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  1 / 2183 MEDLINE  
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[PMID]:29237407
[Au] Autor:Ajmal M; Mir A; Wahid S; Khor CC; Foo JN; Siddiqi S; Kauser M; Malik SA; Nasir M
[Ad] Endereço:Institute of Biomedical and Genetic Engineering, 24-Mauve area, G-9/1, Islamabad, 44000, Pakistan.
[Ti] Título:Identification and in silico characterization of a novel p.P208PfsX1 mutation in V-ATPase a3 subunit associated with autosomal recessive osteopetrosis in a Pakistani family.
[So] Source:BMC Med Genet;18(1):148, 2017 12 13.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Osteopetrosis is a rare inherited bone disorder mainly described as an increased bone density caused by defective osteoclastic bone resorption. To date, genetic variants of eleven genes have been reported so far to be associated with different types of osteopetrosis. However, malignant infantile osteopetrosis, a lethal form of the disease, is mostly (50%) caused by mutation(s) in TCIRG1 gene. In this study, we investigated a consanguineous Pakistani family clinically and genetically to elucidate underlying molecular basis of the infantile osteopetrosis. METHODS: DNA samples from five family members were subjected to SNP-array based whole genome homozygosity mapping. Data was analyzed and potentially pathogenic mutation was identified by Sanger sequencing of two affected as well as three phenotypically healthy individuals in the family. The significance of identified pathogenic variation and its impact on protein structure and function was studied using various bioinformatics tools. RESULTS: DNA samples from five family members were subjected to genome-wide SNP array genotyping and homozygosity mapping which identified ~4 Mb region on chr11 harboring the TCIRG1 gene. Sanger sequencing unveiled a novel homozygous deletion c. 624delC in exon 6 of the TCIRG1 gene encodes a3 subunit of V-ATPase complex. The identified deletion resulted in a frame shift producing a truncated protein of 208 aa. In silico analysis of premature termination of the a3 subunit of V-ATPase complex revealed deleterious effects on the protein structure, predicting impaired or complete loss of V-ATPase function causing infantile osteopetrosis. CONCLUSIONS: Since a3 subunit of V-ATPase complex plays a crucial role in bone resorption process, structurally abnormal a3 subunit might have adversely affected bone resorption process, leading to infantile osteopetrosis in Pakistani family. Therefore, the present study not only expands the genotypic spectrum of osteopetrosis but also improve understandings of the role of V-ATPase a3 subunit in bone resorption process. Moreover, our findings should help in genetic counseling and provide further insight into the disease pathogenesis and potential targeted therapy.
[Mh] Termos MeSH primário: Simulação por Computador
Mutação
Osteopetrose/genética
ATPases Vacuolares Próton-Translocadoras/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Reabsorção Óssea/metabolismo
Pré-Escolar
Análise Mutacional de DNA
Éxons
Genótipo
Homozigoto
Seres Humanos
Lactente
Simulação de Acoplamento Molecular
Osteopetrose/diagnóstico por imagem
Osteopetrose/fisiopatologia
Paquistão
Deleção de Sequência
ATPases Vacuolares Próton-Translocadoras/metabolismo
ATPases Vacuolares Próton-Translocadoras/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (TCIRG1 protein, human); EC 3.6.1.- (Vacuolar Proton-Translocating ATPases)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171231
[Lr] Data última revisão:
171231
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0506-4


  2 / 2183 MEDLINE  
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[PMID]:29182138
[Au] Autor:Behera P; Khurana A; Saibaba B; Aggarwal S
[Ti] Título:Dealing with sub-trochanteric fracture in a child with osteopetrosis : A case report.
[So] Source:Acta Orthop Belg;82(4):907-912, 2016 Dec.
[Is] ISSN:0001-6462
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:Osteopetrosis is a rare hereditary condition which may have autosomal recessive or autosomal dominant inheritance. Patients tend to present most commonly with fractures but involvement of cranial nerves and hematopoetic system is not uncommon. Patients with infantile and intermediate type tend to present more often with problems other than orthopaedic problems. While diagnosis can be made on the basis of radiographs, management needs to be customized for every patient. Non operative and operative management both have their advantages and disadvantages. We are here reporting a case of sub-trochanteric fracture in an eight-year-old child which was managed successfully with a dynamic hip screw (DHS). Surgery could be performed successfully by taking precautions during reduction, drilling and screw placement. At the latest follow up, which was after one and half years of surgery, the fracture had united well and the child faced no limitations of activities. Thus, open reduction and fixation with DHS can be considered as an effective management modality for pediatric sub-trochanteric fractures in osteopetrosis.
[Mh] Termos MeSH primário: Ciclismo/lesões
Fraturas do Fêmur/cirurgia
Fraturas do Quadril/cirurgia
Osteopetrose/diagnóstico por imagem
[Mh] Termos MeSH secundário: Acidentes por Quedas
Parafusos Ósseos
Criança
Fraturas do Fêmur/complicações
Fraturas do Fêmur/diagnóstico por imagem
Fraturas do Quadril/complicações
Fraturas do Quadril/diagnóstico por imagem
Seres Humanos
Masculino
Osteopetrose/complicações
Radiografia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


  3 / 2183 MEDLINE  
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[PMID]:28457121
[Au] Autor:Cainelli F; Tastanbekova V; Nurgaliev D; Lim N; Vento S
[Ad] Endereço:Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
[Ti] Título:Infantile Osteopetrosis in a Kazakh Boy.
[So] Source:Isr Med Assoc J;19(1):65-66, 2017 Jan.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Mh] Termos MeSH primário: Osteopetrose/diagnóstico
[Mh] Termos MeSH secundário: Anemia/etiologia
Hepatomegalia/etiologia
Seres Humanos
Lactente
Cazaquistão
Masculino
Doenças Raras
Esplenomegalia/etiologia
Trombocitopenia/etiologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  4 / 2183 MEDLINE  
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[PMID]:28816960
[Au] Autor:Huang J; Pan J; Xu M; Xu S
[Ad] Endereço:Department of Orthopaedics, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
[Ti] Título:Successful open reduction and internal fixation for displaced femoral fracture in a patient with osteopetrosis: Case report and lessons learned.
[So] Source:Medicine (Baltimore);96(33):e7777, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Osteopetrosis is a rare disease that predominantly occurs in descendants of inbreeding families. In the case of fractures happen in patients with osteopetrosis, the choice between operative or conservative treatment is still controversial. Open reduction and internal fixation (ORIF) is a conventional treatment for fractures, and it possesses more applicability than conservative treatment. During this surgical treatment, ensure that bone union in the right way is pivotal to success and simultaneously prevents refracture and displacement after the operation. Herein, we present a case of femoral fracture of a patient with osteopetrosis via open reduction and internal fixation. To illustrate successful factors during the treatment process, we discuss experience combined with literature review following case report. PATIENT CONCERNS: A 67-year-old man who has diagnosed with osteopetrosis over 20 years ago suffered from pain in the left hip last for more than 1 month and he was incapable of walking recently. Before this incident, he had sustained 4 femoral fractures that treated insufficiently by open reduction surgery. DIAGNOSIS: Physical, radiological, and biological examinations indicated a femoral subtrochanteric fracture that was overlapping displacement between fracture ends. INTERVENTIONS AND OUTCOMES: Treated with surgery by open reduction with internal fixation and osteotomy, the fracture united in 12 months, and he returned to walk with full weight bearing, during which no complication occurred. LESSONS: Open reduction and internal fixation is also suitable for the patient with osteopetrosis, and they have similar union ability to the normal. To guarantee successful treatment, specific strategies of operation and rehabilitation program are necessary.
[Mh] Termos MeSH primário: Fraturas do Fêmur/etiologia
Fraturas do Fêmur/cirurgia
Fixação Interna de Fraturas/métodos
Redução Aberta/métodos
Osteopetrose/complicações
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007777


  5 / 2183 MEDLINE  
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[PMID]:28655174
[Au] Autor:Wu CC; Econs MJ; DiMeglio LA; Insogna KL; Levine MA; Orchard PJ; Miller WP; Petryk A; Rush ET; Shoback DM; Ward LM; Polgreen LE
[Ad] Endereço:Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502.
[Ti] Título:Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group.
[So] Source:J Clin Endocrinol Metab;102(9):3111-3123, 2017 Sep 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Osteopetrosis encompasses a group of rare metabolic bone diseases characterized by impaired osteoclast activity or development, resulting in high bone mineral density. Existing guidelines focus on treatment of the severe infantile forms with hematopoietic cell transplantation (HCT) but do not address the management of patients with less severe forms for whom HCT is not the standard of care. Therefore, our objective was to develop expert consensus guidelines for the management of these patients. Methods: A modified Delphi method was used to build consensus among participants of the Osteopetrosis Working Group, with responses to an anonymous online survey used to identify areas of agreement and conflict and develop a follow-up survey. The strength of recommendations and quality of evidence was graded using the Grading of Recommendations Assessment, Development and Evaluation system. Results: Consensus was found in the areas of diagnosis, monitoring, and treatment. We recommend relying on characteristic radiographic findings to make the diagnosis and found that genetic testing adds important information by identifying mutations associated with unique disease complications. We recommend ongoing monitoring for changes in mineral metabolism and other complications, including cranial nerve impingement, anemia, leukopenia, and dental disease. We suggest that calcitriol should not be used in high doses and instead recommend symptom-based supportive therapy for disease complications because noninfantile osteopetrosis has no effective treatment. Conclusions: Scarcity of published studies on osteopetrosis reduce the ability to develop evidence-based guidelines for the management of these patients. Expert opinion-based guidelines for this rare condition are nevertheless important to enable improved care.
[Mh] Termos MeSH primário: Transplante de Células-Tronco Hematopoéticas/métodos
Osteopetrose/genética
Osteopetrose/terapia
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Calcitriol/uso terapêutico
Terapia Combinada
Consenso
Medicina Baseada em Evidências
Feminino
Seres Humanos
Incidência
Masculino
Osteopetrose/epidemiologia
Osteopetrose/patologia
Prognóstico
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
FXC9231JVH (Calcitriol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2017-01127


  6 / 2183 MEDLINE  
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[PMID]:28604959
[Au] Autor:Wang M; Chen T; Jin L; Qu L; Wang J; Li Y; Cheng J; Xu Z; Wang C; Gao S
[Ad] Endereço:Department of Hematology, Anhui Provincial Children's Hospital, Hefei, Anhui 230001, China. qulijun12345@qq.com.
[Ti] Título:[Analysis of TCIRG1 gene mutation in a Chinese family affected with infantile malignant osteopetrosis].
[So] Source:Zhonghua Yi Xue Yi Chuan Xue Za Zhi;34(3):377-381, 2017 Jun 10.
[Is] ISSN:1003-9406
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To detect potential mutation of the TCIRG1 gene in a boy with infantile malignant osteopetrosis. METHODS: Target sequence capture and next-generation sequencing were applied for the proband and his parents to identify the causative mutation, and Sanger sequencing was used to verify the suspected mutation. RESULTS: The proband manifested at 4 months of age with symptoms including anemia, thrombocytopenia, hepatosplenomegaly, and cephalus quadratus. X-ray revealed generalized increased bone density. A novel compound heterozygous mutation, c.796G to T (p.E266X) and c.1372G to A (p.G458S), were identified in the boy. His father and grandmother also carried the c.796G to T (p.E266X) mutation, and his mother carried the c.1372G to A (p.G458S) mutation. Neither mutation was found in the PubMed and ClinVar databases. CONCLUSION: The novel compound heterozygous mutation c.796G to T (p.E266X) and c.1372G to A (p.G458S) probably underlies the disease in the proband. Above results may enrich the mutation spectrum of the TCIRG1 gene and provide new evidence for the molecular basis of infantile malignant osteopetrosis.
[Mh] Termos MeSH primário: Doenças do Recém-Nascido/genética
Osteopetrose/genética
ATPases Vacuolares Próton-Translocadoras/genética
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Asiático
Sequência de Bases
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Dados de Sequência Molecular
Mutação
Linhagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (TCIRG1 protein, human); EC 3.6.1.- (Vacuolar Proton-Translocating ATPases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1003-9406.2017.03.014


  7 / 2183 MEDLINE  
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[PMID]:28423297
[Au] Autor:Yaga U; Panta P
[Ad] Endereço:MNR Dental College, Telangana, India maithreya.prashanth@gmail.com.
[Ti] Título:Osteopetrosis.
[So] Source:N Engl J Med;376(16):e34, 2017 Apr 20.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Osteopetrose/diagnóstico por imagem
Crânio/diagnóstico por imagem
Punho/diagnóstico por imagem
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Radiografia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1609871


  8 / 2183 MEDLINE  
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[PMID]:28233026
[Au] Autor:Saglam D; Bilgici MC; Bekçi T; Albayrak C; Albayrak D
[Ad] Endereço:Department of Radiology, School of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, Turkey. dilekuzman@hotmail.com.
[Ti] Título:Autosomal recessive osteopetrosis with a unique imaging finding: multiple encephaloceles.
[So] Source:Skeletal Radiol;46(5):701-704, 2017 May.
[Is] ISSN:1432-2161
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Osteopetrosis is a hereditary form of sclerosing bone dysplasia with various radiological and clinical presentations. The autosomal recessive type, also known as malignant osteopetrosis, is the most severe type, with the early onset of manifestations. A 5-month-old infant was admitted to our hospital with recurrent respiratory tract infections. Chest X-ray and skeletal survey revealed the classic findings of osteopetrosis, including diffuse osteosclerosis and bone within a bone appearance. At follow-up, the patient presented with, thickened calvarium, multiple prominent encephaloceles, and dural calcifications leading to the intracranial clinical manifestations with bilateral hearing and sight loss. Autosomal recessive osteopetrosis is one of the causes of encephaloceles and this finding may become dramatic if untreated.
[Mh] Termos MeSH primário: Encefalocele/complicações
Encefalocele/diagnóstico por imagem
Osteopetrose/complicações
Osteopetrose/diagnóstico por imagem
[Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem
Seres Humanos
Lactente
Imagem por Ressonância Magnética
Costelas/diagnóstico por imagem
Coluna Vertebral/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1007/s00256-017-2595-8


  9 / 2183 MEDLINE  
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[PMID]:27723141
[Au] Autor:Chiu YH; Schwarz E; Li D; Xu Y; Sheu TR; Li J; de Mesy Bentley KL; Feng C; Wang B; Wang JC; Albertorio-Saez L; Wood R; Kim M; Wang W; Ritchlin CT
[Ad] Endereço:Division of Allergy/Immunology and Rheumatology, The University of Rochester, Rochester, New York.
[Ti] Título:Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca /NFATc1 Axis.
[So] Source:J Cell Physiol;232(9):2538-2549, 2017 Sep.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:DC-STAMP is a multi-pass transmembrane protein essential for cell-cell fusion between osteoclast precursors during osteoclast (OC) development. DC-STAMP-/- mice have mild osteopetrosis and form mononuclear cells with limited resorption capacity. The identification of an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) on the cytoplasmic tail of DC-STAMP suggested a potential signaling function. The absence of a known DC-STAMP ligand, however, has hindered the elucidation of downstream signaling pathways. To address this problem, we engineered a light-activatable DC-STAMP chimeric molecule in which light exposure mimics ligand engagement that can be traced by downstream Ca signaling. Deletion of the cytoplasmic ITIM resulted in a significant elevation in the amplitude and duration of intracellular Ca flux. Decreased NFATc1 expression in DC-STAMP-/- cells was restored by DC-STAMP over-expression. Multiple biological phenotypes including cell-cell fusion, bone erosion, cell mobility, DC-STAMP cell surface distribution, and NFATc1 nuclear translocation were altered by deletion of the ITIM and adjacent amino acids. In contrast, mutations on each of the tyrosine residues surrounding the ITIM showed no effect on DC-STAMP function. Collectively, our results suggest that the ITIM on DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca axis. J. Cell. Physiol. 232: 2538-2549, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Células da Medula Óssea/metabolismo
Sinalização do Cálcio
Diferenciação Celular
Proteínas de Membrana/metabolismo
Fatores de Transcrição NFATC/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Osteoclastos/metabolismo
Osteogênese
Osteopetrose/metabolismo
[Mh] Termos MeSH secundário: Transporte Ativo do Núcleo Celular
Animais
Células da Medula Óssea/patologia
Fusão Celular
Movimento Celular
Forma Celular
Células Cultivadas
Predisposição Genética para Doença
Proteínas de Membrana/deficiência
Proteínas de Membrana/genética
Camundongos Knockout
Mutação
Proteínas do Tecido Nervoso/deficiência
Proteínas do Tecido Nervoso/genética
Osteoclastos/patologia
Osteólise/metabolismo
Osteólise/patologia
Osteólise/fisiopatologia
Osteopetrose/genética
Osteopetrose/patologia
Osteopetrose/fisiopatologia
Fenótipo
Domínios e Motivos de Interação entre Proteínas
Fatores de Tempo
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DC-STAMP protein, mouse); 0 (Membrane Proteins); 0 (NFATC Transcription Factors); 0 (Nerve Tissue Proteins); 0 (Nfatc1 protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.25638


  10 / 2183 MEDLINE  
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[PMID]:28005799
[Au] Autor:Sun HJ; Xue L; Wu CB; Zhou Q
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Heping District, Shenyang, China.
[Ti] Título:Clinical Characteristics and Treatment of Osteopetrosis Complicated by Osteomyelitis of the Mandible.
[So] Source:J Craniofac Surg;27(8):e728-e730, 2016 Nov.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteopetrosis represents a heterogeneous group of rare, hereditary bone disorders with variable clinical features, and an increase in bone density. Osteomyelitis of the jaws is a significant complication of osteopetrosis. In this article, a reported patient with osteopetrosis complicated by osteomyelitis of the mandible was examined. The patient was treated with intravenous antibiotic therapy, debridement of necrotic bone and hyperbaric oxygen therapy; in addition, the authors attempted to implant the calcium sulfate and vancomycin to reconstruct the bone defect. The patient demonstrated satisfactory healing, and no recurrence of osteomyelitis was observed during the 6-month follow-up period. The treatment of osteopetrosis complicated by osteomyelitis of the mandible is difficult. The treatment of osteopetrosis complicated by osteomyelitis is controversial. The authors recommend the following sequential treatment of osteopetrosis complicated by osteomyelitis of the mandible: systemic antibiotic therapy and hyperbaric oxygen therapy before and after surgery; debridement of the necrotic bone; sufficient periosteal coverage and adequate soft tissue to cover the wound; implantation with calcium sulfate and vancomycin to reconstruct the bone defect as much as possible, which may be helpful in treating the disease.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Desbridamento/métodos
Oxigenação Hiperbárica/métodos
Mandíbula
Osteomielite/cirurgia
Osteopetrose/cirurgia
[Mh] Termos MeSH secundário: Idoso
Densidade Óssea
Feminino
Seres Humanos
Injeções Intravenosas
Osteomielite/diagnóstico
Osteomielite/etiologia
Osteopetrose/complicações
Osteopetrose/diagnóstico
Recidiva
Cicatrização
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003048



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