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[PMID]:29182373
[Au] Autor:Nakajo M; Jinguji M; Shinaji T; Nakajo M; Aoki M; Tani A; Sato M; Yoshiura T
[Ad] Endereço:1 Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences , Kagoshima , Japan.
[Ti] Título:Texture analysis of F-FDG PET/CT for grading thymic epithelial tumours: usefulness of combining SUV and texture parameters.
[So] Source:Br J Radiol;91(1083):20170546, 2018 Feb.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To retrospectively investigate the standardized uptake value (SUV)-related and heterogeneous texture parameters individually and in combination for differentiating between low- and high-risk Fluorone-fludeoxyglucose ( F-FDG)-avid thymic epithelial tumours (TETs) with positron emission tomography (PET)/CT. METHODS: SUV-related and 6 texture parameters (entropy, homogeneity, dissimilarity, intensity variability, size-zone variability and zone percentage) were compared between 11 low-risk and 23 high-risk TETs (metabolic tumour volume >10.0 cm and SUV ≥2.5). Diagnostic performance was evaluated by receiver operating characteristic analysis. The diagnostic value of combining SUV and texture parameters was examined by a scoring system. RESULTS: High-risk TETs were significantly higher in SUVmax (p = 0.022), entropy (p = 0.038), intensity variability (p = 0.041) and size-zone variability (p = 0.045) than low-risk TETs. Diagnostic accuracies of these 4 parameters, dissimilarity and zone percentage which also showed significance in receiver operating characteristic analysis ranged between 64.7 and 73.5% without significant differences in AUC (range; 0.71 to 0.75) (p ≥ 0.05 each). Each parameter was scored as 0 (negative for high-risk) or 1 (positive for high-risk) according to each threshold criterion, then scores were summed [0 or 1 for low-risk TETs (median; 1); ≥2 for high-risk TETs (median; 4)]. The sensitivity, specificity and accuracy of detecting high-risk TETs were 100, 81.8 and 94.1%, respectively, with an AUC of 0.99. CONCLUSION: The diagnostic performances of individual SUVmax and texture parameters were relatively low. However, combining these parameters can significantly increase diagnostic performance when differentiating between relatively large low- and high-risk F-FDG-avid TETs. Advances in knowledge: Combined use of SUVmax and texture parameters can significantly increase the diagnostic performance when differentiating between low- and high-risk TETs.
[Mh] Termos MeSH primário: Neoplasias Epiteliais e Glandulares/diagnóstico por imagem
Neoplasias Epiteliais e Glandulares/patologia
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Neoplasias do Timo/diagnóstico por imagem
Neoplasias do Timo/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Fluordesoxiglucose F18
Seres Humanos
Masculino
Meia-Idade
Gradação de Tumores
Estadiamento de Neoplasias
Compostos Radiofarmacêuticos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20170546


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[PMID]:29224277
[Au] Autor:Wang XY; Xu M; Shi LG; Ding YZ; Cheng Q; Zhao YW
[Ad] Endereço:Department of Pathology, Henan Provincial People's Hospital, Zhengzhou 470003, China.
[Ti] Título:[Clinicopathologic analysis of micronodular thymoma with lymphoid stroma].
[So] Source:Zhonghua Bing Li Xue Za Zhi;46(12):837-840, 2017 Dec 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinicopathologic features of micronodular thymoma with lymphoid stroma(MNT). Five cases of MNT diagnosed from January 2007 to December 2016 in Henan Provincial People's Hospital were collected.Hematoxylin-Eosin staining and immunohistochemistry were used to evaluate the histological and immunophenotypic characteristics in 5 MNT cases. Epstein-Barr virus (EBV) status was detected by in situ hybridization for EBV-encoded small RNA (EBER). Polymerase chain reaction was used to detect the rearrangement of immunoglobulin genes. Five cases were MNT, including 3 male and 2 female patients, mean aged 59 years (from 43 to 63 years). All patients had ananterior mediastinal mass, with no myasthenia gravis and autoimmune diseases, and underwent surgical resection.Half to ten years follow-up showed no recurrence.Grossly, the tumors were solid in 4 cases, and cystic and solid in 1 case; the border was clear. Histologically, the tumors presented as a distribution of micronodules separated by abundant lymphoid stroma with prominent germinal centers. The nodules were composed of neoplastic spindle, oval cells containing bland, oval nuclei.Immunohistochemical study showed strong positivity of the tumor cells for CKpan, CK19, CK5/6 and p63. Stains for EMA, CD117, calretinin, TTF1 were negative in the tumor cells.Scattered CD3, CD1a, and TdT positive immature T lymphocytes were noted in and around tumor nodules. Many lymphocytes in the stroma, including germinal centers, were positive for CD20.The bcl-2 was also detected in lymphocytes in the stroma, mantle and marginal zone of lymphoid follicles, and in part of tumor cells. Tumor cells and lymphocytes were negative for EBER. Immunoglobulin genes rearrangement analysis showed that B lymphocytes were polyclonal. MNT is a rare thymoma, which occurs in the elderly and has no obvious symptom. After complete resection, the prognosis is very good. The diagnosis should be based on a combination of clinicopathologic features, and other types of thymoma should be excluded.
[Mh] Termos MeSH primário: Tecido Linfoide/patologia
Timoma/patologia
Neoplasias do Timo/patologia
[Mh] Termos MeSH secundário: Adulto
Linfócitos B/patologia
Feminino
Centro Germinativo/patologia
Herpesvirus Humano 4/isolamento & purificação
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Hibridização In Situ
Masculino
Meia-Idade
Proteínas de Neoplasias/análise
Recidiva Local de Neoplasia
Prognóstico
Linfócitos T/patologia
Timoma/química
Timoma/virologia
Neoplasias do Timo/química
Neoplasias do Timo/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neoplasm Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2017.12.005


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[PMID]:29310389
[Au] Autor:Liao H; Pei W; Liu J; Wang K; Xu T; Chen X
[Ad] Endereço:Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, P. R. China.
[Ti] Título:Secondary systemic lupus erythematosus after thymoma resection misdiagnosed as medically unexplained dyspnoea: A case report.
[So] Source:Medicine (Baltimore);96(48):e8944, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Secondary systemic lupus erythematosus (SLE) is an exceedingly rare complication of thymoma resection and is difficult to diagnose because of the insidious and nonspecific clinical manifestations. A case of SLE that occurs secondary to thymoma resection is described in this report. PATIENT CONCERNS: A 43-year-old male came to our hospital with the sole symptom of dyspnea after thymoma resection initially. However, other atypical lesions of SLE occurred over time. DIAGNOSES: Antinuclear antibody spectrum test showed positive results and the diagnosis of SLE was obtained. INTERVENTIONS: Initially the patient was treated for medically unexplained dyspnea (MUD) without much improvement. Following the diagnosis, the methylprednisolone pulse therapy and therapies of immunoglobulin and cyclophosphamide were adopted for the treatment. OUTCOMES: Finally, the patient's symptoms faded rapidly and favorable prognosis has been maintained till now. LESSONS: This case highlights the importance of a serious and comprehensive analysis before we give the diagnosis of MUD. Additionally, ignorance of secondary SLE after thymoma resection should be prevented to avoid a delayed diagnosis and treatment.
[Mh] Termos MeSH primário: Dispneia/diagnóstico
Dispneia/etiologia
Lúpus Eritematoso Sistêmico/diagnóstico
Lúpus Eritematoso Sistêmico/etiologia
Timoma/cirurgia
Neoplasias do Timo/cirurgia
[Mh] Termos MeSH secundário: Adulto
Erros de Diagnóstico
Dispneia/tratamento farmacológico
Seres Humanos
Lúpus Eritematoso Sistêmico/tratamento farmacológico
Masculino
Timoma/diagnóstico por imagem
Timoma/patologia
Neoplasias do Timo/diagnóstico por imagem
Neoplasias do Timo/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008944


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[PMID]:27771373
[Au] Autor:Kiuchi S; Tomaru U; Ishizu A; Imagawa M; Kiuchi T; Iwasaki S; Suzuki A; Otsuka N; Deguchi T; Shimizu T; Marukawa K; Matsuno Y; Kasahara M
[Ad] Endereço:Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
[Ti] Título:Expression of cathepsins V and S in thymic epithelial tumors.
[So] Source:Hum Pathol;60:66-74, 2017 02.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cathepsins are a group of proteolytic enzymes of the endosomal/lysosomal pathway involved in the thymic development of T cells restricted by major histocompatibility complex class II molecules. In the normal thymus, cathepsin V (CTV) and cathepsin S (CTS) are expressed in cortical and medullary epithelial cells, respectively. To investigate whether cathepsins could serve as a diagnostic marker, we performed immunohistochemical analysis for CTV and CTS in 77 cases of thymic epithelial tumors. Almost all cases (59/60) of thymoma expressed CTV, whereas 28 of 60 cases of thymoma expressed CTS. Notably, CTS was expressed in most cases of type A and type AB thymomas, but not in type B thymoma. The expression of cathepsins in type AB thymoma showed a clear correlation with histologic features; CTV was found predominantly in the type B component, and CTS was frequently expressed in the type A component. In thymic carcinoma, CTV was expressed in less than half cases (7/17), and the ratio of CTS-positive cases was equivalent to that of thymoma (8/17). Cases of CTV-negative thymic carcinoma tended to have a higher incidence of recurrence than did CTV-positive cases. Although further studies with a larger number of cases are required to confirm the utility of cathepsin immunostaining, CTV and CTS appear to serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Catepsinas/análise
Cisteína Endopeptidases/análise
Neoplasias Epiteliais e Glandulares/enzimologia
Timoma/enzimologia
Neoplasias do Timo/enzimologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Biópsia
Diagnóstico Diferencial
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Estadiamento de Neoplasias
Neoplasias Epiteliais e Glandulares/patologia
Neoplasias Epiteliais e Glandulares/cirurgia
Valor Preditivo dos Testes
Timoma/patologia
Timoma/cirurgia
Neoplasias do Timo/patologia
Neoplasias do Timo/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 3.4.- (Cathepsins); EC 3.4.22.- (Cysteine Endopeptidases); EC 3.4.22.27 (cathepsin S); EC 3.4.22.43 (CTSL2 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180114
[Lr] Data última revisão:
180114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29245252
[Au] Autor:Gui X; Zhu X; Guo L; Tan G; Liu Y; Tan Y; Chen Q; Song Y; Lin S
[Ad] Endereço:aDepartment of Oncology, The First Affiliated Hospital of Jinan UniversitybDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan UniversitycDepartment of Central Laboratory, The First Affiliated Hospital of Jinan UniversitydDepartment of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
[Ti] Título:Graft-versus-host disease-like erythroderma: a sign of recurrent thymoma: A case report.
[So] Source:Medicine (Baltimore);96(49):e8877, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Thymomas are associated with numerous autoimmune disorders, such as myasthenia gravis (MG), pure red cell aplasia (PRCA), and systemic lupus erythematosus (SLE). However, graft-versus-host disease (GVHD)-like erythroderma is a relatively uncommon paraneoplastic disorder associated with thymomas and signifies a poor prognosis. PATIENT CONCERNS: A 35-year-old woman with medical history significant for stage IVa type AB thymoma presented with patchy erythema over face, trunk, and extremities that failed to respond to topical steroids. DIAGNOSIS: A contrast-enhanced computerized tomography (CECT) scan of the chest demonstrated tumors in the right mediastinum and right pleura. Percutaneous right mediastinal pleural biopsy confirmed recurrent thymoma (WHO type B3, Masaoka stage IVb). Histopathologic examination of her skin lesions revealed GVHD-like erythroderma. INTERVENTIONS: The patient received chemotherapy and local thoracic radiotherapy, as well as corticosteroids. OUTCOMES: The eruptions gradually subsided with hyperpigmentation; however the patient eventually died of multiple organ failure. LESSONS: GVHD-like erythroderma is an uncommon paraneoplastic disorder associated with thymomas. Though its pathogenesis still needs further research, prompt diagnosis and appropriate treatment can improve survival rate in patients.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/patologia
Doença Enxerto-Hospedeiro/patologia
Recidiva Local de Neoplasia/diagnóstico por imagem
Recidiva Local de Neoplasia/patologia
Timoma/diagnóstico por imagem
Timoma/patologia
Neoplasias do Timo/diagnóstico por imagem
Neoplasias do Timo/patologia
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Meios de Contraste
Diagnóstico Diferencial
Evolução Fatal
Feminino
Seres Humanos
Estadiamento de Neoplasias
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008877


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[PMID]:28448415
[Au] Autor:Kan X; Wang P; Gong Z; Gao F; Zhang Y; Ge Y
[Ad] Endereço:From the Departments of *Radiology and †Pathology, Zhengzhou University People's Hospital, Zhengzhou, China.
[Ti] Título:Investigation on Computed Tomography Features of Primary Thymic Atypical Carcinoid Tumors.
[So] Source:J Comput Assist Tomogr;41(6):990-994, 2017 Nov/Dec.
[Is] ISSN:1532-3145
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The thymic atypical carcinoid tumors (aTCs) are rare. The computed tomography (CT) features of aTC were poorly studied, and researches under this topic with large samples are in a small quantity in the literature. Our aim was to investigate the CT features of aTC. METHODS: Eleven cases of aTC (7 men and 4 women; mean age, 56 ± 16 years) proved by pathology were retrospectively analyzed. All the patients underwent contrast-enhanced CT scans with dual phase (25-30 and 60-70 seconds) after contrast agent injection. Two experienced radiologists analyzed the imaging findings. The observing indexes of CT features were based on standard CT reporting terms of mediastinal masses suspicious for thymic malignancy, particularly on the findings of marginal cystic/necrotic component (MCC) sign and hypervascular sign in tumors. RESULTS: All the tumors were located in the anterior and/or middle mediastinum and heterogeneous parenchyma, with moderate to marked enhancement, and had multiple cystic/necrotic components. The maximum diameter of lesions ranged from 5 to 24 cm. Among the 11 patients involved in this study, 6 patients had distant metastases, all of which were identified as skeletal metastases; 9 cases showed MCC sign only at the margin (3 cases) or at both marginal and central margins (6 cases), and 5 cases showed hypervascular sign. CONCLUSIONS: Our results suggested that the MCC and hypervascular signs should be included as characterization in addition to the standard features for the diagnosis of aTC.
[Mh] Termos MeSH primário: Tumor Carcinoide/diagnóstico por imagem
Neoplasias do Timo/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1097/RCT.0000000000000615


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[PMID]:29068978
[Au] Autor:Ma K; Liu Y; Xue Z; Chu X
[Ad] Endereço:aDepartment of Thoracic Surgery, The Chinese People's Liberation Army General Hospital bDepartment of Thoracic Surgery, Beijing Chao-Yang Hospital, Beijing, China.
[Ti] Título:Treatment, prognostic markers, and survival in thymic neuroendocrine tumors: A single center experience of 41 patients.
[So] Source:Medicine (Baltimore);96(43):e7842, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuroendocrine tumors of the thymus (NETTs) are rare but aggressive, and lead to poor overall survival. This retrospective study was designed to analyze factors that correlate with the prognosis of patients with NETTs.From 1999 to 2015, 41 ongoing patients with NETTs were enrolled in this study. The clinical data and outcome were compiled. Overall survival (OS) rate was analyzed using the Kaplan-Meier method in univariate analysis and the Cox-model was used in multivariate analysis.Of the 41 NETTs patients analyzed (31 male and 10 female), 12 were typical carcinoma, 14 were atypical carcinoma, 14 were small-cell carcinoma and, 1 was large-cell carcinoma. The median follow-up time was 29 months (range, 9.0-69.0). In total, 25 patients died of cancer-related disease by the last follow-up. The 3- and 5-year survival rates for all patients were 42.7% and 23.4%, respectively. Among the prognostic factors analyzed by multivariate analysis, low tumor grade, complete resection, and a negative chromogranin A (CgA) expression were positively correlated with survival.The surgical treatment of NETTs, CgA negative, and low grade of NETTs were associated with a statistically significant better prognosis. However, large, multicenter studies are required to fully validate these prognostic factors.
[Mh] Termos MeSH primário: Tumores Neuroendócrinos/patologia
Tumores Neuroendócrinos/cirurgia
Neoplasias do Timo/patologia
Neoplasias do Timo/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Cromogranina A/análise
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Gradação de Tumores
Estadiamento de Neoplasias
Tumores Neuroendócrinos/mortalidade
Estudos Retrospectivos
Análise de Sobrevida
Neoplasias do Timo/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Chromogranin A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007842


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[PMID]:28982856
[Au] Autor:Tarrini G; Ciabatti E; Pacini S; Galimberti S; Petrini I
[Ad] Endereço:Section of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
[Ti] Título: Mutations Are Common in Thymic Epithelial Tumors But Not in Hematological Malignancies.
[So] Source:Anticancer Res;37(10):5459-5462, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mutation of general transcription factor IIi (GTF2I) (chromosome 7 c.74146970T>A) is common in thymic epithelial tumors and is a candidate driver aberration for cancer growth. To our knowledge, this mutation has not been described in other diseases. We evaluated the presence of GTF2I mutation in hematological malignancies. MATERIALS AND METHODS: We sequenced samples from 31 patients with acute leukemia, 29 with chronic leukemia and 12 with myelodysplastic syndrome. The genomic fragment of exon 15 containing the hotspot of mutation was amplified using polymerase chain reaction (PCR) and sequenced. RESULTS: We did not identify any GTF2I mutation in patients with hematological malignancies. CONCLUSION: Even though our sample size was limited, our data and reports from the literature suggest that GTF2I mutation is not present or is uncommon in these diseases.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Leucemia/genética
Mutação
Síndromes Mielodisplásicas/genética
Neoplasias Epiteliais e Glandulares/genética
Neoplasias do Timo/genética
Fatores de Transcrição TFII/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Análise Mutacional de DNA
Predisposição Genética para Doença
Seres Humanos
Leucemia/patologia
Leucemia Linfoide/genética
Leucemia Linfoide/patologia
Leucemia Mielogênica Crônica BCR-ABL Positiva/genética
Leucemia Mielogênica Crônica BCR-ABL Positiva/patologia
Leucemia Mieloide Aguda/genética
Leucemia Mieloide Aguda/patologia
Meia-Idade
Síndromes Mielodisplásicas/patologia
Neoplasias Epiteliais e Glandulares/patologia
Fenótipo
Leucemia-Linfoma Linfoblástico de Células Precursoras/genética
Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia
Neoplasias do Timo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (GTF2I protein, human); 0 (Transcription Factors, TFII)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28969896
[Au] Autor:Zhai Y; Hui Z; Ji W; Wang X; Liang J; Mao Y; Luo Y; Zou S; Lv J; Zhou Z; Chen D; Zhang H; Xiao Z; Wang L; Feng Q
[Ad] Endereço:Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
[Ti] Título:A Single-Center Analysis of the Treatment and Prognosis of Patients With Thymic Carcinoma.
[So] Source:Ann Thorac Surg;104(5):1718-1724, 2017 Nov.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The low incidence of thymic carcinoma has precluded the development of randomized clinical trials, and present knowledge is based on small retrospective studies. We performed this single-center retrospective analysis to evaluate the clinical characteristics, treatments, and prognosis in patients with pathologically confirmed thymic carcinoma. METHODS: Data regarding clinicopathologic characteristics, treatment protocols, toxicities, and survival were collected from 135 patients who attended our institution between January 1980 and January 2010. Survival was assessed using the Kaplan-Meier method. Univariate and multivariate analyses were performed using the log-rank test and Cox proportional hazards model. RESULTS: The 135 patients (88 men) were with a median age of 48 years, and 123 patients were diagnosed with Masaoka stage III to IV disease. R0 resection was performed in 35 patients. Treatment comprised radiotherapy in 121 patients and chemotherapy in 60. The median follow-up time was 12.5 years. At 5 and 10 years, local-regional relapse free survivals were 81.4% and 54.4%, overall survivals were 42.2% and 15.4%, progression-free survivals were 29.7% and 8.0%, and distant metastasis-free survivals were 35.9% and 25.6%, respectively. R0 resection was the only independent prognosticator of overall survival, progression-free survival, and distant metastasis-free survival in univariate and multivariate analyses. CONCLUSIONS: Thymic carcinoma was frequently diagnosed at Masaoka stage III to IV with a poor prognosis. Surgical resection is still the predominant treatment. Radiotherapy may increase local-regional relapse free survival with mild toxicities in advanced-stage patients.
[Mh] Termos MeSH primário: Timectomia/métodos
Timoma/mortalidade
Timoma/cirurgia
Neoplasias do Timo/mortalidade
Neoplasias do Timo/cirurgia
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Adulto
Idoso
China
Bases de Dados Factuais
Intervalo Livre de Doença
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Análise Multivariada
Invasividade Neoplásica/patologia
Estadiamento de Neoplasias
Prognóstico
Modelos de Riscos Proporcionais
Estudos Retrospectivos
Medição de Risco
Análise de Sobrevida
Timectomia/efeitos adversos
Timoma/patologia
Neoplasias do Timo/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:28968686
[Au] Autor:Saito M; Fujiwara Y; Asao T; Honda T; Shimada Y; Kanai Y; Tsuta K; Kono K; Watanabe S; Ohe Y; Kohno T
[Ad] Endereço:Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
[Ti] Título:The genomic and epigenomic landscape in thymic carcinoma.
[So] Source:Carcinogenesis;38(11):1084-1091, 2017 Oct 26.
[Is] ISSN:1460-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thymic carcinoma (TC) is a rare cancer whose genomic features have been examined in only a limited number of patients of European descent. Here, we characterized both genomic and epigenomic aberrations by whole exome sequencing, RNA sequencing, methylation array and copy number analyses in TCs from Asian patients and compared them with those in TCs from USA/European patients. Samples analyzed were 10 pairs of snap-frozen surgical specimens of cancerous and non-cancerous thymic tissue. All 10 cases were Japanese patients treated at the National Cancer Center Hospital, Japan, between 1994 and 2010. Mutational signature analysis indicated that the accumulation of age-related mutations drive TC development. We identified recurrent somatic mutations in TET2, CYLD, SETD2, TP53, FBXW7, HRAS and RB1, and no mutations in GTF2I, supporting the hypothesis that TC and thymoma are distinguishable by their genetic profiles. TCs with TET2 mutations had more hypermethylated genes than those without, and hyper-methylation was associated with downregulation of gene expression. Focal genome copy number gains, associated with elevated gene expression, were observed at the KIT (which is known to drive thymic carcinogenesis) and AHNAK2 gene loci. Taken together, the results suggest that the molecular processes leading to TC depend on the accumulation of genetic and epigenetic aberrations. In addition, epigenetic dysregulation as a result of the TET2 mutation was observed in a subset of TCs.
[Mh] Termos MeSH primário: Epigênese Genética/genética
Genoma/genética
Timoma/genética
Neoplasias do Timo/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Grupo com Ancestrais do Continente Asiático/genética
Variações do Número de Cópias de DNA/genética
Análise Mutacional de DNA/métodos
Epigenômica/métodos
Exoma/genética
Feminino
Expressão Gênica/genética
Genômica/métodos
Seres Humanos
Masculino
Meia-Idade
Mutação/genética
Transcriptoma/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1093/carcin/bgx094



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