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[PMID]:27775688
[Au] Autor:Nomura A; Majumder K; Giri B; Dauer P; Dudeja V; Roy S; Banerjee S; Saluja AK
[Ad] Endereço:Division of Surgical Oncology, Department of Surgery Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
[Ti] Título:Inhibition of NF-kappa B pathway leads to deregulation of epithelial-mesenchymal transition and neural invasion in pancreatic cancer.
[So] Source:Lab Invest;96(12):1268-1278, 2016 12.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:NF-κB has an essential role in the initiation and progression of pancreatic cancer and specifically mediates the induction of epithelial-mesenchymal transition and invasiveness. In this study, we demonstrate the importance of activated NF-κB signaling in EMT induction, lymphovascular metastasis, and neural invasion. Modulation of NF-κB activity was accomplished through the specific NF-κB inhibitor (BAY 11-7085), triptolide, and Minnelide treatment, as well as overexpression of IKBα repressor and IKK activator plasmids. In the classical lymphovascular metastatic cascade, inhibition of NF-κB decreased the expression of several EMT transcription factors (SNAI1, SNAI2, and ZEB1) and mesenchymal markers (VIM and CDH2) and decreased in vitro invasion, which was rescued by IKK activation. This was further demonstrated in vivo via BAY 11-7085 treatment in a orthotopic model of pancreatic cancer. In vivo NF-κB inhibition decreased tumor volume; decreased tumor EMT gene expression, while restoring cell-cell junctions; and decreasing overall metastasis. Furthermore, we demonstrate the importance of active NF-κB signaling in neural invasion. Triptolide treatment inhibits Nerve Growth Factor (NGF) mediated, neural-tumor co-culture in vitro invasion, and dorsal root ganglia (DRG) neural outgrowth through a disruption in tumor-neural cross talk. In vivo, Minnelide treatment decreased neurotrophin expression, nerve density, and sciatic nerve invasion. Taken together, this study demonstrates the importance of NF-κB signaling in the progression of pancreatic cancer through the modulation of EMT induction, lymphovascular invasion, and neural invasion.
[Mh] Termos MeSH primário: Transição Epitelial-Mesenquimal
NF-kappa B/metabolismo
Pâncreas/metabolismo
Neoplasias Pancreáticas/metabolismo
Nervos Periféricos/metabolismo
Neoplasias do Sistema Nervoso Periférico/secundário
Transdução de Sinais
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Antineoplásicos/uso terapêutico
Linhagem Celular
Linhagem Celular Tumoral
Técnicas de Cocultura
Transição Epitelial-Mesenquimal/efeitos dos fármacos
Gânglios Espinais/citologia
Gânglios Espinais/efeitos dos fármacos
Gânglios Espinais/metabolismo
Gânglios Espinais/patologia
Seres Humanos
Metástase Linfática/patologia
Metástase Linfática/prevenção & controle
Camundongos
Camundongos Nus
Inibidor de NF-kappaB alfa/genética
Inibidor de NF-kappaB alfa/metabolismo
NF-kappa B/antagonistas & inibidores
Invasividade Neoplásica/patologia
Transplante de Neoplasias
Pâncreas/efeitos dos fármacos
Pâncreas/patologia
Neoplasias Pancreáticas/tratamento farmacológico
Neoplasias Pancreáticas/patologia
Nervos Periféricos/citologia
Nervos Periféricos/efeitos dos fármacos
Nervos Periféricos/patologia
Neoplasias do Sistema Nervoso Periférico/metabolismo
Neoplasias do Sistema Nervoso Periférico/patologia
Neoplasias do Sistema Nervoso Periférico/prevenção & controle
Proteínas Recombinantes/metabolismo
Nervo Isquiático/citologia
Nervo Isquiático/efeitos dos fármacos
Nervo Isquiático/metabolismo
Nervo Isquiático/patologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (NF-kappa B); 0 (Recombinant Proteins); 139874-52-5 (NF-KappaB Inhibitor alpha)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2016.109


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[PMID]:28458390
[Au] Autor:Fukunaga H; Mutoh T; Tatewaki Y; Shimomura H; Totsune T; Terao C; Miyazawa H; Taki Y
[Ad] Endereço:Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University , Sendai, Japan.
[Ti] Título:Neuro-Myelomatosis of the Brachial Plexus - An Unusual Site of Disease Visualized by FDG-PET/CT: A Case Report.
[So] Source:Am J Case Rep;18:478-481, 2017 May 01.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Peripheral or cranial nerve root dysfunction secondary to invasion of the CNS in multiple myeloma is a rare clinical event that is frequently mistaken for other diagnoses. We describe the clinical utility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scanning for diagnosing neuro-myelomatosis. CASE REPORT A 63-year-old woman whose chief complaints were right shoulder and upper extremity pain underwent MRI and 18F-FDG PET/CT scan. MRI revealed a non-specific brachial plexus tumor. 18F-FDG PET/CT demonstrated intense FDG uptake in multiple intramedullary lesions and in the adjacent right brachial plexus, indicating extramedullary neural involvement associated with multiple myeloma, which was confirmed later by a bone marrow biopsy. CONCLUSIONS This is the first reported case of neuro-myelomatosis of the brachial plexus. It highlights the utility of the 18F-FDG PET/CT scan as a valuable diagnostic modality.
[Mh] Termos MeSH primário: Plexo Braquial/diagnóstico por imagem
Mieloma Múltiplo/diagnóstico por imagem
Neoplasias do Sistema Nervoso Periférico/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
[Mh] Termos MeSH secundário: Feminino
Fluordesoxiglucose F18
Seres Humanos
Meia-Idade
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28858758
[Au] Autor:Booth BJ; Jones RR; Turyk ME; Freels S; Patel DM; Stayner LT; Ward MH
[Ad] Endereço:Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Dr., Room 6E138, Rockville, MD 20850, USA; Division of Epidemiology and Biostatistics, School of Public Health, University o
[Ti] Título:Livestock and poultry density and childhood cancer incidence in nine states in the USA.
[So] Source:Environ Res;159:444-451, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Parental occupational and childhood exposures to farm animals have been positively associated with childhood brain tumors, whereas associations with childhood leukemia are equivocal. The developing immune system may be influenced by allergen, virus, or other exposures from animal sources, which may contribute to childhood cancer incidence. METHODS: Incident cancers (acute lymphoblastic leukemia [ALL], acute myeloid leukemia [AML], central nervous system [CNS], peripheral nervous system [PNS]) for children aged 0-4 diagnosed between 2003 and 2008 were obtained from nine National Cancer Institute Surveillance, Epidemiology and End Results (SEER) registries and were linked to U.S. Census of Agriculture data from 2002 and 2007 by county of diagnosis. Animal densities (animal units [AU]/km ; one animal unit is 1000 pounds of animal weight) were estimated for hogs, cattle, chickens (layers and broilers, separately), equine (horses, ponies, mules, burros, donkeys), goats, sheep, turkeys, and total animals. Animal density was examined in models as both continuous (AU per km ) and categorical variables (quartiles). Animal operation densities (per km ) by size of operation (cattle, hogs, chickens, sheep) were modeled continuously. Rate ratios and 95% confidence intervals were estimated using Poisson regression. RESULTS: We found positive associations between AML and broiler chicken densities (RR = 1.14, 95% CI = 1.02-1.26). ALL rates increased with densities of hog operations (RRper operation/100km = 1.06, 95% CI = 1.02-1.11). PNS cancer rates were inversely associated with layer chicken density (RR = 0.94, 95% CI = 0.89-0.99). No association was found between any cancer type and densities of cattle, equine, or goats. CONCLUSIONS: Although limited by the ecologic study design, some of our findings are novel and should be examined in epidemiological studies with individual level data.
[Mh] Termos MeSH primário: Gado
Neoplasias/epidemiologia
Aves Domésticas
[Mh] Termos MeSH secundário: Animais
Neoplasias do Sistema Nervoso Central/epidemiologia
Pré-Escolar
Feminino
Seres Humanos
Incidência
Lactente
Recém-Nascido
Leucemia Mieloide Aguda/epidemiologia
Masculino
Neoplasias do Sistema Nervoso Periférico/epidemiologia
Densidade Demográfica
Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia
Distribuição Espacial da População
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE


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[PMID]:28604466
[Au] Autor:Kim E; Cucchiaro G
[Ad] Endereço:From the Department of Anesthesiology Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, California.
[Ti] Título:Unique Considerations in Spinal Cord Stimulator Placement in Pediatrics: A Case Report.
[So] Source:A A Case Rep;9(4):112-115, 2017 Aug 15.
[Is] ISSN:2325-7237
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spinal cord stimulation can be a valuable treatment option in the management of neuropathic pain in select pediatric patients. We present a unique case of a 16-year-old girl with Klippel-Trenaunay-Weber syndrome and scoliosis who required the placement of a spinal cord stimulator (SCS) for severe sciatic nerve neuropathic pain after a right above-knee amputation. Several attempts at lead placement were required before successful pain coverage was achieved because of late recognition of significant vertebral body rotation. This case highlights important considerations in pediatric SCS placement including a careful review of the spinal cord anatomy before the placement of an SCS.
[Mh] Termos MeSH primário: Neuroma/complicações
Manejo da Dor/métodos
Neoplasias do Sistema Nervoso Periférico/complicações
Neuropatia Ciática/complicações
Estimulação da Medula Espinal/métodos
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Síndrome de Klippel-Trenaunay-Weber/complicações
Neuroma/terapia
Neoplasias do Sistema Nervoso Periférico/terapia
Neuropatia Ciática/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1213/XAA.0000000000000541


  5 / 4137 MEDLINE  
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[PMID]:28498283
[Au] Autor:Chrisinger JSA; Salem UI; Kindblom LG; Amini B; Hansson M; Meis JM
[Ad] Endereço:Departments of *Pathology †Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX ‡Department of Musculo-Skeletal Pathology, Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, UK §Department of Cytology and Pathology, Sahlgrenska University Hospital, Göteborg, Sweden.
[Ti] Título:Synovial Sarcoma of Peripheral Nerves: Analysis of 15 Cases.
[So] Source:Am J Surg Pathol;41(8):1087-1096, 2017 Aug.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Synovial sarcoma of peripheral nerve (SSPN) is rare with only 26 cases reported in English. SSPN is often mistaken for a benign or malignant peripheral nerve sheath tumor (PNST) by clinicians and pathologists. Fifteen cases of SSPN were retrieved from the pathology files of 3 institutions. All tumors arose in a nerve based on imaging and/or operative findings and the diagnoses were histologically confirmed. Neuropathic symptoms predominated in 11 women and 4 men, 19- to 62-year-old (median, 39 years) with tumors involving the ulnar (5), median (3), peroneal (3) or sciatic (2) nerve, or the L4 or T1 nerve root (2). Tumor sizes ranged from 2 to 13 cm (median, 3.8 cm). The leading clinical diagnosis was PNST (9). Treatment was surgical (14) supplemented with radiation therapy (8) and chemotherapy (6). Fourteen tumors were monophasic and 1 was biphasic; 4 had poorly differentiated (PD) foci (1 rhabdoid). Diagnoses in 12 cases were verified by fluorescence in situ hybridization, reverse transcription polymerase chain reaction or both methods. Follow-up in 14 patients (median, 32 mo) revealed that 2/4 patients with PD tumors died with pulmonary metastases; another was alive with no current evidence of disease (NED) following 2 local recurrences, while the fourth had NED. In contrast, 9/10 patients without PD tumors were alive (7 NED) and 1 died at 12 months with pulmonary infiltrates. SSPN is under-recognized clinically and histologically as it mimics benign and malignant PNST. Molecular analysis is recommended to confirm the diagnosis. PD foci, including rhabdoid areas, may portend a worse outcome, similar to non-neural-based tumors.
[Mh] Termos MeSH primário: Neoplasias do Sistema Nervoso Periférico/patologia
Sarcoma Sinovial/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000874


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[PMID]:28346666
[Au] Autor:Cook RW; Abraham LA; McCowan CI
[Ad] Endereço:Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Victoria, Australia.
[Ti] Título:Disseminated peripheral neuroblastoma in a Rhodesian Ridgeback dog.
[So] Source:Aust Vet J;95(4):129-133, 2017 Apr.
[Is] ISSN:1751-0813
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CASE REPORT: A 4-year-old neutered male Rhodesian Ridgeback dog with right-sided Horner's syndrome, bilateral laryngeal paralysis, neck pain and bilateral hindlimb ataxia was euthanased following deterioration of its neurological status. Necropsy examination revealed an off-white retropharyngeal neoplastic mass (100 × 30 × 30 mm) attached to the base of the skull on the right side and macroscopic nodular metastases in the spleen and three vertebral bodies (C6, C7 and T6), including a nodule attached to the dura at C7. Histological evidence of neuroblastic tumour was detected in these macroscopic lesions, a regional lymph node, bone marrow of a femur and all 15 vertebral bodies (C1-T8) examined, including the three with macroscopic metastases, and in the lumens of small blood vessels in the lungs and liver. Ganglion cell differentiation was detected only in the primary retropharyngeal mass, one splenic nodule and the C7 dural nodule. Neoplastic cells were immunoreactive to neurofilament protein (ganglion cells only), vimentin and synaptophysin, and were negative for S100 protein, GFAP, CD3 and Pax5. CONCLUSION: The diagnosis was disseminated peripheral neuroblastoma, differentiating subtype (International Neuroblastoma Pathology Classification), with likely primary involvement of the right cranial cervical ganglion. This appears to be the first report of neuroblastoma in a dog with widespread occult haematogenous metastasis to bone marrow.
[Mh] Termos MeSH primário: Doenças do Cão/patologia
Neuroblastoma/veterinária
Neoplasias do Sistema Nervoso Periférico/veterinária
[Mh] Termos MeSH secundário: Animais
Ataxia/etiologia
Ataxia/veterinária
Neoplasias da Medula Óssea/secundário
Neoplasias da Medula Óssea/veterinária
Neoplasias Ósseas/secundário
Neoplasias Ósseas/veterinária
Cães
Síndrome de Horner/etiologia
Síndrome de Horner/veterinária
Masculino
Neuroblastoma/complicações
Neuroblastoma/patologia
Neoplasias do Sistema Nervoso Periférico/complicações
Neoplasias do Sistema Nervoso Periférico/patologia
Neoplasias Esplênicas/secundário
Neoplasias Esplênicas/veterinária
Paralisia das Pregas Vocais/etiologia
Paralisia das Pregas Vocais/veterinária
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1111/avj.12565


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[PMID]:28303299
[Au] Autor:Kumar R; Vu L; Madewell JE; Herzog CE; Bird JE
[Ad] Endereço:Department of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Unit 1515 Holcombe Boulevard, Unit 1495, Houston, TX, 77030, USA. rajkumar@mdanderson.org.
[Ti] Título:Glomangiomatosis of the sciatic nerve: a case report and review of the literature.
[So] Source:Skeletal Radiol;46(6):807-815, 2017 Jun.
[Is] ISSN:1432-2161
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Glomus tumors are hamartomas, which tend to occur in sites rich in glomus bodies, such as the subungual regions of digits or the deep dermis of the palm, wrist, forearm, and foot. Very rarely, they may involve peripheral nerves. We describe a patient, who, following surgical resection of a solitary glomus tumor of the left distal sciatic nerve in his teens, had recurrence with development of multiple tumors in the course of the nerve over several years. To our knowledge, this is the only known case of glomangiomatosis involving a major peripheral nerve.
[Mh] Termos MeSH primário: Tumor Glômico/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Recidiva Local de Neoplasia/diagnóstico por imagem
Neoplasias do Sistema Nervoso Periférico/diagnóstico por imagem
Nervo Isquiático/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Tumor Glômico/cirurgia
Seres Humanos
Masculino
Neoplasias do Sistema Nervoso Periférico/cirurgia
Nervo Isquiático/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1007/s00256-017-2594-9


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[PMID]:28261433
[Au] Autor:Lee SJ; Yoon ST
[Ad] Endereço:Department of Orthopedic Surgery, Konkuk University School of Medicine, Seoul, Korea.
[Ti] Título:Ultrasonographic and Clinical Characteristics of Schwannoma of the Hand.
[So] Source:Clin Orthop Surg;9(1):91-95, 2017 Mar.
[Is] ISSN:2005-4408
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study was to report the ultrasonographic findings and clinical features of schwannoma of the hand. METHODS: We enrolled 8 patients who were initially diagnosed with ganglion by ultrasonography but finally with schwannoma by a tissue biopsy. We retrospectively analyzed the ultrasonographic findings of eight patients including echogenicity, internal homogeneity, posterior enhancement, internal vascularity, and clinical manifestations such as the occurrence site, tenderness, Tinel's sign, and paresthesia before the surgery. RESULTS: The occurrence sites were as follows: two cases on the thenar area, one case on the second web space, three cases on the third web space, one case on the radiovolar aspect of the proximal phalanx of the index finger, and one case on the radiovolar aspect of the proximal phalanx of the middle finger. Four patients suffered from tenderness and pain on presentation, and all patients had pain around the mass before presentation. Tinel's sign was present without paresthesia in one case. Ultrasonography revealed cystic lesions showing clear margins in all cases, and two of them had acoustic enhancement without internal flow. CONCLUSIONS: It may not be easy to diagnosis schwannoma of the hand with ultrasonography alone when the lesion is small because of the similarity to the ultrasonographic findings of ganglion. Therefore, it is necessary to consider the possibility of schwannoma if a mass near the digital nerve or cutaneous nerve branch is accompanied by dull pain and tenderness.
[Mh] Termos MeSH primário: Neurilemoma/complicações
Neurilemoma/diagnóstico por imagem
Neoplasias do Sistema Nervoso Periférico/complicações
Neoplasias do Sistema Nervoso Periférico/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Dor do Câncer/etiologia
Feminino
Dedos
Seres Humanos
Masculino
Meia-Idade
Parestesia/etiologia
Estudos Retrospectivos
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.4055/cios.2017.9.1.91


  9 / 4137 MEDLINE  
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[PMID]:28209648
[Au] Autor:Swords C; Coyle P; Qayyum A; Masood A
[Ad] Endereço:Department of ENT, Peterborough City Hospital, Peterborough, UK.
[Ti] Título:Unusual case of nasal obstruction.
[So] Source:BMJ Case Rep;2017, 2017 Feb 16.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Tonsila Faríngea/patologia
Cordoma/complicações
Obstrução Nasal/etiologia
Neoplasias do Sistema Nervoso Periférico/complicações
Raízes Nervosas Espinhais
[Mh] Termos MeSH secundário: Adolescente
Vértebras Cervicais
Cordoma/diagnóstico por imagem
Seres Humanos
Hipertrofia/complicações
Imagem por Ressonância Magnética
Masculino
Neoplasias do Sistema Nervoso Periférico/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28120090
[Au] Autor:Stevanato G; Monteleone G; Sgubin D; Sicolo M; Pastorello G; Vazzana L; Guida F
[Ad] Endereço:Neurosurgery Unit, Dell'Angelo Hospital, Via Paccagnella 11, Mestre-Venezia, 30172, Italy. giorgio.stevanato@ulss12.ve.it.
[Ti] Título:Radioguided Occult Lesion Localization in Deep Schwannomas of the Peripheral Nerves: Results of a Preliminary Case Series.
[So] Source:Acta Neurochir Suppl;124:315-318, 2017.
[Is] ISSN:0065-1419
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The detection of small deep schwannomas of the peripheral nerves has been increasing since the the use of precise neuroimaging techniques has become more widespread; however, although nonpalpable lesions can be well defined by images, it is often difficult to identify them during the surgical procedure. The authors report seven cases of nonpalpable small deep schwannomas surgically treated after their identification using the radioguided occult lesion localization (ROLL) technique. METHODS: Seven men, whose ages ranged from 34 to 70 years (mean 52 years), presented with symptomatic nonpalpable peripheral nerve lesions; two cases involved the sciatic nerve, two the femoral nerve, two the radial nerve, and one the tibial nerve. Before the operation, all the patients were studied by ultrasonography and magnetic resonance imaging (MRI); 1 h before the surgery 3-5 MBq of Tc labeled with human albumin macroaggregates was injected into the lesion. A gamma detection probe permitted the preoperative and intraoperative detection of the nonpalpable schwannomas. CONCLUSIONS: The ROLL technique provides good support for identifying small lesions of the peripheral nerves both preoperatively and intraoperatively. This technique permits the use of minimally invasive approaches performed with local anesthesia, with good cosmetic results and acceptance by the patients.
[Mh] Termos MeSH primário: Neuropatia Femoral/cirurgia
Neurilemoma/cirurgia
Neoplasias do Sistema Nervoso Periférico/cirurgia
Neuropatia Radial/cirurgia
Neuropatia Ciática/cirurgia
Neuropatia Tibial/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Neuropatia Femoral/diagnóstico por imagem
Seres Humanos
Masculino
Meia-Idade
Neurilemoma/diagnóstico por imagem
Procedimentos Neurocirúrgicos
Neoplasias do Sistema Nervoso Periférico/diagnóstico por imagem
Neuropatia Radial/diagnóstico por imagem
Compostos Radiofarmacêuticos
Neuropatia Ciática/diagnóstico por imagem
Agregado de Albumina Marcado com Tecnécio Tc 99m
Neuropatia Tibial/diagnóstico por imagem
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0 (Technetium Tc 99m Aggregated Albumin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-39546-3_46



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