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[PMID]:27771610
[Au] Autor:Agulnik M; Costa RLB; Milhem M; Rademaker AW; Prunder BC; Daniels D; Rhodes BT; Humphreys C; Abbinanti S; Nye L; Cehic R; Polish A; Vintilescu C; McFarland T; Skubitz K; Robinson S; Okuno S; Van Tine BA
[Ad] Endereço:Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, USA.
[Ti] Título:A phase II study of tivozanib in patients with metastatic and nonresectable soft-tissue sarcomas.
[So] Source:Ann Oncol;28(1):121-127, 2017 01 01.
[Is] ISSN:1569-8041
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: Soft tissue sarcomas (STSs) overexpress vascular endothelial growth factors (VEGF) and VEGF-receptors (VEGFR) activation have been associated with tumor aggressiveness. Tivozanib is a potent small molecule tyrosine kinase inhibitor against VEGFR1-3, with activity against PDGFRα/ß and cKIT. The primary endpoint of this study was progression free survival (PFS) rate at 16 weeks. Secondary end points were overall survival (OS), response rate, safety and correlative studies. Patients and methods: A Simon two-stage phase II trial was performed using tivozanib given orally at 1.5 mg daily, 3 week on 1 week off on a 28 day cycle until disease progression or intolerable toxicity. Results: Fifty-eight patients were enrolled and treated with tivozanib. Leiomyosarcoma was the most common STS histological type in our cohort (47%) and 27 patients (46%) had received at least 3 lines of therapy prior to study entry. Up to 24 patients (41%) had prior VEGF targeted therapies. Partial response and stable disease were observed in 2 (3.6%) and 30 (54.5%) patients. The 16 week PFS rate was 36.4% [95% confidence interval (CI) 23.7-49.1] and a median PFS of 3.5 months (95% CI 1.8-3). Median OS observed was 12.2 months (95% CI 8.1-16.8). The most frequent all grade toxicities were fatigue (48.3%), hypertension (43.1%), nausea (31%) and diarrhea (27.6%). The most common grade three toxicity was hypertension (22.4%). Correlative studies demonstrate no correlation between the expression of VEGFR 1, 2 or 3, PDGFRα/ß or FGF, and activity of tivozanib. Conclusion: Tivozanib was well tolerated and showed antitumor activity with a promising median PFS and PFS rate at 4 months in a heavily pretreated population of metastatic STSs. Our results support further studies to assess the clinical efficacy of tivozanib in STS. Clinical Trial Number: NCT01782313.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Compostos de Fenilureia/uso terapêutico
Quinolinas/uso terapêutico
Sarcoma/tratamento farmacológico
Neoplasias de Tecidos Moles/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Intervalo Livre de Doença
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Receptores de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores
Sarcoma/mortalidade
Neoplasias de Tecidos Moles/mortalidade
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Phenylurea Compounds); 0 (Quinolines); 172030934T (tivozanib); EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1093/annonc/mdw444


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[PMID]:29266252
[Au] Autor:Mullen JT; van Houdt W
[Ad] Endereço:Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
[Ti] Título:Soft tissue tumors of the pelvis: Technical and histological considerations.
[So] Source:J Surg Oncol;117(1):48-55, 2018 Jan.
[Is] ISSN:1096-9098
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this review, we first address the anatomic and technical considerations in the resection of pelvic soft tissue tumors, including the challenges unique to these tumors, such as the narrow anatomic confines of the bony pelvis, the often locally aggressive nature of these tumors, as well as the major functional deficits that may result from their resection. We then review the optimal, multidisciplinary, histology-driven treatment approach to pelvic tumors.
[Mh] Termos MeSH primário: Neoplasias Pélvicas/patologia
Neoplasias de Tecidos Moles/patologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1002/jso.24943


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[PMID]:29248129
[Au] Autor:Bas Y; Hassan HA; Adigüzel C; Bulur O; Ibrahim IA; Soydan S
[Ad] Endereço:Department of Pathology, Somalia-Turkey Education and Research Hospital, Mogadishu, Somalia; Hitit University Medical School, Çorum, Turkey. Electronic address: yilbas@yahoo.com.
[Ti] Título:The distribution of cancer cases in Somalia.
[So] Source:Semin Oncol;44(3):178-186, 2017 06.
[Is] ISSN:1532-8708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to investigate the frequency and distribution of cancer cases in a defined time period in Somalia. MATERIALS AND METHODS: A total of 403 cancer cases were diagnosed between January 01, 2016 and March 01, 2017 in the Department of Pathology at the Somalia Mogadishu-Turkey Education and Research Hospital or the Department of Oncology at Uniso Hospital, Somalia University. Data on cancer type, patient age, and gender were obtained from pathology reports and hospital records. RESULTS: Female patients totaled 49.6% (n = 200) and 50.4% of patients were male (n = 203). The youngest patient was 18 years of age, the oldest was 97, and the average age was 53.4 years. The 10 most common types of cancer were esophageal (n = 130, 32.3%), non-Hodgkin lymphoma (n = 35, 8.7%), liver (n = 26, 6.5%), breast (n = 24, 6.0%), skin (n = 17, 4.2%), thyroid (n = 13, 3.2%), brain (n = 12, 3.0%), bone (n = 11, 2.7%), colorectal (n = 11, 2.7%), and soft tissue (n = 11, 2.7%). The most common site of cancer in both males and females was the esophagus. CONCLUSION: These results show a high incidence of esophageal cancer in Somalia, and strongly suggest that environmental risk factors and nutritional habits have a strong impact in this population. Serious and extensive research on the etiology of esophageal cancer is required.
[Mh] Termos MeSH primário: Neoplasias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Neoplasias Ósseas/epidemiologia
Neoplasias Encefálicas/epidemiologia
Neoplasias da Mama/epidemiologia
Neoplasias Colorretais/epidemiologia
Neoplasias Esofágicas/epidemiologia
Feminino
Seres Humanos
Incidência
Neoplasias Hepáticas/epidemiologia
Linfoma não Hodgkin/epidemiologia
Masculino
Meia-Idade
Fatores de Risco
Distribuição por Sexo
Neoplasias Cutâneas/epidemiologia
Neoplasias de Tecidos Moles/epidemiologia
Somália/epidemiologia
Neoplasias da Glândula Tireoide/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171218
[St] Status:MEDLINE


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[PMID]:29201311
[Au] Autor:Savvidou OD; Chloros GD; Koutsouradis P; Megaloikonomos PD; Skarpidi E; Papagelopoulos PJ
[Ad] Endereço:The First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Athens, Greece.
[Ti] Título:Synovial Sarcoma Complicating Total Knee Arthroplasty.
[So] Source:Clin Orthop Surg;9(4):547-552, 2017 Dec.
[Is] ISSN:2005-4408
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Synovial sarcoma is a relatively common periarticular soft tissue malignancy, occurring mostly in the extremities of younger patients. Occasionally, diversity in its clinical features may lead to misdiagnosis and inappropriate management. The authors report herein a unique case of a patient who underwent a primary total knee arthroplasty to treat osteoarthritis. During the operation, a mass was discovered but was attributed to synovitis. Biopsy revealed a rare intra-articular synovial sarcoma. The patient underwent reoperation with wide excision and endoprosthesis placement and is disease-free at the 8-year follow-up.
[Mh] Termos MeSH primário: Artroplastia do Joelho
Sarcoma Sinovial/cirurgia
Neoplasias de Tecidos Moles/cirurgia
[Mh] Termos MeSH secundário: Idoso
Artroplastia do Joelho/instrumentação
Feminino
Seres Humanos
Achados Incidentais
Osteoartrite/complicações
Osteoartrite/cirurgia
Reoperação
Sarcoma Sinovial/complicações
Sarcoma Sinovial/patologia
Neoplasias de Tecidos Moles/complicações
Neoplasias de Tecidos Moles/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.4055/cios.2017.9.4.547


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[PMID]:27777135
[Au] Autor:Haddad J; Kalbacher E; Piccard M; Aubry S; Chaigneau L; Pauchot J
[Ad] Endereço:Service de chirurgie orthopédique, traumatologique et plastique, chirurgie de la main, CHU Jean-Minjoz, 1, boulevard Flemming, 25030 Besançon, France.
[Ti] Título:[Evaluation of the management of soft tissue sarcomas in Franche-Comté since the establishment of a multidisciplinary meeting at University Hospital. About 47 cases].
[Ti] Título:Évaluation de la prise en charge des sarcomes des tissus mous en Franche-Comté depuis l'instauration d'une réunion de concertation pluridisciplinaire au CHRU. À propos de 47 cas..
[So] Source:Ann Chir Plast Esthet;62(1):15-22, 2017 Feb.
[Is] ISSN:1768-319X
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:GOALS OF STUDY: A multidisciplinary meeting (RCP) dedicated to the treatment of sarcoma was established in Franche-Comte in 2010. The goals of the study are: (a) To evaluate the treatment of sarcomas by confrontation with the existing literature; (b) To evaluate the influence of the multidisciplinary meeting on the management of sarcomas by hospitals at the regional level. MATERIALS AND METHODS: This is a retrospective single center study from 2010 to 2015 on patients with sarcoma and peripheral soft tissue drawn from a Netsarc database (National Network of sarcomas) and communicating cancer record. A database Cleanweb especially dedicated is created. RESULTS: Forty-seven patients were included: ten sarcomas at the upper member 26 to the lower limbs, 11 on the trunk. Forty patients were operated on: ten out of the university hospital, 28 at the university hospital and two in a coordinating center. Ninety percent of patients treated at the university hospital were in accordance with the recommandations. None of the patients operated out of the university hospital benefited from medical care in accordance to the recommendations. There is an increase in the number of files sent by the hospitals out of the university hospital discussed in multidisciplinary meeting, before treatment. CONCLUSION: The creation of a dedicated multidisciplinary meeting sarcoma improves the medical management of these tumors and decreases inappropriate medical managements thanks to a better education of the regional physicians.
[Mh] Termos MeSH primário: Comunicação Interdisciplinar
Sarcoma/cirurgia
Neoplasias de Tecidos Moles/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Extremidades/patologia
Feminino
França
Hospitais Universitários
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Sarcoma/patologia
Neoplasias de Tecidos Moles/patologia
Tronco/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29325251
[Au] Autor:Zhao M; Yang ZR; Wang YB; Chen Y; Qi GW; Yan YJ; Xu WJ; Ru GQ; He XL
[Ad] Endereço:Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
[Ti] Título:[Extrapleural solitary fibrous tumor with uncommon histology: a clinicopathologic analysis of 7 cases].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(1):51-56, 2018 Jan 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinicopathologic characteristics, immunophenotypes, and differential diagnostic features of extra-pleural solitary fibrous tumor (SFT) with uncommon histology. Seven cases of extra-pleural SFT with uncommon histology were collected during January 2015 and December 2016 in Zhejiang Provincal People's Hospital; the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed. EnVision method was used for immunohistochemical staining of STAT6, CD34 and other differential diagnosis associated markers. There were five male and two female patients, age from 23 to 54 years (mean=39 years). Three tumors were located in the soft tissue of head and neck, two in trunk subcutaneous soft tissue, one in sella region, and one in the kidney. Grossly the tumors ranged from 0.4 to 8.0 cm (mean=3.1 cm). Microscopically, all three head and neck cases resembled giant cell angiofibroma/giant cell subtype SFT, and one case showed sheet-like pattern of the multinucleated syncytial cells, creating a biphasic arrangement similar to myofibroma. Both truncal tumor resembled lipomatous type SFT, with one similar to dermatofibrosarcoma protuberans and the other to atypical spindle cell lipomatous tumor. The sella tumor showed morphology of a conventional SFT with high grade sarcomatous transformation. The renal tumor demonstrated a malignant SFT with entrapped benign renal tubules, mimicking a biphase synovial sarcoma or a malignant mixed epithelial and stromal tumor. By immunohistochemistry, all seven SFTs showed diffuse and strong nuclear reactivity to antibody against STAT6. Extra-pleural SFTs show a significant heterogeneity of morphology and biological behavior which could cause differential confusion.Careful attention to its characteristic histomorphology with the use of STAT6 immunohistochemistry can help distinguish this tumor from its many mimickers.
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Tecidos Moles/patologia
Tumores Fibrosos Solitários/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
Dermatofibrossarcoma/patologia
Diagnóstico Diferencial
Feminino
Neoplasias de Cabeça e Pescoço/química
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Masculino
Meia-Idade
Prognóstico
Fator de Transcrição STAT6/análise
Sarcoma/patologia
Neoplasias de Tecidos Moles/química
Tumores Fibrosos Solitários/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (STAT6 Transcription Factor); 0 (STAT6 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.01.010


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[PMID]:29202860
[Au] Autor:Hashimoto S; Kikuta K; Sekita T; Nakayama R; Takayama S; Sasaki A; Kameyama K; Nakamura M; Matsumoto M; Morioka H
[Ad] Endereço:Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, 160-8582, Tokyo, Japan.
[Ti] Título:A giant popliteal lipoblastoma in a 23-month-old girl: a case report.
[So] Source:J Med Case Rep;11(1):338, 2017 Dec 05.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lipoblastomas are rare benign tumors that arise from embryonic white fat and almost always occur in babies and children. Here, we report a case of a giant popliteal lipoblastoma in a 23-month-old Japanese girl that was successfully treated via complete resection. CASE PRESENTATION: Our patient was a 23-month-old Japanese girl. At 6 months of age, she presented at a nearby hospital with a mass on the popliteal side of her lower right leg. She had no symptoms and was diagnosed as having a benign adipose tumor via magnetic resonance imaging. The mass gradually increased in size, and she was referred to our hospital at 1 year and 11 months of age. A physical examination and radiology revealed a localized mass 13 × 10 × 7 cm in size in the aforementioned area that restricted knee movement and caused proximal tibia deformity. Magnetic resonance imaging showed a giant circumscribed subcutaneous mass with multiple partitions that was hyperintense on T1-weighted and T2-weighted images but not fat-saturated on T2-weighted images. Based on these findings, she was diagnosed as having a lipoblastoma. Because the mass surrounded her popliteal artery and vein and part of the popliteal nerve, surgical resection was considered risky, and we opted to simply observe her. However, owing to rapid growth of the mass and the worsening of symptoms, she underwent complete resection at 2 years and 6 months of age. A histological examination confirmed the diagnosis of a lipoblastoma. She was discharged from our hospital 3 days after surgery with no symptoms. She could walk without pain at the 6-month follow-up, and no local recurrence was observed. CONCLUSIONS: We successfully treated a giant popliteal lipoblastoma without complications by performing a total resection. Our report provides evidence that lipoblastomas should be considered for surgical resection when they progress or symptoms appear.
[Mh] Termos MeSH primário: Lipoblastoma/diagnóstico por imagem
Neoplasias de Tecidos Moles/diagnóstico por imagem
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lactente
Japão
Lipoblastoma/patologia
Lipoblastoma/cirurgia
Imagem por Ressonância Magnética
Artéria Poplítea/diagnóstico por imagem
Veia Poplítea/diagnóstico por imagem
Radiografia
Neoplasias de Tecidos Moles/patologia
Neoplasias de Tecidos Moles/cirurgia
Procedimentos Cirúrgicos Operatórios
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1513-y


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[PMID]:29172311
[Au] Autor:Rice N; Srinivasan B; Macpherson D
[Ti] Título:Case Report: Metastatic Infratemporal Soft Tissue Myeloma Presenting as a Numb Lower Lip.
[So] Source:Dent Update;44(1):53-4, 2017 Jan.
[Is] ISSN:0305-5000
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This is a case of a patient presenting to his general dental practitioner (GDP) with altered sensation in his lower lip with no obvious cause. Due to a prompt referral, the patient was investigated and diagnosed with an extramedullary presentation of multiple myeloma. A numb lip can present in general dental practice, although this is not common. There are several causes, for example, dental infection or fractured mandible. Clinical relevance: It is very important for the dental practitioner to recognize when there could be a potential sinister underlying cause and prompt referral, under the two week rule referral system, is indicated
[Mh] Termos MeSH primário: Mieloma Múltiplo/secundário
Neoplasias de Tecidos Moles/secundário
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Hipestesia/etiologia
Lábio
Masculino
Mandíbula
Mieloma Múltiplo/complicações
Mieloma Múltiplo/diagnóstico
Neoplasias de Tecidos Moles/complicações
Neoplasias de Tecidos Moles/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29277827
[Au] Autor:Higuchi T; Yamamoto N; Hayashi K; Takeuchi A; Kato S; Miwa S; Abe K; Taniguchi Y; Aiba H; Tsuchiya H
[Ad] Endereço:Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
[Ti] Título:The Efficacy of Wide Resection for Musculoskeletal Metastatic Lesions of Renal Cell Carcinoma.
[So] Source:Anticancer Res;38(1):577-582, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: This study evaluated the outcome of wide resection for metastatic renal cell carcinoma (RCC) to the bone or soft tissue. PATIENTS AND METHODS: Thirty patients who underwent surgery for bone or soft tissue metastatic lesions of RCC were retrospectively evaluated. The surgical procedures were wide resection in 14 patients (group 1) and intralesional resection in 16 (group 2). RESULTS: The 3-, 5-, 10-, and 15-year overall survival (OS) was 76%, 48%, 35%, and 23%, respectively, and OS was significantly favorable in group 1. In addition, recurrence-free survival rate was significantly higher in group 1. In the multivariate analysis, intralesional resection was an independent risk factor for poor prognosis. There was no significant difference in surgical time, though intraoperative hemorrhage was significantly larger in group 2. CONCLUSION: The wide resection of bone and soft tissue metastatic lesions of RCC is a favorable option for controlling local metastasis and improving prognosis.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Carcinoma de Células Renais/patologia
Neoplasias Renais/patologia
Neoplasias Pulmonares/cirurgia
Metastasectomia
Neoplasias de Tecidos Moles/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Ósseas/mortalidade
Neoplasias Ósseas/secundário
Feminino
Seres Humanos
Neoplasias Pulmonares/mortalidade
Neoplasias Pulmonares/secundário
Masculino
Meia-Idade
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Neoplasias de Tecidos Moles/mortalidade
Neoplasias de Tecidos Moles/secundário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:29180217
[Au] Autor:Gong X; Cui J; Jiang Z; Maharjan S; Lu L; Li X
[Ad] Endereço:Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China P.R.
[Ti] Título:Comparison of perioperative complications of pedicled island flap in reconstruction of extremities.
[So] Source:J Surg Res;220:94-104, 2017 Dec.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study was to analyze the differences in perioperative complications for pedicled island flaps in the reconstruction of extremities and to identify the factors contributing to pedicled island flap necrosis. Furthermore, the flap indications based on these outcomes are summarized. METHODS: Based on the inclusion criteria, 228 skin flaps were included in this study. Univariate and multivariate analyses were used to identify the risk factors for pedicled island flap necrosis. Differences in perioperative complications between upper and lower extremities were analyzed using the chi-square test or Fisher's exact test. RESULTS: The average age of the patients was 38 years. The overall complication rate was 21.93%, including partial flap necrosis (10.09%) and total flap necrosis (5.70%). The overall complication rate and flap necrosis rate in upper extremity reconstruction were significantly lower than the rates in lower extremity reconstruction. Flap area and postoperative wound infection were statistically significant risk factors for pedicled island flap necrosis in extremity reconstruction. Preoperative contamination of the wound bed was a statistically significant risk factor for postoperative wound infection. CONCLUSIONS: The flap area and postoperative wound infection were both independent risk factors for pedicled island flap necrosis in extremity reconstruction. The causes contributing to the differences in perioperative complications between upper and lower extremities reconstruction included preoperative contamination of the wound bed, postoperative wound infection, and the flap area but were also related to anatomical factors of the skin flap. Pedicled island flaps are more suitable for small- and medium-sized soft tissue defects.
[Mh] Termos MeSH primário: Período Perioperatório/estatística & dados numéricos
Procedimentos Cirúrgicos Reconstrutivos/efeitos adversos
Pele/patologia
Retalhos Cirúrgicos/patologia
Infecção da Ferida Cirúrgica/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Extremidade Inferior/cirurgia
Masculino
Meia-Idade
Necrose/epidemiologia
Fatores de Risco
Infecções dos Tecidos Moles/cirurgia
Lesões dos Tecidos Moles/cirurgia
Neoplasias de Tecidos Moles/cirurgia
Extremidade Superior/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE



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