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  1 / 1112 MEDLINE  
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[PMID]:28562558
[Au] Autor:Cui W; Xu W; Yang Q; Hu R
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, China.
[Ti] Título:Clinicopathological parameters associated with histological background and recurrence after surgical intervention of vocal cord leukoplakia.
[So] Source:Medicine (Baltimore);96(22):e7033, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Histological examination of biopsy shows usefulness in the diagnosis of vocal cord leukoplakia; however, in considerable amount of cases, the examination cannot provide definitive diagnosis of malignancy from benign conditions such as hyperplasia and dysplasia. The present work therefore was aimed to identify clinicopathological factors and molecular markers predictive of recurrence and malignant transformation of vocal cord leukoplakia.Clinical data of 555 cases of vocal cord leukoplakia enrolled from July 1999 to June 2014 were analyzed. The cohort consisted of keratosis (n = 137), hyperplasia (n = 139), dysplasia (n = 177), and primary (n = 10) and invasive (n = 46) carcinoma. Correlations between patients' backgrounds, clinicopathological factors, molecular markers (p53, p16, Ki67, cytokeratin, and proliferating cell nuclear antigen), and histology backgrounds were examined using by Pearson Chi-squared or Fisher exact test. Reflux symptom index (RSI) and reflux finding score (RFS) before and after treatment were compared using Wilcoxon signed-rank test. Risk factors for disease recurrence were identified using Cox proportional hazards models of multivariate analysis. Time to recurrence was analyzed using log-rank test of Kaplan-Meier method.In the present cohort, alcohol drinking was found associated with GRBAS grade (P = .0258) and the site (P = .0298) of leukoplakia. For the different disease types, chief complaint (P = .0179), GRBAS grade (P = .0101), mucosal wave (P < .0001), and molecular markers p53 (P < .0001) and Ki67 (P < .0001) were identified as correlates. RSI and RFS were significantly lowered by surgical intervention. A single side of leukoplakia was predictive of a lower risk of recurrence (odds ratio, 0.378; 95% confidence interval, 0.197-0.723; P = .0033). Absence of mucosal wave was associated with a shorter time-to-recurrence (P = .0357).The present work identified clinicopathological factors and molecular markers associated with the different histology of vocal cord leukoplakia, and also the prognostic factor for the low risk of recurrence after surgery.
[Mh] Termos MeSH primário: Neoplasias Laríngeas/patologia
Neoplasias Laríngeas/cirurgia
Leucoplasia/patologia
Leucoplasia/cirurgia
Prega Vocal/patologia
Prega Vocal/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Consumo de Bebidas Alcoólicas/metabolismo
Consumo de Bebidas Alcoólicas/patologia
Biomarcadores Tumorais/metabolismo
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Antígeno Ki-67/metabolismo
Neoplasias Laríngeas/metabolismo
Leucoplasia/metabolismo
Masculino
Meia-Idade
Gradação de Tumores
Recidiva Local de Neoplasia/metabolismo
Recidiva Local de Neoplasia/patologia
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Resultado do Tratamento
Proteína Supressora de Tumor p53/metabolismo
Prega Vocal/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Ki-67 Antigen); 0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007033


  2 / 1112 MEDLINE  
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[PMID]:28402761
[Au] Autor:Kelmenson DA; Hanley M
[Ad] Endereço:University of Colorado, Aurora, CO dkelmenson@gmail.com.
[Ti] Título:Dyskeratosis Congenita.
[So] Source:N Engl J Med;376(15):1460, 2017 Apr 13.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Disceratose Congênita/diagnóstico
[Mh] Termos MeSH secundário: Contagem de Células Sanguíneas
Seres Humanos
Leucoplasia
Masculino
Doenças da Unha
Telômero/ultraestrutura
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1613081


  3 / 1112 MEDLINE  
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[PMID]:28103701
[Au] Autor:Lerner MZ; Mor N; Paek H; Blitzer A; Strome M
[Ad] Endereço:1 Department of Otolaryngology-Head and Neck Surgery, Montefiore Medical Center, Bronx, New York, USA.
[Ti] Título:Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients.
[So] Source:Ann Otol Rhinol Laryngol;126(4):340-343, 2017 Apr.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Metformin is an oral anti-hyperglycemic agent used to treat type 2 diabetes mellitus (DM). In vitro and animal models have shown that metformin can prevent the progression of oral lesions to carcinoma; however, there is conflicting data in the clinical literature regarding risk reduction for malignancy in head and neck cancer (HNC). STUDY DESIGN: Case series. METHODS: We present 3 cases in which adjuvant metformin therapy was used to treat recurrent and multifocal dysplastic lesions in previously treated nondiabetic HNC patients. RESULTS: Patients included 1 with a history of oral cavity squamous cell carcinoma (SCC) and 2 with a history of laryngeal SCC. Follow-up time ranged between 3 and 33 months. All 3 patients showed complete or partial regression of the remaining mucosal lesions and did not require any additional surgeries. CONCLUSION: We present 3 cases of nondiabetic HNC patients with field cancerization who showed a good response to adjuvant therapy with metformin. The nondiabetic population is not affected by confounding factors such as increased risk of malignancy and decreased overall survival that is itself associated with abnormal glucose metabolism and is therefore an excellent cohort in which to study the use of adjuvant metformin therapy in HNC patients.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/terapia
Neoplasias de Cabeça e Pescoço/terapia
Hipoglicemiantes/uso terapêutico
Neoplasias Laríngeas/terapia
Leucoplasia/tratamento farmacológico
Metformina/uso terapêutico
Neoplasias Bucais/terapia
Recidiva Local de Neoplasia/tratamento farmacológico
Neoplasias da Língua/terapia
[Mh] Termos MeSH secundário: Idoso
Progressão da Doença
Feminino
Glote
Seres Humanos
Masculino
Membrana Mucosa
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 9100L32L2N (Metformin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1177/0003489416688478


  4 / 1112 MEDLINE  
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[PMID]:28083976
[Au] Autor:Koss SL; Baxter P; Panossian H; Woo P; Pitman MJ
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai.
[Ti] Título:Serial in-office laser treatment of vocal fold leukoplakia: Disease control and voice outcomes.
[So] Source:Laryngoscope;127(7):1644-1651, 2017 Jul.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Although vocal fold (VF) leukoplakia is commonly treated with in-office laser, there is no data on its long-term effectiveness. This study hypothesizes that VF leukoplakia treated by serial in-office laser results in long-term disease control with maintenance of voice and minimal morbidity. STUDY DESIGN: Retrospective review (2008-2015). METHODS: Forty-six patients with VF leukoplakia treated by in-office KTP (potassium titanyl phosphate) or PDL (pulsed dye laser) were included. Median follow-up from final laser treatment was 19.6 months. Main outcomes included: 1) rate of disease control, 2) percentage of disease regression using ImageJ analysis. Secondary outcomes included vocal assessment using the Voice Handicap Index-10 (VHI-10). RESULTS: Patients underwent a median of 2 (range: 1-6) in-office laser treatments. Time between treatments was median 7.6 months. After final treatment, 19 patients (41.3%) had no disease; two patients (4.3%) progressed to invasive cancer; overall disease regression was median 77.1% (P < 0.001); and VHI-10 score decreased by median 5 (P = 0.037). Thirty-one patients (67.4%) were responders (controlled with in-office treatment only); failures were 13 patients (28.3%) who required operative intervention and two patients (4%) who underwent radiation. Compared to responders, failures demonstrated significantly shorter duration between treatments (median 2.3 vs. 8.9 months, P = 0.038) and significantly less regression (median 49.3% vs. 100%, P = 0.006). CONCLUSION: Serial outpatient KTP or PDL treatment of VF leukoplakia is effective for disease control with minimal morbidity and preservation of voice quality. We suggest that patients requiring repeated in-office treatment every 6 months may benefit from earlier operative intervention; other factors associated with in-office success remain unclear. LEVEL OF EVIDENCE: 4. Laryngoscope, 127:1644-1651, 2017.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Ambulatórios
Neoplasias Laríngeas/cirurgia
Terapia a Laser
Lasers de Corante/uso terapêutico
Leucoplasia/cirurgia
Lesões Pré-Cancerosas/cirurgia
Prega Vocal/cirurgia
[Mh] Termos MeSH secundário: Idoso
Algoritmos
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Reoperação
Estudos Retrospectivos
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26445


  5 / 1112 MEDLINE  
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[PMID]:27686889
[Au] Autor:Yang SW; Chao WC; Lee YS; Chang LC; Hsieh TY; Chen TA; Luo CM
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung. No. 222, Mai Chin Road, Keelung 204, Taiwan.
[Ti] Título:Treatment outcome of vocal cord leukoplakia by transoral laser microsurgery.
[So] Source:Lasers Med Sci;32(1):19-27, 2017 Jan.
[Is] ISSN:1435-604X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to evaluate the treatment outcome and analyze the associated factors of postoperative recurrence in patients who received transoral laser microsurgery for vocal cord leukoplakia. The demographic, histopathological data were retrospectively reviewed and the factors associated with recurrence of vocal leukoplakia after surgery were analyzed statistically. A total of 44 patients, including 36 males and 8 females, with a mean age of 50.4 ± 13.4 years, were enrolled. All the patients received excision of the vocal leukoplakia by carbon dioxide laser (2-4 Watt, ultrapulse mode) under general anesthesia. No patients had malignant transformation after surgery. Postoperative recurrence occurred in 10 patients (22.7 %). Univariate analysis showed that patients who had the habit of cigarette smoking, alcohol drinking, and presence of gastroesophageal reflux disease tended to recur. Among these risk factors, presence of gastroesophageal reflux disease (odds ratio 8.43) was the independent prognostic factor for recurrence using multivariate logistic regression analysis. Carbon dioxide laser excision is effective for treating vocal leukoplakia that is still confined to dysplasia of any degree, with acceptable morbidity. This study suggests that the presence of gastroesophageal reflux disease is the prognostic indicator for postoperative recurrence of vocal leukoplakia. Aggressive treatment of reflux disease for those who have received surgical excision for vocal leukoplakia is indicated.
[Mh] Termos MeSH primário: Terapia a Laser
Leucoplasia/cirurgia
Microcirurgia
Prega Vocal/patologia
Prega Vocal/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Endoscopia
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.1007/s10103-016-2078-5


  6 / 1112 MEDLINE  
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[PMID]:27515705
[Au] Autor:Staníková L; Satanková J; Kucová H; Walderová R; Zeleník K; Komínek P
[Ad] Endereço:Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, 17. listopadu 1790, 708 52, Ostrava, Czech Republic.
[Ti] Título:The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia.
[So] Source:Eur Arch Otorhinolaryngol;274(1):355-359, 2017 Jan.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate whether observing microvascular changes by narrow-band imaging (NBI) endoscopy in the area surrounding leukoplakia is sufficient for discriminating between benign and malignant patterns of vocal cord leukoplakia. A total of 282 patients were investigated using white-light high-definition TV laryngoscopy and NBI endoscopy from 6/2013 to 8/2015, and 63 patients with a primary case of laryngeal leukoplakia were enrolled. Patients were divided into two groups based on leukoplakia with surrounding malignant intraepithelial papillary capillary loops (group I; 26/63) and leukoplakia with a surrounding benign vascular network (group II; 37/63), both by NBI endoscopy. All 63 patients were evaluated by blinded histological examination, and results were compared with NBI optical biopsy. Carcinoma in situ or invasive squamous cell carcinoma was confirmed in 22/26 cases (84.6 %) in group I. Hyperkeratosis or low-grade dysplasia was confirmed histologically in 31/37 (83.8 %) and squamous cell carcinoma in 2/37 (5.4 %) cases in group II. Accordance of NBI endoscopy and histopathological features of vocal cord leukoplakia lesions was statistically significant (kappa index 0.77, p < 0.001), with a sensitivity of 88.0 % (95 % CI 67.8-97.5 %) and specificity of 89.5 % (95 % CI 71.2-97.1 %). NBI is convenient for improving evaluation of laryngeal leukoplakias based on optic prehistological diagnosis. The close accordance between NBI features and histological results suggests that a negative NBI endoscopy may be an indication for long-term endoscopy follow-up without histological evaluation.
[Mh] Termos MeSH primário: Carcinoma in Situ/patologia
Carcinoma de Células Escamosas/patologia
Endoscopia
Neoplasias Laríngeas/patologia
Leucoplasia/patologia
Imagem de Banda Estreita
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biópsia
Carcinoma in Situ/diagnóstico por imagem
Carcinoma de Células Escamosas/diagnóstico por imagem
Feminino
Seres Humanos
Hiperplasia/patologia
Neoplasias Laríngeas/diagnóstico por imagem
Laringoscopia
Leucoplasia/diagnóstico por imagem
Masculino
Meia-Idade
Sensibilidade e Especificidade
Prega Vocal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-016-4244-6


  7 / 1112 MEDLINE  
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[PMID]:27148699
[Au] Autor:Liu YC; Ho HC; Lee MR; Yeh CM; Tseng HC; Lin YC; Chung JG
[Ad] Endereço:Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
[Ti] Título:Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis.
[So] Source:Environ Toxicol;32(3):799-812, 2017 Mar.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:EMS1 (chromosome eleven, band q13, mammary tumor and squamous cell carcinoma-associated gene 1) gene amplification and the concomitant cortactin overexpression have been reported to associate with poor prognosis and tumor metastasis. In this study, we examined cortactin expression by immunohistochemistry in human oral tumors and murine tongue tumors which were induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO). The immunostaining results show over- to moderate expression of cortactin in 85% (104/122) of oral squamous cell carcinoma (OSCC) tissues and in all 15 leukoplakia tissues examined. Further, statistical analysis indicates that cortactin overexpression appears to be a predictor for shorter survival and poorer prognosis in OSCC patients. In an animal model, cortactin is shown to upregulate in infiltrating squamous cell carcinoma, papilloma, and epithelia with squamous hyperplasia, indicating that cortactin induction is an early event during oral carcinogenesis. It is suggested that cortactin expression is mediated in the progression of pre-malignancy to papilloma, based on earlier cortactin induction in pre-malignancy preceding cyclin D1 in papilloma. In conclusion, cortactin overexpression is frequently observed in human OSCC and mouse tongue tumors. Thus, cortactin may have an important role in the development of oral tumors in human and mice. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 799-812, 2017.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/patologia
Cortactina/metabolismo
Neoplasias Bucais/patologia
[Mh] Termos MeSH secundário: 4-Nitroquinolina-1-Óxido/toxicidade
Adulto
Animais
Areca/química
Areca/metabolismo
Carcinogênese
Carcinoma de Células Escamosas/metabolismo
Carcinoma de Células Escamosas/mortalidade
Cortactina/genética
Ciclina D1/metabolismo
Modelos Animais de Doenças
Intervalo Livre de Doença
Feminino
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Leucoplasia/metabolismo
Leucoplasia/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Meia-Idade
Neoplasias Bucais/metabolismo
Neoplasias Bucais/mortalidade
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Reação em Cadeia da Polimerase
Prognóstico
Modelos de Riscos Proporcionais
Neoplasias da Língua/induzido quimicamente
Neoplasias da Língua/metabolismo
Neoplasias da Língua/patologia
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cortactin); 0 (Plant Extracts); 136601-57-5 (Cyclin D1); 56-57-5 (4-Nitroquinoline-1-oxide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22280


  8 / 1112 MEDLINE  
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[PMID]:27107249
[Au] Autor:Kono T; Saito K; Yabe H; Ogawa K
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
[Ti] Título:Phonosurgical resection using submucosal infusion technique for precancerous laryngeal leukoplakia.
[So] Source:Laryngoscope;127(1):153-158, 2017 Jan.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: This study was designed to assess the feasibility of the submucosal infusion technique combined with microflap dissection as a radical therapeutic and diagnostic option for precancerous laryngeal leukoplakia. STUDY DESIGN: Retrospective study. METHODS: Severe dysplasia or carcinoma in situ was diagnosed after phonomicrosurgical dissections in 25 patients with unilateral laryngeal leukoplakia. Of these, 15 patients preferred no additional surgery (observation group), whereas 10 patients underwent further laser subligamental cordectomy (additional surgery group). The relationship between the initial surgical margin and histopathological characteristics of additionally excised tissues was assessed to evaluate diagnostic reliability. Disease control was assessed to determine the oncologic efficacy of the therapeutic procedure. Comparative multidimensional vocal assessments were performed in both groups to evaluate functional advantages of one-stage excision. RESULTS: After the initial phonomicrosurgical resection, three patients had residual dysplastic lesions near the vocal process and anterior commissure, whereas three other patients had lesions suspicious for recurrence. No postoperative malignant transformation was observed in any patient. Although well-preserved vocal function was observed in the observation group, vocal quality deteriorated shortly after laser surgery in the additional surgery group. Regarding acoustics, aerodynamics, and quality-of-life evaluations, statistically equivalent scores were observed between the observation and control groups, whereas scores were inferior in the additional surgery group than in the control group. CONCLUSIONS: Phonomicrosurgical resection may be a therapeutic option with oncologic efficacy against precancerous laryngeal leukoplakia. This radical management might achieve more satisfactory postoperative vocal function. LEVEL OF EVIDENCE: NA Laryngoscope, 127:153-158, 2017.
[Mh] Termos MeSH primário: Carcinoma in Situ/cirurgia
Neoplasias Laríngeas/cirurgia
Leucoplasia/cirurgia
Microcirurgia/métodos
Lesões Pré-Cancerosas/cirurgia
Qualidade da Voz
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Biópsia/métodos
Carcinoma in Situ/patologia
Dissecação
Estudos de Viabilidade
Seres Humanos
Hiperplasia/patologia
Hiperplasia/cirurgia
Neoplasias Laríngeas/patologia
Leucoplasia/patologia
Meia-Idade
Lesões Pré-Cancerosas/patologia
Qualidade de Vida
Estudos Retrospectivos
Retalhos Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160424
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26028


  9 / 1112 MEDLINE  
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[PMID]:27765330
[Au] Autor:Bhosale PG; Pandey M; Desai RS; Patil A; Kane S; Prabhash K; Mahimkar MB
[Ad] Endereço:Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India.
[Ti] Título:Low prevalence of transcriptionally active human papilloma virus in Indian patients with HNSCC and leukoplakia.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;122(5):609-618.e7, 2016 Nov.
[Is] ISSN:2212-4411
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: In the present study, we comprehensively analyzed the prevalence of transcriptionally active human papilloma virus (HPV) in tissue samples of Indian patients with leukoplakia, predominantly hyperplastic lesions and head and neck squamous cell carcinoma (HNSCC). In addition, saliva samples from patients with HNSCC were screened for HPV detection. STUDY DESIGN: P16 overexpression was analyzed by immunohistochemistry. Tissue samples of leukoplakia (n = 121) and HNSCC (n = 427) and saliva from patients with HNSCC (n = 215) were tested for HPV using nested polymerase chain reaction. Positive samples were sequenced for subtyping. The presence of HPV E6/E7 mRNA was confirmed by RNA in situ hybridization. RESULTS: P16 expression and HPV DNA were not detected in any of the leukoplakia specimens. Of the 427 HNSCC tumors, 9 showed p16 overexpression and 7/427 cases were positive for HPV16 DNA, in saliva or tissue. E6/E7 mRNA positivity was observed in 8 HNSCC samples, primarily from patients with no habit of tobacco consumption. The prevalence of high-risk HPV was restricted to oropharynx and larynx, with very little concordance between p16 overexpression and HPV positivity. All patients with HPV-positive saliva samples had transcriptionally active HPV present in their tumors. CONCLUSION: The presence of HPV DNA does not necessarily reflect transcriptionally active virus in tumors; hence, it is important to consider this fact while categorizing HPV-associated tumors.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/virologia
Neoplasias de Cabeça e Pescoço/virologia
Papillomavirus Humano 16/genética
Leucoplasia/virologia
Infecções por Papillomavirus/virologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
DNA Viral/análise
Feminino
Testes de DNA para Papilomavírus Humano
Seres Humanos
Imuno-Histoquímica
Hibridização In Situ
Índia
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Saliva/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (DNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


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[PMID]:27625129
[Au] Autor:Tan JJ; Wang L; Huang ZF; Li YF; Tian WD; Liu X; Zeng FF; Li XP
[Ad] Endereço:Department of Otorhinolaryngology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
[Ti] Título:[The expression and significance of pepsin in laryngeal carcinoma].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;51(8):593-9, 2016 Aug 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To evaluate the relationship between pepsin induced by laryngopharyngeal reflux and laryngeal carcinoma. METHODS: Patients with vocal cord leukoplakia(n=18) and laryngeal carcinoma(n=21) encountered in Nanfang Hospital between December 2012 and April 2014 were included and sixteen healthy volunteers were recruited as control. Laryngeal biopsy specimens were taken from the patients with laryngeal carcinoma, or vocal cord leukoplakia and control subjects for the immunohistochemical study of pepsin. The correlation between pepsin expression and reflux events of 24 hour multichannel intraluminal impedance-pH monitoring (MII-pH) was analyzed. RESULTS: The patients with laryngeal carcinoma showed the highest expression of pepsin, followed by the patients with vocal cord leukoplakia and control subjects, with significant difference among the three groups (in strong positive expression, the constituent ratio of each group are 0/16、1/18 and 4/21, P<0.01). The presence of pepsin was associated with upright and total laryngopharyngeal acid reflux (P<0.05), including acid reflux episodes, the percentage of times that the pH was below four, the percentages of acid reflux time and average acid removal time. There was a significant correlation between the pepsin level and the esophageal acid reflux parameters (P<0.05) except supine the percentage of time that the pH was below four. CONCLUSIONS: Pepsin expression in laryngeal tissue increases in patients with vocal cord leukoplakia and laryngeal carcinoma, contributing to the development of laryngopharyngeal carcinogenesis.
[Mh] Termos MeSH primário: Carcinoma/metabolismo
Neoplasias Laríngeas/metabolismo
Refluxo Laringofaríngeo/metabolismo
Pepsina A/metabolismo
[Mh] Termos MeSH secundário: Carcinoma/etiologia
Estudos de Casos e Controles
Refluxo Gastroesofágico/metabolismo
Seres Humanos
Neoplasias Laríngeas/etiologia
Refluxo Laringofaríngeo/complicações
Laringe/metabolismo
Leucoplasia/complicações
Leucoplasia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.23.1 (Pepsin A)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2016.08.007



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