3 and the muscular tension of left limbwas too strong for 1 year. Finally the man was admitted to our department of neurosurgery. DIAGNOSES: According the symptoms, signs and imaging data the patient. The 2 masses was diagnosed as the meningioma.Finally the histological examination showed the meningioma located in the right parietal lobe was diagnosed as fibrous meningioma,WHOgrade I, whereas meningioma reaching to the skull as atypical meningioma, WHO grade II. INTERVENTIONS: The 2 masses including the invaded dura mater,parietal skull, and adjacent subcutaneous tissue were excised wholly In the process of surgery. OUTCOMES: There is no sign caused by recurrent tumor. within the half year.The physical of the patient is good LESSONS:: The patient with multicentric meningiomas should keep follow-up closely in case the meningiomas show the malignant characteristics.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Neoplasias Meníngeas/patologia
Meningioma/patologia
[Mh] Termos MeSH secundário: Idoso
Neoplasias Encefálicas/cirurgia
Seres Humanos
Masculino
Neoplasias Meníngeas/cirurgia
Meningioma/cirurgia
Gradação de Tumores
Lobo Parietal/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009086


  5 / 13545 MEDLINE  
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[PMID]:29254304
[Au] Autor:Li JK; Wang C; Gong HD; Li HZ
[Ad] Endereço:Department of Neurosurgery, Affiliated HongQi Hospital of Mu Dan Jiang Medical University, Mudanjiang City, China.
[Ti] Título:Coagulation in hindbrain membrane meningioma patients treated with different injections using acute hypervolemic hemodilution.
[So] Source:J Biol Regul Homeost Agents;31(4):991-996, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to analyze the changes in coagulation in meningioma patients treated with different injections using the method of acute hypervolemic hemodilution (AHH). One hundred fifty hindbrain membrane meningioma patients were randomly divided into 5 groups, 30 per group. The first group were injected 40ml/time with Danhong after anesthesia induction; the second group were injected with 40ml~60ml/time Kangai and combined with interventional chemotherapy and embolization procedure; the third group of AHH were injected with polygeline 15ml/kg; the fourth group were injected with hydroxyethyl starch (130/0.4) sodium chloride in doses of 15ml/kg; the control group underwent basic treatment for lowering blood pressure and lowering blood fat. The changes of coagulation index were recorded before and after surgery and before and after the injection of different medications. Compared to the control group, for the first group of AHH, after being treated for 10 days and 30 days, the concentrations of bone specific alkaline phosphatase (BALP), bone Gla protein (BGP) and pro-collagen carboxy-terminal propeptide (PICP) were higher than that of the control group, the levels of endotoxin (ET) and C-reactive protein (CRP) were decreased compared to the control group (p less than 0.05); for the second group of AHH, after being treated for 10 days, the index of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fg) were not significantly changed, but the related level of vascular endothelial growth factor (VEGF) significantly decreased (p less than 0.05). Comparing the coagulation function index after surgery in the third and fourth groups, there were no significant changes in mean arterial pressure (MAP) level, heart rate (HR) value presented a low decrease, central venous pressure (CVP) level increased and the level of interleukin IL-6 showed a steady state after increasing. Analyzing the levels of interleukin IL-8 and tumor necrosis factor-α (TNF-α) after surgery, it was seen that in the third group they increased and in the fourth group they decreased (p less than 0.05). Danhong injection improved the coagulation function and microcirculation of patients, Kangai injection and interventional chemotherapy and embolization restrained the appearance of tumor angiogenesis, AHH operation with polygeline injection and hydroxyethyl starch (130/0.4) sodium chloride kept blood flow in normal parameters.
[Mh] Termos MeSH primário: Coagulação Sanguínea/efeitos dos fármacos
Cardiotônicos/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Hemodiluição/métodos
Neoplasias Meníngeas/tratamento farmacológico
Meningioma/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Fosfatase Alcalina/genética
Fosfatase Alcalina/metabolismo
Pressão Arterial/efeitos dos fármacos
Pressão Arterial/fisiologia
Biomarcadores/metabolismo
Viscosidade Sanguínea/efeitos dos fármacos
Proteína C-Reativa/genética
Proteína C-Reativa/metabolismo
Embolização Terapêutica/métodos
Endotoxinas/metabolismo
Feminino
Fibrinogênio/genética
Fibrinogênio/metabolismo
Expressão Gênica
Frequência Cardíaca/efeitos dos fármacos
Frequência Cardíaca/fisiologia
Seres Humanos
Derivados de Hidroxietil Amido/administração & dosagem
Masculino
Neoplasias Meníngeas/sangue
Neoplasias Meníngeas/patologia
Neoplasias Meníngeas/cirurgia
Meningioma/sangue
Meningioma/patologia
Meningioma/cirurgia
Meia-Idade
Osteocalcina/genética
Osteocalcina/metabolismo
Fragmentos de Peptídeos/genética
Fragmentos de Peptídeos/metabolismo
Substitutos do Plasma/administração & dosagem
Poligelina/administração & dosagem
Pró-Colágeno/genética
Pró-Colágeno/metabolismo
Rombencéfalo/efeitos dos fármacos
Rombencéfalo/metabolismo
Rombencéfalo/patologia
Rombencéfalo/cirurgia
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cardiotonic Agents); 0 (Drugs, Chinese Herbal); 0 (Endotoxins); 0 (Hydroxyethyl Starch Derivatives); 0 (Peptide Fragments); 0 (Plasma Substitutes); 0 (Procollagen); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); 0 (danhong); 0 (procollagen type I carboxy terminal peptide); 104982-03-8 (Osteocalcin); 9001-32-5 (Fibrinogen); 9007-41-4 (C-Reactive Protein); 9015-56-9 (Polygeline); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:28449809
[Au] Autor:Rossing M; Yde CW; Sehested A; Østrup O; Scheie D; Dangouloff-Ros V; Geoerger B; Vassal G; Nysom K
[Ad] Endereço:Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: caroline.maria.rossing@regionh.dk.
[Ti] Título:Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma.
[So] Source:Cancer Genet;212-213:32-37, 2017 Apr.
[Is] ISSN:2210-7762
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Meningiomas are rare in children. They are highly complex, harboring unique clinical and pathological characteristics, and many occur in patients with neurofibromatosis type 2. Hereby, we present a case of a two-year-old boy presented with a diagnostically challenging intraventricular tumor. It was incompletely resected 6 times over 14 months but kept progressing and was ultimately deemed unresectable. Histologically, the tumor was initially classified as schwannoma, but extensive international review concluded it was most likely an atypical meningioma, WHO grade II. Comprehensive genomic profiling revealed a TFG-ROS1 fusion, suggesting that ROS1-signaling pathway alterations were driving the tumor growth. In light of this new information, the possibility of a diagnosis of inflammatory myofibroblastic tumor was considered; however the histopathological results were not conclusive. This specific molecular finding allowed the potential use of precision medicine and the patient was enrolled in the AcSé phase 2 trial with crizotinib (NCT02034981), leading to a prolonged partial tumor response which is persisting since 14 months. This case highlights the value of precision cancer medicine in children.
[Mh] Termos MeSH primário: Fusão Gênica
Neoplasias Meníngeas/diagnóstico
Meningioma/diagnóstico
Fatores de Crescimento Transformadores/genética
[Mh] Termos MeSH secundário: Pré-Escolar
Diagnóstico Diferencial
Seres Humanos
Masculino
Neoplasias Meníngeas/tratamento farmacológico
Neoplasias Meníngeas/genética
Meningioma/tratamento farmacológico
Meningioma/genética
Proteínas Tirosina Quinases/genética
Proteínas Proto-Oncogênicas/genética
Pirazóis/uso terapêutico
Piridinas/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins); 0 (Pyrazoles); 0 (Pyridines); 53AH36668S (crizotinib); 76057-06-2 (Transforming Growth Factors); EC 2.7.10.1 (Protein-Tyrosine Kinases); EC 2.7.10.1 (ROS1 protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29381971
[Au] Autor:Yang X; Liu J; Ren Y; Richard SA; Zhang Y
[Ad] Endereço:Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
[Ti] Título:Isolated intracranial Rosai-Dorfman disease mimicking petroclival meningioma in a child: Case report and review of the literature.
[So] Source:Medicine (Baltimore);96(47):e8754, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Rosai -Dorfman disease (RDD) is a rare, idiopathic, and non-neoplastic histioproliferative disease with distinctive entity of unknown etiology. Central nervous system (CNS) RDD is uncommon, hence, isolated intracranial RDD is extremely rare. So far only 6 cases of CNS RDD with the lesions originating from petroclival region have been reported. We present a case of isolated intracranial RDD mimicking petroclival meningioma. PATIENT CONCERNS: A 14-year-old girl was admitted at our hospital with a 3-month history of dizziness, slowly progressing headache, and 2-month history of instability in walking. Cranial nerve deficits, including left facial paralysis, left facial numbness and left hearing loss, were evident on examination. DIAGNOSES: Initial diagnosis of petroclival meningioma was made according to preoperative magnetic resonance imaging. INTERVENTIONS: The lesion was resected subtotally and pathology confirmed RDD. The patient received gamma-knife treatment for the residual lesion. OUTCOMES: The patient recovered well and the residual lesion significantly retrogressed on follow-up images. LESSONS: Preoperative diagnosis of petroclival RDD is full of challenges. Although surgical resection of lesions is an effective treatment option, total resection is not highly recommended because the surgery-related defect must be minimal. Patient with residual lesion can be put on steroid therapy and/or radiotherapy, especially for IgG4 positive subset of RDD.
[Mh] Termos MeSH primário: Encefalopatias/diagnóstico
Histiocitose Sinusal/diagnóstico
Neoplasias Meníngeas/diagnóstico
Meningioma/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Diagnóstico Diferencial
Feminino
Seres Humanos
Neoplasias da Base do Crânio/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008754


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[PMID]:28468210
[Au] Autor:Çelik M; Sahin B; Enver N; Orhan KS
[Ad] Endereço:*Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul Medical Faculty, University of Istanbul †Department of Otorhinolaryngology and Head and Neck Surgery, University of Marmara, Istanbul, Turkey.
[Ti] Título:Nasopharyngeal Extension of Giant Meningioma.
[So] Source:J Craniofac Surg;28(3):e254-e255, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Meningiomas are common intracranial neoplasms but extracranial meningioma of the paranasal sinus is extremely rare. The recommended treatment of these meningothelial tumors is complete surgical excision. The authors report a 79-year-old woman presenting with facial pain and nasal obstruction for several months. Endoscopic nasopharyngeal examination showed a right nasal mass that arose from the nasopharynx and reached around the middle meatus. Gadolinium-enhanced magnetic resonance imaging showed a well-circumscribed nasopharyngeal mass, which originates from the right rosenmuller fossa and extends to the right nasal cavity. A biopsy was made with nasal endoscopy under local anesthesia for definitive diagnosis. Histopathologic examination was reported as benign meningothelial meningioma.In conclusion, physicians should keep in mind uncommon tumors in the nasal cavity and paranasal sinuses. Surgical resection is the primary treatment choice; however, close follow-up could be an option in patients with comorbidities.
[Mh] Termos MeSH primário: Neoplasias Meníngeas/diagnóstico
Meningioma/diagnóstico
Neoplasias Nasofaríngeas/diagnóstico
Neoplasias dos Seios Paranasais/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Neoplasias Meníngeas/patologia
Meningioma/patologia
Cavidade Nasal/patologia
Neoplasias Nasofaríngeas/patologia
Invasividade Neoplásica
Neoplasias dos Seios Paranasais/patologia
Seios Paranasais/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003475


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[PMID]:29173769
[Au] Autor:Chalmers A; Jensen L; Akerley W
[Ad] Endereço:Department of Internal Medicine, Division of Oncology, Huntsman Cancer Institute, University of Utah, 2000 Cir of Hope Dr, Salt Lake City, UT 84112, United States. Electronic address: Anna.Chalmers@hci.utah.edu.
[Ti] Título:Durable response to osimertinib in EGFR mutated T790M wildtype non-small cell lung cancer with leptomeningeal metastases: A case report.
[So] Source:Lung Cancer;114:68-69, 2017 Dec.
[Is] ISSN:1872-8332
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In patients with non-small cell lung cancer (NSCLC) progression with leptomeningeal (LM) metastases is a catastrophic event with limited treatment options. We report a patient who developed leptomeningeal disease while on front-line erlotinib. High-dose tyrosine kinase inhibitor was started but ineffective. She was transitioned to third-generation TKI osimertinib, despite lacking a T790M mutation, and responded with complete resolution of symptoms and malignant cytology in the cerebrospinal fluid (CSF). Recent phase one data and our case indicate osimertinib should be viewed as a best practice for treatment of LM disease in epidermal growth factor receptor (EGFR) mutated NSCLC regardless of T790M status.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/secundário
Líquido Cefalorraquidiano/citologia
Neoplasias Pulmonares/secundário
Neoplasias Meníngeas/tratamento farmacológico
Neoplasias Meníngeas/secundário
Piperazinas/farmacologia
Receptor do Fator de Crescimento Epidérmico/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso
Encéfalo/diagnóstico por imagem
Carcinoma Pulmonar de Células não Pequenas/genética
Carcinoma Pulmonar de Células não Pequenas/patologia
Líquido Cefalorraquidiano/efeitos dos fármacos
Progressão da Doença
Intervalo Livre de Doença
Resistência a Medicamentos Antineoplásicos
Cloridrato de Erlotinib/uso terapêutico
Feminino
Seres Humanos
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/patologia
Imagem por Ressonância Magnética/métodos
Neoplasias Meníngeas/patologia
Mutação/efeitos dos fármacos
Piperazinas/administração & dosagem
Inibidores de Proteínas Quinases/uso terapêutico
Receptor do Fator de Crescimento Epidérmico/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Piperazines); 0 (Protein Kinase Inhibitors); 3C06JJ0Z2O (osimertinib); DA87705X9K (Erlotinib Hydrochloride); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:27778211
[Au] Autor:Magill ST; Theodosopoulos PV; McDermott MW
[Ad] Endereço:Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA, 94143-0112, USA.
[Ti] Título:Resection of falx and parasagittal meningioma: complication avoidance.
[So] Source:J Neurooncol;130(2):253-262, 2016 11.
[Is] ISSN:1573-7373
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Falx and parasagittal meningiomas are common locations for meningiomas of the cranial vault. Many of these tumors are now discovered incidentally during cranial imaging for other reasons. Therefore, in the calculation of the risks and benefits of surgery it behooves the surgeon to do all he/she can to avoid surgical complications. This is a heavily experience based article based off the senior author's experience with over 1200 intracranial meningiomas. We present three cases to illustrate some of the decision-making and techniques used to reduce complications in the management of these cases treated with an open operation.
[Mh] Termos MeSH primário: Complicações Intraoperatórias
Neoplasias Meníngeas/cirurgia
Meningioma/cirurgia
Procedimentos Neurocirúrgicos/efeitos adversos
Medula Espinal/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias Meníngeas/diagnóstico por imagem
Meningioma/diagnóstico por imagem
Neuroimagem
Complicações Pós-Operatórias
Cuidados Pré-Operatórios
Medula Espinal/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE



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