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[PMID]:29304057
[Au] Autor:Lavado-García J; Roncero-Martin R; Moran JM; Pedrera-Canal M; Aliaga I; Leal-Hernandez O; Rico-Martin S; Canal-Macias ML
[Ad] Endereço:Metabolic Bone Diseases Research Group (GIEMO), Nursing Department, University of Extremadura, Caceres, Spain.
[Ti] Título:Long-chain omega-3 polyunsaturated fatty acid dietary intake is positively associated with bone mineral density in normal and osteopenic Spanish women.
[So] Source:PLoS One;13(1):e0190539, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The regular consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) results in general health benefits. The intake of LCO3-PUFAs has been reported to contribute to bone metabolism. We aimed to investigate the relationships between dietary intakes of LCO3-PUFAs and bone mineral density (BMD) in Spanish women aged 20-79 years old. A total of 1865 female subjects (20-79 years old) were enrolled, and lumbar (L2, L3, L3 and total spine), hip (femoral neck (FN), femoral trochanter (FT) and Ward's triangle (WT)) bone mineral density (BMD) were measured by dual energy X-ray absorptiometry (DXA). Dietary intakes of total energy, calcium, vitamin D, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and n-6 fatty acids (linoleic acid (LA) and arachidonic acid (AA)) were assessed by a self-administered food frequency questionnaire (FFQ). Spearman's rank correlations between LCO3-PUFAs and BMD were estimated. Partial correlations controlling for age, weight, height, dietary calcium, vitamin D, menopausal status and energy were calculated. A multiple regression analysis was computed to assess significant associations with BMD in this population. After adjustment for potential confounding factors, there were positive correlations between ALA, EPA and DHA intake and BMD. According to the WHO diagnosis criteria for osteoporosis, in this population of normal and osteopenic women, the dietary intake of ALA was also significantly associated with BMD at the hip. In normal women, the dietary intake of DHA was also significantly associated with BMD at the lumbar spine. No significant associations between LCO3-PUFAs and BMD were detected in the lumbar spine of osteopenic or osteoporotic women. The dietary intake of LCO3-PUFAs was positively associated with BMD in Spanish women at both the hips and the lumbar spine. We highlight that the intake of LCO3-PUFAs is not significantly associated with BMD in osteoporotic women; however, the intake of LCO3-PUFAs seems to be positively associated with BMD at both the hips and the lumbar spine in normal and osteopenic women.
[Mh] Termos MeSH primário: Densidade Óssea
Doenças Ósseas Metabólicas/prevenção & controle
Gorduras Insaturadas na Dieta/administração & dosagem
Ácidos Graxos Ômega-3/administração & dosagem
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Estudos de Casos e Controles
Estudos de Coortes
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats, Unsaturated); 0 (Fatty Acids, Omega-3)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190539


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[PMID]:29182822
[Au] Autor:Basic-Jukic N; Pavlovic D; Smalcelj R; Tomic-Brzac H; Orlic L; Radic J; Vujicic B; Lovcic V; Pavic E; Klaric D; Gulin M; Spasovski G; Ljutic D; Danic D; Prgomet D; Resic H; Ratkovic M; Kes P; Racki S
[Ti] Título:[[GUIDELINES FOR THE PREVENTION, MONITORING AND THERAPY OF CHRONIC KIDNEY DISEASE-METABOLIC BONE DISEASE IN PATIENTS WITH CHRONIC KIDNEY DISEASE].]
[So] Source:Lijec Vjesn;138(5-6):107-120, 2016 May.
[Is] ISSN:0024-3477
[Cp] País de publicação:Croatia
[La] Idioma:hrv
[Ab] Resumo:Chronic kidney disease (CKD) is a systemic disease with numerous complications associated with increased morbidity and mortality. Chronic kidney disease-metabolic bone disease (CKD-MBD) starts at early stages of CKD with phosphorus accumulation and consequent initiation of numerous events that result with the development of secondary hyperparathyroidism with changes on bones and extraskeletal tissues. The most important and clinically most relevant consequences of CKD-MBD are vascular calcifications which contribute to cardiovascular mortality. Patients with the increased risk for the development of CKD-MBD should be recognized and treated. Prevention is the most important therapeutic option. The first step should be nutritional counseling with vitamin supplementation if necessary and correction of mineral status. Progression of CKD requires more intensive medicamentous treatment with the additional correction of metabolic acidosis and anemia. Renal replacement therapy should be timely initiated, with the adequate dose of dislaysis. Ideally, preemptive renal transplantion should be offered in individuals without contraindication for immunosuppressive therapy.
[Mh] Termos MeSH primário: Doenças Ósseas Metabólicas
Administração dos Cuidados ao Paciente
Insuficiência Renal Crônica
[Mh] Termos MeSH secundário: Doenças Ósseas Metabólicas/diagnóstico
Doenças Ósseas Metabólicas/etiologia
Doenças Ósseas Metabólicas/prevenção & controle
Doenças Ósseas Metabólicas/terapia
Croácia
Progressão da Doença
Diagnóstico Precoce
Seres Humanos
Monitorização Fisiológica/métodos
Administração dos Cuidados ao Paciente/métodos
Administração dos Cuidados ao Paciente/organização & administração
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/diagnóstico
Insuficiência Renal Crônica/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:27771736
[Au] Autor:Wang J; Ishimoto T; Nakano T
[Ad] Endereço:School of Material Science and Engineering, Zhengzhou University, Zhengzhou, 450001, China.
[Ti] Título:Unloading-Induced Degradation of the Anisotropic Arrangement of Collagen/Apatite in Rat Femurs.
[So] Source:Calcif Tissue Int;100(1):87-94, 2017 Jan.
[Is] ISSN:1432-0827
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The specific orientation of collagen and biological apatite (BAp) is an anisotropic feature of bone micro-organization; it is an important determinant of bone mechanical function and performance under anisotropic stress. However, it is poorly understood how this microstructure orientation is altered when the mechanical environment changes. We hypothesized that the preferential orientation of collagen/BAp would change in response to changes in mechanical conditions, similar to the manner in which bone mass and bone shape change. In the present study, we investigated the effect of unloading (removal of anisotropic stress) on the preferential orientation of collagen/BAp using a rat sciatic neurectomy model. Bone tissue that formed under unloaded conditions showed a more disordered collagen/BAp orientation than bone tissue that formed under physiological conditions. Coincidentally, osteocytes in unloaded bone displayed spherical morphology and random alignment. To the best of our knowledge, this study is the first to demonstrate the degradation of preferential collagen/BAp orientation in response to unloading conditions. In summary, we identified alterations in bone material anisotropy as an important aspect of the bone's response to unloading, which had previously been examined with regard to bone loss only.
[Mh] Termos MeSH primário: Apatitas/metabolismo
Colágeno/metabolismo
Fêmur/metabolismo
Osteócitos/metabolismo
[Mh] Termos MeSH secundário: Animais
Anisotropia
Densidade Óssea/fisiologia
Doenças Ósseas Metabólicas/metabolismo
Osso e Ossos/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apatites); 9007-34-5 (Collagen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1007/s00223-016-0200-0


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[PMID]:28471445
[Au] Autor:Wang L; Zhou F; Zhang P; Wang H; Qu Z; Jia P; Yao Z; Shen G; Li G; Zhao G; Li J; Mao Y; Xie Z; Xu W; Xu Y; Xu Y
[Ad] Endereço:Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
[Ti] Título:Human type H vessels are a sensitive biomarker of bone mass.
[So] Source:Cell Death Dis;8(5):e2760, 2017 May 04.
[Is] ISSN:2041-4889
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vascularization is fundamental for bone formation and bone tissue homeostasis. However, in human subjects, a direct molecular relationship has not been identified between angiogenesis and agents that promote bone disease or factors related to age. Osteopenia is a condition in which bone mineral density is lower than normal, and it represents a sign of normal aging. Here we tested whether the type H vessel, which was recently identified as strongly positive for CD31 and Endomucin (CD31 Emcn ) in mice, is an important indicator of aging and osteopenia in human subjects. We found that age-dependent losses of type H vessels in human bone sections conform to the observations in aged mice. The abundance of human type H vessels and osteoprogenitors may be relevant to changes in the skeletal microarchitecture and advanced osteopenia. Furthermore, ovariectomized mice, a widely used model for postmenopausal osteoporosis, exhibited significantly reduced type H vessels accompanied by reduced osteoprogenitors, which is consistent with impaired bone microarchitecture and osteoporosis, suggesting that this feature is an indicator of bone mass independent of aging. More importantly, administration of desferrioxamine led to significantly increased bone mass via enhanced angiogenesis and increased type H vessels in ovariectomized mice. Altogether, these data represent a novel finding that type H vessels are regulated in aged and osteopenia subjects. The abundance of human type H vessels is an early marker of bone loss and represents a potential target for improving bone quality via the induction of type H vessels.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Vasos Sanguíneos/metabolismo
Densidade Óssea/fisiologia
Osso e Ossos/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Envelhecimento
Animais
Vasos Sanguíneos/patologia
Doenças Ósseas Metabólicas/metabolismo
Doenças Ósseas Metabólicas/patologia
Osso e Ossos/diagnóstico por imagem
Osso e Ossos/patologia
Modelos Animais de Doenças
Fêmur/irrigação sanguínea
Fêmur/metabolismo
Fêmur/patologia
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Meia-Idade
Osteoporose/metabolismo
Osteoporose/patologia
Osteoporose/veterinária
Sialoglicoproteínas/metabolismo
Células-Tronco/metabolismo
Células-Tronco/patologia
Tíbia/irrigação sanguínea
Tíbia/metabolismo
Tíbia/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (EMCN protein, human); 0 (Sialoglycoproteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1038/cddis.2017.36


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[PMID]:28458076
[Au] Autor:Ding Z; Chen Y; Wang X; Zhou X; Xu Y; Ma Z; Sun Y; Jiang M
[Ad] Endereço:Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, PR China; Department of Automation, University of Science and Technology of China, Hefei, Anhui, PR China.
[Ti] Título:A comparison of bone quality and its determinants in young opioid-dependent women with healthy control group.
[So] Source:Drug Alcohol Depend;175:232-236, 2017 06 01.
[Is] ISSN:1879-0046
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Little is known about bone quality and its determinants in patients with opioid addiction. The goal of this study was to compare bone quality and its determinants in young opioid addicted women with a local group of young healthy women. METHOD: Using cross-sectional design, 104 women (mean age 29.9 yrs, range: 20-40 yrs, SD=7.8) with previous opioid addiction and current methadone substitution (3-30mg, daily) for 1-16 weeks were compared to 117 healthy women (mean age 31.0 yrs, range: 20-40 yrs, SD=5.9). Bone quality was examined with quantitative ultrasound. Anthropometric characteristics (body weight, fat free mass (FFM), fat mass) were obtained by bioelectrical impedance analysis. Substance use and other risk factors for low bone quality were assessed by questionnaire-based interviews. RESULTS: More than one-quarter (34%) of patients had osteopenia (n=31) or osteoporosis (n=4), compared to 16% of the healthy control group having osteopenia (n=18). Bivariate correlation analysis demonstrated that age, body weight, and FFM correlated with bone quality (p<0.05) in healthy women, which were not found in patients. Multivariate analyses showed that in healthy controls, the determinants of bone quality were age, body height, physical activity, and BMI, but in patients, the determinant of bone quality was duration of drug intake. CONCLUSIONS: Long-term opioid dependence in young women may lead to low bone quality. Efforts to increase awareness of low bone quality in young opioid addicted women should be considered so that effective treatment may be employed to lower future fracture risk.
[Mh] Termos MeSH primário: Doenças Ósseas Metabólicas/induzido quimicamente
Osso e Ossos/efeitos dos fármacos
Transtornos Relacionados ao Uso de Opioides/fisiopatologia
Osteoporose/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Analgésicos Opioides/uso terapêutico
Composição Corporal/efeitos dos fármacos
Estatura/efeitos dos fármacos
Índice de Massa Corporal
Peso Corporal/efeitos dos fármacos
Estudos de Casos e Controles
Estudos Transversais
Exercício
Feminino
Seres Humanos
Metadona/uso terapêutico
Transtornos Relacionados ao Uso de Opioides/complicações
Transtornos Relacionados ao Uso de Opioides/tratamento farmacológico
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:27772638
[Au] Autor:Collins AJ; Chan CT
[Ad] Endereço:Minneapolis Medical Research Foundation and University of Minnesota, Minneapolis, Minnesota. Electronic address: acollins@cdrg.org.
[Ti] Título:Intensive Hemodialysis: Time to Give the Therapy Greater Consideration.
[So] Source:Am J Kidney Dis;68(5 Suppl 1):S1-S4, 2016 11.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Falência Renal Crônica/terapia
Diálise Renal/métodos
[Mh] Termos MeSH secundário: Doenças Ósseas Metabólicas
Nível de Saúde
Insuficiência Cardíaca
Seres Humanos
Hipertensão
Hipertrofia Ventricular Esquerda
Qualidade de Vida
Fatores de Tempo
Estados Unidos
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29100095
[Au] Autor:Nguyen TTM; Murakami Y; Sheridan E; Ehresmann S; Rousseau J; St-Denis A; Chai G; Ajeawung NF; Fairbrother L; Reimschisel T; Bateman A; Berry-Kravis E; Xia F; Tardif J; Parry DA; Logan CV; Diggle C; Bennett CP; Hattingh L; Rosenfeld JA; Perry MS; Parker MJ; Le Deist F; Zaki MS; Ignatius E; Isohanni P; Lönnqvist T; Carroll CJ; Johnson CA; Gleeson JG; Kinoshita T; Campeau PM
[Ad] Endereço:Centre Hospitalier Universitaire Sainte Justine Research Center, University of Montreal, Montreal, QC H3T1C5, Canada.
[Ti] Título:Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia.
[So] Source:Am J Hum Genet;101(5):856-865, 2017 Nov 02.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Approximately one in every 200 mammalian proteins is anchored to the cell membrane through a glycosylphosphatidylinositol (GPI) anchor. These proteins play important roles notably in neurological development and function. To date, more than 20 genes have been implicated in the biogenesis of GPI-anchored proteins. GPAA1 (glycosylphosphatidylinositol anchor attachment 1) is an essential component of the transamidase complex along with PIGK, PIGS, PIGT, and PIGU (phosphatidylinositol-glycan biosynthesis classes K, S, T, and U, respectively). This complex orchestrates the attachment of the GPI anchor to the C terminus of precursor proteins in the endoplasmic reticulum. Here, we report bi-allelic mutations in GPAA1 in ten individuals from five families. Using whole-exome sequencing, we identified two frameshift mutations (c.981_993del [p.Gln327Hisfs 102] and c.920delG [p.Gly307Alafs 11]), one intronic splicing mutation (c.1164+5C>T), and six missense mutations (c.152C>T [p.Ser51Leu], c.160_161delinsAA [p.Ala54Asn], c.527G>C [p.Trp176Ser], c.869T>C [p.Leu290Pro], c.872T>C [p.Leu291Pro], and c.1165G>C [p.Ala389Pro]). Most individuals presented with global developmental delay, hypotonia, early-onset seizures, cerebellar atrophy, and osteopenia. The splicing mutation was found to decrease GPAA1 mRNA. Moreover, flow-cytometry analysis of five available individual samples showed that several GPI-anchored proteins had decreased cell-surface abundance in leukocytes (FLAER, CD16, and CD59) or fibroblasts (CD73 and CD109). Transduction of fibroblasts with a lentivirus encoding the wild-type protein partially rescued the deficiency of GPI-anchored proteins. These findings highlight the role of the transamidase complex in the development and function of the cerebellum and the skeletal system.
[Mh] Termos MeSH primário: Aciltransferases/genética
Atrofia/genética
Doenças Ósseas Metabólicas/genética
Deficiências do Desenvolvimento/genética
Epilepsia/genética
Glicoproteínas de Membrana/genética
Mutação/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alelos
Cerebelo/patologia
Criança
Pré-Escolar
Exoma/genética
Feminino
Fibroblastos/patologia
Glicosilfosfatidilinositóis/genética
Seres Humanos
Masculino
Hipotonia Muscular/genética
Linhagem
RNA Mensageiro/genética
Convulsões/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GPAA1 protein, human); 0 (Glycosylphosphatidylinositols); 0 (Membrane Glycoproteins); 0 (RNA, Messenger); EC 2.3.- (Acyltransferases); EC 2.3.2.- (COOH-terminal signal transamidase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


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[PMID]:28973122
[Au] Autor:Lyon J
[Ti] Título:Study Questions Use of Acid Suppressors to Curb Mild Infant Reflux.
[So] Source:JAMA;318(15):1427-1428, 2017 Oct 17.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças Ósseas Metabólicas/induzido quimicamente
Refluxo Gastroesofágico/tratamento farmacológico
Antagonistas dos Receptores Histamínicos H2/efeitos adversos
Inibidores da Bomba de Prótons/efeitos adversos
[Mh] Termos MeSH secundário: Esofagite Péptica/tratamento farmacológico
Esofagite Péptica/etiologia
Refluxo Gastroesofágico/complicações
Antagonistas dos Receptores Histamínicos H2/uso terapêutico
Seres Humanos
Lactente
Inibidores da Bomba de Prótons/uso terapêutico
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Histamine H2 Antagonists); 0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.12160


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[PMID]:28911171
[Au] Autor:Ho L; Wang L; Roth TM; Pan Y; Verdin EM; Hsiao EC; Nissenson RA
[Ad] Endereço:Endocrine Research Unit, VA Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, San Francisco, California 94158.
[Ti] Título:Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.
[So] Source:Endocrinology;158(9):2741-2753, 2017 Sep 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sirtuin-3 (Sirt3) is an essential metabolic regulatory enzyme that plays an important role in mitochondrial metabolism, but its role in bone marrow and skeletal homeostasis remains largely unknown. In this study, we hypothesize that increased expression of Sirt3 plays a role in skeletal aging. Using mice that overexpress Sirt3 [i.e., Sirt3 transgenic (Sirt3Tg)], we show that Sirt3 is a positive regulator of adipogenesis and osteoclastogenesis and a negative regulator of skeletal homeostasis. Sirt3Tg mice exhibited more adipocytes in the tibia compared with control mice. Bone marrow stromal cells (BMSCs) from Sirt3Tg mice displayed an enhanced ability to differentiate into adipocytes compared with control BMSCs. We found a 2.5-fold increase in the number of osteoclasts on the bone surface in Sirt3Tg mice compared with control mice (P < 0.03), and increased osteoclastogenesis in vitro. Importantly, Sirt3 activates the mechanistic target of rapamycin (mTOR) pathway to regulate osteoclastogenesis. Sirt3Tg male mice exhibited a significant reduction in cortical thickness at the tibiofibular junction (P < 0.05). In summary, Sirt3 activity in bone marrow cells is associated with increased adipogenesis, increased osteoclastogenesis through activation of mTOR signaling, and reduced bone mass. Interestingly, Sirt3 expression in bone marrow cells increases during aging, suggesting that Sirt3 promotes age-related adipogenesis and osteoclastogenesis associated with bone loss. These findings identify Sirt3 as an important regulator of adipogenesis and skeletal homeostasis in vivo and identify Sirt3 as a potential target for the treatment of osteoporosis.
[Mh] Termos MeSH primário: Adipogenia/genética
Envelhecimento/fisiologia
Osteoclastos/fisiologia
Osteogênese/genética
Osteoporose/genética
Sirtuína 3/fisiologia
[Mh] Termos MeSH secundário: Animais
Doenças Ósseas Metabólicas/genética
Doenças Ósseas Metabólicas/metabolismo
Doenças Ósseas Metabólicas/patologia
Células Cultivadas
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Osteoblastos/fisiologia
Osteoporose/metabolismo
Osteoporose/patologia
Sirtuína 3/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sirt3 protein, mouse); EC 3.5.1.- (Sirtuin 3)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1210/en.2016-1739


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[PMID]:28893586
[Au] Autor:Hwang YH; Son YJ; Paik MJ; Yee ST
[Ad] Endereço:College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon, 540-950, Republic of Korea.
[Ti] Título:Effects of diisononyl phthalate on osteopenia in intact mice.
[So] Source:Toxicol Appl Pharmacol;334:120-128, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteopenia is characterized by bone loss and deterioration of trabecular bone, which leads to osteoporotic fractures. This disease is highly prevalent in industrialized areas and is associated with exposure to endocrine disrupting chemicals (EDCs). Diisononyl phthalate (DINP) is one of these EDCs and is mainly used as a plasticizer in flexible polyvinyl chloride (PVC) products. Although it is well known that exposure to DINP is harmful to humans, no studies have been reported concerning its contribution to osteopenia. Therefore, in this study, we injected DINP (2, 20, and 200mg/kg) into C3H/HeN mice for 6weeks and found that the uterus weight, bone (femur and tibia) weight, and bone length of the DINP-exposed mice were reduced compared to those of the SHAM group. On the other hand, body weight, the serum alkaline phosphatase (ALP) and inorganic phosphorus (IP) levels in the DINP treated mice were increased compared with those of the SHAM group. The tartrate-resistant acid phosphatase (TRAP) activity (bone resorption marker) was increased and the bone alkaline phosphatase (BALP) activity was lowered by the treatment with DINP as compared with the SHAM group. Furthermore, the microarchitecture of the femur and tibia in the intact mice was destroyed by the DINP injection. The tissue volume (TV), bone volume (BV), BV/TV, bone surface (BS), BS/TV, trabecular thickness (Tb.Th), and trabecular number (Tb.N) were reduced and the trabecular pattern factor (Tb.Pf), structure model index (SMI), and trabecular separation (Tb.Sp) were increased by the DINP injection. The bone mineral density (BMD) of the femur and tibia was lower in the DINP group than in the SHAM group. These results indicate that DINP contributes to an increased risk of osteopenia via destruction of the microarchitecture and enhancement of osteoclast activity.
[Mh] Termos MeSH primário: Doenças Ósseas Metabólicas/induzido quimicamente
Osso e Ossos/efeitos dos fármacos
Osso e Ossos/patologia
Ácidos Ftálicos/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Biomarcadores
Peso Corporal/efeitos dos fármacos
Densidade Óssea/efeitos dos fármacos
Relação Dose-Resposta a Droga
Esquema de Medicação
Feminino
Camundongos
Camundongos Endogâmicos C3H
Estrutura Molecular
Ovariectomia
Ácidos Ftálicos/administração & dosagem
Ácidos Ftálicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Phthalic Acids); 4010KIX4CK (diisononyl phthalate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE



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