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[PMID]:28132791
[Au] Autor:Stuart S; Auten J
[Ad] Endereço:Emergency Department, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, United States. Electronic address: sean.m.stuart4.mil@mail.mil.
[Ti] Título:A rare seizure: Tumor lysis syndrome after radiation therapy of a solid tumor.
[So] Source:Am J Emerg Med;35(6):941.e3-941.e4, 2017 Jun.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tumor lysis syndrome (TLS) is an uncommon but life threatening condition seen in oncology patients. Due to its underlying pathophysiology, it is classically associated with hematologic malignancies following chemotherapeutic treatment. In this article, we present a case of TLS in the setting of two rare features: a solid tumor malignancy and the absence of recent chemotherapy. We briefly review risk factors and the diagnosis of this potentially fatal but treatable condition.
[Mh] Termos MeSH primário: Carcinoma Broncogênico/radioterapia
Neoplasias Pulmonares/radioterapia
Linfadenopatia/diagnóstico por imagem
Radioterapia/efeitos adversos
Convulsões/etiologia
Síndrome de Lise Tumoral/etiologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
Radiografia
Fatores de Risco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE


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[PMID]:27910778
[Au] Autor:Ozbayer C; Degirmenci I; Ustuner D; Ak G; Saydam F; Colak E; Gunes HV; Metintas M
[Ad] Endereço:School of Health Sciences, Dumlupinar University, Kutahya, Turkey.
[Ti] Título:miRSNPs of miR1274 and miR3202 Genes that Target MeCP2 and DNMT3b Are Associated with Lung Cancer Risk: A Study Conducted on MassARRAY Genotyping.
[So] Source:J Environ Pathol Toxicol Oncol;35(3):223-236, 2016.
[Is] ISSN:2162-6537
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genetic variants of miRNAs that target DNMTs and MBDs involved in DNA methylation were scanned with current databases, and 35 miRSNPs in 22 miRNA genes were identified. The aim of the study was to determine the association between these variants of miRNA genes and lung cancer (LC). DNA samples were isolated from blood samples and genotyped using a Sequenom MassARRAY System. An association between the rs188912830 gene variant of miR3202 that targets the MeCP2 protein and LC was indicated in both subtypes. The presence of the C-allele in patients with LC and its subtypes was significantly lower, and the absence of the C-allele was determined to increase the risk of LC by 7,429-times compared to the presence (p=0,010). The rs318039 gene variant of miR1274 that targets DNMT3b was found to be associated with LC subtypes. When allele distributions were compared, the numbers of individuals with the C-allele were significantly lower in the NSCLC and SCLC groups. No significant associations were found for the rs72563729 variant of the miR200b gene that targets DNMT3a or for the rs145416750 variant of the miR513c gene that targets TRDMT1. The other 33 variants were found to be ancestral genotypes. Consequently, rs188912830 and rs318039 variations were associated with LC subtypes. Importantly, this study is the first to indicate the functional characterisation of miRSNPs of genes that target DNA methylation.
[Mh] Termos MeSH primário: Carcinoma Broncogênico/genética
Proteínas Cromossômicas não Histona/genética
DNA (Citosina-5-)-Metiltransferases/genética
Metilação de DNA
Neoplasias Pulmonares/genética
MicroRNAs/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma Broncogênico/metabolismo
Proteínas Cromossômicas não Histona/metabolismo
DNA (Citosina-5-)-Metiltransferases/metabolismo
Feminino
Predisposição Genética para Doença
Seres Humanos
Neoplasias Pulmonares/epidemiologia
Masculino
MicroRNAs/metabolismo
Meia-Idade
Fatores de Risco
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromosomal Proteins, Non-Histone); 0 (MIRN1275 microRNA, human); 0 (MIRN3202 microRNA, human); 0 (MicroRNAs); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


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[PMID]:27902464
[Au] Autor:Wang X; Liu F; Qin X; Huang T; Huang B; Zhang Y; Jiang B
[Ad] Endereço:Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201999, China.
[Ti] Título:Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.
[So] Source:Aging (Albany NY);8(11):2790-2798, 2016 Nov 29.
[Is] ISSN:1945-4589
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rab1A expression is associated with malignant phenotypes in several human tumors; however, the role of Rab1A in lung cancer is still unclear. In this study, we attempted to establish the role of Rab1A in major human lung cancer subtypes. Rab1A expression in different histological types of human lung cancer was analyzed in lung cancer tissues with paired adjacent noncancerous tissues and a large panel of lung cancer cell lines. The effect of Rab1A expression on multiple cancer-associated signaling pathways was also examined. The results demonstrated that Rab1A was significantly overexpressed in the different histological types of lung cancer as compared to non-cancerous tissues, and Rab1A expression was correlated with tumor volume and stage. In a large panel of lung cancer cell lines, high Rab1A expression was observed as compared to a normal lung/bronchus epithelial cell line. However, Rab1A protein levels were not correlated with mTORC1 (P-S6K1), mTORC2 (P-AKT), MEK (P-ERK), JNK (P-c-Jun) or p38MAPK (P-MK2) signaling. Rab1A knockdown had no effect on mTOR signaling or cell growth. These data suggested that Rab1A may be involved in the pathogenesis of human lung cancer in an mTOR- and MAPK-independent manner.
[Mh] Termos MeSH primário: Regulação Neoplásica da Expressão Gênica
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/patologia
Transdução de Sinais
Proteínas rab1 de Ligação ao GTP/metabolismo
[Mh] Termos MeSH secundário: Adenocarcinoma/genética
Adenocarcinoma/metabolismo
Adenocarcinoma/patologia
Biomarcadores Tumorais/metabolismo
Carcinoma Broncogênico/genética
Carcinoma Broncogênico/metabolismo
Carcinoma Broncogênico/patologia
Carcinoma de Células Escamosas/genética
Carcinoma de Células Escamosas/metabolismo
Carcinoma de Células Escamosas/patologia
Linhagem Celular Tumoral
Proliferação Celular
Feminino
Seres Humanos
Neoplasias Pulmonares/genética
Masculino
Meia-Idade
Estadiamento de Neoplasias
Serina-Treonina Quinases TOR
Proteínas rab1 de Ligação ao GTP/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 3.6.5.2 (rab1 GTP-Binding Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.18632/aging.101087


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[PMID]:27863670
[Au] Autor:Chen W; Clauser J; Thiebes AL; McGrath DJ; McHugh PE; Steinseifer U; Jockenhoevel S; Hennink WE; Kok RJ
[Ad] Endereço:Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
[Ti] Título:Selection and fabrication of a non-woven polycarbonate urethane cover for a tissue engineered airway stent.
[So] Source:Int J Pharm;514(1):255-262, 2016 Nov 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:One of the major problems in end-stage bronchotracheal cancer is stenosis of the upper airways, either due to luminal ingrowth of the tumor or mucus plugging. Airway stents that suppress tumor ingrowth and sustain mucociliary transport can alleviate these problems in end-stage bronchial cancer. We evaluated different types of polymeric covers for a tissue engineered airway stent. The distinguishing feature of this stent concept is that respiratory epithelial cells can grow on the luminal surface of the stent which facilitates mucociliary clearance. To facilitate growth of epithelial cells at the air-liquid interface of the stent, we developed a polyurethane cover that allows transport of nutrients to the cells. Nonwoven polycarbonate urethane (PCU) covers were prepared by a spraying process and evaluated for their porosity and glucose permeability. Respiratory epithelial cells harvested from sheep trachea were cultured onto the selected PCU cover and remained viable at the air-liquid interface when cultured for 21days. Lastly, we evaluated the radial force of a PCU-covered nitinol stent, and showed the PCU covers did not adversely affect the mechanical properties of the stents for their intended application in the smaller bronchi. These in vitro data corroborate the design of a novel airway stent for palliative treatment of bronchotracheal stenosis by combination of stent-technology with tissue-engineered epithelial cells.
[Mh] Termos MeSH primário: Cimento de Policarboxilato/química
Poliuretanos/química
Sistema Respiratório/química
Engenharia Tecidual/instrumentação
[Mh] Termos MeSH secundário: Ligas/química
Animais
Brônquios/metabolismo
Carcinoma Broncogênico/complicações
Células Cultivadas
Constrição Patológica/etiologia
Constrição Patológica/metabolismo
Constrição Patológica/terapia
Células Epiteliais/metabolismo
Desenho de Equipamento/instrumentação
Desenho de Equipamento/métodos
Glucose/metabolismo
Permeabilidade
Porosidade
Ovinos
Stents
Engenharia Tecidual/métodos
Traqueia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alloys); 0 (Polycarboxylate Cement); 0 (Polyurethanes); 25766-59-0 (polycarbonate); 2EWL73IJ7F (nitinol); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


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[PMID]:27545644
[Au] Autor:Beil FT; Amling M; Ruether W
[Ad] Endereço:Department of Trauma-, Orthopedic- and Plastic-Surgery, University Medical Center Göttingen, Göttingen, Germany. Electronic address: frank-timo.beil@med.uni-goettingen.de.
[Ti] Título:Joint effusion as an indication of a lung disease.
[So] Source:Eur J Intern Med;36:e5-e6, 2016 Dec.
[Is] ISSN:1879-0828
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma Broncogênico/diagnóstico por imagem
Articulação do Joelho/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
Osteoartropatia Hipertrófica Secundária/diagnóstico por imagem
[Mh] Termos MeSH secundário: Carcinoma Broncogênico/complicações
Seres Humanos
Neoplasias Pulmonares/complicações
Masculino
Meia-Idade
Osteoartropatia Hipertrófica Secundária/etiologia
Radiografia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


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[PMID]:27417315
[Au] Autor:Chrysou K; Gioutsos K; Filips A; Schmid R; Schmid RA; Kocher GJ
[Ad] Endereço:Division of General Thoracic Surgery, University Hospital of Bern, Bern, Switzerland.
[Ti] Título:Spontaneous right whole-lung torsion secondary to bronchial carcinoma: a case report.
[So] Source:J Cardiothorac Surg;11(1):107, 2016 Jul 14.
[Is] ISSN:1749-8090
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Spontaneous whole lung torsion is an absolut rarity and most cases occur after previous surgery. CASE PRESENTATION: We present the case of a spontaneous whole-lung torsion in a 82-year old man. The patient was referred to our thoracic surgery department from the emergency department of a referring hospital with rapidly progressive dyspnea. CT-scan revealed a 180° degree counterclockwise torsion of the entire right lung with complete atelectasis and congestion of the upper lobe as well as pleural effusion. Thoracoscopy confirmed lung torsion and revealed hemorrhagic infarction of the upper lobe. Subsequently thoracotomy and upper lobectomy were performed. Most likely the lung torsion occurred due to a combination of pleural effusion and venous congestion with complete atelectasis of the upper lobe as a result of adenocarcinoma of the upper lobe. CONCLUSIONS: To our knowledge this is the first reported case of a patient presenting with lung torsion as the first symptom of lung cancer. When lung torsion is suspected rapid diagnosis is crucial in order to prevent hemorrhagic lung infarction.
[Mh] Termos MeSH primário: Adenocarcinoma/complicações
Carcinoma Broncogênico/complicações
Neoplasias Pulmonares/complicações
Anormalidade Torcional/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico por imagem
Adenocarcinoma/cirurgia
Idoso de 80 Anos ou mais
Carcinoma Broncogênico/diagnóstico por imagem
Carcinoma Broncogênico/cirurgia
Seres Humanos
Pneumopatias/diagnóstico por imagem
Pneumopatias/etiologia
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/cirurgia
Masculino
Pneumonectomia
Tomografia Computadorizada por Raios X
Anormalidade Torcional/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE
[do] DOI:10.1186/s13019-016-0506-z


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[PMID]:27284583
[Au] Autor:Salaric I; Milos M; Brajdic D; Manojlovic S; Trutin Ostovic K; Macan D
[Ti] Título:Bronchogenic adenocarcinoma metastatic tumor mimicking a dentoalveolar abscess in the maxilla.
[So] Source:Quintessence Int;47(9):785-90, 2016.
[Is] ISSN:1936-7163
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Intraosseous metastatic tumors (IOM) in maxilla are less frequent than the soft tissue metastatic tumors. Lung and bronchogenic metastatic tumors are uncommon in the maxilla. We present a maxillary bronchogenic metastasis with a rare clinical appearance. IOM was misdiagnosed as a dentoalveolar abscess and treated with antibiotics for 3 weeks. After not responding to antibiotics, the patient's general dental practitioner forwarded the patient to the Department of Oral and Maxillofacial Surgery. The associated tooth was extracted and the patient was recalled 1 week later. No signs of improvement were observed, and cytology, biopsy, and radiology diagnostics were performed. Cytologic results and biopsy could not differentiate a metastatic tumor from a salivary duct carcinoma. Ultimately, negative androgen receptors immunohistochemistry supported the diagnosis of bronchogenic metastatic adenocarcinoma. This case report stresses the importance of taking a thorough medical history. To our knowledge, this is the third bronchogenic IOM to the maxilla reported, mimicking a dentoalveolar abscess. General dental practitioners are among the first in contact with oral metastatic tumors and it is therefore important to report unusual clinical cases, as they present a diagnostic challenge for both the clinician and the pathologist.
[Mh] Termos MeSH primário: Carcinoma Broncogênico/diagnóstico
Neoplasias Maxilares/diagnóstico
[Mh] Termos MeSH secundário: Neoplasias das Glândulas Suprarrenais/secundário
Biópsia
Carcinoma Broncogênico/patologia
Diagnóstico Diferencial
Evolução Fatal
Seres Humanos
Imuno-Histoquímica
Metástase Linfática
Masculino
Neoplasias Maxilares/patologia
Meia-Idade
Abscesso Periapical/diagnóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE
[do] DOI:10.3290/j.qi.a36324


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[PMID]:27273232
[Au] Autor:Afghani R; Khandashpour Ghomi M; Khandoozi SR; Yari B
[Ad] Endereço:Department of Surgery, 5 Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran af_med75@yahoo.com.
[Ti] Título:Neglected foreign body aspiration mimicking bronchial carcinoma.
[So] Source:Asian Cardiovasc Thorac Ann;24(6):601-3, 2016 Jul.
[Is] ISSN:1816-5370
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Foreign body aspiration can occur in any age group, but it is more commonly seen in children. In adults, there is usually a predisposing condition that poses a risk of aspiration. If aspiration occurs, prompt diagnosis and extraction of the foreign body is needed to prevent early and late complications. We report a rare case of neglected foreign body aspiration in a 45-year-old schizophrenic opium addicted patient, which resulted in an occlusive lesion in the bronchus, mimicking bronchial carcinoma.
[Mh] Termos MeSH primário: Osso e Ossos
Carcinoma Broncogênico/diagnóstico
Corpos Estranhos/diagnóstico
Granuloma de Corpo Estranho/diagnóstico
Neoplasias Pulmonares/diagnóstico
[Mh] Termos MeSH secundário: Animais
Biópsia
Broncoscopia
Galinhas
Diagnóstico Diferencial
Ingestão de Alimentos
Corpos Estranhos/etiologia
Corpos Estranhos/cirurgia
Granuloma de Corpo Estranho/etiologia
Granuloma de Corpo Estranho/cirurgia
Seres Humanos
Masculino
Meia-Idade
Transtornos Relacionados ao Uso de Opioides/complicações
Ópio
Pneumonectomia
Aves Domésticas
Valor Preditivo dos Testes
Esquizofrenia/complicações
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
Tomografia Computadorizada por Raios X
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
8008-60-4 (Opium)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1177/0218492316653864


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[PMID]:27170139
[Au] Autor:Weinrich MJ; Avanesov M
[Ad] Endereço:Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland.
[Ti] Título:[Follow-up for subsolid pulmonary nodules with low-dose CT : Evidence-based scheme for participants of a bronchial carcinoma screening].
[Ti] Título:Verlaufskontrolle für subsolide Lungenrundherde mit Low­dose­CT : Evidenzbasiertes Schema bei Teilnehmern eines Bronchialkarzinomscreenings..
[So] Source:Radiologe;56(7):577-8, 2016 Jul.
[Is] ISSN:1432-2102
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Carcinoma Broncogênico
Nódulos Pulmonares Múltiplos
[Mh] Termos MeSH secundário: Seguimentos
Seres Humanos
Neoplasias Pulmonares
Nódulo Pulmonar Solitário
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160513
[St] Status:MEDLINE
[do] DOI:10.1007/s00117-016-0110-1


  10 / 7190 MEDLINE  
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[PMID]:27083009
[Au] Autor:Sehgal IS; Dhooria S; Gupta N; Bal A; Ram B; Aggarwal AN; Behera D; Agarwal R
[Ad] Endereço:Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
[Ti] Título:Impact of Endobronchial Ultrasound (EBUS) Training on the Diagnostic Yield of Conventional Transbronchial Needle Aspiration for Lymph Node Stations 4R and 7.
[So] Source:PLoS One;11(4):e0153793, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is sparse literature on whether training in endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) improves the diagnostic yield of conventional TBNA (cTBNA). OBJECTIVES: The aim of this study was to evaluate the diagnostic yield of cTBNA before and after the introduction of EBUS. METHODS: This was a retrospective analysis of patients who underwent cTBNA at our center. The study was divided into two periods, before and after the introduction of EBUS at our facility. The diagnostic yield of cTBNA was compared between the study periods. Rapid on-site cytological examination was not available. RESULTS: A total of 1,050 patients (61.6% men; mean age 45.6 years) underwent cTBNA during the study period (849 before EBUS; 201 after EBUS). Sarcoidosis (n = 527) followed by bronchogenic carcinoma (n = 222) formed the most common indications for performing cTBNA. There was a significant increase in both the success of obtaining a representative sample (from 71% to 85%), and the diagnostic yield (from 33% to 49.5%) of cTBNA, after the introduction of EBUS. The increase in the diagnostic yield of cTBNA after introduction of EBUS remained significant even after adjusting for years of performing cTBNA and the type of anesthesia (topical vs. sedation and topical) on a multivariate analysis. CONCLUSION: The diagnostic yield of cTBNA at our facility increased after the introduction of EBUS-TBNA. However, given the retrospective nature of the study, prospective studies are required to confirm our findings.
[Mh] Termos MeSH primário: Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico/métodos
Linfonodos/patologia
[Mh] Termos MeSH secundário: Adulto
Anestesia
Broncoscopia/métodos
Carcinoma Broncogênico/diagnóstico
Carcinoma Broncogênico/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Estudos Retrospectivos
Sarcoidose/diagnóstico
Sarcoidose/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0153793



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