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[PMID]: 28453802 [Au] Autor: Kostron A; Friess M; Inci I; Hillinger S; Schneiter D; Gelpke H; Stahel R; Seifert B; Weder W; Opitz I [Ad] Endereço: Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland. [Ti] Título: Propensity matched comparison of extrapleural pneumonectomy and pleurectomy/decortication for mesothelioma patients. [So] Source: Interact Cardiovasc Thorac Surg;24(5):740-746, 2017 05 01. [Is] ISSN: 1569-9285 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: The objective of this retrospective study was to assess perioperative outcomes, overall survival and freedom from recurrence after induction chemotherapy followed by extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D) in patients with mesothelioma in a propensity score matched analysis. METHODS: Between September 1999 and August 2015, 167 patients received multimodality treatment (platinum-based chemotherapy followed by EPP [ n = 141] or P/D [ n = 26]). We performed 2:1 propensity score matching for gender, laterality, epithelioid histological subtype and International Mesothelioma Interest Group (iMig) stage (52 EPP and 26 P/D). RESULTS: Postoperative major morbidity (48% vs 58%, P = 0.5) was similar in both groups; however, the complication profile and severity were different and favoured P/D; the 90-day mortality (8% vs 0%, P = 0.3) rate was lower in P/D although not statistically significant. Prolonged air leak (≥10 days) occurred in 15 patients (58%) undergoing P/D. The intensive care unit stay was significantly longer after EPP ( P = 0.001). Freedom from recurrence was similar for both groups (EPP: median 15 months, 95% confidence interval [CI]: 10-21; P/D: 13 months, 95% CI: 11-17) ( P = 0.2). Overall survival was significantly longer for patients undergoing P/D (median 32 months, 95% CI: 29-35) compared to EPP (23 months, 95% CI: 21-25) ( P = 0.031), but in the P/D group many cases were censored (73%) and the follow-up time was relatively short. CONCLUSIONS: P/D and EPP seem to have similar rates of major morbidity, although the profile of complications is different and more severe after EPP. Freedom from recurrence is comparable in both groups whereas improved overall survival needs to be confirmed in a large patient group with longer follow-up. [Mh] Termos MeSH primário: Mesotelioma/cirurgia Pleura/cirurgia Neoplasias Pleurais/cirurgia Pneumonectomia/métodos Complicações Pós-Operatórias/epidemiologia Pontuação de Propensão [Mh] Termos MeSH secundário: Adulto Idoso Feminino Seguimentos Seres Humanos Masculino Mesotelioma/diagnóstico Meia-Idade Morbidade/tendências Recidiva Local de Neoplasia/epidemiologia Neoplasias Pleurais/diagnóstico Estudos Retrospectivos Taxa de Sobrevida/tendências Suíça/epidemiologia Fatores de Tempo Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1093/icvts/ivw422

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[PMID]: 28460459 [Au] Autor: Inaguma S; Wang Z; Lasota J; Onda M; Czapiewski P; Langfort R; Rys J; Szpor J; Waloszczyk P; Okon K; Biernat W; Ikeda H; Schrump DS; Hassan R; Pastan I; Miettinen M [Ad] Endereço: Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA. [Ti] Título: Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma. [So] Source: Oncotarget;8(16):26744-26754, 2017 Apr 18. [Is] ISSN: 1949-2553 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly expressed in several types of malignant tumors sometimes in association with increased tumor aggressiveness and poor clinical outcome. In the present study, 1562 tumors were immunohistochemically analyzed for mesothelin expression using two different types of mouse monoclonal antibodies (5B2 and MN-1) to determine the clinical usefulness of mesothelin immunohistochemistry as well as to pinpoint potential targets for future anti-mesothelin therapy. Also, characterization of selected mesothelin-positive tumors was performed by immunohistochemistry and oncogene sequencing. Among the tumors analyzed, the highest frequencies of mesothelin-positivity were detected in ovarian serous carcinoma (90% in 5B2 and 94% in MN-1). Both antibodies showed frequent positivity in pancreatic adenocarcinoma (71% using 5B2 and 87% using MN-1) and malignant pleural mesothelioma (75% using 5B2 and 78% using MN-1). In malignant mesothelioma, overall survival was significantly longer in the cohort of patients with diffuse membranous expression of mesothelin (P < 0.001). Both antibodies showed positive staining in thymic carcinoma (77% in 5B2 and 59% in MN-1), however, no expression was detected in thymoma. No correlation was detected between mesothelin expression and mismatch repair system deficient phenotype or gene mutation (BRAF and RAS) status in gastrointestinal adenocarcinomas. Mesothelin immunohistochemistry may assist the differential diagnosis of thymoma vs. thymic carcinoma as well as prognostication of mesothelioma patients. Our results demonstrate that patients with solid tumors expressing mesothelin could be targeted by anti-mesothelin therapies. [Mh] Termos MeSH primário: Biomarcadores Tumorais Proteínas Ligadas por GPI/metabolismo Neoplasias Pulmonares/metabolismo Neoplasias Pulmonares/mortalidade Mesotelioma/metabolismo Mesotelioma/mortalidade Neoplasias Pleurais/metabolismo Neoplasias Pleurais/mortalidade [Mh] Termos MeSH secundário: Anticorpos Monoclonais Diagnóstico Diferencial Expressão Gênica Seres Humanos Imuno-Histoquímica Neoplasias Pulmonares/diagnóstico Neoplasias Pulmonares/genética Mesotelioma/diagnóstico Mesotelioma/genética Mutação Neoplasias Pleurais/diagnóstico Neoplasias Pleurais/genética Prognóstico Análise de Sobrevida [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Monoclonal); 0 (Biomarkers, Tumor); 0 (GPI-Linked Proteins); 0 (mesothelin) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.18632/oncotarget.15814

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[PMID]: 29361614 [Au] Autor: Nakano T [Ad] Endereço: Division of Respiratory Medicine, Dept. of Internal Medicine, Otemae Hospital. [Ti] Título: [Systemic Treatment of Malignant Pleural Mesothelioma]. [So] Source: Gan To Kagaku Ryoho;44(13):2041-2047, 2017 Dec. [Is] ISSN: 0385-0684 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: Malignant pleural mesothelioma(MPM)is a highly aggressive tumor with a poor prognosis and an increasing incidence worldwide. The only standard first-line chemotherapy for patients with unresectable MPM is cisplatin(CDDP)plus peme- trexed(PEM)(CDDP/PEM), with a median overall survival of about 12months and a median progression-free survival(PFS) of less than 6 months. There are no treatments with proven benefit on survival for relapsed MPM patients. Therefore, novel therapeutic strategies are urgently required. Several molecular pathways involved in MPM have been identified; these include growth factor signaling pathways, cell cycle regulation, apoptosis, and angiogenesis. Fortunately, several agents targeting these processes have yielded promising results in preliminary trials. The addition of vascular endothelial growth factor(VEGF) inhibitor bevacizumab to the standard CDDP/PEM provides a 2.7-month survival benefit. Triple angiokinase inhibitor nintedanib, inhibiting the VEGFR, PDGFR, and FGFR, plus standard chemotherapy demonstrated a significant improvement in median PFS of 3.7 months in the overall study population, and a greater median PFS benefit of 4.0 months in epithelioid MPM. Mesothelin is an attractive target protein expressed on mesothelioma cells. Amatuximab, a chimeric anti-mesothelin antibody, in combination with CDDP/PEM, is currently being tested in randomized, double-blind, placebo-controlled phase II study. Anetumab ravtansine, mesothelin-directed antibody drug conjugate, was evaluated in a randomized trial to compare to vinorelbine in patients with MPM who have high mesothelin expression and have progressed on CDDP/PEM-based first-line chemotherapy. However, anetumab ravtansine was not superior to vinorelbine in primary endpoint of PFS(4.3 months vs 4.5 months). Immune checkpoint blockades have demonstrated promising preclinical and clinical results in several cancer types, and are currently being investigated in clinical trials for MPM patients. PD-L1 expression in tumor tissue of MPM was reported, ranging between 20% and 70%. PD-L1 expression was significantly associated with a worse survival and overexpression was more common in sarcomatoid histology. This review summarizes clinical results for the latest systemic treatments in MPM. [Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico Neoplasias Pulmonares/tratamento farmacológico Mesotelioma/tratamento farmacológico Neoplasias Pleurais/tratamento farmacológico [Mh] Termos MeSH secundário: Seres Humanos Neoplasias Pulmonares/irrigação sanguínea Mesotelioma/irrigação sanguínea Neovascularização Patológica Neoplasias Pleurais/irrigação sanguínea Neoplasias Pleurais/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antineoplastic Agents) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180124 [St] Status: MEDLINE

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[PMID]: 29390282 [Au] Autor: Nakaya T; Oshiro H; Takigami A; Kanai Y; Tetsuka K; Hagiwara K; Fujii H; Endo S; Tanaka A [Ad] Endereço: Department of Pathologyy. [Ti] Título: Giant solitary fibrous tumor of the pleura with high-grade sarcomatous overgrowth accompanied by lipid-rich, rhabdomyosarcomatous, and pleomorphic components: A case report. [So] Source: Medicine (Baltimore);96(50):e8926, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Solitary fibrous tumors are mesenchymal tumors presenting as fibroblastic neoplasms with prominent branching vascular patterns, which are often generated from the pleura. Most solitary fibrous tumors are benign; however, some can turn malignant. High-grade sarcomas from solitary fibrous tumors include multidirectional histopathological components. PATIENT CONCERNS: We describe our experience of a giant high-grade sarcoma with mixed components generated from a solitary fibrous tumor of the pleura in a 67-year-old female patient presenting with cough and left-sided chest pain. The patient had been diagnosed with a pleural mass in the left chest by X-ray about 30 years earlier. However, the tumor was allowed to grow, without surgical intervention, for a long time. INTERVENTIONS: Thoracic surgeons performed the removal of the giant pleural tumor; the tumor measured 18.0 × 14.5 × 10 cm in size, and was considered a giant tumor generated from the pleura of the left chest cavity. DIAGNOSES: The surgically removed tumor was solid and light brownish, and included myxoid and arabesque pattern lesions. The tumor also showed hemorrhagic and necrotic lesions. Moreover, spindle cells with less atypia, resembling fibroblasts, were noted. These spindle tumor cells were CD34- and Stat6-positive, suggesting a solitary fibrous tumor. Some of the spindle tumor cells were surrounded by thick collagenous fibers. Considering that the tumor originated from the parietal pleura, the tumor was defined as a solitary fibrous tumor in origin. The tumor also comprised high-grade sarcomatous components; these included lipid-rich, rhabdomyosarcomatous, and pleomorphic components. The high-grade sarcoma component included bizarre tumor cells with severe atypia. OUTCOMES: Tumor recurrence occurred in the left chest about 4 months after the surgery, and the patient died 8 months postoperatively. LESSONS: The present case clearly demonstrates that a solitary fibrous tumor can develop into high-grade sarcomatous overgrowth, including lipid-rich, rhabdomyosarcoma, and pleomorphic sarcoma components, if left untreated for a prolonged period. This case provides profound insights about the natural history, histogenesis, differentiation, and malignant transformation of solitary fibrous tumors. [Mh] Termos MeSH primário: Neoplasias Pleurais/patologia Rabdomiossarcoma/patologia Sarcoma/patologia Tumor Fibroso Solitário Pleural/patologia [Mh] Termos MeSH secundário: Idoso Evolução Fatal Feminino Seres Humanos Gradação de Tumores Recidiva Local de Neoplasia Neoplasias Pleurais/cirurgia Rabdomiossarcoma/cirurgia Sarcoma/cirurgia Tumor Fibroso Solitário Pleural/cirurgia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008926

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[PMID]: 28464918 [Au] Autor: Lam SK; Li YY; Xu S; Leung LL; U KP; Zheng YF; Cheng PN; Ho JC [Ad] Endereço: Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, SAR, Hong Kong. [Ti] Título: Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. [So] Source: Respir Res;18(1):80, 2017 May 02. [Is] ISSN: 1465-993X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in hepatocellular carcinoma, acute myeloid leukemia and melanoma. This study aims to investigate the effects of PEG-BCT-100 in MPM. METHODS: A panel of 5 mesothelioma cell lines (H28, 211H, H226, H2052 and H2452) was used to study the in vitro effects of BCT-100 by crystal violet staining. The in vivo effects of BCT-100 were studied using 211H and H226 nude mice xenografts. Protein expression (argininosuccinate synthetase, ornithine transcarbamylase, cleaved PARP, cleaved caspase 3, cyclins (A2, D3, E1 and H), CDK4 and Ki67) and arginine concentration were evaluated by Western blot and ELISA respectively. Cellular localization of BCT-100 was detected by immunohistochemistry and immunoflorescence. TUNEL assay was used to identify cellular apoptotic events. RESULTS: Argininosuccinate synthetase was expressed in H28, H226, and H2452 cells as well as 211H and H266 xenografts. Ornithine transcarbamylase was undetectable in all cell lines and xenograft models. BCT-100 reduced in vitro cell viability (IC values at 13-24 mU/ml, 72 h) across different cell lines and suppressed tumor growth in both 211H and H226 xenograft models. BCT-100 (60 mg/kg) significantly suppressed tumor growth (p < 0.01) with prolonged median survival (p < 0.01) in both xenograft models. Combining BCT-100 with pemetrexed or cisplatin conferred no additional benefits over single agents. Serum and intratumoral arginine levels were effectively decreased by BCT-100, associated with cytosolic accumulation of BCT-100 within tumor cells. Apoptosis (PARP cleavage in 211H xenografts; Bcl-2 downregulation, and cleavage of PARP and caspase 3 in H226 xenografts; positive TUNEL staining in both) and G1 arrest (downregulation of cyclin A2, D3, E1 and CDK4 in 211H xenografts; suppression of cyclin A2, E1, H and CDK4 in H226 xenografts) were evident with BCT-100 treatment. Furthermore, proliferative factor Ki67 was downregulated in BCT-100 treatments arms. CONCLUSIONS: BCT-100 suppressed tumor growth with prolonged median survival partially mediated by intratumoral arginine depletion resulting in apoptosis and G1 arrest in mesothelioma xenograft models. The findings provide scientific evidence to support further clinical development of BCT-100 in treatment of MPM. [Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos Arginase/administração & dosagem Proliferação Celular/efeitos dos fármacos Neoplasias Pulmonares/tratamento farmacológico Neoplasias Pulmonares/patologia Mesotelioma/tratamento farmacológico Mesotelioma/patologia Neoplasias Pleurais/tratamento farmacológico Neoplasias Pleurais/patologia [Mh] Termos MeSH secundário: Animais Antineoplásicos/administração & dosagem Linhagem Celular Tumoral Relação Dose-Resposta a Droga Feminino Seres Humanos Camundongos Camundongos Endogâmicos BALB C Camundongos Nus Polietilenoglicóis/química Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 30IQX730WE (Polyethylene Glycols); EC 3.5.3.1 (Arginase) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE [do] DOI: 10.1186/s12931-017-0564-3

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[PMID]: 28462689 [Au] Autor: Ulger S; Cetin E; Catli S; Sarac H; Kilic D; Bora H [Ad] Endereço: 1 Department of Radiation Oncology, Faculty of Medicine, Gazi University, Ankara, Turkey. [Ti] Título: Intensity-Modulated Radiation Therapy Improves the Target Coverage Over 3-D Planning While Meeting Lung Tolerance Doses for All Patients With Malignant Pleural Mesothelioma. [So] Source: Technol Cancer Res Treat;16(3):332-338, 2017 Jun. [Is] ISSN: 1533-0338 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To investigate high conformality on target coverage and the ability on creating strict lung dose limitation of intensity-modulated radiation therapy in malignant pleural mesothelioma. PATIENTS AND METHODS: Twenty-four radiation therapy plannings were evaluated and compared with dosimetric outcomes of conformal radiation therapy and intensity-modulated radiation therapy. Hemithoracal radiation therapy was performed on 12 patients with a fraction of 1.8 Gy to a total dose of 50.4 Gy. All organs at risk were contoured. Radiotherapy plannings were differed according to the technique; conformal radiation therapy was planned with conventionally combined photon-electron fields, and intensity-modulated radiation therapy was planned with 7 to 9 radiation beam angles optimized in inverse planning. Strict dose-volume constraints were applied. RESULTS: Intensity-modulated radiation therapy was statistically superior in target coverage and dose homogeneity (intensity-modulated radiation therapy-planning target volume 95 mean 100%; 3-dimensional conformal radiation therapy-planning target volume 95 mean 71.29%, P = .0001; intensity-modulated radiation therapy-planning target volume 105 mean 11.14%; 3-dimensional conformal radiation therapy-planning target volume 105 mean 35.69%, P = .001). The dosimetric results of the remaining lung was below the limitations on intensity-modulated radiation therapy planning data (intensity-modulated radiation therapy-lung mean dose mean 7.5 [range: 5.6%-8.5%]; intensity-modulated radiation therapy-lung V5 mean 55.55% [range: 47%-59.9%]; intensity-modulated radiation therapy-lung V20 mean 4.5% [range: 0.5%-9.5%]; intensity-modulated radiation therapy-lung V13 mean 13.43% [range: 4.2%-22.9%]). CONCLUSION: With a complex and large target volume of malignant pleural mesothelioma, intensity-modulated radiation therapy has the ability to deliver efficient tumoricidal radiation dose within the safe dose limits of the remaining lung tissue. [Mh] Termos MeSH primário: Neoplasias Pulmonares/radioterapia Pulmão/efeitos da radiação Mesotelioma/radioterapia Neoplasias Pleurais/radioterapia Radioterapia de Intensidade Modulada/métodos [Mh] Termos MeSH secundário: Feminino Seres Humanos Pulmão/patologia Neoplasias Pulmonares/patologia Masculino Mesotelioma/patologia Neoplasias Pleurais/patologia Dosagem Radioterapêutica Planejamento da Radioterapia Assistida por Computador Radioterapia de Intensidade Modulada/efeitos adversos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1177/1533034616678110

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[PMID]: 29277245 [Au] Autor: Tranchant R; Montagne F; Jaurand MC; Jean D [Ad] Endereço: Inserm, UMR-1162, génomique fonctionnelle des tumeurs solides, équipe 1 « Génomique des tumeurs hépatiques et mésothéliales ¼, 75010 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Labex Immuno-oncology, 12, rue de l'école de Médecine, 75006 Paris, France; Université Paris Diderot, S [Ti] Título: [Molecular heterogeneity of malignant pleural mesotheliomas]. [Ti] Título: Hétérogénéité moléculaire des mésothéliomes pleuraux malins.. [So] Source: Bull Cancer;105(1):35-45, 2018 Jan. [Is] ISSN: 1769-6917 [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: Malignant pleural mesothelioma (MPM) is predominantly an occupational cancer, most often linked to asbestos exposure. Malignant pleural mesothelioma prognosis is poor with a short survival median, due to the aggressiveness of tumor cells and the weak efficiency of conventional anti-cancer therapies. Clinical, histological, and molecular data suggest tumor heterogeneity between patients as it was also shown for other cancer types. Consequently, there is an urgent need to develop new therapies that take into account this heterogeneity and the molecular characteristics of malignant pleural mesothelioma, in particular by identifying new anti-cancer drugs targeting the molecular specificities of each malignant pleural mesothelioma. Malignant pleural mesothelioma is characterized by numerous molecular alterations at the chromosomal, genetic and epigenetic levels. Molecular classification based on gene expression profile has firstly defined two tumor groups, C1 and C2, and more recently, four groups. By integrating genetic and transcriptomic analysis, a C2 tumor subgroup of the C2 group has been identified and characterized. In addition to tumor heterogeneity between patients, intra-tumor heterogeneity is supported by several evidences. Most therapeutic strategies that take into account the tumor molecular characteristics have focused on targeted therapies based on mutated genes. A more appropriate strategy would be to consider better-defined tumor groups on the basis of several molecular alterations types as it has been proposed for the C2 subgroup. A robust definition of homogeneous tumor groups sharing common molecular characteristics is necessary for the development of effective precision medicine for malignant pleural mesothelioma. [Mh] Termos MeSH primário: Neoplasias Pulmonares/genética Mesotelioma/genética Neoplasias Pleurais/genética [Mh] Termos MeSH secundário: Asbestos/toxicidade Carcinógenos/toxicidade Aberrações Cromossômicas Epigênese Genética Seres Humanos Neoplasias Pulmonares/classificação Neoplasias Pulmonares/etiologia Neoplasias Pulmonares/terapia Mesotelioma/classificação Mesotelioma/etiologia Mesotelioma/terapia Neoplasias Pleurais/classificação Neoplasias Pleurais/etiologia Neoplasias Pleurais/terapia Prognóstico Transcrição Genética [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Carcinogens); 1332-21-4 (Asbestos) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171227 [St] Status: MEDLINE

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[PMID]: 29374723 [Au] Autor: Robella M; Vaira M; Borsano A; Mossetti C; DE Simone M [Ad] Endereço: Unit of Surgical Oncology, Candiolo Cancer Institute, IRCCS - FPO, Candiolo, Italy manuela.robella@ircc.it. [Ti] Título: Low-dose Pressurized Intrathoracic Aerosol Chemotherapy (PITAC) as an Alternative Therapy for Pleuropulmonary Involvement in Pseudomyxoma Peritonei. [So] Source: Anticancer Res;38(2):929-932, 2018 02. [Is] ISSN: 1791-7530 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: BACKGROUND/AIM: Pseudomyxoma peritonei (PMP) is a rare disease characterized by mucinous ascites and widespread peritoneal implants. It usually originates from the rupture of an adenoma/adenocarcinoma of the appendix. Although this tumor is only superficially invasive and does not metastasize, it could be a fatal disease. Extra-abdominal spread of PMP is an unusual occurrence with few reports in medical literature. CASE REPORT: A 50-year-old man was diagnosed with PMP according to the findings of thorax and abdomen CT scan and cytologic and histological examinations. The radiological exam showed irregular thickening on the surface of left diaphragmatic and parietal pleura. RESULTS: First, cytoreductive surgery associated with hyperthermic intraperitoneal chemotherapy (HIPEC) for the abdominal disease was performed. Histopathological examination confirmed the diagnosis of low grade PMP. The radiological evaluation performed 5 months later showed a dimensional increase in pleural nodules. The treatment consisted of an extensive intrathoracic cytoreductive surgery in combination with pressurized intra-thoracic aerosol chemotherapy (PITAC). Postoperative course was uneventful. CONCLUSION: PMP with pleural extension is a rare phenomenon and carries an unfavourable prognosis. Due to the rarity of this presentation, its correct treatment is still unclear. We present a therapeutic approach to be applied in selected patients. [Mh] Termos MeSH primário: Terapias Complementares Procedimentos Cirúrgicos de Citorredução Hipertermia Induzida Neoplasias Pulmonares/terapia Neoplasias Peritoneais/terapia Neoplasias Pleurais/terapia Pseudomixoma Peritoneal/terapia [Mh] Termos MeSH secundário: Terapia Combinada Seres Humanos Neoplasias Pulmonares/patologia Masculino Meia-Idade Neoplasias Peritoneais/patologia Neoplasias Pleurais/patologia Prognóstico Pseudomixoma Peritoneal/patologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180207 [Lr] Data última revisão: 180207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180129 [St] Status: MEDLINE

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[PMID]: 29310415 [Au] Autor: Abramavicius S; Zemaitis M; Pilvinis V; Kadusevicius E [Ad] Endereço: Institute of Physiology and Pharmacology. [Ti] Título: Cisplatin-induced sudden cardiac death with hemodynamic collapse: a severe adverse drug reaction: Case report. [So] Source: Medicine (Baltimore);96(48):e8995, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Cisplatin is responsible for a significant percentage of adverse drug reactions (ADRs) in oncology setting. A great proportion of cisplatin-induced severe adverse events are difficult to foresee, and giving premedication does not always prevent the occurrence of such events. PATIENT CONCERNS: A 53-year-old woman with progressive T4 N0 M0 stage IV pleural mesothelioma experienced cardiac arrest with hemodynamic collapse after cisplatin and pemetrexed chemotherapy administration. DIAGNOSES: Progressive pleural T4 N0 M0 stage IV mesothelioma of the right lung, primary arterial hypertension, and cardiac arrest with hemodynamic collapse. INTERVENTIONS: The cisplatin and pemetrexed chemotherapy was administered intravenously for progressive pleural T4 N0 M0 stage IV mesothelioma of the right lung. During infusion of cisplatin the patient developed cardiac arrest, and cardiopulmonary resuscitation was initiated. OUTCOMES: The patient was treated in intensive care unit and recovered successfully. Further chemotherapy with cisplatin and pemetrexed was withheld due to this severe adverse reaction to cisplatin. LESSONS: Cisplatin therapy should be thoroughly monitored including electrolyte, especially magnesium levels. Absence of previous ADRs to cisplatin and premedication should not give false sense of security. [Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos Cisplatino/efeitos adversos Morte Súbita Cardíaca/etiologia [Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos Cisplatino/uso terapêutico Feminino Seres Humanos Neoplasias Pulmonares/tratamento farmacológico Mesotelioma/tratamento farmacológico Meia-Idade Pemetrexede/uso terapêutico Neoplasias Pleurais/tratamento farmacológico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 04Q9AIZ7NO (Pemetrexed); Q20Q21Q62J (Cisplatin) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180110 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008995

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MEDLINE

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[PMID]: 27771374 [Au] Autor: McGregor SM; McElherne J; Minor A; Keller-Ramey J; Dunning R; Husain AN; Vigneswaran W; Fitzpatrick C; Krausz T [Ad] Endereço: Department of Pathology, University of Chicago Medicine, Chicago, IL 60637; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53792. Electronic address: smcgregor@wisc.edu. [Ti] Título: BAP1 immunohistochemistry has limited prognostic utility as a complement of CDKN2A (p16) fluorescence in situ hybridization in malignant pleural mesothelioma. [So] Source: Hum Pathol;60:86-94, 2017 02. [Is] ISSN: 1532-8392 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BRCA-associated protein 1 (BAP1) immunohistochemistry (IHC) and CDKN2A (p16) fluorescence in situ hybridization (FISH) have shown clinical utility in confirming the diagnosis of malignant pleural mesothelioma (MPM), but the role for using these 2 markers to guide clinical management is not yet clear. Although p16 loss is predictive of poor prognosis, there is controversy as to whether BAP1 loss is predictive of a more favorable prognosis; how these results interact with one another has not been explored. We performed CDKN2A FISH on a previously published tissue microarray on which we had performed BAP1 IHC, revealing combined BAP1/p16 status for 93 MPM cases. As expected, BAP1 IHC in combination with CDKN2A FISH resulted in high sensitivity (84%) and specificity (100%) for MPM, and p16 loss was an independent predictor of poor survival (hazard ratio, 2.2553; P = .0135). There was no association between BAP1 loss and p16 loss, as 26%, 28%, 30%, and 16% of overall cases demonstrated loss of BAP1 alone, loss of p16 alone, loss of both BAP1 and p16, or neither abnormality, respectively. Although multivariate analysis demonstrated that BAP1 IHC is not an independent predictor of prognosis, when viewed in combination with homozygous CDKN2A deletion, risk stratification was evident. More specifically, patients with CDKN2A disomy and loss of BAP1 expression had improved outcomes compared with those with CDKN2A disomy and retained BAP1 expression (hazard ratio, 0.2286; P = .0017), and this finding was notably evident among epithelioid cases. We conclude that BAP1 IHC provides prognostic information within the context of CDKN2A FISH that may have clinical utility beyond diagnosis. [Mh] Termos MeSH primário: Biomarcadores Tumorais Inibidor de Quinase Dependente de Ciclina p18/genética Imuno-Histoquímica Hibridização in Situ Fluorescente Neoplasias Pulmonares/química Neoplasias Pulmonares/genética Mesotelioma/química Mesotelioma/genética Neoplasias Pleurais/química Neoplasias Pleurais/genética Proteínas Supressoras de Tumor/análise Ubiquitina Tiolesterase/análise [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Biomarcadores Tumorais/análise Biomarcadores Tumorais/genética Biópsia Feminino Predisposição Genética para Doença Seres Humanos Neoplasias Pulmonares/patologia Neoplasias Pulmonares/terapia Masculino Mesotelioma/patologia Mesotelioma/terapia Meia-Idade Análise Multivariada Fenótipo Neoplasias Pleurais/patologia Neoplasias Pleurais/terapia Valor Preditivo dos Testes Modelos de Riscos Proporcionais Reprodutibilidade dos Testes Fatores de Risco Análise Serial de Tecidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers, Tumor); 0 (CDKN2A protein, human); 0 (Cyclin-Dependent Kinase Inhibitor p18); 0 (Tumor Suppressor Proteins); EC 3.1.2.15 (BAP1 protein, human); EC 3.4.19.12 (Ubiquitin Thiolesterase) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 180114 [Lr] Data última revisão: 180114 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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