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[PMID]:29429160
[Au] Autor:Zhao M; Wang YB; Yan YJ; Wang W; Ru GQ; He XL
[Ad] Endereço:Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
[Ti] Título:[Clinicopathologic features of atypical spindle cell lipomatous tumor].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):99-104, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinicopathologic characteristics, immunophenotype, differential and diagnostic features of atypical spindle cell lipomatous tumor (ASLT). Three cases of ASLT were collected from January 2010 to March 2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, histomorphology, immunophenotype and prognosis were analyzed. Fluorescence in situ hybridization (FISH) was used to detect MDM2 gene amplification, and relevant literature was reviewed. All three patients were adult males, aged 38, 43 and 54 years, respectively. One tumor originated in the subcutaneous soft tissue in the head and neck, one was located in the left primary bronchus and one in the latissimus dorsi muscle. Grossly, all three tumors were circumscribed and ranged from 4.0 to 5.8 cm in size. Microscopically, all showed a focally infiltrative front. These tumors were composed of variable proportions of spindle-shaped and adipocytic cells in a background of variable fibrous and edematous matrix. Scattered lipoblasts were easily seen. One tumor was composed predominately of spindle tumor cells, one of adipocytic cells, and one of equally mixed cell populations. The spindle tumor cells were generally bland-appearing with focal nuclear enlargement and hyperchromasia noted in one case. Mitosis was not seen in neither the spindle cells nor the adipocytic cells. By immunohistochemistry, diffuse and strong reactivity to CD34 of the spindle cells was noted in all cases, definite loss of Rb expression was noted in one of three cases, and S-100 protein was expressed only in the adipocytic cells. INI-1 was intact and Ki-67 index was 1% to 3%. All other markers including CDK4, MDM2, STAT6, SOX10, CD99, bcl-2, ß-catenin, CD117, GFAP, CK, EMA, SMA and desmin were negative. FISH of MDM2 was done in two cases, and both showed no amplification. The ASLT in the head and neck had two recurrences during 17 months of follow-up, whereas the tumor in the latissimus dorsi was free of disease during 33 months of follow-up. ASLT is a rare subtype of low-grade adipocytic neoplasm and is distinctive from atypical lipomatous tumor/well-differentiated liposarcoma. The histomorpholgy of ASLT has significant heterogeneity and forms a continuous spectrum. ASLT needs to be distinguished from a series of benign and malignant soft tissue tumors.
[Mh] Termos MeSH primário: Neoplasias Brônquicas/patologia
Neoplasias de Cabeça e Pescoço/patologia
Lipoma/patologia
Neoplasias Musculares/patologia
[Mh] Termos MeSH secundário: Adulto
Neoplasias Brônquicas/química
Neoplasias de Cabeça e Pescoço/química
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Lipoma/química
Lipossarcoma/química
Lipossarcoma/patologia
Masculino
Meia-Idade
Neoplasias Musculares/química
Recidiva Local de Neoplasia
Proteínas S100/análise
Fator de Transcrição STAT6/análise
Músculos Superficiais do Dorso
beta Catenina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CTNNB1 protein, human); 0 (S100 Proteins); 0 (STAT6 Transcription Factor); 0 (STAT6 protein, human); 0 (beta Catenin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.004


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[PMID]:29310392
[Au] Autor:Cui B; Wang DH; Wang GJ; Cheng P; Zhang F; Duan XB; Zhao ZF
[Ad] Endereço:Department of neurosurgery.
[Ti] Título:Cavernous hemangiomas of the temporalis muscle with prominent formation of phleboliths: Case report and review of the literature.
[So] Source:Medicine (Baltimore);96(48):e8948, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Hemangiomas are benign tumors characterized by an abnormal proliferation of blood vessels, most often occur in the skin and subcutaneous tissue, intramuscular hemangioma, a distinctive type of hemangioma within the skeletal muscle, account for <1% of all hemangiomas, temporalis muscle is a very uncommon site, cavernous hemangioma of the temporalis muscle with prominent formation of phleboliths is rare reported. PATIENT CONCERNS: A 62-year-old man presented with a slowly increased mass in his right temporal fossa. DIAGNOSES: Computed tomography (CT) scan showed the lesion across the zygomatic arch, with many calcified nodules differ in sizes and no erosion to the bone, magnetic resonance imaging (MRI) showed an oval lesion with hypointense and isointense on T2-weighted imaging within the temporal muscle, and preoperation diagnosis was hemangioma. INTERVENTIONS: The tumor was resected under general anesthesia. OUTCOMES: The mass was excised completely, and the histopathology examination confirmed the diagnosis of cavernous hemangioma with prominent formation of phleboliths. The patient recovered very well without dysfunctions. LESSONS: Cavernous hemangioma should be suspected when mass occurs in this region. CT and MRI are important for the early diagnosis of tumor, and resection the tumor completely is recommended.
[Mh] Termos MeSH primário: Hemangioma Cavernoso/complicações
Neoplasias Musculares/complicações
Calcificação Vascular/complicações
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Hemangioma Cavernoso/diagnóstico por imagem
Hemangioma Cavernoso/patologia
Hemangioma Cavernoso/cirurgia
Seres Humanos
Masculino
Meia-Idade
Neoplasias Musculares/diagnóstico por imagem
Neoplasias Musculares/patologia
Neoplasias Musculares/cirurgia
Músculo Temporal/diagnóstico por imagem
Músculo Temporal/patologia
Músculo Temporal/cirurgia
Calcificação Vascular/diagnóstico por imagem
Calcificação Vascular/patologia
Calcificação Vascular/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008948


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[PMID]:28743162
[Au] Autor:Cahn DB; Handorf EA; Ghiraldi EM; Ristau BT; Geynisman DM; Churilla TM; Horwitz EM; Sobczak ML; Chen DYT; Viterbo R; Greenberg RE; Kutikov A; Uzzo RG; Smaldone MC
[Ad] Endereço:Department of Urology, Einstein Healthcare Network, Philadelphia, Pennsylvania.
[Ti] Título:Contemporary use trends and survival outcomes in patients undergoing radical cystectomy or bladder-preservation therapy for muscle-invasive bladder cancer.
[So] Source:Cancer;123(22):4337-4345, 2017 Nov 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The current study was performed to examine temporal trends and compare overall survival (OS) in patients undergoing radical cystectomy (RC) or bladder-preservation therapy (BPT) for muscle-invasive urothelial carcinoma of the bladder. METHODS: The authors reviewed the National Cancer Data Base to identify patients with AJCC stage II to III urothelial carcinoma of the bladder from 2004 through 2013. Patients receiving BPT were stratified as having received any external-beam radiotherapy (any XRT), definitive XRT (50-80 grays), and definitive XRT with chemotherapy (CRT). Treatment trends and OS outcomes for the BPT and RC cohorts were evaluated using Cochran-Armitage tests, unadjusted Kaplan-Meier curves, adjusted Cox multivariate regression, and propensity score matching, using increasingly stringent selection criteria. RESULTS: A total of 32,300 patients met the inclusion criteria and were treated with RC (22,680 patients) or BPT (9620 patients). Of the patients treated with BPT, 26.4% (2540 patients) and 15.5% (1489 patients), respectively, were treated with definitive XRT and CRT. Improved OS was observed for RC in all groups. After adjustments with more rigorous statistical models controlling for confounders and with more restrictive BPT cohorts, the magnitude of the OS benefit became attenuated on multivariate (any XRT: hazard ratio [HR], 2.115 [95% confidence interval [95% CI], 2.045-2.188]; definitive XRT: HR, 1.870 [95% CI, 1.773-1.972]; and CRT: HR, 1.578 [95% CI, 1.474-1.691]) and propensity score (any XRT: HR, 2.008 [95% CI, 1.871-2.154]; definitive XRT: HR, 1.606 [95% CI, 1.453-1.776]; and CRT: HR, 1.406 [95% CI, 1.235-1.601]) analyses. CONCLUSIONS: In the National Cancer Data Base, receipt of BPT was associated with decreased OS compared with RC in patients with stage II to III urothelial carcinoma. Increasingly stringent definitions of BPT and more rigorous statistical methods adjusting for selection biases attenuated observed survival differences. Cancer 2017;123:4337-45. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Carcinoma de Células de Transição/mortalidade
Carcinoma de Células de Transição/cirurgia
Cistectomia
Neoplasias Musculares/mortalidade
Neoplasias Musculares/cirurgia
Tratamentos com Preservação do Órgão
Neoplasias da Bexiga Urinária/mortalidade
Neoplasias da Bexiga Urinária/cirurgia
[Mh] Termos MeSH secundário: Músculos Abdominais/patologia
Neoplasias Abdominais/mortalidade
Neoplasias Abdominais/secundário
Neoplasias Abdominais/cirurgia
Adulto
Idoso
Carcinoma de Células de Transição/patologia
Quimiorradioterapia
Cistectomia/métodos
Cistectomia/mortalidade
Cistectomia/estatística & dados numéricos
Cistectomia/tendências
Bases de Dados Factuais
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias Musculares/secundário
Invasividade Neoplásica
Estadiamento de Neoplasias
Tratamentos com Preservação do Órgão/mortalidade
Tratamentos com Preservação do Órgão/estatística & dados numéricos
Tratamentos com Preservação do Órgão/tendências
Análise de Sobrevida
Resultado do Tratamento
Neoplasias da Bexiga Urinária/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30900


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[PMID]:28743155
[Au] Autor:Vetterlein MW; Wankowicz SAM; Seisen T; Lander R; Löppenberg B; Chun FK; Menon M; Sun M; Barletta JA; Choueiri TK; Bellmunt J; Trinh QD; Preston MA
[Ad] Endereço:Division of Urological Surgery, Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
[Ti] Título:Neoadjuvant chemotherapy prior to radical cystectomy for muscle-invasive bladder cancer with variant histology.
[So] Source:Cancer;123(22):4346-4355, 2017 Nov 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neoadjuvant chemotherapy in pure urothelial bladder cancer provides a significant survival benefit. However, to the authors' knowledge, it is unknown whether this benefit persists in histological variants. The objective of the current study was to assess the effect of neoadjuvant chemotherapy on the probability of non-organ-confined disease and overall survival after radical cystectomy (RC) in patients with histological variants. METHODS: Querying the National Cancer Data Base, the authors identified 2018 patients with histological variants who were undergoing RC for bladder cancer between 2003 and 2012. Variants were categorized as micropapillary or sarcomatoid differentiation, squamous cell carcinoma, adenocarcinoma, neuroendocrine tumors, and other histology. Logistic regression models estimated the odds of non-organ-confined disease at the time of RC for each histological variant, stratified by the receipt of neoadjuvant chemotherapy. Cox regression models were used to examine the effect of neoadjuvant chemotherapy on overall mortality in each variant subgroup. RESULTS: Patients with neuroendocrine tumors (odds ratio [OR], 0.16; 95% confidence interval [95% CI], 0.08-0.32 [P<.001]), micropapillary differentiation (OR, 0.30; 95% CI, 0.10-0.95 [P=.041]), sarcomatoid urothelial carcinoma (OR, 0.40; 95% CI, 0.17-0.94 [P=.035]), and adenocarcinoma (OR, 0.24; 95% CI, 0.06-0.91 [P=.035]) were less likely to harbor non-organ-confined disease at the time of RC when treated with neoadjuvant chemotherapy. An overall survival benefit for neoadjuvant chemotherapy was only found in patients with neuroendocrine tumors (hazard ratio, 0.49; 95% CI, 0.33-0.74 [P=.001]). CONCLUSIONS: Patients with neuroendocrine tumors benefit from neoadjuvant chemotherapy, as evidenced by better overall survival and lower rates of non-organ-confined disease at the time of RC. For tumors with micropapillary differentiation, sarcomatoid differentiation, or adenocarcinoma, neoadjuvant chemotherapy decreased the frequency of non-organ-confined disease at the time of RC. However, this favorable effect did not translate into a statistically significant overall survival benefit for these patients, potentially due to the aggressive tumor biology. Cancer 2017;123:4346-55. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Carcinoma de Células de Transição/tratamento farmacológico
Carcinoma de Células de Transição/cirurgia
Cistectomia/métodos
Neoplasias Musculares/tratamento farmacológico
Neoplasias Musculares/cirurgia
Neoplasias da Bexiga Urinária/tratamento farmacológico
Neoplasias da Bexiga Urinária/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma de Células de Transição/epidemiologia
Carcinoma de Células de Transição/patologia
Quimioterapia Adjuvante
Cistectomia/estatística & dados numéricos
Bases de Dados Factuais
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias Musculares/epidemiologia
Neoplasias Musculares/secundário
Terapia Neoadjuvante
Invasividade Neoplásica
Resultado do Tratamento
Neoplasias da Bexiga Urinária/epidemiologia
Neoplasias da Bexiga Urinária/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30907


  5 / 2426 MEDLINE  
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[PMID]:28982887
[Au] Autor:Fujimoto Y; Nakashima Y; Sasaki S; Jogo T; Hirose K; Edahiro K; Korehisa S; Taniguchi D; Kudou K; Nakaji YU; Nakanishi R; Ando K; Saeki H; Oki E; Fujiwara M; Oda Y; Maehara Y
[Ad] Endereço:Department of Surgery and Science, Graduate School of Medical Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
[Ti] Título:Chemoradiotherapy for Solitary Skeletal Muscle Metastasis from Oesophageal Cancer: Case Report and Brief Literature Review.
[So] Source:Anticancer Res;37(10):5687-5691, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The incidence of skeletal muscle metastasis from oesophageal cancer is very low, and the treatment strategy has not been established. CASE REPORT: A 77-year-old man underwent oesophagectomy following neoadjuvant chemotherapy for oesophageal squamous cell carcinoma (CT-pT3 N0 M0, CT-pStage II). Fourteen months after surgery, he became aware of a subcutaneous tumour in his left forearm. Computed tomography and fluorodeoxyglucose positron-emission tomography revealed a 65×75 mm intramuscular nodular lesion with a standardized uptake value of 8.5. Further examination by biopsy strongly suggested this was a solitary metastasis from oesophageal cancer. The patient received chemoradiotherapy with two cycles of 5-fluorouracil combined with cisplatin and radiation. Clinical complete response was confirmed by imaging 7 months after chemoradiation and no recurrence has occurred at 20 months since chemoradiation. CONCLUSION: Radiotherapy or chemoradiotherapy can be an alternative locoregional therapy to surgery for solitary skeletal muscle metastasis.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Quimiorradioterapia
Neoplasias Esofágicas/patologia
Neoplasias Musculares/secundário
Neoplasias Musculares/terapia
Músculo Esquelético/patologia
Neoplasias de Células Escamosas/secundário
Neoplasias de Células Escamosas/terapia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Biópsia
Carcinoma de Células Escamosas
Cisplatino/administração & dosagem
Fluoruracila/administração & dosagem
Antebraço
Seres Humanos
Imuno-Histoquímica
Imagem por Ressonância Magnética
Masculino
Neoplasias Musculares/química
Músculo Esquelético/química
Estadiamento de Neoplasias
Neoplasias de Células Escamosas/química
Tomografia por Emissão de Pósitrons
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor); Q20Q21Q62J (Cisplatin); U3P01618RT (Fluorouracil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28979627
[Au] Autor:Bousbaa H; Amhajji L
[Ad] Endereço:Department of Orthopaedics and Traumatology, Military Hospital Moulay Ismail, BP 50000 Meknes, Morocco.
[Ti] Título:[Hemangioma of the knee].
[Ti] Título:À propos d'un hémangiome du genou..
[So] Source:Pan Afr Med J;27:225, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Angioma or hemangioma is a benign vascular tumor which rarely occurs in muscles. It mostly affects young adults. We report a case of intramuscular hemangioma of quadriceps with painless extension contracture of the knee and a mass in the thigh. MRI allowed preoperative diagnosis of intramuscular hemangiomas and, primarily, T2-weighted images allow specific topographic assessment and give an indication to the diagnosis.
[Mh] Termos MeSH primário: Hemangioma/diagnóstico por imagem
Articulação do Joelho/patologia
Imagem por Ressonância Magnética/métodos
Neoplasias Musculares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Feminino
Hemangioma/patologia
Seres Humanos
Meia-Idade
Neoplasias Musculares/patologia
Coxa da Perna/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.225.12341


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[PMID]:28777648
[Au] Autor:Kurup AN; Morris JM; Callstrom MR
[Ad] Endereço:1 Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905.
[Ti] Título:Ablation of Musculoskeletal Metastases.
[So] Source:AJR Am J Roentgenol;209(4):713-721, 2017 Oct.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this article is to summarize the evidence supporting thermal ablation of musculoskeletal metastases on the basis of clinical application and to describe an approach to percutaneous ablative treatment, including patient workup, procedural strategy and techniques, and postablation follow-up. CONCLUSION: Percutaneous ablation of musculoskeletal metastases may result in significant pain palliation, prevention of morbidity from skeletal-related events, and local tumor control. This minimally invasive approach has unique advantages compared with surgery or radiation therapy.
[Mh] Termos MeSH primário: Técnicas de Ablação
Neoplasias Ósseas/secundário
Neoplasias Ósseas/cirurgia
Metastasectomia/métodos
Neoplasias Musculares/secundário
Neoplasias Musculares/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.17.18527


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[PMID]:28668397
[Au] Autor:Assi M; Kenawi M; Ropars M; Rébillard A
[Ad] Endereço:EA1274 Laboratory "Movement, Sport and Health Sciences" M2S, University of Rennes 2-ENS Rennes, 35170 Bruz, France.
[Ti] Título:Interleukin-6, C/EBP-ß and PPAR-γ expression correlates with intramuscular liposarcoma growth in mice: The impact of voluntary physical activity levels.
[So] Source:Biochem Biophys Res Commun;490(3):1026-1032, 2017 Aug 26.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IL-6 is an axial cytokine overexpressed in cancer to promote growth and increase resistance to anti-cancer therapies. As the application of IL-6-targeting therapies are still limited, alternative non-aggressive and adjuvant approaches, like physical activity (PA) could be useful to reverse IL-6 effects. To get more insights into liposarcoma (LS) pathophysiology, we investigated potential molecular links between IL-6 and LS growth and we tested the impact of PA on such mechanism in an orthotopic model of intramuscular LS. Initially active nude mice have received an intramuscular injection of either human SW872 cells or vehicle, then were respectively randomized into voluntary-active or inactive mice with open or restricted access to activity-wheels. We found that LS-bearing mice exhibited ∼6 fold increase in circulating IL-6 comparing to controls, with a concomitant decrease in hepatic drug-metabolizing enzymes expression. Circulating IL-6 levels were positively correlated with intra-tumor IL-6 expression (r = 0.85, P < 0.01). Interestingly, intra-tumor IL-6, C/EBP-α/ß and PPAR-γ expression were correlated together and with greater tumor mass and autophagy markers, notably, GABARAPL-1. Intriguingly, we found that maintaining a spontaneous PA after tumor injection did not reduce the levels of IL-6, but even enhanced tumor growth, induced body weight loss and increased the risk of developing lung metastasis. Our findings suggest that (1) IL-6, C/EBP-ß and PPAR-γ exert a potential role in promoting growth of dedifferentiated LS and (2) that PA failed to mechanistically interfere with these factors, but enhanced LS growth via other independent-mechanisms. The preclinical data reported here could be helpful in the sub-molecular classification of LS patients to improve diagnosis and design a low-risk treatment. Circulating IL-6 could serve as an indicator for treatment follow-up and, perhaps, for infra-radiologic LS relapses.
[Mh] Termos MeSH primário: Proteína beta Intensificadora de Ligação a CCAAT/genética
Interleucina-6/genética
Lipossarcoma/genética
Neoplasias Musculares/genética
Músculos/patologia
PPAR gama/genética
[Mh] Termos MeSH secundário: Animais
Autofagia
Regulação Neoplásica da Expressão Gênica
Interleucina-6/sangue
Lipossarcoma/sangue
Lipossarcoma/patologia
Lipossarcoma/fisiopatologia
Masculino
Camundongos
Camundongos Nus
Neoplasias Musculares/sangue
Neoplasias Musculares/patologia
Neoplasias Musculares/fisiopatologia
Músculos/metabolismo
Músculos/fisiopatologia
Condicionamento Físico Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCAAT-Enhancer-Binding Protein-beta); 0 (Interleukin-6); 0 (PPAR gamma)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


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[PMID]:28560530
[Au] Autor:Uehara K; Ogura K; Akiyama T; Shinoda Y; Iwata S; Kobayashi E; Tanzawa Y; Yonemoto T; Kawano H; Kawai A
[Ad] Endereço:Department of Orthopaedic Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
[Ti] Título:Reliability and Validity of the Musculoskeletal Tumor Society Scoring System for the Upper Extremity in Japanese Patients.
[So] Source:Clin Orthop Relat Res;475(9):2253-2259, 2017 Sep.
[Is] ISSN:1528-1132
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Musculoskeletal Tumor Society (MSTS) scoring system developed in 1993 is a widely used disease-specific evaluation tool for assessment of physical function in patients with musculoskeletal tumors; however, only a few studies have confirmed its reliability and validity. QUESTIONS/PURPOSES: The aim of this study was to validate the MSTS scoring system for the upper extremity (MSTS-UE) in Japanese patients with musculoskeletal tumors for use by others in research. Does the MSTS-UE have: (1) sufficient reliability and internal consistency; (2) adequate construct validity; and (3) reasonable criterion validity in comparison to the Toronto Extremity Salvage Score (TESS) or SF-36? METHODS: Reliability was performed using test-retest analysis, and internal consistency was evaluated with Cronbach's alpha coefficient. Construct validity was evaluated using a scree plot to confirm the construct number and the Akaike information criterion network. Criterion validity was evaluated by comparing the MSTS-UE with the TESS and SF-36. RESULTS: The test-retest reliability with intraclass correlation coefficient (0.95; 95% CI, 0.91-0.97) was excellent, and internal consistency with Cronbach's α (0.7; 95% CI, 0.53-0.81) was acceptable. There were no ceiling and floor effects. The Akaike Information Criterion network showed that lifting ability, pain, and dexterity played central roles among the components. The MSTS-UE showed substantial correlation with the TESS scoring scale (r = 0.75; p < 0.001) and fair correlation with the SF-36 physical component summary (r = 0.37; p = 0.007). Although the MSTS-UE showed slight correlation with the SF-36 mental component summary, the emotional acceptance component of the MSTS-UE showed fair correlation (r = 0.29; p = 0.039). CONCLUSIONS: We can conclude that the MSTS is not an adequate measure of general health-related quality of life; however, this system was designed mainly to be a simple measure of function in a single extremity. To evaluate the mental state of patients with musculoskeletal tumors in the upper extremity, further study is needed.
[Mh] Termos MeSH primário: Neoplasias Ósseas/fisiopatologia
Avaliação da Deficiência
Tumor de Células Gigantes do Osso/fisiopatologia
Neoplasias Musculares/fisiopatologia
Sarcoma/fisiopatologia
Índice de Gravidade de Doença
Inquéritos e Questionários/normas
Extremidade Superior
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Ósseas/cirurgia
Comparação Transcultural
Estudos Transversais
Feminino
Tumor de Células Gigantes do Osso/cirurgia
Seres Humanos
Japão
Masculino
Meia-Idade
Neoplasias Musculares/cirurgia
Psicometria
Qualidade de Vida
Reprodutibilidade dos Testes
Sarcoma/cirurgia
Sociedades Médicas/normas
Traduções
Resultado do Tratamento
Extremidade Superior/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1007/s11999-017-5390-x


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[PMID]:28502967
[Au] Autor:Kogure K; Yamazaki M; Tamaki T; Node Y; Morita A
[Ad] Endereço:Department of Neurological Surgery, Nippon Medical School Tama Nagayama Hospital.
[Ti] Título:Neck and Occipital Pain Caused by Deep Cervical Intramuscular Lipoma: A Surgical Case.
[So] Source:J Nippon Med Sch;84(2):96-99, 2017.
[Is] ISSN:1347-3409
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A lipoma is a slow-growing, benign tumor and is usually asymptomatic; hence, surgical intervention can often be avoided in patients with these tumors in the cervical and cranial area. Lipomas arise most commonly in the subcutaneous fat, but occasionally in muscle tissue. Intramuscular lipomas in the cervico-cranial area have rarely been reported. We describe here a patient with a large intramuscular lipoma in the deep cervical tissue. The patient experienced troublesome pain in the neck and occipital area, and surgical treatment was therefore suggested. Particularly in the cervical area, intramuscular lipomas sometimes invade the surrounding muscles and tissue layers and develop into an irregular mass, despite being benign. In addition, the cervical area has one of the most complex muscle structures. Nevertheless, surgical management of intramuscular lipoma in the cervical and cranial area is sometimes indicated, for example, in patients with clinical symptoms or masses with a tendency to grow large.
[Mh] Termos MeSH primário: Cefaleia/etiologia
Lipoma/complicações
Neoplasias Musculares/complicações
Cervicalgia/etiologia
Osso Occipital
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Lipoma/diagnóstico por imagem
Lipoma/patologia
Lipoma/cirurgia
Imagem por Ressonância Magnética
Masculino
Neoplasias Musculares/diagnóstico por imagem
Neoplasias Musculares/patologia
Neoplasias Musculares/cirurgia
Pescoço
Crânio
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1272/jnms.84.96



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