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[PMID]:27779297
[Au] Autor:Han KH; Kim MA; Park NH
[Ad] Endereço:Department of Obstetrics and Gynecology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea.
[Ti] Título:Expression of aurora kinases: Predictor of tumor dissemination in uterine carcinosarcoma.
[So] Source:Histol Histopathol;32(7):717-724, 2017 Jul.
[Is] ISSN:1699-5848
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:Uterine carcinosarcoma is a rare, aggressive, and biphasic tumor. It comprises carcinomatous and sarcomatous components, and mitosis-associated factors are thought to discriminate these two lesions. Aurora kinases are mitotic enzymes that are highly expressed in uterine malignancies. To identify the clinical significance of aurora kinase expression, we performed immunohistochemistry on tissue microarrays using cores selected from areas with typical carcinomatous and sarcomatous characteristics. A total of 24 samples were included, from patients at Seoul National University Hospital diagnosed with uterine carcinosarcoma, and who undergone a staging operation between 1997 and 2012. Patients' clinical and pathological data were analyzed, and expression patterns of aurora kinases were investigated. Aurora kinases A and B were dominantly expressed in the cytoplasm, and phospho-aurora kinases A and B were expressed in the nuclei. Phospho-aurora kinase A and aurora kinase B showed significantly higher expression in the carcinomatous component (P=0.012 and 0.008). High expression of phospho-aurora kinase A was associated with lymphatic metastasis such as positive pelvic lymph node and omental involvement (P=0.012 and 0.037). Overexpression of aurora kinase B was related to vascular invasion (P=0.011). High expression of both phospho-aurora kinase A and aurora kinase B was a prognostic factor for progression-free survival in uterine carcinosarcoma (P=0.049). In conclusion, expression of aurora kinases is associated with bidirectional tumor dissemination into the lymphatic and hematogenous pathways. In addition, high expression of phospho-aurora kinase A and aurora kinase B is a predictor of progression-free survival. Therefore, inhibitors of aurora kinases might be a prospective therapeutic options for uterine carcinosarcoma.
[Mh] Termos MeSH primário: Aurora Quinases/biossíntese
Carcinossarcoma/enzimologia
Carcinossarcoma/patologia
Neoplasias Uterinas/enzimologia
Neoplasias Uterinas/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Aurora Quinase A/metabolismo
Aurora Quinase B/metabolismo
Aurora Quinases/genética
Biomarcadores Tumorais
Intervalo Livre de Doença
Feminino
Regulação Enzimológica da Expressão Gênica/genética
Regulação Neoplásica da Expressão Gênica/genética
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Menopausa
Meia-Idade
Metástase Neoplásica/patologia
Estadiamento de Neoplasias
Valor Preditivo dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 2.7.11.1 (AURKA protein, human); EC 2.7.11.1 (AURKB protein, human); EC 2.7.11.1 (Aurora Kinase A); EC 2.7.11.1 (Aurora Kinase B); EC 2.7.11.1 (Aurora Kinases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.14670/HH-11-834


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[PMID]:29403338
[Au] Autor:Rasool N; Lefebvre DR; Latina MA; Dunn IF; Santagata S; Freitag SK; Cestari DM
[Ad] Endereço:Edward Harkness Eye Institute, Columbia University, New York.
[Ti] Título:Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor.
[So] Source:Digit J Ophthalmol;23(4):22-26, 2017.
[Is] ISSN:1542-8958
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leiomyosarcomas, neoplasms of smooth muscle, are rarely found within the orbit. Orbital leiomyosarcoma may be primary, metastatic, or secondary to radiation. When they are metastatic, patients almost exclusively have a history of a primary leiomyosarcoma, often occurring in the spermatic cord, skin, gastrointestinal tract, or the uterus. We present the case of 48-year-old woman who presented with a metastatic orbital leiomyosarcoma, which was identified before the primary tumor.
[Mh] Termos MeSH primário: Leiomiossarcoma/secundário
Neoplasias Orbitárias/patologia
Neoplasias Uterinas/secundário
[Mh] Termos MeSH secundário: Biópsia
Diagnóstico Diferencial
Feminino
Seres Humanos
Leiomiossarcoma/diagnóstico
Imagem por Ressonância Magnética
Meia-Idade
Metástase Neoplásica
Tomografia por Emissão de Pósitrons
Neoplasias Uterinas/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.5693/djo.02.2017.02.004


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[PMID]:29236373
[Au] Autor:Couillard K
[Ti] Título:Fibromes utérins. L'ulipristal approuvé pour une utilisation prolongée..
[So] Source:Perspect Infirm;14(2):57, 2017 Mar-Apr.
[Is] ISSN:1708-1890
[Cp] País de publicação:Canada
[La] Idioma:fre
[Mh] Termos MeSH primário: Leiomioma/tratamento farmacológico
Norpregnadienos/uso terapêutico
Neoplasias Uterinas/tratamento farmacológico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Norpregnadienos/administração & dosagem
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Norpregnadienes); YF7V70N02B (ulipristal acetate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:29202956
[Au] Autor:Bray MJ; Edwards TL; Wellons MF; Jones SH; Hartmann KE; Velez Edwards DR
[Ad] Endereço:Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee.
[Ti] Título:Admixture mapping of uterine fibroid size and number in African American women.
[So] Source:Fertil Steril;108(6):1034-1042.e26, 2017 Dec.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the relationship between genetic ancestry and uterine fibroid characteristics. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 609 African American participants with image- or surgery-confirmed fibroids in a biorepository at Vanderbilt University electronic health record biorepository and the Coronary Artery Risk Development in Young Adults studies were included. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Outcome measures include fibroid number (single vs. multiple), volume of largest fibroid, and largest fibroid dimension of all fibroid measurements. RESULT(S): Global ancestry meta-analyses revealed a significant inverse association between percentage of European ancestry and risk of multiple fibroids (odds ratio: 0.78; 95% confidence interval 0.66, 0.93; P=6.05 × 10 ). Local ancestry meta-analyses revealed five suggestive (P<4.80 × 10 ) admixture mapping peaks in 2q14.3-2q21.1, 3p14.2-3p14.1, 7q32.2-7q33, 10q21.1, 14q24.2-14q24.3, for number of fibroids and one suggestive admixture mapping peak (P<1.97 × 10 ) in 10q24.1-10q24.32 for volume of largest fibroid. Single variant association meta-analyses of the strongest associated region from admixture mapping of fibroid number (10q21.1) revealed a strong association at single nucleotide polymorphism variant rs12219990 (odds ratio: 0.41; 95% confidence interval 0.28, 0.60; P=3.82 × 10 ) that was significant after correction for multiple testing. CONCLUSION(S): Increasing African ancestry is associated with multiple fibroids but not with fibroid size. Local ancestry analyses identified several novel genomic regions not previously associated with fibroid number and increasing volume. Future studies are needed to explore the genetic impact that ancestry plays into the development of fibroid characteristics.
[Mh] Termos MeSH primário: Afroamericanos/genética
Biomarcadores Tumorais/genética
Leiomioma/genética
Leiomioma/patologia
Leiomiomatose/genética
Leiomiomatose/patologia
Carga Tumoral/genética
Neoplasias Uterinas/genética
Neoplasias Uterinas/patologia
[Mh] Termos MeSH secundário: Adulto
Bancos de Espécimes Biológicos
Estudos Transversais
Bases de Dados Factuais
Registros Eletrônicos de Saúde
Feminino
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Hereditariedade
Seres Humanos
Leiomioma/etnologia
Leiomiomatose/etnologia
Modelos Lineares
Modelos Logísticos
Meia-Idade
Razão de Chances
Fenótipo
Polimorfismo de Nucleotídeo Único
Fatores de Risco
Estados Unidos/epidemiologia
Neoplasias Uterinas/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:28465008
[Au] Autor:Holman LL; Pal N; Iglesias DA; Soliman PT; Balakrishnan N; Klopp A; Broaddus RR; Fleming ND; Munsell MF; Lu KH; Westin SN
[Ad] Endereço:Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
[Ti] Título:Factors prognostic of survival in advanced-stage uterine serous carcinoma.
[So] Source:Gynecol Oncol;146(1):27-33, 2017 07.
[Is] ISSN:1095-6859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The study objective was to analyze the impact of prognostic factors, including treatment modality, on outcome in patients with advanced-stage uterine serous carcinoma (USC). METHODS: A retrospective review of patients diagnosed with stage III or IV USC between 1993 and 2012 was performed. Summary statistics were used to describe demographic and clinical characteristics. Overall survival (OS) and recurrence free survival (RFS) were estimated by Kaplan-Meier analysis. Cox proportional hazards regression was used to model the association of potential prognostic factors with OS and RFS. RESULTS: The study included 260 patients with median follow-up of 26.6months (range 1-172.8). Median age was 63years (range 30-88) and 52.3% had stage III disease. In all, 60% were treated with surgery followed by chemotherapy, 18.1% received surgery, chemotherapy, and radiotherapy, 11.5% had surgery and radiotherapy, and 10.4% had neoadjuvant chemotherapy. The overall complete response rate was 68.9%, and the cumulative incidence of recurrence was 82.7%. Treatment that included surgery, chemotherapy, and radiation and stage III disease were associated with improved RFS on multivariate analysis. For OS, therapy with surgery, chemotherapy, and radiation, mixed histology, and stage III disease were associated with better OS on multivariate analysis. CONCLUSIONS: Patients with advanced-stage USC have a poor prognosis, regardless of clinical factors or treatment received. However, combination therapy that includes chemotherapy and radiation appears to be associated with improved survival in these women.
[Mh] Termos MeSH primário: Cistadenocarcinoma Seroso/diagnóstico
Neoplasias Uterinas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Terapia Combinada
Cistadenocarcinoma Seroso/patologia
Cistadenocarcinoma Seroso/terapia
Feminino
Seres Humanos
Meia-Idade
Análise Multivariada
Estadiamento de Neoplasias
Prognóstico
Estudos Retrospectivos
Análise de Sobrevida
Neoplasias Uterinas/patologia
Neoplasias Uterinas/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:29480840
[Au] Autor:De Nola R; Di Naro E; Schonauer LM; Lucarelli G; Battaglia M; Fiore MG; Mastrolia SA; Loverro G
[Ad] Endereço:Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic.
[Ti] Título:Clinical management of a unique case of PNET of the uterus during pregnancy, and review of the literature.
[So] Source:Medicine (Baltimore);97(2):e9505, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. PATIENT CONCERNS: In this case report, we describe the obstetric and oncological outcome of a huge mass diagnosed as a leiomyoma in a 39-year-old pregnant woman who complained of low back pain, dysuria, and urinary frequency at 22 weeks of gestation. DIAGNOSES: During the 25th week of pregnancy, the patient was referred to our hospital at night with severe anemia and suspected hemoperitoneum. She underwent an emergency caesarean section, delivering a female fetus weighing 400 g, with an Apgar score of 7 at 1 minute and 9 at 5 minutes. INTERVENTION: During surgery, we found a huge uterine sarcoma-like metastatic tumor, invading the pelvic peritoneum and parametria bilaterally; the adnexae seemed disease-free. We performed a type B radical hysterectomy, bilateral salpingo-oophorectomy, pelvic peritonectomy, omentectomy, appendectomy, and excision of a bulky lymph node. Seven days after delivery, staging computed tomography (CT) scan demonstrated a large lombo-aortic lymph node compressing the left renal vein and we completed debulking with a second surgery, including diaphragmatic peritonectomy and excision of a huge lymph node by lombo-aortic lymphadenectomy, requiring partial reconstruction of an infiltrated renal vein. OUTCOME: Ten days after the second surgery, echo-color Doppler showed a regular microcirculation in the left kidney. The patient was discharged after 10 days, and the baby after 1 month, both in good health.Histological examination revealed a uterine body cPNET (central primitive neuroectodermal tumor) orienting the clinical management toward chemotherapy with cisplatin and etoposide. LESSONS: PNETs are aggressive neoplasms, usually diagnosed at an advanced stage. Due to their low incidence, universally accepted guidelines are still unavailable. Radical surgery leaving no macroscopic residual disease is mandatory in advanced stages. A good fertility-sparing procedure can be performed only in young women at early stages of disease, when the wish for childbearing is not yet fulfilled.
[Mh] Termos MeSH primário: Tumores Neuroectodérmicos Primitivos/cirurgia
Complicações Neoplásicas na Gravidez/cirurgia
Neoplasias Uterinas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Cesárea
Serviços Médicos de Emergência
Feminino
Seres Humanos
Recém-Nascido
Tumores Neuroectodérmicos Primitivos/diagnóstico por imagem
Tumores Neuroectodérmicos Primitivos/tratamento farmacológico
Tumores Neuroectodérmicos Primitivos/patologia
Gravidez
Complicações Neoplásicas na Gravidez/diagnóstico por imagem
Complicações Neoplásicas na Gravidez/tratamento farmacológico
Complicações Neoplásicas na Gravidez/patologia
Neoplasias Uterinas/diagnóstico por imagem
Neoplasias Uterinas/tratamento farmacológico
Neoplasias Uterinas/patologia
Útero/diagnóstico por imagem
Útero/patologia
Útero/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009505


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[PMID]:29424980
[Au] Autor:Alcalá-Alcalde MM; Pantoja-Garrido M; Frías-Sánchez Z
[Ti] Título:[Primary intestinal parasitic fibroid, an incidental finding during gynecological laparoscopic surgery].
[Ti] Título:Mioma parasitario intestinal primario como hallazgo durante la cirugía laparoscópica ginecológica..
[So] Source:Ginecol Obstet Mex;84(9):593-600, 2016 Sep.
[Is] ISSN:0300-9041
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Ab] Resumo:Background: Uterine fibroids are the most frequent solid pelvic benign tumors in women. Their most common location is the uterine corpus, cervix and broad ligament but they can also be found in other areas, less commonly as extragenital locations and/or in a parasitic way. Clinical case: A 40 years old patient, who consulted for menorrhagia and dysmenorrhea on long evolution. On physical examination, the enlarged uterus, inflamated, hard consistency and normal mobility was identified. The sonographic features and location suggested a fibroid nodule type II (Wamsteker classification), which deformed the endometrial cavity. It was decided to perform the surgery and during the procedure the enlarged uterus, deformed at the expense of a localized fundal formation, like a intramural fibroid. By mobilizing the intestinal loops and change the position of the patient (Trendelenburg) a solid tumor, cranially separated from the internal genitals it was observed. In reviewing the insertion site, it was visualized that remained attached to antimesial of the jejunum. Total hysterectomy was performed with monopolar and bipolar energy, and vascular sealant. The postoperative was favorable, without complication. The pathological study reported a primary leiomyoma of the small intestine, while in the uterus of multiple myomas was confirmed. Conclusión: The parasitic fibroids are those located separately from the uterus that receive vascular irrigation from another organ or abdominopelvic structure. They are a very rare pathology. The diagnosis has made as an accidental event, during an abdominal surgery or during the differential diagnosis of a abdominopelvic tumor. The therapeutical choice depends on the clinical presentation, the location of the fibroid and the reproductive desires of the patient, most commonly recomending their surgycal removal.
[Mh] Termos MeSH primário: Enteropatias Parasitárias/diagnóstico
Laparoscopia/métodos
Leiomioma/diagnóstico
Neoplasias Uterinas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Feminino
Procedimentos Cirúrgicos em Ginecologia/métodos
Seres Humanos
Achados Incidentais
Enteropatias Parasitárias/parasitologia
Leiomioma/parasitologia
Neoplasias Uterinas/parasitologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:29390412
[Au] Autor:Liang Y; Ren Y; Wan Z; Guo L; Dong J; Chen Y; Lv L
[Ad] Endereço:Gynaecology and Obstetrics, Huzhou Maternity and Child Care Hospital, Huzhou, Zhejiang, China.
[Ti] Título:Clinical evaluation of improved MyoSure hysteroscopic tissue removal system for the resection of type II submucosal myomas.
[So] Source:Medicine (Baltimore);96(50):e9363, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aims to determine whether clinical evaluation of improved MyoSure hysteroscopic tissue removal system can remove type II submucosal myomas with safety and high success rate of the first operation.Fifty-three patients with type II submucosal myomas hospitalized in the Huzhou Maternity and Child Care Hospital were enrolled in this study. The submucosal myomas were with the diameter of >2 cm and ≤5 cm. All patients have surgical indications.Fifty-one of 53 hysteromyomas were successfully resected through 1-time operation. The average time was 37.92 ±â€Š18.57 minutes, average amount of bleeding: 24.80 ±â€Š12.12 mL, average length of stay: 2.02 ±â€Š0.14 days. One patient had a transient postoperative fever and one patient had slight fluid overload with hyponatremia.The success rate of the first operation for resecting type II submucosal myomas showed an increase using improved MyoSure hysteroscopic tissue removal system, which can be a new, safer, and more efficient operation for treating type II submucosal myomas.
[Mh] Termos MeSH primário: Histeroscopia/instrumentação
Leiomioma/cirurgia
Miomectomia Uterina/instrumentação
Neoplasias Uterinas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009363


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[PMID]:28744668
[Au] Autor:Sano A; Yotsumoto T
[Ad] Endereço:Department of Thoracic Surgery, Chigasaki Municipal Hospital, Honson 5-15-1, Chigasaki, Kanagawa, 253-0042, Japan. sanoa-tky@umin.ac.jp.
[Ti] Título:Single-port thoracoscopic lung wedge resection using the Endo GIA Radial Reload.
[So] Source:Surg Today;48(2):248-251, 2018 Feb.
[Is] ISSN:1436-2813
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The GIA Radial Reload is a surgical stapler with a curved cut line that is perpendicular to the direction of instrument insertion. We used the GIA Radial Reload in three cases of single-port thoracoscopic lung wedge resection. The operations were performed through a 3.0-4.5-cm incision. For the first stapler, we selected the GIA Radial Reload. The orientation of this device's cut line enabled us to easily cut the lung behind the lesion during single-port thoracoscopic surgery.
[Mh] Termos MeSH primário: Pneumonectomia/instrumentação
Grampeadores Cirúrgicos
Toracoscopia/instrumentação
[Mh] Termos MeSH secundário: Idoso
Fístula Arteriovenosa/cirurgia
Feminino
Seres Humanos
Leiomiossarcoma/secundário
Leiomiossarcoma/cirurgia
Neoplasias Pulmonares/secundário
Neoplasias Pulmonares/cirurgia
Meia-Idade
Pneumonectomia/métodos
Artéria Pulmonar/anormalidades
Veias Pulmonares/anormalidades
Toracoscopia/métodos
Neoplasias Uterinas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1007/s00595-017-1572-0


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[PMID]:29465578
[Au] Autor:Wu CJ; Hwa HL; Chang WC; Hsu HC; Wu MZ; Sheu BC
[Ad] Endereço:Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, Taipei.
[Ti] Título:Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman.
[So] Source:Medicine (Baltimore);97(8):e9899, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Rare uterine choriocarcinoma can be differentiated gestational from nongestational choriocarcinoma by using short tandem repeats (STRs). PATIENT CONCERNS: A 56-year-old Taiwanese woman underwent staging surgery because of suspicion of high-grade endometrial cancer. The pathology-confirmed uterine tumor with syncytiotrophoblasts and decidual change of the endometrium was harvested. DIAGNOSIS: Uterine nongestational choriocarcinoma. INTERVENTIONS: The tumor specimen, the patient's blood, and her husband's blood were drawn for STRs analysis using polymerase chain reaction amplification kit. The genotype of the tumor cells was solely maternal and made the diagnosis of uterine nongestational choriocarcinoma. OUTCOME: Adjuvant chemotherapy with etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine regimen achieved good response in the patient. The patient is now recurrence-free for 12 months. LESSONS: STRs aid precise classification of rare choriocarcinoma. We encourage using the method to analyze suspicious choriocarcinoma.
[Mh] Termos MeSH primário: Coriocarcinoma não Gestacional/genética
Coriocarcinoma não Gestacional/patologia
Repetições de Microssatélites
Estadiamento de Neoplasias/métodos
Neoplasias Uterinas/genética
Neoplasias Uterinas/patologia
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Quimioterapia Adjuvante
Coriocarcinoma não Gestacional/tratamento farmacológico
Coriocarcinoma não Gestacional/cirurgia
Feminino
Seres Humanos
Meia-Idade
Pós-Menopausa
Neoplasias Uterinas/tratamento farmacológico
Neoplasias Uterinas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009899



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