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  1 / 61942 MEDLINE  
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[PMID]:29505548
[Au] Autor:Xu M; Zhou F; Huang L
[Ad] Endereço:Department of Pathology.
[Ti] Título:Concomitant endometrial and cervical adenocarcinoma: A case report and literature review.
[So] Source:Medicine (Baltimore);97(1):e9596, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Concomitant malignancy of the endometrium and cervix is extremely rare. PATIENT CONCERNS: A 56-year-old female presented to the Women's Hospital, School of Medicine, Zhejiang University, complaining of irregular vaginal bleeding. The human papillomavirus test (type 18/45) was positive. We performed dilation and curettage; pathology revealed moderately differentiated endometrial carcinoma exhibiting squamous differentiation. The epithelium of the cervical uterus was atypical upon biopsy. DIAGNOSES: Histological and immunochemical tests confirmed a diagnosis of endometrial carcinoma concomitant with cervical adenocarcinoma. INTERVENTIONS: She underwent laparoscopic staging surgery. OUTCOMES: The patient fully recovered with only surgery. LESSONS: Endometrial carcinoma concomitant with cervical adenocarcinoma is very rare. It is imperative to schedule adequate examination, and to perform careful preoperative diagnosis and appropriate treatment to minimize relapse.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Neoplasias do Endométrio/patologia
Neoplasias Primárias Múltiplas/patologia
Neoplasias do Colo do Útero/patologia
Útero/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009596


  2 / 61942 MEDLINE  
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[PMID]:29505536
[Au] Autor:Founta C; Papagiannakis E; Ratnavelu N; Feusi A; Natsis S; Bradbury M; Fisher A; Naik R
[Ad] Endereço:Northern Gynaecological Oncology Centre, Queen Elizabeth Hospital Gateshead, Gateshead.
[Ti] Título:Diagnostic accuracy of colposcopy with dynamic spectral imaging for cytology-negative/high-risk HPV positive (failed test of cure) after large loop excision of the transformation zone (LLETZ) of the cervix: Results of the DySIS colposcopy 1 study.
[So] Source:Medicine (Baltimore);97(1):e9560, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to colposcopy. This pilot study assessed the incidence of residual/recurrent CIN and the diagnostic accuracy of colposcopy with dynamic spectral imaging (DSI) mapping in their detection.This was a prospective service evaluation carried out in a UK National Health Service (NHS) colposcopy clinic. All women, referred with negative cytology/HR-HPV positive result following treatment for CIN from March 2013 until November 2014, who were examined with the DSI digital colposcope were included. We excluded 3 cases because of poor-quality imaging from user errors. Everyday clinical practice was followed. Initial colposcopic impression, DSI map indication, and biopsy site selections were recorded. CIN2+ was considered the primary outcome and CIN of any grade a secondary outcome.A total of 105 women were included of which 5 (4.8%) had CIN2+ histology and 24 (22.9%) had CIN1. Pre-DSI map colposcopy suggested normal/low grade in all 5 of the CIN2+ cases and DSI suggested high-grade (HG) CIN in 4 of the 5 cases. Sensitivity of standard colposcopy for CIN2+ was 0%, improving to 80% with the incorporation of the DSI map.The CIN burden in this population is higher than previously expected. Colposcopic identification of HG CIN appears to improve significantly with DSI in this cohort leading to refinement in patient management. A larger, multicentric prospective study (DySIS colposcopy 2) is planned to confirm these initial findings.
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical/diagnóstico
Colposcopia/estatística & dados numéricos
Recidiva Local de Neoplasia/diagnóstico
Neoplasias do Colo do Útero/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasia Intraepitelial Cervical/cirurgia
Neoplasia Intraepitelial Cervical/virologia
Colposcopia/métodos
Feminino
Seres Humanos
Meia-Idade
Recidiva Local de Neoplasia/virologia
Papillomaviridae
Projetos Piloto
Estudos Prospectivos
Análise Espectral
Neoplasias do Colo do Útero/cirurgia
Neoplasias do Colo do Útero/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009560


  3 / 61942 MEDLINE  
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[PMID]:29444073
[Au] Autor:Hall MT; Simms KT; Lew JB; Smith MA; Saville M; Canfell K
[Ad] Endereço:Cancer Research Division, Cancer Council NSW, Sydney, Australia.
[Ti] Título:Projected future impact of HPV vaccination and primary HPV screening on cervical cancer rates from 2017-2035: Example from Australia.
[So] Source:PLoS One;13(2):e0185332, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many countries are transitioning from cytology-based to longer-interval HPV screening. Trials comparing HPV-based screening to cytology report an increase in CIN2/3 detection at the first screen, and longer-term reductions in CIN3+; however, population level year-to-year transitional impacts are poorly understood. We undertook a comprehensive evaluation of switching to longer-interval primary HPV screening in the context of HPV vaccination. We used Australia as an example setting, since Australia will make this transition in December 2017. METHODS: Using a model of HPV vaccination, transmission, natural history and cervical screening, Policy1-Cervix, we simulated the planned transition from recommending cytology every two years for sexually-active women aged 18-20 to 69, to recommending HPV screening every five years for women aged 25-74 years. We estimated rates of CIN2/3, cervical cancer incidence, and mortality for each year from 2005 to 2035, considering ranges for HPV test accuracy and screening compliance in the context of HPV vaccination (current coverage ~82% in females; ~76% in males). FINDINGS: Transient increases are predicted to occur in rates of CIN2/3 detection and invasive cervical cancer in the first two to three years following the screening transition (of 16-24% and 11-14% in respectively, compared to 2017 rates). However, by 2035, CIN2/3 and invasive cervical cancer rates are predicted to fall by 40-44% and 42-51%, respectively, compared to 2017 rates. Cervical cancer mortality rates are predicted to remain unchanged until ~2020, then decline by 34-45% by 2035. Over the period 2018-2035, switching to primary HPV screening in Australia is expected to avert 2,006 cases of invasive cervical cancer and save 587 lives. CONCLUSIONS: Transient increases in detected CIN2/3 and invasive cancer, which may be detectable at the population level, are predicted following a change to primary HPV screening. This is due to improved test sensitivity bringing forward diagnoses, resulting in longer term reductions in both cervical cancer incidence and mortality. Fluctuations in health outcomes due to the transition to a longer screening interval are predicted to occur for 10-15 years, but cervical cancer rates will be significantly reduced thereafter due to the impact of HPV vaccination and HPV screening. In order to maintain confidence in primary HPV screening through the transitional phase, it is important to widely communicate that an initial increase in CIN2/3 and perhaps even invasive cervical cancer is expected after a national transition to primary HPV screening, that this phenomenon is due to increased prevalent disease detection, and that this effect represents a marker of screening success.
[Mh] Termos MeSH primário: Infecções por Papillomavirus/diagnóstico
Vacinas contra Papillomavirus/administração & dosagem
Neoplasias do Colo do Útero/epidemiologia
[Mh] Termos MeSH secundário: Austrália/epidemiologia
Feminino
Seres Humanos
Modelos Biológicos
Infecções por Papillomavirus/prevenção & controle
Cooperação do Paciente
Neoplasias do Colo do Útero/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185332


  4 / 61942 MEDLINE  
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[PMID]:28455170
[Au] Autor:D'Addario M; Redmond S; Scott P; Egli-Gany D; Riveros-Balta AX; Henao Restrepo AM; Low N
[Ad] Endereço:Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland.
[Ti] Título:Two-dose schedules for human papillomavirus vaccine: Systematic review and meta-analysis.
[So] Source:Vaccine;35(22):2892-2901, 2017 05 19.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Simpler schedules for human papillomavirus (HPV) vaccine delivery could improve vaccine coverage and the effectiveness of cervical cancer prevention. The objective of this study was to systematically review evidence about the effects of two-dose compared with three-dose schedules for human papillomavirus (HPV) vaccine and to describe the uptake of two-dose HPV vaccination schedules globally. We searched PubMed, the Cochrane Central Registry of Controlled Trials, trials registers, and manufacturers' databases from their earliest date to February 2016. We selected randomised controlled trials and controlled clinical trials that directly compared HPV vaccine schedules with two or three doses. We extracted data on immunological and clinical outcomes and used meta-analysis where appropriate. We also described the use of two-dose HPV vaccine schedules globally. We screened 1464 items and included seven eligible noninferiority trials in 11 countries. In randomised comparisons amongst adolescent girls (three trials), geometric mean concentrations (GMC) of antibodies against HPV16 and HPV18 were non-inferior or inconclusive, up to 24months after a two-dose compared with a three-dose schedule. One trial with a clinical outcome found no persistent HPV infections occurred after either two or three doses. In non-randomised comparisons, GMC were non-inferior or superior in adolescent girls receiving the two-dose schedule compared with women receiving the three-dose schedule for at least 21months after vaccination. By February 2017, 23 low and middle income and 25 high income countries had adopted a two-dose HPV vaccination schedule. A two-dose HPV vaccine schedule provides satisfactory immunological outcomes in adolescent girls, but uptake globally is limited, particularly in countries with the highest burden of cervical cancer.
[Mh] Termos MeSH primário: Esquemas de Imunização
Vacinas contra Papillomavirus/administração & dosagem
Vacinas contra Papillomavirus/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticorpos Antivirais/biossíntese
Ensaios Clínicos como Assunto
Feminino
Vacina Quadrivalente Recombinante contra HPV tipos 6, 11, 16, 18/administração & dosagem
Seres Humanos
Papillomaviridae/imunologia
Infecções por Papillomavirus/prevenção & controle
Neoplasias do Colo do Útero/prevenção & controle
Vacinação
Potência de Vacina
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18); 0 (Papillomavirus Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  5 / 61942 MEDLINE  
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[PMID]:29487080
[Au] Autor:Cruickshank M
[Ad] Endereço:Institute of Applied Health Sciences, School of Medicine, University of Aberdeen, Aberdeen AB25 7ZD, UK.
[Ti] Título:Treatment or surveillance for CIN2?
[So] Source:BMJ;360:k771, 2018 02 27.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasia Intraepitelial Cervical
Colposcopia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Papillomaviridae
Infecções por Papillomavirus
Neoplasias do Colo do Útero
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k771


  6 / 61942 MEDLINE  
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[PMID]:29480845
[Au] Autor:Zhang J; Zhang Y; Zhang Z
[Ad] Endereço:Department of Gynecology and Obstetrics, Capital Medical University affiliated Beijing Chaoyang Hospital, Beijing, China.
[Ti] Título:Association of rs2279744 and rs117039649 promoter polymorphism with the risk of gynecological cancer: A meta-analysis of case-control studies.
[So] Source:Medicine (Baltimore);97(2):e9554, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Increasing evidence has suggested that rs2279744 is associated with rs117039649 polymorphism, which can increase the risk of gynecological cancers, including cervical, ovarian, breast, and endometrial cancer. The results are inconsistent so that we performed a meta-analysis of current literature to clarify the impacts of these polymorphisms on gynecological cancer. METHODS: Eligible articles were identified through an exhaustive search of relevant databases including PubMed, Embase, Web of science, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Weipu database for the period up to July 2016. Data about the association between single nucleotide polymorphisms (SNPs) and cancer risk were refined from the selected articles as well as other information about cases and controls, and all of them were extracted by 2 independent researchers and pooled odds ratio with 95% confidence interval was calculated. RESULTS: This analysis included 24 articles, 27 case-control studies of rs2279744 polymorphism and 3 case-control studies of rs117039649 polymorphism. Significant association with the risk of gynecological cancer was observed for both SNPs. Subgroup analysis by ethnicity and cancer type (cervical, ovarian, breast, and endometrial) also showed a positive relationship between rs2279744 polymorphism and gynecological cancer risk in Caucasian; and there was also a notable association between rs2279744 polymorphism and cervical cancer. CONCLUSIONS: We found that rs2279744 (SNP309) and rs117039649 (SNP285) were both associated with the risk of gynecological cancers. Subgroup analysis showed that rs2279744 (SNP309) was associated with the risk of gynecological cancers in Caucasian and Asian according to the ethnicity and cancer type, especially for endometrial cancer.
[Mh] Termos MeSH primário: Neoplasias da Mama/genética
Neoplasias do Endométrio/genética
Predisposição Genética para Doença
Neoplasias Ovarianas/genética
Proteínas Proto-Oncogênicas c-mdm2/genética
Neoplasias do Colo do Útero/genética
[Mh] Termos MeSH secundário: Neoplasias da Mama/etnologia
Neoplasias do Endométrio/etnologia
Feminino
Seres Humanos
Neoplasias Ovarianas/etnologia
Polimorfismo de Nucleotídeo Único
Regiões Promotoras Genéticas
Neoplasias do Colo do Útero/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
EC 2.3.2.27 (MDM2 protein, human); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009554


  7 / 61942 MEDLINE  
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[PMID]:29183021
[Au] Autor:Chantziantoniou N; Mukherjee M; Donnelly AD; Pantanowitz L; Austin RM
[Ad] Endereço:Department of Pathology, Cytopathology Section, Sidra Medicine, Qatar Foundation, Doha, Qatar.
[Ti] Título:Digital Applications in Cytopathology: Problems, Rationalizations, and Alternative Approaches.
[So] Source:Acta Cytol;62(1):68-76, 2018.
[Is] ISSN:1938-2650
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this work was to raise awareness of problems using digital applications for examining, teaching, and applying telecytology at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia; University of Nebraska Medical Center (UNMC), Omaha, NE, USA; and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA. The objective was to rationalize problems and propose alternative digital approaches. STUDY DESIGN: We sought to identify solutions to improve the following: (a) interpretive examination scores at KAMC for complex cytological templates (i.e., high-grade squamous intraepithelial lesions [HSIL]) when using static digital images (SDI) of cells in regions of interest (ROI); (b) visualization of cells in 3D clusters when teaching at UNMC using 2D and 3D whole-slide imaging (WSI); and (c) visualization of cells through streaming telecytology at UPMC. RESULTS: Composite SDI (CSDI) improved test scores for complex interpretations (i.e., HSIL) by converging diagnostic criteria from multiple ROI. Multiplane focusing through z-stacked WSI facilitated the teaching of cytological entities characterized by 3D cell clusters and consultative telecytology through robotic cell analysis. CONCLUSIONS: Adequately visualized cytomorphology and multiplane focusing are essential for virtual cytopathology examinations, teaching, or consultative telecytology. Visualization of diagnostic criteria through 2D or 3D imaging is critical. Panoptiq panoramic WSI with integrated z-stacked video clips enables optimal applied telecytology.
[Mh] Termos MeSH primário: Instrução por Computador
Educação Médica/métodos
Interpretação de Imagem Assistida por Computador/métodos
Microscopia/métodos
Patologia/educação
Lesões Intraepiteliais Escamosas Cervicais/patologia
Telepatologia/métodos
Neoplasias do Colo do Útero/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Nebraska
Teste de Papanicolaou
Pennsylvania
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Arábia Saudita
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1159/000484434


  8 / 61942 MEDLINE  
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[PMID]:28471315
[Au] Autor:Tung WC; Lu M; Granner M; Sohn J
[Ad] Endereço:a Orvis School of Nursing, University of Nevada , Reno , Nevada , USA.
[Ti] Título:Assessing perceived benefits/barriers and self-efficacy for cervical cancer screening among Korean American women.
[So] Source:Health Care Women Int;38(9):945-955, 2017 09.
[Is] ISSN:1096-4665
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A large proportion of Korean American women (KAW) do not receive regular cervical cancer screening. Self-report data from 102 KAW were analyzed by multiple linear regressions. As compared to women in action/maintenance, women in precontemplation/relapse stages were less likely to agree that a Pap test is important for health and were more likely to endorse barriers to testing (cost, not having a female doctor, preference for Korean medicine). Women in precontemplation/relapse stages also reported lower scores on self-efficacy items (travel large distances, pain perceptions, financial costs, and time). Differences in specific aspects may be informative for interventions to improve screening rates among KAW.
[Mh] Termos MeSH primário: Americanos Asiáticos/psicologia
Conhecimentos, Atitudes e Prática em Saúde/etnologia
Aceitação pelo Paciente de Cuidados de Saúde/etnologia
Autoeficácia
Neoplasias do Colo do Útero/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Americanos Asiáticos/estatística & dados numéricos
Estudos Transversais
Detecção Precoce de Câncer
Feminino
Seres Humanos
Programas de Rastreamento
Meia-Idade
Teste de Papanicolaou
Aceitação pelo Paciente de Cuidados de Saúde/psicologia
Percepção
República da Coreia/etnologia
Neoplasias do Colo do Útero/prevenção & controle
Neoplasias do Colo do Útero/psicologia
Esfregaço Vaginal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180304
[Lr] Data última revisão:
180304
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1080/07399332.2017.1326495


  9 / 61942 MEDLINE  
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[PMID]:29480826
[Au] Autor:Zhou J; Chen Y; Xu X; Yan D; Lou H
[Ad] Endereço:Key Laboratory of Radiation Oncology of Zhejiang Province.
[Ti] Título:Postoperative clinicopathological factors affecting cervical adenocarcinoma: Stages I-IIB.
[So] Source:Medicine (Baltimore);97(2):e9323, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Currently, cervical adenocarcinoma (ADC) receives the same standard treatment as squamous cell carcinoma, but this treatment regimen is not wholly suited for ADC. The present study was conducted to assess the prognostic role of postoperative clinicopathological factors in patients with stage I-IIB cervical ADC.The study examined 312 patients with stage I-IIB cervical ADC who underwent radical hysterectomy, including pelvic lymphadenectomy, at our institutions between October 2006 and September 2014. Overall survival (OS) and relapse-free survival (RFS) was analyzed by the Kaplan-Meier method. Sites of recurrence were classified as local and distant locations.The 5-year OS and RFS rates were 88.2% and 83.8%, respectively. The 5-year OS rates for patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA, IB, IIA, and IIB were 100.0%, 90.7%, 82.8%, and 55.6%, respectively. The Cox model identified number of positive pelvic nodes and age at surgery as independent prognostic factors for survival, and number of positive pelvic nodes and postoperative tumor diameter (≥4 cm) as independent prognostic factors for relapse. Cancer recurrence developed in 35 women. The top three recurrence sites were pelvis, vaginal stump, and lung.A more aggressive therapeutic strategy different from current practice in cervical cancer is urgently required for cervical ADC. As a new prognostic factor, postoperative tumor diameter should receive special attention in ADC treatment.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Adenocarcinoma/cirurgia
Neoplasias do Colo do Útero/patologia
Neoplasias do Colo do Útero/cirurgia
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico
Adulto
Fatores Etários
Idoso
Intervalo Livre de Doença
Feminino
Seguimentos
Seres Humanos
Histerectomia
Estimativa de Kaplan-Meier
Excisão de Linfonodo
Meia-Idade
Estadiamento de Neoplasias
Prognóstico
Modelos de Riscos Proporcionais
Resultado do Tratamento
Carga Tumoral
Neoplasias do Colo do Útero/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009323


  10 / 61942 MEDLINE  
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[PMID]:29352278
[Au] Autor:Teame H; Addissie A; Ayele W; Hirpa S; Gebremariam A; Gebreheat G; Jemal A
[Ad] Endereço:Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
[Ti] Título:Factors associated with cervical precancerous lesions among women screened for cervical cancer in Addis Ababa, Ethiopia: A case control study.
[So] Source:PLoS One;13(1):e0191506, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cervical cancer is the second most prevalent cancer among women in the developing countries including Ethiopia. Precancerous lesions can be developed and risk to the development of cervical cancer over time. Early identification of the precancerous lesion and its risk factor is paramount in preventing cervical cancer. However, the determinants of cervical precancerous lesions are not well documented in Ethiopia. Therefore, this study is conducted to determine factors associated with cervical precancerous lesion among women screened for cervical cancer. METHODS: A hospital-based unmatched case-control study was conducted in selected health facilities in Addis Ababa from March to April 2016. Data were collected from 114 cases and 229 controls using an interviewer-administered questionnaire, entered to Epi Info version 7, and exported to SPSS version 20 for analysis. Odds ratios with its 95% confidence intervals and two-tailed P-value were calculated. Variables with P-value ≤ 0.2 in the bivariate analysis were included in the multivariate logistic regression model. RESULTS: Women aged 40-49 years had 2.4-fold higher odds of precancerous lesions compared to those aged 30-39 (Adjusted Odds Ratio = 2.4, 95% Confidence Interval: 1.27-4.54). Women having history of sexually transmitted infections were significantly associated with cervical precancerous lesion compared to their counterparts (Adjusted Odds Ratio = 3.20, 95% Confidence Interval: 1.26-8.10). Similarly, those women who had two or more lifetime sexual partners (Adjusted Odds Ratio = 2.17 95% Confidence Interval: 1.01-4.67), and women whose husbands had two or more lifetime sexual partners (Adjusted Odds Ratio = 3.03, 95% Confidence Interval: 1.25, 7.33) had higher odds of cervical precancerous lesions. CONCLUSIONS: Older age, history of multiple sexual partners and sexual transmitted infections were associated with increased risk of precancerous lesion. Therefore, women with higher risk of precancerous lesions should be encouraged to be screened more frequently for cervical cancer.
[Mh] Termos MeSH primário: Lesões Pré-Cancerosas/epidemiologia
Neoplasias do Colo do Útero/epidemiologia
[Mh] Termos MeSH secundário: Ácido Acético
Adulto
Fatores Etários
Estudos de Casos e Controles
Etiópia/epidemiologia
Feminino
Seres Humanos
Modelos Logísticos
Programas de Rastreamento/métodos
Meia-Idade
Razão de Chances
Lesões Pré-Cancerosas/diagnóstico
Prevalência
Fatores de Risco
Comportamento Sexual
Parceiros Sexuais
Neoplasias do Colo do Útero/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191506



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