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  1 / 3077 MEDLINE  
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[PMID]:29194630
[Au] Autor:Tzanis D; Bouhadiba T; Gaignard E; Bonvalot S
[Ad] Endereço:Department of Surgery, Sarcoma Unit, Institute Curie, PSL University, Paris, France.
[Ti] Título:Major vascular resections in retroperitoneal sarcoma.
[So] Source:J Surg Oncol;117(1):42-47, 2018 Jan.
[Is] ISSN:1096-9098
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Retroperitoneal sarcomas (RPS) frequently involve major vessels, which either originate from them or secondarily encase or invade them. In this field, major vascular resections result in increased morbidity. However, survival does not seem to be affected by the need for vascular resection or by this higher morbidity. This paper aims to provide descriptions of the surgical strategy and outcomes for retroperitoneal sarcomas involving major vessels.
[Mh] Termos MeSH primário: Neoplasias Retroperitoneais/cirurgia
Sarcoma/cirurgia
Neoplasias Vasculares/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias Retroperitoneais/patologia
Sarcoma/patologia
Resultado do Tratamento
Neoplasias Vasculares/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1002/jso.24920


  2 / 3077 MEDLINE  
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[PMID]:29181924
[Au] Autor:Vetrhus M; Fjetland L
[Ti] Título:Intravenøst lipom..
[So] Source:Tidsskr Nor Laegeforen;137(22), 2017 11 28.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:nor
[Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada
Lipoma/diagnóstico por imagem
Neoplasias Vasculares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Veias Braquiocefálicas/diagnóstico por imagem
Veias Braquiocefálicas/patologia
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.17.0646


  3 / 3077 MEDLINE  
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[PMID]:29173765
[Au] Autor:Kuijvenhoven JC; Crombag L; Breen DP; van den Berk I; Versteegh MIM; Braun J; Winkelman TA; van Boven W; Bonta PI; Rabe KF; Annema JT
[Ad] Endereço:Department of Respiratory Medicine, Academic Medical Center (AMC), Amsterdam, The Netherlands.
[Ti] Título:Esophageal ultrasound (EUS) assessment of T4 status in NSCLC patients.
[So] Source:Lung Cancer;114:50-55, 2017 Dec.
[Is] ISSN:1872-8332
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mediastinal and central large vessels (T4) invasion by lung cancer is often difficult to assess preoperatively due to the limited accuracy of computed tomography (CT) scan of the chest. Esophageal ultrasound (EUS) can visualize the relationship of para-esophageally located lung tumors to surrounding mediastinal structures. AIM: To assess the value of EUS for detecting mediastinal invasion (T4) of centrally located lung tumors. METHODS: Patients who underwent EUS for the diagnosis and staging of lung cancer and in whom the primary tumor was detected by EUS and who subsequently underwent surgical- pathological staging (2000-2016) were retrospectively selected from two university hospitals in The Netherlands. T status of the lung tumor was reviewed based on EUS, CT and thoracotomy findings. Surgical- pathological staging was the reference standard. RESULTS: In 426 patients, a lung malignancy was detected by EUS of which 74 subjects subsequently underwent surgical- pathological staging. 19 patients (26%) were diagnosed with stage T4 based on vascular (n=8, 42%) or mediastinal (n=8, 42%) invasion or both (n=2, 11%), one patient (5%) had vertebral involvement. Sensitivity, specificity, PPV and NPV for assessing T4 status were: for EUS (n=74); 42%, 95%, 73%, 83%, for chest CT (n=66); 76%, 61%, 41%, 88% and the combination of EUS and chest CT (both positive or negative for T4, (n=34); 83%, 100%, 100% 97%. CONCLUSION: EUS has a high specificity and NPV for the T4 assessment of lung tumors located para-esophageally and offers further value to chest CT scan.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/diagnóstico por imagem
Esôfago/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
Invasividade Neoplásica/diagnóstico por imagem
Estadiamento de Neoplasias/métodos
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma Pulmonar de Células não Pequenas/patologia
Carcinoma Pulmonar de Células não Pequenas/cirurgia
Endossonografia/métodos
Feminino
Seres Humanos
Neoplasias Pulmonares/patologia
Neoplasias Pulmonares/cirurgia
Masculino
Neoplasias do Mediastino/diagnóstico por imagem
Neoplasias do Mediastino/patologia
Neoplasias do Mediastino/secundário
Mediastino/diagnóstico por imagem
Mediastino/patologia
Meia-Idade
Invasividade Neoplásica/patologia
Países Baixos/epidemiologia
Estudos Retrospectivos
Toracotomia/métodos
Toracotomia/estatística & dados numéricos
Tomografia Computadorizada por Raios X/métodos
Neoplasias Vasculares/diagnóstico por imagem
Neoplasias Vasculares/patologia
Neoplasias Vasculares/secundário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  4 / 3077 MEDLINE  
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[PMID]:29245342
[Au] Autor:Gao L; Wang Y; Jiang Y; Lai X; Wang M; Li J
[Ad] Endereço:Department of Ultrasound, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
[Ti] Título:Intravascular epithelioid hemangioendothelioma of the femoral vein diagnosed by contrast-enhanced ultrasonography: A care-compliant case report.
[So] Source:Medicine (Baltimore);96(49):e9107, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Intravascular epithelioid hemangioendothelioma (EHE) is a rare endothelial tumor with an intermediate grade of malignancy. We present a case of one woman affected by EHE of the femoral vein. Contrast-enhanced ultrasonography played a role in diagnosing EHE and helped differentiate it from thrombosis. To our knowledge, this is the first reported contrast-enhanced ultrasonography of intravascular EHE in the imaging literature. PATIENT CONCERNS: A 46-year-old woman presented to our hospital due to pain and swelling in her right lower limb since 5 years prior to her presentation. DIAGNOSES: The patient was misdiagnosed as having thrombosis by ultrasound. Contrast-enhanced ultrasonography showed solid lesions with visible blood supply, suggesting angiogenic tumors. INTERVENTIONS: The patient was treated by complete surgical removal of the mass and postoperative radiotherapy. Pathological examination confirmed the diagnosis of EHE. OUTCOMES: During follow-up, there were no signs of local or distant relapse. LESSONS: Intravenous EHE may be misdiagnosed as thrombosis by ultrasound and contrast-enhanced ultrasonography can help make the differential diagnosis.
[Mh] Termos MeSH primário: Veia Femoral/diagnóstico por imagem
Hemangioendotelioma Epitelioide/diagnóstico
Ultrassonografia/métodos
Neoplasias Vasculares/diagnóstico
[Mh] Termos MeSH secundário: Meios de Contraste
Diagnóstico Diferencial
Feminino
Hemangioendotelioma Epitelioide/diagnóstico por imagem
Hemangioendotelioma Epitelioide/cirurgia
Seres Humanos
Meia-Idade
Trombose/diagnóstico
Neoplasias Vasculares/diagnóstico por imagem
Neoplasias Vasculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009107


  5 / 3077 MEDLINE  
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[PMID]:27778254
[Au] Autor:Jeong Y; Shin MH; Yoon SM; Song GW; Kim KH; Ahn CS; Moon DB; Hwang S; Park JH; Kim JH; Lee SG
[Ad] Endereço:Department of Radiation Oncology, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
[Ti] Título:Liver Transplantation After Transarterial Chemoembolization and Radiotherapy for Hepatocellular Carcinoma with Vascular Invasion.
[So] Source:J Gastrointest Surg;21(2):275-283, 2017 02.
[Is] ISSN:1873-4626
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The study aims to analyze the oncologic outcomes of living donor liver transplantation (LDLT) after combined transarterial chemoembolization (TACE) and radiotherapy for hepatocellular carcinoma (HCC) with major vascular invasion. METHODS: We retrospectively reviewed 17 HCC patients with major vascular invasion who underwent LDLT after combined treatment modality between May 2007 and September 2014. The LDLT timing was determined by the surgeons depending on the disease status and liver function. The intrahepatic recurrence-free survival, disease-free survival (DFS), and overall survival (OS) rates were estimated from the date of the LDLT. RESULTS: The median follow-up period was 24.5 months (range, 6.4-66.0 months) after the LDLT. The interval between the combined treatment and the LDLT was a median of 5 months (range, 0.4-65.3 months). On the explanted liver, total necrosis was shown in five patients (29.4 %). The 1- and 3-year DFS rates were 70.6 and 57.8 %, respectively. The 1- and 3-year OS rates were 87.4 and 60.5 %, respectively. The major pattern of failure was distant metastasis (35.3 %), and intrahepatic recurrence occurred in three patients (17.6 %) who experienced distant metastasis. CONCLUSIONS: In the selected HCC patients with major vascular invasion, LDLT after combined TACE and radiotherapy showed acceptable oncologic outcomes.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/cirurgia
Quimioembolização Terapêutica
Neoplasias Hepáticas/cirurgia
Transplante de Fígado/mortalidade
Neoplasias Vasculares/terapia
[Mh] Termos MeSH secundário: Adulto
Carcinoma Hepatocelular/patologia
Carcinoma Hepatocelular/radioterapia
Carcinoma Hepatocelular/terapia
Feminino
Seres Humanos
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/radioterapia
Neoplasias Hepáticas/terapia
Doadores Vivos
Masculino
Meia-Idade
Invasividade Neoplásica/patologia
Recidiva Local de Neoplasia
Radioterapia Adjuvante
Estudos Retrospectivos
Análise de Sobrevida
Resultado do Tratamento
Neoplasias Vasculares/patologia
Neoplasias Vasculares/radioterapia
Neoplasias Vasculares/secundário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s11605-016-3302-0


  6 / 3077 MEDLINE  
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[PMID]:29195579
[Au] Autor:Abdelhady K; Durgam S; Ernst L; Massad MG
[Ad] Endereço:Division of Cardiothoracic Surgery, Department of Surgery, The University of Illinois at Chicago, Chicago, Illinois. Electronic address: khaled1@uic.edu.
[Ti] Título:Primary Pulmonary Vein Leiomyosarcoma With Left Atrial Extension.
[So] Source:Semin Thorac Cardiovasc Surg;29(3):428-430, 2017 Autumn.
[Is] ISSN:1532-9488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leiomyosarcoma (LMS) is a mesenchymal tumor originating from the smooth muscle cells. LMS of the great vessels accounts for 60% of cases, with inferior vena cava being the most common site. Pulmonary vein LMS is an extremely rare subset that was first reported in 1939. LMS is an aggressive tumor, making surgical resection the treatment of choice. Herein, we present a rare case of pulmonary vein LMS extending into the left atrium, which was resected.
[Mh] Termos MeSH primário: Átrios do Coração/patologia
Leiomiossarcoma/patologia
Veias Pulmonares/patologia
Neoplasias Vasculares/patologia
[Mh] Termos MeSH secundário: Ecocardiografia
Feminino
Átrios do Coração/diagnóstico por imagem
Átrios do Coração/cirurgia
Seres Humanos
Leiomiossarcoma/diagnóstico por imagem
Leiomiossarcoma/cirurgia
Imagem por Ressonância Magnética
Meia-Idade
Invasividade Neoplásica
Veias Pulmonares/diagnóstico por imagem
Veias Pulmonares/cirurgia
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Neoplasias Vasculares/diagnóstico por imagem
Neoplasias Vasculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE


  7 / 3077 MEDLINE  
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[PMID]:28461685
[Au] Autor:di Fonzo H; Contardo D; Carrozza D; Finocchietto P; Rojano Crisson A; Cabral C; de Los Angeles Juarez M
[Ad] Endereço:Department of Internal Medicine, Hospital de Clinicas "Jose de San Martin", University of Buenos Aires, Buenos Aires, Argentina.
[Ti] Título:Intravascular Large B Cell Lymphoma Presenting as Fever of Unknown Origin and Diagnosed by Random Skin Biopsies: A Case Report and Literature Review.
[So] Source:Am J Case Rep;18:482-486, 2017 May 02.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Intravascular lymphoma (IVL) is a rare lymphoproliferative disorder characterized by the proliferation of large B lymphoma cells within the lumen of small-caliber blood vessels. Clinical features are nonspecific, presenting as a systemic disease with fever and may be life-threatening. Antemortem diagnosis is difficult but may be made with biopsies of affected tissues or with random skin biopsies. CASE REPORT We report the case of a 66-year-old white woman presenting with fever of unknown origin (FUO) who developed neurologic, pulmonary, and hematologic manifestations. The diagnosis of intravascular large B cell lymphoma (IVLBCL) was made by random skin biopsies. She received treatment with steroids, rituximab, cyclophosphamide, vincristine, and doxorubicin (R-CHOP). Her disease evolution was unfavorable and she died after her first cycle of chemotherapy. CONCLUSIONS Our case illustrates that IVL can present as FUO and should be considered in the differential diagnosis of this syndrome, especially in patients with neurologic compromise and persistently elevated serum lactate dehydrogenase. In this case, the diagnosis was made with cutaneous biopsies of visibly unaffected skin. As in our patient, the course of IVL is usually fatal within a few months.
[Mh] Termos MeSH primário: Febre de Causa Desconhecida/etiologia
Linfoma Difuso de Grandes Células B/patologia
Pele/patologia
Neoplasias Vasculares/patologia
[Mh] Termos MeSH secundário: Idoso
Biópsia
Evolução Fatal
Feminino
Seres Humanos
L-Lactato Desidrogenase/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 1.1.1.27 (L-Lactate Dehydrogenase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  8 / 3077 MEDLINE  
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[PMID]:28852831
[Au] Autor:Hadjadj J; Nielly H; Piekarski E; Cuccuini W; Deau-Fischer B; Hourseau M; Benali K; Fieschi C; Aletti M; Papo T; Oksenhendler E; Galicier L; Boutboul D
[Ad] Endereço:Clinical Immunology Department, Hôpital Saint Louis, Assistance Publique Hôpitaux de Paris, Université Paris Diderot, 1 Avenue Claude Vellefaux, Paris, France.
[Ti] Título:Uterine intravascular lymphoma as a cause of fever of unknown origin.
[So] Source:Ann Hematol;96(11):1891-1896, 2017 Nov.
[Is] ISSN:1432-0584
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant FDG uptake on FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had gynaecological symptom, contrasting with the literature data. Structural imaging (including whole-body CT scan and pelvic RMI) failed to yield any diagnosis. FDG-PET/CT showed intense uterine uptake in all cases. Endometrial biopsy was performed in three cases and was positive in one. Diagnosis was obtained from coelioscopic iliac adenopathy biopsy in one case and from total hysterectomy in another. Punch biopsy of skin lesions led to diagnosis in the two remaining cases. Bone marrow biopsy was normal in all cases. Clinicians should be aware of potential isolated uterine involvement in IVL, especially in elderly women with FUO. Normal structural imaging does not rule out the diagnosis and FDG-TEP/CT should be performed to guide high-yielding biopsy.
[Mh] Termos MeSH primário: Febre de Causa Desconhecida/diagnóstico por imagem
Linfoma Difuso de Grandes Células B/diagnóstico por imagem
Neoplasias Uterinas/diagnóstico por imagem
Neoplasias Vasculares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Feminino
Febre de Causa Desconhecida/etiologia
Fluordesoxiglucose F18
Seres Humanos
Linfoma Difuso de Grandes Células B/complicações
Meia-Idade
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Estudos Retrospectivos
Neoplasias Uterinas/complicações
Neoplasias Vasculares/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-017-3117-4


  9 / 3077 MEDLINE  
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[PMID]:28804112
[Au] Autor:Tsuda Y; Oguri T; Sakurai K; Kajiguchi T; Kato H; Yuasa H
[Ad] Endereço:Department of Neurology, Tosei General Hospital.
[Ti] Título:Low signal intensity lesions on brain susceptibility-weighted MRI in a patient with intravascular large B-cell lymphoma.
[So] Source:Rinsho Shinkeigaku;57(9):504-508, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 71-year-old man was admitted to our hospital because of abnormal behavior and generalized convulsion. Brain MRI revealed no abnormalities upon admission. Levels of serum lactate dehydrogenase and soluble interleukin-2 receptors were significantly elevated, whereas the initial bone marrow puncture and random skin biopsy findings were non-malignant. On the tenth day of admission, brain MRI revealed dot and strip-shaped low signal intensity lesions on susceptibility-weighted images (SWI) disseminated mainly within the cerebral cortex. Administration of high dose methyl-prednisolone improved neither his condition nor these MRI findings. Ground-glass opacities within the bilateral lungs later emerged on the chest CT. The results of a transbronchial lung biopsy and second bone marrow puncture were consistent with a diagnosis of intravascular large B-cell lymphoma (IVLBCL). Despite the lack of histopathological confirmation, the low signal intensities on brain SWI in this case were also considered IVLBCL lesions, reflective of micro-hemorrhagic changes.
[Mh] Termos MeSH primário: Córtex Cerebral/diagnóstico por imagem
Aumento da Imagem/métodos
Linfoma Difuso de Grandes Células B/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Neoplasias Vasculares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Anticorpos Monoclonais Murinos/administração & dosagem
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Ciclofosfamida/administração & dosagem
Doxorrubicina/administração & dosagem
Seres Humanos
Linfoma Difuso de Grandes Células B/terapia
Masculino
Metotrexato/administração & dosagem
Prednisona/administração & dosagem
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Vincristina/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Murine-Derived); 0 (R-CHOP protocol); 5J49Q6B70F (Vincristine); 80168379AG (Doxorubicin); 8N3DW7272P (Cyclophosphamide); VB0R961HZT (Prednisone); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001027


  10 / 3077 MEDLINE  
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[PMID]:28719463
[Au] Autor:Gordetsky J; Sanfrancesco J; Epstein JI; Trevino K; Xu H; Osunkoya A; Xiao GQ; Kao CS; Unger P; Hashemi-Sadraei N; Albany C; Jorns JM; Lu DY; Matoso A; Rais-Bahrami S; Schwartz LE; Ulbright TM; Idrees MT
[Ad] Endereço:Departments of *Pathology †Urology ¶¶Radiology, University of Alabama at Birmingham, Birmingham, AL Departments of ‡Pathology ∥Biostatistics ‡‡Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN §Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD ¶Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA #Department of Pathology, Keck School of Medicine of University of Southern California ∥∥Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles **Department of Pathology, Stanford Medicine, Stanford, CA ††Department of Pathology, Lenox Hill Hospital, New York, NY §§Department of Pathology, University of Michigan, Ann Arbor, MI ##Department of Pathology, University of Pennsylvania, Philadelphia, PA.
[Ti] Título:Do Nonseminomatous Germ Cell Tumors of the Testis With Lymphovascular Invasion of the Spermatic Cord Merit Staging as pT3?
[So] Source:Am J Surg Pathol;41(10):1397-1402, 2017 Oct.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The staging of testicular nonseminomatous germ cell tumors (NSGCTs) with lymphovascular invasion (LVI) of the spermatic cord in the absence of cord parenchymal involvement remains controversial. Our previous study showed that tumors with spermatic cord LVI present at a higher clinical stage than tumors with LVI confined to the testis (pT2). We compared NSGCTs with LVI of the spermatic cord without direct involvement of the spermatic cord soft tissues to pT3 tumors to help clarify the appropriate staging of this histologic finding. A retrospective, multi-institutional review was performed to identify cases of NSGCTs with LVI in the spermatic cord without soft tissue invasion of the cord. The clinical-pathologic findings were compared with NSGCTs with spermatic cord soft tissue invasion (pT3). We identified 38 pT2 NSGCTs with LVI in the spermatic cord without soft tissue invasion of the cord and 89 pT3 tumors. There were no significant differences in patient age, tumor size, or clinical stage at presentation between the 2 groups. There were no significant differences in dominant histologic subtype, rete testis invasion, hilar soft tissue invasion, or margin status. There were no significant differences in disease recurrence/progression (P=0.63), recurrence/progression after chemotherapy (P=0.35), or death (P=0.51) between patients with only spermatic cord LVI versus patients with cord soft tissue invasion. In patients with pT2 NSGCTs according to the current staging, LVI in the spermatic cord without cord soft tissue invasion is comparable with pT3 tumors in terms of clinical stage at presentation as well as disease recurrence and survival.
[Mh] Termos MeSH primário: Neoplasias Embrionárias de Células Germinativas/patologia
Cordão Espermático/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Seres Humanos
Metástase Linfática
Masculino
Meia-Idade
Invasividade Neoplásica
Estadiamento de Neoplasias
Estudos Retrospectivos
Cordão Espermático/irrigação sanguínea
Neoplasias Vasculares/patologia
Neoplasias Vasculares/secundário
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000917



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