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[PMID]:29442028
[Au] Autor:Ng PY; Ong AJ; Gale LS; Dass CR
[Ti] Título:Treatment of bone disorders with parathyroid hormone: success and pitfalls.
[So] Source:Pharmazie;71(8):427-433, 2016 08 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Bone diseases such as osteoporosis, osteoarthritis, bone tumours and bone fractures are rather common and not just in the elderly. Parathyroid hormone (PTH) is responsible for maintaining calcium homeostasis, increasing bone mineral density (BMD), increasing cortical and trabecular bone thickness and thus increasing bone strength. Teriparatide (PTH 1-34) has the same effects as endogenous PTH and is pharmacologically used to treat bone diseases such as osteoporosis, osteoarthritis, bone fractures and bone tumours. This review discusses how PTH 1-34 plays a role in managing bone diseases. Clinical studies have shown that short or intermittent dosing of PTH 1-34 has minimal adverse effects, while long-term dosing (over two years) has been linked to de novo osteoarthritis and bone deformation. Currently PTH therapy is only approved in the treatment of post-menopausal osteoporosis, however it is also proven to have effects in treating osteoarthritis, bone tumours and bone fractures. If the patient undergoing therapy is closely monitored, the major pitfalls are very unlikely to take place, thus it is highly recommended that patients be closely monitored by a medical practitioner.
[Mh] Termos MeSH primário: Doenças Ósseas/tratamento farmacológico
Hormônio Paratireóideo/efeitos adversos
Hormônio Paratireóideo/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Conservadores da Densidade Óssea/uso terapêutico
Difosfonatos/uso terapêutico
Seres Humanos
Hormônio Paratireóideo/fisiologia
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Diphosphonates); 0 (Parathyroid Hormone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6008


  2 / 16892 MEDLINE  
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[PMID]:29390269
[Au] Autor:Wang J; Wang D; Du J; Lin Z
[Ti] Título:A new strategy to reconstruct type III acetabular bone defect associated with inflammatory pseudotumor: combined medial and lateral acetabular bone grafting: A case report.
[So] Source:Medicine (Baltimore);96(50):e8777, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Inflammatory pseudotumor has been commonly reported in patients undergoing total hip arthroplasty (THA). PATIENT CONCERNS: We reported a patient who had a massive intra-pelvic pseudotumour and acetabular bone defect underwent two-stage revision THA. DIAGNOSES: A new surgical strategy for pseudotumor after THA is performed. INTERVENTIONS: Thorough debridement intra-pelvic pseudotumour via Smith-Petersen approach, bone grafting on iliac medial surface and plate-screw internal fixation were performed in the first stage, followed by revision of the loosened prosthesis to a cementless primary prosthesis in the second stage. OUTCOMES: A follow-up for 5 years showed satisfactory recovery of function. LESSONS: This surgical revision is less invasive than conventional methods, resulting in a stable and well-functioning hip joint after mid-term follow-up for 5 years.
[Mh] Termos MeSH primário: Acetábulo/transplante
Artroplastia de Quadril/efeitos adversos
Doenças Ósseas/cirurgia
Granuloma de Células Plasmáticas/cirurgia
Ossos Pélvicos/cirurgia
[Mh] Termos MeSH secundário: Adulto
Desbridamento
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008777


  3 / 16892 MEDLINE  
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[PMID]:29465576
[Au] Autor:Diao Y; Sun Y; Wang S; Zhang F; Pan S; Liu Z
[Ad] Endereço:Department of Orthopaedics, Peking University Third Hospital, Beijing, China. Beijing Key Laboratory of Spinal Disease, Beijing, China.
[Ti] Título:Delayed epidural pseudoaneurysm following cervical laminectomy and instrumentation in a patient with canal stenosis secondary to skeletal fluorosis: A case report.
[So] Source:Medicine (Baltimore);97(8):e9883, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: The typical intraoperative presentation of vertebral artery injury (VAI) usually involves profuse bleeding and requires immediate treatment. However, an occult VAI may occur intraoperatively and result in delayed life-threatening epidural pseudoaneurysm several days postoperatively. PATIENT CONCERNS: A 21-year-old man with compressive cervical myelopathy resulting from canal stenosis of skeletal fluorosis underwent decompression of C1 to C7 and instrumentation from C2 to C7. No impressive bleeding event occurred during the operation. On postoperative day 40, progressive quadriplegia developed. DIAGNOSES: Pseudoaneurysm of the VA was established by angiography. INTERVENTIONS: After occlusion of the right VA, the patient underwent hematoma clearing. OUTCOMES: Fortunately, the patient experienced significant recovery of neurologic function after the second surgery. LESSONS: From this case, we realize even in the absence of obvious signs of VAI during a cervical operation, postoperative evaluation should be mandatory for suspected bleeding events occurring at VAI-prone sites during surgery. Moreover, the bone morphological abnormality of skeletal fluorosis was determined to be the most important risk contributing to VAI in this case. The safety limits of bone removal should be determined preoperatively to avoid the effects of bone morphological abnormalities.
[Mh] Termos MeSH primário: Falso Aneurisma/etiologia
Doenças Ósseas/complicações
Vértebras Cervicais/cirurgia
Intoxicação por Flúor/complicações
Laminectomia/efeitos adversos
Compressão da Medula Espinal/cirurgia
Estenose Espinal/cirurgia
Artéria Vertebral/lesões
[Mh] Termos MeSH secundário: Constrição Patológica
Seres Humanos
Complicações Intraoperatórias
Masculino
Complicações Pós-Operatórias
Compressão da Medula Espinal/etiologia
Estenose Espinal/etiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009883


  4 / 16892 MEDLINE  
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Texto completo SciELO Saúde Pública
[PMID]:28453030
[Au] Autor:Cortés-Muñoz C; Cardona-Arango D; Segura-Cardona Á; Garzón-Duque MO
[Ad] Endereço:Universidad CES, Medellín, Colombia, dcardona@ces.edu.co.
[Ti] Título:[Demographic, social, physical and mental factors associated with functional capacity in the elderly, Antioquia, Colombia, 2012].
[Ti] Título:Factores físicos y mentales asociados con la capacidad funcional del adulto mayor, Antioquia, Colombia, 2012..
[So] Source:Rev Salud Publica (Bogota);18(2):167-178, 2016 Apr.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:spa
[Ab] Resumo:Objective To describe the demographic, social, physical and mental health factors associated with the functional capacity of older adults in the Department of Antioquia in 2012. Materials and Methods A descriptive study with the records of 4 248 adults aged 60 years or more as the population, surveyed in the Department of Antioquia, in 2012. They were asked about their functional capacity through a Katz survey consisting of 6 items. With the independent variables, frequency measurements were calculated, along with crude and adjusted prevalence ratios (PR) with their respective 95 % CI. Results Being single, widowed or separated, presenting little or no educational level (66.4 %), suffering from hypertension (56.7 %), diabetes (16.8 %) and bone problems (22.0 %), cigarette smoking (64.6 %), nutritional risk, suffering from depression (20.1 %), or anxiety and cognitive impairment (49.6 %), impact negatively on functional capacity of older adults in Antioquia. However, younger ages, active social lives, and proper use of leisure strengthen good functional capacity in the same population group. Conclusions The results of this study indicate that there are demographic factors of physical and mental health that negatively affect the functional capacity of older adults. Therefore, training them on the issue, in order to recognize these factors and their influence on the weakening of functional capacity, is required.
[Mh] Termos MeSH primário: Nível de Saúde
Saúde Mental
Fatores Socioeconômicos
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Doenças Ósseas/epidemiologia
Colômbia/epidemiologia
Estudos Transversais
Depressão/epidemiologia
Diabetes Mellitus/epidemiologia
Feminino
Seres Humanos
Hipertensão/epidemiologia
Masculino
Meia-Idade
Estado Nutricional
Prevalência
Fatores de Risco
Fumar/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  5 / 16892 MEDLINE  
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[PMID]:29265417
[Au] Autor:Boskey AL; Imbert L
[Ad] Endereço:Mineralized Tissue Laboratory, Hospital for Special Surgery, New York, New York.
[Ti] Título:Bone quality changes associated with aging and disease: a review.
[So] Source:Ann N Y Acad Sci;1410(1):93-106, 2017 Dec.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity, and composition, including collagen structure, mineral composition, and crystal size. These factors all are known to vary with tissue and animal ages, and health status. Bone morphology and presence of microcracks, which also contribute to bone quality, will not be discussed in this review. Correlations with mechanical performance for collagen cross-linking, crystallinity, and carbonate content are contrasted with mineral content. Age-dependent changes in humans and rodents are discussed in relation to rodent models of disease. Examples are osteoporosis, osteomalacia, osteogenesis imperfecta (OI), and osteopetrosis in both humans and animal models. Each of these conditions, along with aging, is associated with increased fracture risk for distinct reasons.
[Mh] Termos MeSH primário: Envelhecimento
Densidade Óssea
Doenças Ósseas/metabolismo
Osso e Ossos/metabolismo
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Fraturas Ósseas/metabolismo
Seres Humanos
Minerais/metabolismo
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Minerals)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13572


  6 / 16892 MEDLINE  
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[PMID]:29406067
[Au] Autor:Miner MM; Heidelbaugh J; Paulos M; Seftel AD; Jameson J; Kaplan SA
[Ad] Endereço:Department of Family Medicine and Urology, The Men's Health Center, The Miriam Hospital, The Warren Alpert Medical School of Brown University, 164 Summitt Avenue, Providence, RI 02906, USA. Electronic address: Martin_Miner@Brown.edu.
[Ti] Título:The Intersection of Medicine and Urology: An Emerging Paradigm of Sexual Function, Cardiometabolic Risk, Bone Health, and Men's Health Centers.
[So] Source:Med Clin North Am;102(2):399-415, 2018 Mar.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Men's mental health and how they think about their health are critical to the future of men's health. Poor health choice patterns are established under age 50, when men are twice as likely to die than women. As the future of medicine focuses on quality and value, a better understanding of the social determinants of men's health will identify areas for improvement. The presentation of a man to a clinician's office with a sexual health complaint presents an opportunity for more complete evaluation. The future of men's health will be well served by integrated men's health centers that focus on the entire man.
[Mh] Termos MeSH primário: Medicina Interna
Saúde do Homem
Urologia
[Mh] Termos MeSH secundário: Instituições de Assistência Ambulatorial
Doenças Ósseas
Doenças Cardiovasculares
Seres Humanos
Masculino
Saúde Mental
Educação de Pacientes como Assunto
Medição de Risco
Disfunções Sexuais Fisiológicas
Disfunções Sexuais Psicogênicas
Saúde Sexual
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  7 / 16892 MEDLINE  
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[PMID]:29226660
[Au] Autor:Nakashima Y; Okazak K; Nakayama K; Okada S; Mizu-uchi H
[Ti] Título:Bone and Joint Diseases in Present and Future.
[So] Source:Fukuoka Igaku Zasshi;108(1):1-7, 2017 01.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:With the increase of elderly population, orthopaedic surgeons need to deal with the diseases related to aging, such as joint disorders and fragility fractures. The number of total joint replacements, for example, is two times more than it was 10 years ago. With these backgrounds, the Japanese Orthopaedic Association (JOA) has proposed the concept of locomotive syndrome; conditions under which the elderly have been receiving care services due to problems of the locomotive organs. To prevent geriatric or disuse syndrome, JOA is currently providing the care‒prevention programs such as the loco-check and loco-training. Recent advances in the orthopaedic fields were cited in this review article, including the topics of new biomaterials, regenerative medicine of cartilage, spinal cord injury and computer assisted orthopaedic surgery. These new technologies and knowledge are changing or have potential to change the future orthopedic medical care.
[Mh] Termos MeSH primário: Doenças Ósseas/cirurgia
Artropatias/cirurgia
[Mh] Termos MeSH secundário: Doenças Ósseas/complicações
Transtornos Neurológicos da Marcha/complicações
Seres Humanos
Artropatias/complicações
Próteses e Implantes
Regeneração
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; ENGLISH ABSTRACT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  8 / 16892 MEDLINE  
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[PMID]:28457365
[Au] Autor:Gregorini M; Sileno G; Pattonieri EF; Corradetti V; Abelli M; Ticozzelli E; Scudeller L; Grignano MA; Esposito P; Bogliolo L; Giacomoni A; Rampino T
[Ad] Endereço:Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
[Ti] Título:Understanding Bone Damage After Kidney Transplantation: A Retrospective Monocentric Cross Sectional Analysis.
[So] Source:Transplant Proc;49(4):650-657, 2017 May.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Kidney transplantation (KT) immunosuppression may induce bone tissue damage with bone mineral density (BMD) loss increasing bone fractures risk. Steroid therapy is considered the major player, but others factors are still under review. PATIENTS AND METHODS: We designed an observational retrospective cohort study to evaluate bone damage after KT. The prevalence of osteopenia, osteoporosis, bone fractures, and the associated risk factors were investigated. The following parameters were recorded before transplantation and at the last follow-up: demographic indexes, cumulative steroid dose (CSD), dialytic and transplantologic age, previous nephropathy, femoral and lumbar BMD, fractures, immunosuppressors, calcemia, phosphoremia, rejection episodes, estimated glomerular filtration rate, and parathyroid hormone and vitamin D levels. Stata software (Stata Corporation, College Station, Texas, United States) was used for the statistical analysis, to perform the Fisher's exact test, Kruskal-Wallis test, Student t test, as well as univariate and multivariate analyses. RESULTS: The analyzed cohort was composed of 297 patients (65.3% males and 34.7% females). Sixty percent of KT patients had normal BMD, 24% had osteopenia, and 15% had osteoporosis. Twelve percent were victims of bone fractures (8.4% minor, 2% femoral, and 1.7% vertebral). A significant correlation (P <.05) was observed for both osteopenia and osteoporosis with menopause, transplantologic age, CSD, previous glomerulonephritis, and mammalian target of rapamycin (mTOR) inhibitors treatment (imTOR). CONCLUSION: This study confirms the correlation between CSD (both before and after transplantation) and post-transplantation bone damage. It also shows that a large fraction of these patients had normal BMD related with a low steroid dose in our protocols. This correlation between imTOR assumption and osteoporosis deserves attention and warrants further in vitro analyses to be performed.
[Mh] Termos MeSH primário: Corticosteroides/efeitos adversos
Doenças Ósseas/epidemiologia
Doenças Ósseas/etiologia
Hospedeiro Imunocomprometido
Imunossupressores/efeitos adversos
Transplante de Rim
[Mh] Termos MeSH secundário: Adulto
Idoso
Densidade Óssea/efeitos dos fármacos
Estudos de Coortes
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Prevalência
Estudos Retrospectivos
Fatores de Risco
Texas
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  9 / 16892 MEDLINE  
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[PMID]:28469115
[Au] Autor:Babaji P; Devanna R; Jagtap K; Chaurasia VR; Jerry JJ; Choudhury BK; Duhan D
[Ad] Endereço:Department of Pedodontics, Sharavathi Dental College, Shimoga, Karnataka, India.
[Ti] Título:The cell biology and role of resorptive cells in diseases: A review.
[So] Source:Ann Afr Med;16(2):39-45, 2017 Apr-Jun.
[Is] ISSN:0975-5764
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Resorptive cells are responsible for the resorption of mineralized matrix of hard tissues. Bone-resorbing cells are called osteoclasts; however, they can resorb mineralized dental tissues or calcified cartilage and then they are called odontoclasts and chondroclasts, respectively. Resorptive cells form when mononuclear precursors derived from a monocyte-macrophage cell lineage are attracted to certain mineralized surfaces and subsequently fuse and adhere onto them for exerting their resorbing activity. These cells are responsible for degradation of calcified extracellular matrix composed of organic molecules and hydroxyapatite. The activity of these cells can be observed in both physiological and pathological processes throughout life and their activity is mainly required in bone turnover and growth, spontaneous and induced (orthodontic) tooth movement, tooth eruption, and bone fracture healing, as well as in pathological conditions such as osteoporosis, osteoarthritis, and bone metastasis. In addition, they are responsible for daily control of calcium homeostasis. Clastic cells also resorb the primary teeth for shedding before the permanent teeth erupt into the oral cavity.
[Mh] Termos MeSH primário: Calcificação Fisiológica/fisiologia
Odontogênese/fisiologia
Osteoclastos/fisiologia
[Mh] Termos MeSH secundário: Doenças Ósseas/patologia
Doenças Ósseas/fisiopatologia
Reabsorção Óssea
Seres Humanos
Dente Decíduo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4103/aam.aam_97_16


  10 / 16892 MEDLINE  
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[PMID]:28743847
[Au] Autor:Matsukawa M
[Ad] Endereço:Faculty of Science and Engineering, Doshisha University, Kyoto, Japan.
[Ti] Título:[New methods for the evaluation of bone quality. Bone Quality Evaluation by QUS.]
[So] Source:Clin Calcium;27(8):1113-1120, 2017.
[Is] ISSN:0917-5857
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The conventional ultrasonic bone densitometry systems(quantitative ultrasound:QUS)are now popular for the initial screening of osteoporosis. These systems can give us velocity(SOS)and broadband attenuation(BUA)of ultrasonic waves, which propagated in the heel. This paper describes the physical meaning of these parameters and introduces the idea of standardization, s-SOS and s-BUA. In addition, new QUS techniques for the further investigation of bone quality are also introduced. These techniques, two wave phenomenon and Axial Transmission(AT)can induce the individual properties of cortical and cancellous bones by the ultrasonic measurements.
[Mh] Termos MeSH primário: Densidade Óssea
Osso e Ossos/diagnóstico por imagem
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Doenças Ósseas/diagnóstico por imagem
Seres Humanos
Ultrassonografia/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:CliCa170811131120



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