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[PMID]:28949246
[Au] Autor:de la Fuente J; Garrett CG; Ossoff R; Vinson K; Francis DO; Gelbard A
[Ad] Endereço:1 Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
[Ti] Título:A Case Series of the Probability Density and Cumulative Distribution of Laryngeal Disease in a Tertiary Care Voice Center.
[So] Source:Ann Otol Rhinol Laryngol;126(11):748-754, 2017 Nov.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To examine the distribution of clinic and operative pathology in a tertiary care laryngology practice. METHODS: Probability density and cumulative distribution analyses (Pareto analysis) was used to rank order laryngeal conditions seen in an outpatient tertiary care laryngology practice and those requiring surgical intervention during a 3-year period. RESULTS: Among 3783 new clinic consultations and 1380 operative procedures, voice disorders were the most common primary diagnostic category seen in clinic (n = 3223), followed by airway (n = 374) and swallowing (n = 186) disorders. Within the voice strata, the most common primary ICD-9 code used was dysphonia (41%), followed by unilateral vocal fold paralysis (UVFP) (9%) and cough (7%). Among new voice patients, 45% were found to have a structural abnormality. The most common surgical indications were laryngotracheal stenosis (37%), followed by recurrent respiratory papillomatosis (18%) and UVFP (17%). CONCLUSIONS: Nearly 55% of patients presenting to a tertiary referral laryngology practice did not have an identifiable structural abnormality in the larynx on direct or indirect examination. The distribution of ICD-9 codes requiring surgical intervention was disparate from that seen in clinic. Application of the Pareto principle may improve resource allocation in laryngology, but these initial results require confirmation across multiple institutions.
[Mh] Termos MeSH primário: Doenças da Laringe/diagnóstico
Doenças da Laringe/cirurgia
Atenção Terciária à Saúde
[Mh] Termos MeSH secundário: Efeitos Psicossociais da Doença
Tosse/diagnóstico
Tosse/cirurgia
Disfonia/diagnóstico
Disfonia/cirurgia
Seres Humanos
Laringoestenose/diagnóstico
Laringoestenose/cirurgia
Papiloma/diagnóstico
Papiloma/cirurgia
Neoplasias do Sistema Respiratório/diagnóstico
Neoplasias do Sistema Respiratório/cirurgia
Tennessee
Centros de Atenção Terciária
Estenose Traqueal/diagnóstico
Estenose Traqueal/cirurgia
Paralisia das Pregas Vocais/diagnóstico
Paralisia das Pregas Vocais/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417728945


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[PMID]:28588319
[Au] Autor:Ebadi M; Martin L; Ghosh S; Field CJ; Lehner R; Baracos VE; Mazurak VC
[Ad] Endereço:Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB T6G 2E1, Canada.
[Ti] Título:Subcutaneous adiposity is an independent predictor of mortality in cancer patients.
[So] Source:Br J Cancer;117(1):148-155, 2017 Jun 27.
[Is] ISSN:1532-1827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prognostic significance of adiposity, at the time of cancer diagnosis, on survival is not clear. Body mass index (kg m ) does not provide an appropriate assessment of body composition; therefore, the concept of the 'obesity paradox' needs to be investigated based on the prognostic significance of fat and muscle. Independent prognostic significance of adipose tissue in predicting mortality, importance of visceral and subcutaneous adiposity in the presence and absence of sarcopenia on survival, was investigated. METHODS: Adiposity markers including total adipose index (TATI), visceral adipose tissue index (VATI) and subcutaneous adipose tissue index (SATI) were estimated for 1473 gastrointestinal and respiratory cancer patients and 273 metastatic renal cell carcinoma patients using computed tomography. Univariate and multivariate analysis to determine mortality hazard ratios (HR) were conducted using cox proportional hazard models. RESULTS: Low SATI (SATI <50.0 cm m in males and <42.0 cm m in females) independently associated with increased mortality (HR: 1.26; 95% CI: 1.11-1.43; P<0.001) and shorter survival (13.1 months; 95% CI, 11.4-14.7) compared to patients with high SATI (19.3 months; 95% CI, 17.6-21.0; P<0.001). In the presence of sarcopenia, the longest survival was observed in patients with high subcutaneous adiposity. CONCLUSIONS: Subcutaneous adipose tissues appear to associate with reduction in mortality risk demonstrating the prognostic importance of fat distribution. The effect of sarcopenia on survival was more pronounced in patients with low subcutaneous adiposity.
[Mh] Termos MeSH primário: Gordura Intra-Abdominal/diagnóstico por imagem
Neoplasias/mortalidade
Obesidade Abdominal/epidemiologia
Sarcopenia/epidemiologia
Gordura Subcutânea/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adiposidade
Idoso
Alberta/epidemiologia
Carcinoma de Células Renais/mortalidade
Feminino
Neoplasias Gastrointestinais/mortalidade
Seres Humanos
Neoplasias Renais/mortalidade
Masculino
Meia-Idade
Análise Multivariada
Obesidade Abdominal/diagnóstico por imagem
Prognóstico
Modelos de Riscos Proporcionais
Fatores de Proteção
Neoplasias do Sistema Respiratório/mortalidade
Fatores de Risco
Sarcopenia/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2017.149


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[PMID]:28323575
[Au] Autor:Cahoon EK; Preston DL; Pierce DA; Grant E; Brenner AV; Mabuchi K; Utada M; Ozasa K
[Ad] Endereço:a Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
[Ti] Título:Lung, Laryngeal and Other Respiratory Cancer Incidence among Japanese Atomic Bomb Survivors: An Updated Analysis from 1958 through 2009.
[So] Source:Radiat Res;187(5):538-548, 2017 May.
[Is] ISSN:1938-5404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Life Span Study (LSS) of Japanese atomic bomb survivors is comprised of a large, population-based cohort offering one of the best opportunities to study the relationship between exposure to radiation and incidence of respiratory cancers. Risks of lung, laryngeal and other cancers of the respiratory system were evaluated among 105,444 LSS subjects followed from 1958 to 2009. During this period, we identified 2,446 lung, 180 laryngeal and 115 other respiratory (trachea, mediastinum and other ill-defined sites) first primary incident cancer cases. Ten additional years of follow-up, improved radiation dose estimates, revised smoking data, and updated migration information were used to investigate the joint effects of radiation and smoking using Poisson regression methods. For nonsmokers, the sex-averaged excess relative risk per Gy (ERR/Gy) for lung cancer (at age 70 after radiation exposure at age 30) was estimated as 0.81 (95% CI: 0.51, 1.18) with a female-to-male ratio of 2.83. There was no evidence of curvature in the radiation dose-response relationship overall or by sex. Lung cancer risks increased with pack-years of smoking and decreased with time since quitting smoking at any level of radiation exposure. Similar to the previously reported study, which followed cohort members through 1999, the ERR/Gy for lung cancer was significantly higher for low-to-moderate smokers than for heavy smokers, with little evidence of any radiation-associated excess risk in heavy smokers. Of 2,446 lung cancer cases, 113 (5%) could be attributed to radiation exposure. Of the 1,165 lung cancer cases occurring among smokers, 886 (76%) could be attributed to smoking. While there was little evidence of a radiation effect for laryngeal cancer, a nonsignificantly elevated risk of other respiratory cancers was observed. However, significant smoking effects were observed for both laryngeal (ERR per 50 pack-years = 23.57; 95% CI: 8.44, 71.05) and other respiratory cancers (ERR per 50 pack-years = 1.21; 95% CI: 0.10, 3.25).
[Mh] Termos MeSH primário: Expectativa de Vida/tendências
Neoplasias Induzidas por Radiação/mortalidade
Armas Nucleares/estatística & dados numéricos
Exposição à Radiação/estatística & dados numéricos
Neoplasias do Sistema Respiratório/mortalidade
Sobreviventes/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Incidência
Lactente
Recém-Nascido
Japão/epidemiologia
Masculino
Meia-Idade
Modelos de Riscos Proporcionais
Fatores de Risco
Distribuição por Sexo
Análise de Sobrevida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1667/RR14583.1


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[PMID]:28276881
[Au] Autor:Al-Hamdan AZ; Albashaireh RN; Al-Hamdan MZ; Crosson WL
[Ad] Endereço:a Department of Civil and Environmental Engineering , University of Alabama in Huntsville , Huntsville , Alabama , USA.
[Ti] Título:The association of remotely sensed outdoor fine particulate matter with cancer incidence of respiratory system in the USA.
[So] Source:J Environ Sci Health A Tox Hazard Subst Environ Eng;52(6):547-554, 2017 May 12.
[Is] ISSN:1532-4117
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to assess the association between exposure to fine particulate matter (PM ) and respiratory system cancer incidence in the US population (n = 295,404,580) using a satellite-derived estimate of PM concentrations. Linear and logistic regression analyses were performed to determine whether PM was related to the odds of respiratory system cancer (RSC) incidence based on gender and race. Positive linear regressions were found between PM concentrations and the age-adjusted RSC incidence rates for all groups (Males, Females, Whites, and Blacks) except for Asians and American Indians. The linear relationships between PM and RSC incidence rate per 1 µg/m PM increase for Males, Females, Whites, Blacks, and all categories combined had slopes of, respectively, 7.02 (R = 0.36), 2.14 (R = 0.14), 3.92 (R = 0.23), 5.02 (R = 0.21), and 4.15 (R = 0.28). Similarly, the logistic regression odds ratios per 10 µg/m increase of PM were greater than one for all categories except for Asians and American Indians, indicating that PM is related to the odds of RSC incidence. The age-adjusted odds ratio for males (OR = 2.16, 95% CI = 1.56-3.01) was higher than that for females (OR = 1.50, 95% CI = 1.09-2.06), and it was higher for Blacks (OR = 2.12, 95% CI = 1.43-3.14) than for Whites (OR = 1.72, 95% CI = 1.23-2.42). The odds ratios for all categories were attenuated with the inclusion of the smoking covariate, reflecting the effect of smoking on RSC incidence besides PM .
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Material Particulado/análise
Tecnologia de Sensoriamento Remoto/métodos
Neoplasias do Sistema Respiratório/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Incidência
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Tamanho da Partícula
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Particulate Matter)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/10934529.2017.1284432


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[PMID]:28069971
[Au] Autor:Vainio H; Weiderpass E
[Ad] Endereço:Environmental and Occupational Health, Faculty of Public Health, Kuwait University, Kuwait.
[Ti] Título:Importance of updating old cohorts for new findings.
[So] Source:Occup Environ Med;74(5):311-312, 2017 05.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Substâncias para a Guerra Química/efeitos adversos
Gás de Mostarda/efeitos adversos
Neoplasias do Sistema Respiratório/induzido quimicamente
[Mh] Termos MeSH secundário: Carcinógenos
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Exposição Ocupacional
Fatores de Risco
Veteranos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Chemical Warfare Agents); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-103981


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[PMID]:28017340
[Au] Autor:Sykes SE; Byfield V; Sullivan L; Bender SJ; Moore PF; Sánchez MD
[Ad] Endereço:Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce St, Philadelphia, Pennsylvania, USA. Electronic address: sykessa@vet.upenn.edu.
[Ti] Título:Feline Respiratory Extramedullary Plasmacytoma with Lymph Node Metastasis and Intrahistiocytic Amyloid.
[So] Source:J Comp Pathol;156(2-3):173-177, 2017 Feb - Apr.
[Is] ISSN:1532-3129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 14-year-old domestic longhaired cat presented with a 2-year history of nasal discharge and a recent onset of inappetence and submandibular lymphadenopathy. The cat was humanely destroyed after developing severe respiratory distress. Necropsy examination revealed thickened nasal turbinates and soft palate, and friable red-tan material within the frontal sinus, nasal cavity and nasopharynx. The lungs contained multifocal irregular friable tan nodules. Multiple lymph nodes were enlarged, friable and red-tan in colour. Histopathology revealed a mature type extramedullary plasmacytoma (EMP) within the frontal sinus, nasal cavity, soft palate, larynx, trachea, lungs and multiple lymph nodes. The lymph nodes and larynx also contained marked granulomatous inflammation with extensive intrahistiocytic (and lesser amounts of extracellular) lambda light chain amyloid, confirmed by electron microscopy and immunohistochemistry. Neoplastic cells expressed CD79a and MUM1. This is the first report of an infiltrative EMP of the feline respiratory tract with lymph node metastasis and predominantly intrahistiocytic amyloid.
[Mh] Termos MeSH primário: Amiloide/metabolismo
Doenças do Gato/patologia
Metástase Linfática/patologia
Plasmocitoma/veterinária
Neoplasias do Sistema Respiratório/veterinária
[Mh] Termos MeSH secundário: Animais
Gatos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


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[PMID]:27922210
[Au] Autor:Fouriez-Lablée V; Vergneau-Grosset C; Kass PH; Zwingenberger AL
[Ad] Endereço:Medical Imaging Department, Alfort University Veterinary Hospital, National Veterinary School of Alfort, 94700, Maisons-Alfort, France.
[Ti] Título:COMPARISON BETWEEN THORACIC RADIOGRAPHIC FINDINGS AND POSTMORTEM DIAGNOSIS OF THORACIC DISEASES IN DYSPNEIC COMPANION RATS (RATTUS NORVEGICUS).
[So] Source:Vet Radiol Ultrasound;58(2):133-143, 2017 Mar.
[Is] ISSN:1740-8261
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Companion rats are often presented to veterinarians for respiratory difficulties. Dyspnea in rats is most commonly due to infectious pneumonia, and thoracic neoplasia can go undiagnosed ante mortem due to a mistaken interpretation of pneumonia. In domestic carnivores, pulmonary nodular patterns have been shown to correlate with lung neoplastic diseases and infectious diseases. The main objective of this retrospective case series study was to determine whether certain radiographic criteria could be correlated with the presence of thoracic infectious disease and neoplastic disease in companion rats. A secondary objective was to determine whether the patient's sex and age were different between rats diagnosed with infectious versus neoplastic disease. Medical records and thoracic radiographs of dyspneic companion rats presented to the University of California at Davis, William R. Pritchard Veterinary Medical Teaching Hospital during the time period from January 2000 to December 2014 were reviewed. Rats with postmortem confirmation of thoracic lesions were included in the study. Thoracic radiographs were evaluated for positioning, lesion distribution, lung lobe involved, pulmonary pattern, mediastinal and pleural lesions by three observers blinded to diagnosis. Thirty rats were included in the study, including 23 rats with an infectious disease and seven with neoplasia. Mediastinal lesions were significantly more prevalent in the group diagnosed with thoracic neoplasia (P = 0.031), in particular cranially (P = 0.048). Although there was an overlap between the two groups, findings indicated that the presence of cranial mediastinal lesions may be helpful for differentiating neoplastic from infectious disease in rats.
[Mh] Termos MeSH primário: Diagnóstico
Dispneia/veterinária
Radiografia Torácica/veterinária
Infecções Respiratórias/veterinária
Neoplasias do Sistema Respiratório/veterinária
Doenças Torácicas/veterinária
[Mh] Termos MeSH secundário: Animais
Dispneia/diagnóstico
Dispneia/diagnóstico por imagem
Feminino
Masculino
Animais de Estimação
Ratos
Infecções Respiratórias/diagnóstico
Infecções Respiratórias/diagnóstico por imagem
Neoplasias do Sistema Respiratório/diagnóstico
Neoplasias do Sistema Respiratório/diagnóstico por imagem
Estudos Retrospectivos
Doenças Torácicas/diagnóstico
Doenças Torácicas/diagnóstico por imagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.1111/vru.12459


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[PMID]:27878600
[Au] Autor:Arens C; Betz C; Kraft M; Voigt-Zimmermann S
[Ad] Endereço:Department of Otorhinolaryngology, University Hospital Magdeburg A. ö. R., Otto-von-Guericke-University Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Saxony-Anhalt, Germany. christoph.arens@med.ovgu.de.
[Ti] Título:Narrow band imaging for early diagnosis of epithelial dysplasia and microinvasive tumors in the upper aerodigestive tract.
[Ti] Título:"Narrow band imaging" zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg..
[So] Source:HNO;65(Suppl 1):5-12, 2017 Jan.
[Is] ISSN:1433-0458
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The various stages of tumor growth are characterized by typical epithelial, vascular, and secondary connective tissue changes. Narrow Band Imaging (NBI) endoscopy is a minimally invasive imaging technique that presents vascular structures in particular at a higher contrast than white light endoscopy alone. In combination with high-resolution image recording and reproduction (high-definition television, HDTV; ultra-high definition, 4K), progress has been made in otolaryngological differential diagnostics, both pre- and intraoperatively. This progress represents an important step toward a so-called optical biopsy. Flexible endoscopy in combination with NBI allows for a detailed assessment of areas of the upper aerodigestive tract that are difficult to assess by rigid endoscopy. Papillomas along with precancerous and cancerous lesions are characterized by epithelial and connective tissue changes as well as by typical perpendicular vascular changes. Systematic use of NBI is recommended in the differential diagnosis of malignant lesions of the upper aerodigestive tract. NBI also offers a significant improvement in the pre- and intraoperative assessment of superficial resection margins. In particular, the combination of NBI and contact endoscopy (compact endoscopy) facilitates excellent therapeutic decisions during tumor surgery. Intraoperative determination of resection margins at an unprecedented precision is possible. In addition, assessment of the form and extent of the perpendicular vessel loops stimulated by epithelial signaling enables differential diagnostic decisions to be made, approximating our goal of an optical biopsy.
[Mh] Termos MeSH primário: Diagnóstico Precoce
Endoscopia/métodos
Neoplasias Gastrointestinais/patologia
Imagem de Banda Estreita/métodos
Neoplasias Epiteliais e Glandulares/patologia
Neoplasias do Sistema Respiratório/patologia
[Mh] Termos MeSH secundário: Neoplasias Gastrointestinais/diagnóstico por imagem
Seres Humanos
Invasividade Neoplásica
Estadiamento de Neoplasias
Neoplasias Epiteliais e Glandulares/diagnóstico por imagem
Reprodutibilidade dos Testes
Neoplasias do Sistema Respiratório/diagnóstico por imagem
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE
[do] DOI:10.1007/s00106-016-0284-x


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[PMID]:27282555
[Au] Autor:Seilkop SK; Lightfoot NE; Berriault CJ; Conard BR
[Ad] Endereço:a SKS Consulting Services , Siler City , North Carolina , USA.
[Ti] Título:Respiratory cancer mortality and incidence in an updated cohort of Canadian nickel production workers.
[So] Source:Arch Environ Occup Health;72(4):204-219, 2017 Jul 04.
[Is] ISSN:1933-8244
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory cancer mortality and incidence were examined in an updated cohort of >56,000 Canadian nickel mining and refining workers. There was little evidence to suggest increased lung cancer risk in workers who had no experience in high-risk sintering operations that were closed by 1972, apart from that which would be expected from probable increased smoking prevalence relative to the comparison population. There was no substantive evidence of increased laryngeal cancer risk in the cohort, nor was there evidence of increased pharyngeal cancer risk in nonsinter workers. Nasal cancer incidence was elevated in nonsinter workers, but excess risks appeared to be confined to those hired prior to 1960. These findings lead us to tentatively conclude that occupationally-related respiratory risks in workers hired over the past 45 years are either very low or nonexistent.
[Mh] Termos MeSH primário: Metalurgia
Níquel/toxicidade
Exposição Ocupacional
Neoplasias do Sistema Respiratório/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos de Coortes
Seres Humanos
Incidência
Masculino
Meia-Idade
Ontário/epidemiologia
Neoplasias do Sistema Respiratório/induzido quimicamente
Neoplasias do Sistema Respiratório/mortalidade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7OV03QG267 (Nickel)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE
[do] DOI:10.1080/19338244.2016.1199532


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[PMID]:27209488
[Au] Autor:Nielsen GD; Larsen ST; Wolkoff P
[Ad] Endereço:National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark. gdn@nrcwe.dk.
[Ti] Título:Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment.
[So] Source:Arch Toxicol;91(1):35-61, 2017 Jan.
[Is] ISSN:1432-0738
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In 2010, the World Health Organization (WHO) established an indoor air quality guideline for short- and long-term exposures to formaldehyde (FA) of 0.1 mg/m (0.08 ppm) for all 30-min periods at lifelong exposure. This guideline was supported by studies from 2010 to 2013. Since 2013, new key studies have been published and key cancer cohorts have been updated, which we have evaluated and compared with the WHO guideline. FA is genotoxic, causing DNA adduct formation, and has a clastogenic effect; exposure-response relationships were nonlinear. Relevant genetic polymorphisms were not identified. Normal indoor air FA concentrations do not pass beyond the respiratory epithelium, and therefore FA's direct effects are limited to portal-of-entry effects. However, systemic effects have been observed in rats and mice, which may be due to secondary effects as airway inflammation and (sensory) irritation of eyes and the upper airways, which inter alia decreases respiratory ventilation. Both secondary effects are prevented at the guideline level. Nasopharyngeal cancer and leukaemia were observed inconsistently among studies; new updates of the US National Cancer Institute (NCI) cohort confirmed that the relative risk was not increased with mean FA exposures below 1 ppm and peak exposures below 4 ppm. Hodgkin's lymphoma, not observed in the other studies reviewed and not considered FA dependent, was increased in the NCI cohort at a mean concentration ≥0.6 mg/m and at peak exposures ≥2.5 mg/m ; both levels are above the WHO guideline. Overall, the credibility of the WHO guideline has not been challenged by new studies.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Poluição do Ar em Ambientes Fechados/prevenção & controle
Carcinógenos Ambientais/toxicidade
Formaldeído/toxicidade
Saúde Global
Guias como Assunto
Neoplasias do Sistema Respiratório/prevenção & controle
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/análise
Poluentes Atmosféricos/metabolismo
Poluição do Ar em Ambientes Fechados/efeitos adversos
Animais
Carcinógenos Ambientais/análise
Carcinógenos Ambientais/metabolismo
Desinfetantes/análise
Desinfetantes/metabolismo
Desinfetantes/toxicidade
Formaldeído/análise
Formaldeído/metabolismo
Seres Humanos
Exposição por Inalação/efeitos adversos
Exposição por Inalação/prevenção & controle
Exposição por Inalação/normas
Mutagênicos/análise
Mutagênicos/metabolismo
Mutagênicos/toxicidade
Neoplasias/induzido quimicamente
Neoplasias/epidemiologia
Neoplasias/prevenção & controle
Estresse Oxidativo/efeitos dos fármacos
Neoplasias do Sistema Respiratório/induzido quimicamente
Neoplasias do Sistema Respiratório/epidemiologia
Medição de Risco
Toxicocinética
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Carcinogens, Environmental); 0 (Disinfectants); 0 (Mutagens); 1HG84L3525 (Formaldehyde)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160523
[St] Status:MEDLINE
[do] DOI:10.1007/s00204-016-1733-8



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