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[PMID]:28468645
[Au] Autor:Sæther SG; Schou M; Kondziella D
[Ad] Endereço:Department of Psychiatry, St. Olav's University Hospital, Pb. 3008, Lade, 7441, Trondheim, Norway. sverrege@gmail.com.
[Ti] Título:What is the significance of onconeural antibodies for psychiatric symptomatology? A systematic review.
[So] Source:BMC Psychiatry;17(1):161, 2017 05 03.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients with intracellular onconeural antibodies may present with neuro-psychiatric syndromes. We aimed to evaluate the evidence for an association between well-characterized onconeural antibodies and psychiatric symptoms in patients with and without paraneoplastic central nervous system syndromes. METHODS: Eligible studies were selected from 1980 until February 2017 according to standardized review criteria and evaluated using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). We included studies describing the psychiatric symptomatology of onconeural antibody positive patients and the prevalence of onconeural antibodies in patients with psychiatric disorders. RESULTS: Twenty-seven studies met the inclusion criteria. Six studies reported on the prevalence of well-characterized onconeural antibodies in patients with different psychiatric disorders, ranging from 0% to 4.9%. Antibody prevalence in controls was available from three studies, ranging from 0% to 2.8%. Data heterogeneity precluded a meta-analysis. Two cerebrospinal fluid studies found well-characterized onconeural antibodies in 3.5% and 0% of patients with psychotic and depressive syndromes, respectively. CONCLUSIONS: The available evidence suggests that the prevalence of well-characterized onconeural antibodies in patients with psychiatric disorders is generally low. However, the question whether onconeural antibodies are important in select patients with a purely psychiatric phenotype needs to be addressed by appropriately designed studies in the future.
[Mh] Termos MeSH primário: Anticorpos Antineoplásicos/imunologia
Transtornos Mentais/psicologia
Síndromes Paraneoplásicas do Sistema Nervoso/psicologia
[Mh] Termos MeSH secundário: Seres Humanos
Transtornos Mentais/líquido cefalorraquidiano
Transtornos Mentais/imunologia
Síndromes Paraneoplásicas do Sistema Nervoso/líquido cefalorraquidiano
Síndromes Paraneoplásicas do Sistema Nervoso/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Neoplasm)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-017-1325-z


  2 / 703 MEDLINE  
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[PMID]:28984777
[Au] Autor:Ju W; Qi B; Wang X; Yang Y
[Ad] Endereço:aDepartment of Neurology bDepartment of Orthopedic Trauma, the First Hospital of Jilin University, Changchun, Jilin, China.
[Ti] Título:Anti-Ma2-associated limbic encephalitis with coexisting chronic inflammatory demyelinating polyneuropathy in a patient with non-Hodgkin lymphoma: A case report.
[So] Source:Medicine (Baltimore);96(40):e8228, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report the rare case of a 74-year-old man with anti-Ma2-associated paraneoplastic neurologic syndrome (PNS), and review and analyze the clinical manifestations, diagnosis, and treatment of the disease. PATIENT CONCERNS: The patient presented with a 5-month history of muscle weakness, progressive body aches, and weakness and numbness in both lower extremities. Before his hospitalization, he had experienced cognitive function decline; ptosis, inward gaze, and vertical gaze palsy in the right eye; and occasional visual hallucinations. Brain and spinal cord magnetic resonance imaging (MRI) yielded normal results. Anti-Ma2 antibodies were detected in both serum and cerebrospinal fluid. A 4-hour electroencephalogram showed irregular sharp slow waves and δ waves in the temporal region. Electromyography showed peripheral nerve demyelination. Positron-emission tomography/computed tomography (PET-CT) examination revealed hypermetabolism in the lymph nodes of the whole body. Biopsy of the lymph nodes showed non-Hodgkin lymphoma. DIAGNOSIS: A clinical diagnosis of lymphoma and PNS was made. INTERVENTIONS: The patient was treated with intravenous dexamethasone (15 mg/day) for 3 days. LESSONS: We have presented a rare case of a PNS involving both the central and peripheral nervous systems. The clinical features of this case indicated anti-Ma2-associated encephalitis and chronic inflammatory demyelinating polyneuropathy. PET-CT played a critical role in enabling early diagnosis and prompt treatment in this case.
[Mh] Termos MeSH primário: Encefalite Límbica/imunologia
Linfoma não Hodgkin/complicações
Síndromes Paraneoplásicas do Sistema Nervoso/complicações
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/imunologia
[Mh] Termos MeSH secundário: Idoso
Anticorpos/sangue
Anticorpos/líquido cefalorraquidiano
Antígenos de Neoplasias/imunologia
Seres Humanos
Encefalite Límbica/complicações
Linfoma não Hodgkin/imunologia
Masculino
Proteínas do Tecido Nervoso/imunologia
Síndromes Paraneoplásicas do Sistema Nervoso/imunologia
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Antigens, Neoplasm); 0 (Ma2 antigen); 0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008228


  3 / 703 MEDLINE  
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[PMID]:28655412
[Au] Autor:Viau M; Renaud MC; Grégoire J; Sebastianelli A; Plante M
[Ad] Endereço:Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Université Laval 2705 boulevard Laurier, Québec City, Québec G1V 4G2, Canada. Electronic address: Mathieu.Viau.1@ULaval.ca.
[Ti] Título:Paraneoplastic syndromes associated with gynecological cancers: A systematic review.
[So] Source:Gynecol Oncol;146(3):661-671, 2017 Sep.
[Is] ISSN:1095-6859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A number of paraneoplastic syndromes have been described with gynecological cancers. These syndromes are induced by substances secreted by the tumor or by an immune response triggered by the cancer. Each system of the human body can be affected by different syndromes. Indeed, paraneoplastic syndromes occurring from tumors of the gynecologic tract were found to involve the nervous, ophthalmologic, dermatologic, rheumatologic, endocrine, hematologic and renal systems. These syndromes can manifest before, at the time, or after the diagnosis of cancer. They can also occur at the time of a recurrence. Knowledge about these syndromes is important for physicians caring for patients with cancers, as they can result in severe morbidity and must be treated appropriately. Literature regarding paraneoplastic syndromes associated with tumors of the female genital tract is scattered and the subject has not been reviewed recently. A systematic literature search was thus conducted to identify paraneoplastic syndromes associated with gynecologic cancers. This review focuses on the cancers involved with each paraneoplastic syndrome, and on their pathophysiology, clinical manifestations, possible complications, outcomes, and treatments. As the mainstay of treatment in these conditions is often to address the underlying tumor, it is of upmost importance that physicians be aware of these rare cancer manifestations.
[Mh] Termos MeSH primário: Neoplasias dos Genitais Femininos/complicações
Doenças Hematológicas/etiologia
Síndromes Paraneoplásicas/etiologia
Dermatopatias/etiologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Nefropatias/etiologia
Síndromes Endócrinas Paraneoplásicas/etiologia
Síndromes Paraneoplásicas do Sistema Nervoso/etiologia
Síndromes Paraneoplásicas Oculares/etiologia
Doenças Reumáticas/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


  4 / 703 MEDLINE  
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[PMID]:28120349
[Au] Autor:Flanagan EP; Hinson SR; Lennon VA; Fang B; Aksamit AJ; Morris PP; Basal E; Honorat JA; Alfugham NB; Linnoila JJ; Weinshenker BG; Pittock SJ; McKeon A
[Ad] Endereço:Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN.
[Ti] Título:Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: Analysis of 102 patients.
[So] Source:Ann Neurol;81(2):298-309, 2017 Feb.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: A novel autoimmune central nervous system (CNS) disorder with glial fibrillary acidic protein (GFAP)-IgG as biomarker was recently characterized. Here, 102 patients with GFAP-IgG positivity are described. METHODS: The 102 included patients had: (1) serum, cerebrospinal fluid (CSF), or both that yielded a characteristic astrocytic pattern of mouse tissue immunostaining; (2) confirmation of IgG reactive with specific GFAP isoforms (α, É›, or κ) by cell-based assays; and (3) clinical data available. Control specimens (n = 865) were evaluated by tissue (n = 542) and cell-based (n = 323) assays. RESULTS: Median symptom onset age was 44 years (range = 8-103), and 54% were women. The predominant phenotype (83 patients; 81%) was inflammation of meninges, brain, spinal cord, or all 3 (meningoencephalomyelitis). Among patients, highest specificity for those phenotypes was observed for CSF testing (94%), and highest sensitivity was for the GFAPα isoform (100%). Rare GFAP-IgG positivity was encountered in serum controls by tissue-based assay (0.5%) or cell-based assay (1.5%), and in CSF controls by cell-based assay (0.9%). Among patients, striking perivascular radial enhancement was found on brain magnetic resonance imaging in 53%. Although cases frequently mimicked vasculitis, angiography was uniformly negative, and spinal imaging frequently demonstrated longitudinally extensive myelitic lesions. Diverse neoplasms encountered were found prospectively in 22%. Ovarian teratoma was most common and was predicted best when both N-methyl-D-aspartate receptor-IgG and aquaporin-4-IgG coexisted (71%). Six patients with prolonged follow-up had brisk corticosteroid response, but required additional immunosuppression to overcome steroid dependency. INTERPRETATION: GFAPα-IgG, when detected in CSF, is highly specific for an immunotherapy-responsive autoimmune CNS disorder, sometimes with paraneoplastic cause. Ann Neurol 2017;81:298-309.
[Mh] Termos MeSH primário: Astrócitos/patologia
Autoanticorpos/líquido cefalorraquidiano
Doenças Autoimunes do Sistema Nervoso/líquido cefalorraquidiano
Proteína Glial Fibrilar Ácida/imunologia
Síndromes Paraneoplásicas do Sistema Nervoso/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Biomarcadores/líquido cefalorraquidiano
Criança
Feminino
Seres Humanos
Imunoglobulina G
Imagem por Ressonância Magnética
Masculino
Camundongos
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Biomarkers); 0 (Glial Fibrillary Acidic Protein); 0 (Immunoglobulin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24881


  5 / 703 MEDLINE  
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[PMID]:28104720
[Au] Autor:Yong L; Asimakopoulos P; Mumford C; Fragkandrea Nixon I
[Ad] Endereço:Department of ENT, St John's Hospital, Livingston, UK.
[Ti] Título:When dizziness becomes sinister: oropharyngeal carcinoma presenting as a paraneoplastic neurological disorder.
[So] Source:BMJ Case Rep;2017, 2017 Jan 19.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Paraneoplastic neurological disorders are uncommon presentations of head and neck cancers. We present a case of a 68-year-old male patient who presented with dizziness, nausea and memory problems. MRI of his brain showed bilateral cerebellar leptomeningeal enhancing signal abnormality with cervical lymphadenopathy. CT imaging of his neck raised the suspicion of a tonsillar primary, which was later confirmed on biopsy. His poorly differentiated HPV positive squamous cell carcinoma was treated with chemoradiotherapy. Subsequent MRI imaging showed progressive cerebellar atrophy and his presenting symptoms persisted, but he remained disease free 6 months post-treatment for his primary malignancy.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/complicações
Doenças Cerebelares/etiologia
Tontura/etiologia
Neoplasias de Cabeça e Pescoço/complicações
Infecções por Papillomavirus/complicações
Síndromes Paraneoplásicas do Sistema Nervoso/etiologia
Neoplasias Tonsilares/complicações
[Mh] Termos MeSH secundário: Idoso
Antineoplásicos/uso terapêutico
Carcinoma de Células Escamosas/diagnóstico por imagem
Carcinoma de Células Escamosas/terapia
Carcinoma de Células Escamosas/virologia
Doenças Cerebelares/diagnóstico por imagem
Quimiorradioterapia
Cisplatino/uso terapêutico
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/terapia
Neoplasias de Cabeça e Pescoço/virologia
Seres Humanos
Linfadenopatia
Imagem por Ressonância Magnética
Masculino
Transtornos da Memória/etiologia
Náusea/etiologia
Pescoço
Neoplasias Orofaríngeas/complicações
Neoplasias Orofaríngeas/diagnóstico por imagem
Neoplasias Orofaríngeas/terapia
Neoplasias Orofaríngeas/virologia
Síndromes Paraneoplásicas do Sistema Nervoso/diagnóstico por imagem
Radioterapia
Tomografia Computadorizada por Raios X
Neoplasias Tonsilares/diagnóstico por imagem
Neoplasias Tonsilares/terapia
Neoplasias Tonsilares/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


  6 / 703 MEDLINE  
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[PMID]:28092909
[Au] Autor:Mohyuddin GR; Uy J; Medhavi H; Faisal MS; Qazilbash MH
[Ad] Endereço:University of Kansas Medical Center, Kansas City, KS, USA.
[Ti] Título:Immune-Mediated Neuropathies following Autologous Stem Cell Transplantation for Multiple Myeloma: Case Series and Review of the Literature.
[So] Source:Acta Haematol;137(2):86-88, 2017.
[Is] ISSN:1421-9662
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Neuropathy is a common finding in patients with multiple myeloma. Several different factors can cause neuropathy in these patients, such as the underlying disease itself, medications used for treatment, or immune-mediated processes. Immune-mediated neuropathies (IMN) consist of a heterogeneous spectrum of peripheral nerve disorders. Although IMN is associated with several hematological disorders, it remains a very rare complication of hematopoietic stem cell transplantation (HCT). We describe our experiences of 3 patients with multiple myeloma who experienced IMN following autologous HCT (auto-HCT). These 3 patients were felt to have IMN clearly attributable to auto-HCT because of a clear temporal association with auto-HCT and absence of any other obvious causative factor. The variety in their clinical presentations, diagnostic approach, and approaches to management are explained. The pathophysiology of how HCT may predispose to IMN remains poorly understood. Our report helps highlight several potential causes of this phenomenon, such as a paraneoplastic syndrome, immune reconstitution syndrome, or drug toxicity. We emphasize that a comprehensive approach is needed to address this rare entity, and that there should be a low threshold to initiate immune-specific therapy, such as plasmapheresis, if symptoms do not resolve spontaneously.
[Mh] Termos MeSH primário: Transplante de Células-Tronco Hematopoéticas
Mieloma Múltiplo
Síndromes Paraneoplásicas do Sistema Nervoso
Doenças do Sistema Nervoso Periférico
[Mh] Termos MeSH secundário: Idoso
Autoenxertos
Feminino
Seres Humanos
Masculino
Meia-Idade
Mieloma Múltiplo/imunologia
Mieloma Múltiplo/patologia
Mieloma Múltiplo/terapia
Síndromes Paraneoplásicas do Sistema Nervoso/imunologia
Síndromes Paraneoplásicas do Sistema Nervoso/patologia
Síndromes Paraneoplásicas do Sistema Nervoso/terapia
Doenças do Sistema Nervoso Periférico/etiologia
Doenças do Sistema Nervoso Periférico/imunologia
Doenças do Sistema Nervoso Periférico/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1159/000453390


  7 / 703 MEDLINE  
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[PMID]:28074593
[Au] Autor:Gadoth A; Kryzer TJ; Fryer J; McKeon A; Lennon VA; Pittock SJ
[Ad] Endereço:Departments of Laboratory Medicine and Pathology.
[Ti] Título:Microtubule-associated protein 1B: Novel paraneoplastic biomarker.
[So] Source:Ann Neurol;81(2):266-277, 2017 Feb.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To report the identification of microtubule-associated protein (MAP) 1B as the antigen of the previously described Purkinje cell cytoplasmic antibody type 2 (PCA-2) antibody, its frequency, and clinical, oncological, and serological associations. METHODS: Archival serum or cerebrospinal fluid (CSF) specimens were available from 96 of 118 consecutive PCA-2-IgG-seropositive patients identified during 1993-2016. The autoantigen, defined in mouse brain lysate by Western blot and mass spectrometry, was confirmed by dual immunohistochemical staining using commercial antibodies. The major antigenic region was defined by Western blot using recombinant protein fragments. RESULTS: IgG in 95 of 96 patients' serum or CSF (but in none of 98 healthy or disease control subjects' serum specimens) bound to recombinant MAP1B. A minority (17.5%) of patients' IgG also bound to MAP1A. PCA-2 was often accompanied by additional neural autoantibody markers of small-cell carcinoma, including collapsin response-mediated protein 5 (CRMP5) IgG (26%) or antineuronal nuclear antibody type 1 (ANNA-1) IgG (also known as anti-Hu; 13%). Neurological manifestations in 95 patients were (in decreasing frequency): peripheral neuropathy, 53%; cerebellar ataxia, dysmetria, or dysarthria, 38%; and encephalopathy, 27%. Cancer (majority small-cell lung carcinoma [SCLC]) was detected in 66 of 84 evaluated patients (79%). The MAP1B (PCA-2) autoantibody detection rate, among approximately 70,000 patients undergoing service neural autoantibody evaluation in 2015, was 0.024%, equaling amphiphysin IgG (0.026%) and more common than ANNA-2 (also known as anti-Ri; 0.016%) and PCA-Tr (also known as delta/notch-like epidermal growth factor-related receptor [DNER]; 0.006%). INTERPRETATION: MAP1B, the PCA-2 autoantigen, represents a novel target in paraneoplastic neurological disorders and has high predictive value for SCLC. Its relatively high prevalence, compared with other recognized paraneoplastic neural autoantibodies, justifies its testing in comprehensive paraneoplastic neural autoantibody evaluation. Ann Neurol 2017;81:266-277.
[Mh] Termos MeSH primário: Autoanticorpos/imunologia
Autoantígenos/imunologia
Biomarcadores Tumorais/imunologia
Neoplasias Pulmonares/imunologia
Proteínas Associadas aos Microtúbulos/imunologia
Síndromes Paraneoplásicas do Sistema Nervoso/imunologia
Células de Purkinje/imunologia
Carcinoma de Pequenas Células do Pulmão/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Imunoglobulina G/imunologia
Neoplasias Pulmonares/diagnóstico
Camundongos
Síndromes Paraneoplásicas do Sistema Nervoso/sangue
Síndromes Paraneoplásicas do Sistema Nervoso/líquido cefalorraquidiano
Proteínas Recombinantes
Carcinoma de Pequenas Células do Pulmão/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Autoantigens); 0 (Biomarkers, Tumor); 0 (Immunoglobulin G); 0 (Microtubule-Associated Proteins); 0 (Recombinant Proteins); 0 (microtubule-associated protein 1B)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24872


  8 / 703 MEDLINE  
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[PMID]:28009765
[Au] Autor:Kalman B
[Ad] Endereço:*University of Pecs, Pecs †Markusovszky University Teaching Hospital, Center for Research and Education, Szombathely, Hungary.
[Ti] Título:Autoimmune Encephalitides: A Broadening Field of Treatable Conditions.
[So] Source:Neurologist;22(1):1-13, 2017 Jan.
[Is] ISSN:2331-2637
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neurology has been continuously transforming by the refinement of molecular diagnostics and the development of disease-modifying treatments. The discovery of new antibody markers has elucidated the pathogenesis, provided the means of diagnostics, and offered cure or treatment for several immune-mediated neurological and neuropsychiatric disorders. The identification of pathogenic and marker autoantibodies has also facilitated defining the associated phenotypic spectra and the overlap among the phenotypes linked to individual immune markers. REVIEW SUMMARY: This survey presents the list of currently known autoimmune encephalitis entities along with the associated marker autoantibodies, highlights the phenotypic and immune pathogenic relationships, calls attention to the recently described rare syndromes, discusses the biological significance of the autoantibodies and targeted molecules, points out the potential postinfectious origin of immune pathogenesis in several of the disorders, and directs the readers to the latest diagnostic guidelines as well as to the generally used treatment approaches. CONCLUSIONS AND FUTURE DIRECTIONS: Owing to the successful and usually combined use of various methods to detect serum and cerebrospinal fluid autoantibodies on rodent brain sections, in primary neuronal cell culture, in immune precipitation, and cell-based assays, or in other antigen-specific immune assays (Western blot, enzyme-linked immunosorbent assay, and radioimmune assay), the subgroup of antibody marker-negative autoimmune encephalopathy syndromes is contracting, whereas the numbers of entities within the overall group are expanding. Recognition of the correct diagnosis is becoming increasingly rewarding not only for neurologists, but also for pediatric neurologists and psychiatrists.
[Mh] Termos MeSH primário: Doenças Autoimunes do Sistema Nervoso/imunologia
Encefalite/imunologia
Síndromes Paraneoplásicas do Sistema Nervoso/imunologia
[Mh] Termos MeSH secundário: Doenças Autoimunes do Sistema Nervoso/epidemiologia
Doenças Autoimunes do Sistema Nervoso/fisiopatologia
Encefalite/epidemiologia
Encefalite/fisiopatologia
Seres Humanos
Síndromes Paraneoplásicas do Sistema Nervoso/epidemiologia
Síndromes Paraneoplásicas do Sistema Nervoso/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1097/NRL.0000000000000087


  9 / 703 MEDLINE  
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[PMID]:27919464
[Au] Autor:Bompaire F; Zinchenko L; Lahutte M; Mokhtari K; Psimaras D; Gaultier C; Monjour A; Delattre JY; Ricard D
[Ad] Endereço:Service de neurologie, HIA du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France. Electronic address: fbompaire@gmail.com.
[Ti] Título:SMART syndrome: Classic transient symptoms leading to an unusual unfavorable outcome.
[So] Source:Rev Neurol (Paris);173(1-2):67-73, 2017 Jan - Feb.
[Is] ISSN:0035-3787
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare complication of cerebral radiation therapy that usually presents>10 years after treatment as reversible paroxysmal episodes of neurological dysfunction associated with headaches. CASES: We report here on two cases of SMART syndrome in long-term survivors of high-grade glioma for whom neuropathological data were available. The course of the disease was unfavorable. Although the clinico-radiological picture of SMART syndrome clearly differs from classic cerebral radionecrosis, the gross neuropathological lesions observed in our two patients appeared to be similar to those described in focal radionecrosis. CONCLUSION: SMART syndrome may progress from a benign reversible form to a severe and eventually irreversible form. This severe course may also be confused with tumor progression, and lead to permanent disability and inadequate antitumor treatment. Clinicians should be aware of this latter atypical presentation.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/radioterapia
Glioma/radioterapia
Cefaleia/etiologia
Síndromes Paraneoplásicas do Sistema Nervoso/etiologia
Lesões por Radiação/complicações
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Adulto
Evolução Fatal
Feminino
Cefaleia/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Transtornos de Enxaqueca/diagnóstico
Transtornos de Enxaqueca/etiologia
Síndromes Paraneoplásicas do Sistema Nervoso/diagnóstico
Acidente Vascular Cerebral/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


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[PMID]:27578448
[Au] Autor:Sæther SG; Schou M; Stoecker W; Teegen B; Borowski K; Vaaler A; Kondziella D; Reitan SK
[Ad] Endereço:From the Dept. of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway (SGS, MS, AV, DK, SKR); the Dept. of Psychiatry, St. Olav's University Hospital, Trondheim, Norway (SGS, MS, AV, SKR); the Institute for Experimental Immunology, Euroimmun AG, Lübeck, Germany (WS, BT, K
[Ti] Título:Onconeural Antibodies in Acute Psychiatric Inpatient Care.
[So] Source:J Neuropsychiatry Clin Neurosci;29(1):74-76, 2017.
[Is] ISSN:1545-7222
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Paraneoplastic neurological disorders associated with onconeural antibodies often appear with neuropsychiatric symptoms. To study the prevalence of onconeural antibodies in patients admitted to acute psychiatric inpatient care, the serum of 585 such patients was tested for antibodies targeting MOG, GLRA1B, DPPX, GRM1, GRM5, DNER, Yo, ZIC4, GAD67, amphiphysin, CV2, Hu, Ri, Ma2, and recoverin. Only one sample was positive (antirecoverin IgG). The present findings suggest that serum onconeural antibody positivity is rare among patients acutely admitted for inpatient psychiatric care. The clinical implications of this finding are discussed.
[Mh] Termos MeSH primário: Anticorpos Antineoplásicos/sangue
Transtornos Mentais/imunologia
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Análise Química do Sangue
Estudos Transversais
Feminino
Hospitais Psiquiátricos
Hospitais Universitários
Seres Humanos
Pacientes Internados
Masculino
Transtornos Mentais/epidemiologia
Transtornos Mentais/etiologia
Transtornos Mentais/terapia
Meia-Idade
Síndromes Paraneoplásicas do Sistema Nervoso/epidemiologia
Síndromes Paraneoplásicas do Sistema Nervoso/imunologia
Síndromes Paraneoplásicas do Sistema Nervoso/psicologia
Síndromes Paraneoplásicas do Sistema Nervoso/terapia
Prevalência
Análise Serial de Proteínas
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neoplasm)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160901
[St] Status:MEDLINE
[do] DOI:10.1176/appi.neuropsych.16050110



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