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[PMID]:28979650
[Au] Autor:Touzani MA; Yddoussalah O
[Ad] Endereço:Université Mohammed V, Faculté de Médecine et de Pharmacie de Rabat, Hopital Ibn Sina, Service d'Urologie B, Rabat, Maroc.
[Ti] Título:[Urethral ectropion may hide a carcinoma!]
[Ti] Título:Un ectropion urétral peut cacher un carcinome!.
[So] Source:Pan Afr Med J;27:249, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:The incidence of female urethral cancer is rare and accounts for 0.02% of all women's cancers. It is dominated by epidermoid carcinoma, which most commonly develops in the distal portion of the urethra, extending to inguinal lymph nodes. The diagnosis is confirmed in the distal forms on the basis of uretrocystoscopy with biopsy. Abdominopelvic MRI allows to determine tumor extension as well as its infiltration into tissues and peri-urethral organs. As in superficial tumors of the distal urethra, simple circumferential resection of the urethra associated with resection of the adjacent portion of the anterior surface of the vagina is sufficient. We here report the case of a 59-year old diabetic and hypertensive female patient presenting for irritative lower urinary tract symptoms, associated with vulvar mass. Clinical examination showed mucosal ectropion extending from the urethral meatus associated with extensive local inflammation. The patient underwent wide excision of the ectropion which was diagnosed as squamous cell carcinoma. Abdominopelvic MRI was normal.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/diagnóstico
Sintomas do Trato Urinário Inferior/etiologia
Uretra/patologia
Neoplasias Uretrais/diagnóstico
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/cirurgia
Feminino
Seres Humanos
Meia-Idade
Uretra/cirurgia
Neoplasias Uretrais/patologia
Neoplasias Uretrais/cirurgia
Neoplasias Vulvares/diagnóstico
Neoplasias Vulvares/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.249.13260


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[PMID]:28353601
[Au] Autor:Li CC; Li CZ; Yen CH; Tsai WC; Wu ST; Cha TL; Meng E
[Ad] Endereço:aDivision of Urology, Department of Surgery bDepartment of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei cDepartment of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung dDepartment of Surgery, Tri-Service General Hospital Songshan Branch eDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
[Ti] Título:Urethral hemangioma in a prepubertal female patient: Report of a rare case.
[So] Source:Medicine (Baltimore);96(13):e6502, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Urethral hemangiomas commonly occur in men or elderly women. We presented a rare case of urethral hemangioma in a prepubertal female patient. PATIENTS CONCERNS: An 8-year-old girl had the complaints of bloody staining of clothing, a foul perineal odor, and urethral pain. She was brought to our genitourinary outpatient department for survey and a single, 1-cm compressible reddish nodule at the 10-2 o'clock position in the distal urethra was found. DIAGNOSES: Urethral hemangioma in a prepubertal girl was diagnosed after excision of the urethral nodule. INTERVENTIONS: Excision with 8 "stay" sutures in the protruding urethral mucosa was performed. OUTCOMES: Normal micturition without symptom recurrence was noted at the 3-month follow-up. LESSONS: Urethral hemangioma is also found in prepubertal female patient. Increased physician awareness and early recognition of a urethral hemangioma can avoid unnecessary examinations and patient anxiety. The procedure of excision with 8 "stay" sutures in the protruding urethral mucosa facilitates mobilization from the distal urethra and provides a good surgical view of abnormal proliferative blood vessels. Therefore, the lesion can be removed as clean as possible.
[Mh] Termos MeSH primário: Hemangioma/patologia
Neoplasias Uretrais/patologia
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006502


  3 / 2117 MEDLINE  
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[PMID]:28341930
[Au] Autor:Darling D; Luxmanan C; O'Sullivan P; Lough T; Suttie J
[Ad] Endereço:Pacific Edge Ltd., Dunedin, New Zealand.
[Ti] Título:Clinical Utility of Cxbladder for the Diagnosis of Urothelial Carcinoma.
[So] Source:Adv Ther;34(5):1087-1096, 2017 May.
[Is] ISSN:1865-8652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: This study aimed to demonstrate the clinical utility of non-invasive multigene Cxbladder urine tests in reducing the overall number of diagnostic tests and invasive procedures used in the clinical evaluation of patients presenting with microhematuria, a key symptom of urothelial carcinoma (UC). There is a belief that using non-invasive molecular diagnostic tests in patients with hematuria may lead to patients undergoing unnecessary and costly invasive procedures that can cause adverse events and decrease patient quality of life. The objective of this study was to determine whether or not this was the case, using Cxbladder. METHODS: Data from 396 patient-by-urologist interactions generated 792 decision points from a standardized cohort of 33 patients evaluated by 12 urologists. Participant physicians recommended a selection of tests and procedures based on referral data, then reviewed and amended their recommendations in the context of diagnostic information from Cxbladder used in the Triage and Triage and Detect clinical modalities. RESULTS: All urologists changed their diagnostic behavior in at least one patient case with the addition of Cxbladder results. The total number of diagnostic procedures was reduced by 5% and 25% following disclosure of results from Cxbladder in the Triage and the Triage and Detect modalities, respectively. The total number of requested invasive procedures was reduced from 425 at referral to 379 (-11%) and 292 (-31%) following disclosure of Cxbladder information in the Triage and Triage and Detect modalities, respectively. CONCLUSIONS: Urologists made compelling changes to their clinical decision-making when they were provided with Cxbladder results for patients presenting with hematuria. Cxbladder provides an increase in clinical utility by focusing the use of invasive diagnostic procedures to appropriate patients, reducing both the total number and number of invasive procedures used in the clinical management of patients with hematuria, thereby improving the diagnostic experience and outcomes for patients. FUNDING: Pacific Edge Ltd.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/urina
Carcinoma/diagnóstico
Carcinoma/genética
Hematúria/diagnóstico
RNA/urina
Neoplasias Uretrais/diagnóstico
Neoplasias Uretrais/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 63231-63-0 (RNA)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE
[do] DOI:10.1007/s12325-017-0518-7


  4 / 2117 MEDLINE  
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[PMID]:28140610
[Au] Autor:Kim TH; Kim SY; Moon KC; Lee J; Cho JY; Kim SH
[Ad] Endereço:1 Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea.
[Ti] Título:Clear Cell Adenocarcinoma of the Urethra in Women: Distinctive MRI Findings for Differentiation From Nonadenocarcinoma and Non-Clear Cell Adenocarcinoma of the Urethra.
[So] Source:AJR Am J Roentgenol;208(4):805-811, 2017 Apr.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study is to evaluate the MRI findings differentiating clear cell adenocarcinoma of the urethra (CCAU) from nonadenocarcinoma of the urethra (NACU) and non-clear cell adenocarcinoma of the urethra (NCCAU) in women. MATERIALS AND METHODS: Six women with pathologically proven CCAU, six women with pathologically confirmed NACU (two squamous cell carcinomas and four transitional cell carcinomas), and nine women with NCCAU underwent preoperative MRI. The MRI findings for CCAU, NACU, and NCCAU were reviewed by a radiologist who was blinded to the histopathologic findings and were compared using the Mann-Whitney U test and the Fisher exact test. RESULTS: CCAU was shorter in height than NACU (3.4 cm vs 5.5 cm; p = 0.020) and also had a smaller height-to-width ratio than NACU (0.85 vs 1.51; p < 0.001) and NCCAU (0.85 vs 1.48; p = 0.002). The proportion of preserved urethra in CCAU (67%) was larger than that in either NACU (9%; p < 0.001) or NCCAU (22%; p < 0.001). All cases of CCAU originated within a diverticulum, whereas none of the cases of NACU and only one NCCAU originated in a diverticulum. Intratumoral septation was more frequently observed in CCAU (100%) than in NACU (16.6%; p = 0.015) or NCCAU (11.1%; p = 0.001). CONCLUSION: MRI findings for CCAU were significantly distinctive, compared with findings for NACU and NCCAU. All cases of CCAU were associated with a urethral diverticulum, and CCAU had a lower height-to-width ratio, more frequent intratumoral septation, and greater preservation of normal urethra than did NACU and NCCAU.
[Mh] Termos MeSH primário: Adenocarcinoma de Células Claras/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Neoplasias Uretrais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenocarcinoma de Células Claras/patologia
Adulto
Idoso
Diagnóstico Diferencial
Feminino
Seres Humanos
Meia-Idade
Variações Dependentes do Observador
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Neoplasias Uretrais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.16929


  5 / 2117 MEDLINE  
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[PMID]:28101735
[Au] Autor:Berjeaut RH; Persaud MD; Sopko N; Burnett AL
[Ad] Endereço:Division of Urology, Hospital das Clinicas, University of Sao Paulo School of Medicine, São Paulo, Brazil.
[Ti] Título:Urethral carcinoma in situ: recognition and management.
[So] Source:Int Urol Nephrol;49(4):637-641, 2017 Apr.
[Is] ISSN:1573-2584
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Urethral carcinoma in situ (CIS) is an uncommon malignancy that is poorly described in the published literature and is often under-recognized in the clinical setting. This short case series reports some challenges associated with the recognition and management of this disease. METHODS: A retrospective chart review was done over a 12-year period of patients presenting with urethral cancer to the Johns Hopkins Hospital. Four patients were identified with CIS of the anterior urethra, and their demographic and clinical data were recorded. RESULTS: Three patients presented with meatal lesions that were initially treated as infectious/inflammatory diseases before diagnoses of malignancy were determined following lesion biopsy. The fourth patient presented with painless hematuria and had a cystoscopy and biopsy of urethral polyps. All patients were treated surgically by sequential distal urethrectomy and various reconstructive procedures. Concurrent lymph node dissections were undertaken in two patients who had clinical or radiologic evidence of lymphadenopathy. One patient had persistent disease even after aggressive urethral resection, and he succumbed to his illness 2 years later. CONCLUSION: This is the largest series of urethral CIS, a disease with potentially serious consequences. A high index of suspicion should be maintained when evaluating and managing these patients.
[Mh] Termos MeSH primário: Carcinoma in Situ/diagnóstico
Excisão de Linfonodo
Recidiva Local de Neoplasia
Neoplasias Uretrais/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Carcinoma in Situ/tratamento farmacológico
Carcinoma in Situ/cirurgia
Erros de Diagnóstico
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Neoplasias Uretrais/tratamento farmacológico
Neoplasias Uretrais/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s11255-017-1512-3


  6 / 2117 MEDLINE  
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[PMID]:28052688
[Au] Autor:Wang X; Lopez-Beltran A; Osunkoya AO; Wang M; Zhang S; Davidson DD; Emerson RE; Williamson SR; Tan PH; Kaimakliotis HZ; Baldridge LA; MacLennan GT; Montironi R; Cheng L
[Ad] Endereço:Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.
[Ti] Título:TERT promoter mutation status in sarcomatoid urothelial carcinomas of the upper urinary tract.
[So] Source:Future Oncol;13(8):705-714, 2017 Apr.
[Is] ISSN:1744-8301
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To determine TERT promoter mutation status as well as the expression of PAX8, GATA3, p63, p40, p53 and uroplakin III in 17 patients with the upper urinary tract sarcomatoid urothelial carcinoma. METHODS & RESULTS:  TERT C228T mutations were found in six of 17 cases (35%). p53 was expressed in 77% of these tumors. PAX8, GATA3, p40 and uroplakin III are less frequently expressed. Lymph node metastases were present in ten cases (59%). Eight patients (47%), including all three patients with TERT mutation, died of cancer within 2 years after surgery. CONCLUSION: Sarcomatoid carcinoma of the upper urinary tract is an aggressive tumor and the presence of TERT mutation may portend poor prognosis.
[Mh] Termos MeSH primário: Carcinoma/genética
Mutação
Regiões Promotoras Genéticas
Telomerase/genética
Neoplasias Uretrais/genética
Neoplasias Urológicas/genética
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Biomarcadores
Carcinoma/metabolismo
Carcinoma/mortalidade
Carcinoma/patologia
Feminino
Fator de Transcrição GATA3/metabolismo
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Estadiamento de Neoplasias
Fator de Transcrição PAX8/metabolismo
Prognóstico
Proteína Supressora de Tumor p53/metabolismo
Neoplasias Uretrais/metabolismo
Neoplasias Uretrais/mortalidade
Neoplasias Uretrais/patologia
Neoplasias Urológicas/metabolismo
Neoplasias Urológicas/mortalidade
Neoplasias Urológicas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (GATA3 Transcription Factor); 0 (PAX8 Transcription Factor); 0 (PAX8 protein, human); 0 (Tumor Suppressor Protein p53); EC 2.7.7.49 (Telomerase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.2217/fon-2016-0414


  7 / 2117 MEDLINE  
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[PMID]:27890404
[Au] Autor:Thierry F; Drew S; Del-Pozo J; Fernandez-Salesa N; Woods S; Stanzani G; Liuti T
[Ad] Endereço:University of Edinburgh, Royal (Dick) School of Veterinary Studies, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, UK. Electronic address: fthierry@exseed.ed.ac.uk.
[Ti] Título:Incomplete Urethral Duplication Associated with a Dermoid Cyst in a Dog with Urinary Obstruction.
[So] Source:J Comp Pathol;156(1):29-32, 2017 Jan.
[Is] ISSN:1532-3129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 20-month-old male miniature dachshund was evaluated for a 10-week history of intermittent stranguria, pollakiuria, haematuria and obstructive urolithiasis. Retrograde urethrocystography revealed a subcutaneous saccular structure in the perineal area connected to the intrapelvic urethra associated with urolithiasis. After excision of the perineal saccular structure, microscopical examination confirmed the presence of transitional epithelium lining the diverticulum, with isolated submucosal smooth muscle bundles. This structure was attached to another saccular structure lined by stratified squamous keratinizing epithelium with hair follicles, sebaceous glands and apocrine glands. An incomplete urethral duplication with dermoid cyst was diagnosed. The dog recovered uneventfully from surgery and was still urinary continent and free from clinical signs 5 months after surgery. To the authors' knowledge this is the first report of an incomplete urethral duplication with a dermoid cyst and concurrent obstructive urolithiasis in a dog.
[Mh] Termos MeSH primário: Cisto Dermoide/veterinária
Doenças do Cão/patologia
Uretra/anormalidades
Neoplasias Uretrais/veterinária
[Mh] Termos MeSH secundário: Animais
Cães
Masculino
Obstrução Uretral/veterinária
Urolitíase/veterinária
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE


  8 / 2117 MEDLINE  
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[PMID]:27797877
[Au] Autor:Cicilet S; Joseph T; Furruqh F; Biswas A
[Ad] Endereço:Department of Radiodiagnosis, St John's Medical College Hospital, Bangalore, Karnataka, India.
[Ti] Título:Urethral leiomyoma: a rare case of voiding difficulty.
[So] Source:BMJ Case Rep;2016, 2016 Oct 25.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Disuria/etiologia
Leiomioma/complicações
Leiomioma/diagnóstico por imagem
Neoplasias Uretrais/complicações
Neoplasias Uretrais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Meios de Contraste
Diagnóstico Diferencial
Feminino
Seres Humanos
Leiomioma/patologia
Leiomioma/cirurgia
Imagem por Ressonância Magnética
Ultrassonografia Doppler
Neoplasias Uretrais/patologia
Neoplasias Uretrais/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE


  9 / 2117 MEDLINE  
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[PMID]:27739563
[Au] Autor:Pirola GM; Martorana E; Fidanza FA; Bonetti LR; Puliatti S; Bonora A; Micali S; Bianchi G
[Ad] Endereço: Department of Urology, University of Modena and Reggio Emilia, Modena - Italy.
[Ti] Título:Rare metastatic sites of renal cell carcinoma: urethra and spermatic cord.
[So] Source:Urologia;83(4):214-217, 2016 Nov 18.
[Is] ISSN:0391-5603
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: About 20% of patients with a diagnosis of primary renal cell carcinoma (RCC) present directly with metastatic disease. The aim of the present manuscript is to describe, for the first time a RCC metastasis located to the distal female urethra and to present an update on metastatic locations to the male spermatic cord. MATERIALS AND METHODS: We report two cases of rare RCC metastases. The first concerns a 92-year-old female patient who came to our attention for recurrent urethral bleeding, which was initially believed to be secondary to urethral mucosal ectropion. Pathology demonstrated a RCC metastasis. The second concerns a 67-year-old male patient with a previous history of RCC who came to our attention for the finding of palpable, mobile and indolent right inguinal lump. Given the past history of malignancy, it was excised and revealed to be a RCC metastasis. DISCUSSION: In the first case, the pathologic specimen allowed the detection of an unknown renal tumor, whereas in the second, the previous neoplastic history of the patient has led clinicians to focus on a possible neoplastic recurrence, perform a correct excision of the node, and begin an early systemic therapy. CONCLUSIONS: These cases are emblematic of possible unexpected RCC metastasis. These findings should be taken into account in order to clarify the differential diagnosis and to address these patients to a correct therapeutic course.
[Mh] Termos MeSH primário: Carcinoma de Células Renais/secundário
Neoplasias dos Genitais Masculinos/secundário
Neoplasias Renais/patologia
Cordão Espermático
Neoplasias Uretrais/secundário
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.5301/uro.5000200


  10 / 2117 MEDLINE  
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[PMID]:27717442
[Au] Autor:Spiess PE
[Ad] Endereço:Departments of GU Oncology and Tumor Biology, Moffitt Cancer Center, Department of Urology, University of South Florida, NCCN Bladder and Penile Cancer, 12902 Magnolia Drive, Tampa, FL 33612, USA. Electronic address: philippe.spiess@moffitt.org.
[Ti] Título:Penile, Urethral, and Scrotal Cancer.
[So] Source:Urol Clin North Am;43(4):xvii-xviii, 2016 Nov.
[Is] ISSN:1558-318X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias dos Genitais Masculinos/terapia
Escroto
Neoplasias Uretrais/terapia
[Mh] Termos MeSH secundário: Terapia Combinada
Seres Humanos
Masculino
Neoplasias Penianas/terapia
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE



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