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[PMID]:28288232
[Au] Autor:Zúñiga M; Galindo A; Galaz MI; Vivanco M; Romero P; Balboa P; Torrejón C
[Ad] Endereço:Departamentos de Pediatría y Cirugía Norte, Hospital Roberto del Río, Universidad de Chile, Santiago, Chile.
[Ti] Título:[Tenofovir-associated Fanconi`s syndrome and rickets in a HIV infected girl].
[Ti] Título:Síndrome de Fanconi y raquitismo hipofosfatémico asociado al uso de tenofovir en una niña infectada con VIH..
[So] Source:Rev Chil Pediatr;88(1):148-152, 2017 Feb.
[Is] ISSN:0717-6228
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:Tenofovir (TDF) is an inhibitor of reverse transcriptase nucleotide analogue, although it has good tolerability and high anti-retroviral activity, its effect on the kidney has been a concern. OBJECTIVE: To describe a girl infected with HIV who presented Fanconi syndrome during antiretroviral therapy with TDF. CLINICAL CASE: We describe a HIV-1-infected girl, who after 18 months treatment with TDF presented loss of strength and pain of the lower extremities with functional impairment. Laboratory findings were consistent with Fanconi syndrome. Radiographs showed bilateral hip fracture and wrists. Full recovery of Fanconi syndrome was achieved four months after changing antiretroviral therapy. CONCLUSIONS: TDF-prescribing physicians must be prepared to detect signs and symptoms of renal dysfunction and immediately consider switching to another antiviral drug.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/efeitos adversos
Síndrome de Fanconi/induzido quimicamente
Raquitismo/induzido quimicamente
Tenofovir/efeitos adversos
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/administração & dosagem
Criança
Síndrome de Fanconi/diagnóstico
Feminino
Infecções por HIV/tratamento farmacológico
Seres Humanos
Tenofovir/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 99YXE507IL (Tenofovir)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:27922335
[Au] Autor:Creo AL; Thacher TD; Pettifor JM; Strand MA; Fischer PR
[Ad] Endereço:a Department of Pediatric and Adolescent Medicine , Mayo Clinic , Rochester , MN , USA.
[Ti] Título:Nutritional rickets around the world: an update.
[So] Source:Paediatr Int Child Health;37(2):84-98, 2017 May.
[Is] ISSN:2046-9055
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Worldwide, nutritional rickets continues to be an evolving problem with several causes. This paper provides an updated literature review characterising the prevalence, aetiology, pathophysiology and treatment of nutritional rickets worldwide. A systematic review of articles on nutritional rickets from various geographical regions was undertaken. For each region, key information was extracted, including prevalence, cause of rickets specific to the region, methods of confirming the diagnosis and current treatment and preventive measures. Calcium deficiency continues to be a major cause of rickets in Africa and Asia. Vitamin D deficiency rickets is perhaps increasing in the Americas, Europe and parts of the Middle East. There continues to be a distinct presentation of calcium-predominant versus vitamin D predominant rickets, although there are overlapping features. More careful diagnosis of rickets and reporting of 25-OHD concentrations has improved accurate knowledge of rickets prevalence and better delineated the cause. Nutritional rickets continues to be an evolving and multi-factorial problem worldwide. It is on a spectrum, ranging from isolated vitamin D deficiency to isolated calcium deficiency. Specific areas which require emphasis include a consistent community approach to screening and diagnosis, vitamin D supplementation of infants and at-risk children, prevention of maternal vitamin D deficiency and the provision of calcium in areas with low calcium diets.
[Mh] Termos MeSH primário: Desnutrição/complicações
Raquitismo/epidemiologia
Raquitismo/patologia
[Mh] Termos MeSH secundário: Cálcio/deficiência
Saúde Global
Seres Humanos
Prevalência
Raquitismo/terapia
Deficiência de Vitamina D
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.1080/20469047.2016.1248170


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[PMID]:27820122
[Au] Autor:Crossen SS; Zambrano E; Newman B; Bernstein JA; Messner AH; Bachrach LK; Twist CJ
[Ad] Endereço:Divisions of *Pediatric Endocrinology and Diabetes §Medical Genetics ¶Pediatric Hematology and Oncology Departments of †Pathology ‡Radiology ∥Otolaryngology, Stanford University School of Medicine, Stanford, CA.
[Ti] Título:Tumor-induced Osteomalacia in a 3-Year-Old With Unresectable Central Giant Cell Lesions.
[So] Source:J Pediatr Hematol Oncol;39(1):e21-e24, 2017 Jan.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tumor-induced osteomalacia (TIO) is a rare cause of hypophosphatemia involving overproduction of fibroblast growth factor 23. TIO has been described largely in adults with small mesenchymal tumors. We report a case of TIO in a child who presented with knee pain and radiographic findings concerning for rickets, and was found to have maxillomandibular giant cell lesions. The patient was treated with oral phosphorus and calcitriol, surgical debulking, and intralesional corticosteroids, which resulted in tumor regression and normalization of serum fibroblast growth factor 23 and phosphorus. This case illustrates the occurrence of this rare paraneoplastic syndrome in children and adds to our knowledge about clinical manifestations and pathologic findings associated with pediatric TIO.
[Mh] Termos MeSH primário: Tumores de Células Gigantes/complicações
Neoplasias Mandibulares/complicações
Neoplasias Maxilares/complicações
Osteomalacia/etiologia
Síndromes Paraneoplásicas/etiologia
[Mh] Termos MeSH secundário: Alopecia/etiologia
Calcitriol/uso terapêutico
Pré-Escolar
Terapia Combinada
Procedimentos Cirúrgicos de Citorredução
Diagnóstico Diferencial
Fatores de Crescimento de Fibroblastos/biossíntese
Genu Valgum/etiologia
Tumores de Células Gigantes/tratamento farmacológico
Tumores de Células Gigantes/secreção
Tumores de Células Gigantes/cirurgia
Seres Humanos
Hipofosfatemia/etiologia
Injeções Intralesionais
Masculino
Neoplasias Mandibulares/tratamento farmacológico
Neoplasias Mandibulares/secreção
Neoplasias Mandibulares/cirurgia
Neoplasias Maxilares/tratamento farmacológico
Neoplasias Maxilares/secreção
Neoplasias Maxilares/cirurgia
Proteínas de Neoplasias/biossíntese
Úlceras Orais/etiologia
Osteomalacia/diagnóstico
Osteomalacia/tratamento farmacológico
Síndromes Paraneoplásicas/diagnóstico
Síndromes Paraneoplásicas/tratamento farmacológico
Fósforo/uso terapêutico
Raquitismo/diagnóstico
Triancinolona/administração & dosagem
Triancinolona/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neoplasm Proteins); 0 (fibroblast growth factor 23); 1ZK20VI6TY (Triamcinolone); 27YLU75U4W (Phosphorus); 62031-54-3 (Fibroblast Growth Factors); FXC9231JVH (Calcitriol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


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[PMID]:27798933
[Au] Autor:Ertl DA; Raimann A; Csaicsich D; Patsch JM; Laccone F; Haeusler G
[Ad] Endereço:University Clinic for Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
[Ti] Título:A Pediatric Patient with a CYP24A1 Mutation: Four Years of Clinical, Biochemical, and Imaging Follow-Up.
[So] Source:Horm Res Paediatr;87(3):196-204, 2017.
[Is] ISSN:1663-2826
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A female infant was admitted to hospital due to failure to thrive. She presented hypercalcemia (4.09 mmol/L, normal range: 2.2-2.65 mmol/L), high 25-hydroxyvitamin D (283 nmol/L, normal range: 75-250 nmol/L), 1,25-dihydroxyvitamin D in the upper normal range, and low parathyroid hormone. Vitamin D intoxication was suspected. The patient had received routine rickets prophylaxis. METHODS: Williams-Beuren syndrome was genetically excluded. Sequencing of CYP24A1 showed 2 mutations: c.443T>C and c.1186C>T. RESULTS: The patient's clinical status improved after intravenous rehydration, cessation of supplementation, and on a low-calcium diet. 25-Hydroxyvitamin D concentrations normalized within days, while 1,25-dihydroxyvitamin D remained in the upper normal range. We also investigated our patient's bone health. CONCLUSION: The patient was hospitalized initially on suspicion of vitamin D intoxication but proved to be a case of compound heterozygosity. Data on the long-term clinical and biochemical evolution of patients with idiopathic infantile hypercalcemia are sparse. Our follow-up showed seasonal variations of vitamin D and calcium parameters, with no influence on kidney function or bone health for the investigated period.
[Mh] Termos MeSH primário: Hipercalcemia/genética
Hipercalcemia/terapia
Mutação Puntual
Raquitismo/genética
Raquitismo/terapia
Vitamina D3 24-Hidroxilase/genética
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Lactente
Vitamina D3 24-Hidroxilase/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.15.16 (CYP24A1 protein, human); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE
[do] DOI:10.1159/000450947


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[PMID]:27691906
[Au] Autor:Dittmer KE; Morley RE; Smith RL
[Ad] Endereço:a Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11222, Palmerston North , New Zealand.
[Ti] Título:Skeletal deformities associated with nutritional congenital rickets in newborn lambs.
[So] Source:N Z Vet J;65(1):51-55, 2017 Jan.
[Is] ISSN:1176-0710
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CASE HISTORY: A group of 545 pregnant rising 2-year-old Coopdale ewes on a Southland sheep farm were grazed over winter on a fodder beet (Beta vulgaris) crop. Subsequently, 45 out of approximately 750 lambs were born with a variety of skeletal deformities, including shortened limbs, varus and valgus angular limb deformities, palmar grade stance and cranial bowing of the carpus. Analysis of the crop showed the fodder beet contained a low percentage of phosphorus. In addition, 60 out of 460 rising 2-year-old ewes that had been grazed on the fodder beet crop as 1-year-olds had incisor abnormalities and malocclusion. PATHOLOGICAL FINDINGS: Two affected lambs (1-day-old and 3-days-old) with representative clinical signs examined postmortem were found to have markedly enlarged costochondral junctions, and noticeably enlarged long bone metaphyses. In addition, one lamb had a dense band of metaphyseal sclerosis beneath the physes of all long bones examined. Histopathological findings included small islands and columns of chondrocytes and eosinophilic cartilage matrix present in the metaphysis. Metaphyseal trabeculae were disorganised and often lined by accumulations of pale pink osteoid; similar pale pink osteoid was also present in the cortices. Unerupted molar teeth in the affected lambs lacked a layer of enamel, and the dentine was irregular with globular basophilia. DIAGNOSIS: The gross and histopathological lesions were consistent with a diagnosis of rickets. CLINICAL RELEVANCE: Nutritional congenital rickets has not been previously diagnosed in sheep, but is a recognised disease of human infants with vitamin D deficient mothers. The rickets in affected lambs was most likely associated with phosphorus deficiency as a result of the pregnant ewes grazing fodder beet during gestation. While vitamin D deficiency was not definitively ruled out in these cases, practitioners are alerted to the possible effects of feeding phosphorus-deficient fodder beet to ewes for long periods during gestation and to 1-year-old sheep during important growth periods.
[Mh] Termos MeSH primário: Raquitismo/veterinária
Doenças dos Ovinos/congênito
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/patologia
Anormalidades Múltiplas/veterinária
Ração Animal
Fenômenos Fisiológicos da Nutrição Animal
Animais
Feminino
Anormalidades Musculoesqueléticas/patologia
Anormalidades Musculoesqueléticas/veterinária
Raquitismo/congênito
Ovinos
Doenças dos Ovinos/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:27550890
[Au] Autor:Chatterjee D; Swamy MK; Gupta V; Sharma V; Sharma A; Chatterjee K
[Ad] Endereço:Vardhaman Mahavir Medical College, Department of Orthopedics, New Delhi, India Phone: 9007930192 E-mail: daipayan27@yahoo.co.in.
[Ti] Título:Safety and Efficacy of Stosstherapy in Nutritional Rickets.
[So] Source:J Clin Res Pediatr Endocrinol;9(1):63-69, 2017 Mar 01.
[Is] ISSN:1308-5735
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Stosstherapy has been used since early 19 century for treating nutritional rickets. However, there are no clear cut guidelines for the biochemical monitoring of this treatment. Repeated blood tests at short intervals increase the cost of therapy and noncompliance. METHODS: A prospective study was conducted on 191 cases of nutritional rickets below 10 years of age to evaluate the effectivity of stosstherapy. All cases were treated with a single intramuscular injection of vitamin D (600.000 IU) along with oral calcium (50 mg/kg) and vitamin D (400 IU per day) until radiological resolution. Dietary modifications and adequate sunlight exposure were also recommended. RESULTS: The mean age of presentation was 2 years 9 months. Mean sunlight exposure was 17 minutes/week with 90% having low sunlight exposure (<30 minutes/week). Prolonged breast feeding (>6 months) was found in 93.7% of the cases. With treatment, the clinical features started resolving by 1 month with complete resolution of most of the features over a period of 1 year. By 6 months, all the study subjects had complete radiological resolution. Serum levels of calcium and alkaline phosphatase (ALP) were restored by 6 months in most cases while phosphate and vitamin D levels normalized by 6 weeks. CONCLUSION: Stosstherapy is a safe, cheap and effective method of treating nutritional rickets. Biochemical tests at initial presentation followed by vitamin D assay at 6 weeks and calcium, phosphate and ALP assays at 6 months is recommended in the monitoring of these patients. For regular monitoring, only ALP assay is recommended, provided one abstains from repeat injection of vitamin D based on high ALP levels.
[Mh] Termos MeSH primário: Cálcio/uso terapêutico
Raquitismo/tratamento farmacológico
Luz Solar
Vitamina D/uso terapêutico
[Mh] Termos MeSH secundário: Administração Oral
Fosfatase Alcalina/sangue
Cálcio/administração & dosagem
Cálcio/sangue
Criança
Pré-Escolar
Terapia Combinada
Feminino
Seres Humanos
Lactente
Injeções Intramusculares
Estudos Longitudinais
Masculino
Estado Nutricional
Estudos Prospectivos
Fatores de Tempo
Resultado do Tratamento
Vitamina D/administração & dosagem
Vitaminas/administração & dosagem
Vitaminas/uso terapêutico
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vitamins); 1406-16-2 (Vitamin D); EC 3.1.3.1 (Alkaline Phosphatase); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE
[do] DOI:10.4274/jcrpe.3557


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[PMID]:27060335
[Au] Autor:Miller WL
[Ad] Endereço:Center for Reproductive Sciences and Department of Pediatrics, HSE 1634, University of California San Francisco, San Francisco, CA 94143-0556, USA. Electronic address: wlmlab@ucsf.edu.
[Ti] Título:Genetic disorders of Vitamin D biosynthesis and degradation.
[So] Source:J Steroid Biochem Mol Biol;165(Pt A):101-108, 2017 Jan.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vitamin D, an inactive secosteroid pro-hormone, is produced by the action of ultraviolet light on 7-dehydrocholesterol in the skin. The active hormone, 1,25(OH) D is produced by sequential 25-hydroxylation in the liver, principally by CYP2R1, and 1α-hydroxylation in the kidney by CYP27B1. Mutations in CYP27B1 cause 1α-hydroxylase deficiency, also known as vitamin D dependent rickets type I or hereditary pseudo-vitamin D deficient rickets; very rare mutations in CYP2R1 can cause 25-hydroxylase deficiency. Both deficiencies cause hypocalcemia, secondary hyperparathyroidism, severe rickets in infancy, and low serum concentrations of 1,25(OH) D; both disorders respond to hormonal replacement therapy with calcitriol. The inactivation of vitamin D is principally initiated by its 23- and 24-hydroxylation by CYP24A1. Mutations in CYP24A1 can cause both severe neonatal hypercalcemia and a less severe adult hypercalcemic syndrome. Other pathways of vitamin D metabolism are under investigation, notably its 20-hydroxylation by the cholesterol side-chain cleavage enzyme, CYP11A1.
[Mh] Termos MeSH primário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/genética
Colestanotriol 26-Mono-Oxigenase/genética
Família 2 do Citocromo P450/genética
Vitamina D3 24-Hidroxilase/genética
Vitamina D/biossíntese
Vitamina D/metabolismo
[Mh] Termos MeSH secundário: Animais
Calcitriol/química
Proliferação Celular
Colesterol/metabolismo
Enzima de Clivagem da Cadeia Lateral do Colesterol/genética
Análise Mutacional de DNA
Desidrocolesteróis/metabolismo
Seres Humanos
Hipercalcemia/genética
Camundongos
Mutação
Ratos
Raquitismo/diagnóstico
Raquitismo/genética
Esteroides/metabolismo
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dehydrocholesterols); 0 (Steroids); 1406-16-2 (Vitamin D); 97C5T2UQ7J (Cholesterol); BK1IU07GKF (7-dehydrocholesterol); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.13.13 (CYP27B1 protein, human); EC 1.14.14.1 (Cytochrome P450 Family 2); EC 1.14.14.24 (CYP2R1 protein, human); EC 1.14.15.15 (Cholestanetriol 26-Monooxygenase); EC 1.14.15.16 (CYP24A1 protein, human); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase); EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme); FXC9231JVH (Calcitriol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160410
[St] Status:MEDLINE


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[PMID]:27854286
[Au] Autor:Zhang M; Shen F; Petryk A; Tang J; Chen X; Sergi C
[Ad] Endereço:Department of Orthopedics, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan 430064, China. zhangmingyong-08@163.com.
[Ti] Título:"English Disease": Historical Notes on Rickets, the Bone-Lung Link and Child Neglect Issues.
[So] Source:Nutrients;8(11), 2016 Nov 15.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Nutritional or classical rickets (here labeled as "rickets") is a worldwide disease involving mostly infants and young children having inadequate sunlight exposure, often associated with a low dietary intake of Vitamin D. Rickets targets all layers of society independently of economic status with historical information spanning more than two millennia. Vitamin D is critical for the absorption of calcium and prevention of rickets in children as well as osteomalacia in adults. The initial and misleading paradigm of the 19th and 20th centuries that rickets may have been the consequence of infection has been, indeed, reversed following the identification of the Vitamin D molecule's important role in the function of the immune system. Although traditionally considered limited to osteopathology, Vitamin D deficiency is now known to be linked to infection, inflammation, and carcinogenesis. In this review, we consider the key historical (Whistler, pre-Whistler and post-Whistler descriptors) and social facts around rickets; highlight the osteo-pathological features of rickets and the pathology of the upper and lower respiratory tract, stressing the fact that lungs remain the main secondary organ affected by Vitamin D deficiency; and emphasize the public health role in identifying the cases of child neglect or abuse based on the evaluation of the costochondral region.
[Mh] Termos MeSH primário: Maus-Tratos Infantis/história
Pneumopatias/história
Raquitismo/história
[Mh] Termos MeSH secundário: Criança
História do Século XIX
História do Século XX
Seres Humanos
Pneumopatias/etiologia
Raquitismo/complicações
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE


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[PMID]:27710917
[Au] Autor:Ganie MA; Raizada N; Chawla H; Singh AK; Aggarwala S; Bal CS
[Ti] Título:Primary hyperparathyroidism may masquerade as rickets-osteomalacia in vitamin D replete children.
[So] Source:J Pediatr Endocrinol Metab;29(10):1207-1213, 2016 Oct 01.
[Is] ISSN:2191-0251
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Primary hyperparathyroidism, typically a disease of the middle aged and the old, is less commonly seen in children. In children the disease has a bimodal age distribution with calcium sensing receptor mutation presenting in infancy as hypercalcemic crises and parathyroid adenoma or hyperplasia presenting later in childhood with bone disease. The childhood parathyroid adenomas are often familial with multiglandular disease and manifest with severe bone disease unlike adults. We report a series of four male patients with juvenile primary hyperparathyroidism, three of whom presented with bone disease masquerading as rickets-osteomalacia. One patient had asymptomatic hypercalcemia with short stature. Parathyroid adenoma was detected in all the four cases and all of them underwent resection of parathyroid adenomas confirmed on histopathology. Post-surgery all the cases had initial hypocalcaemia followed by normocalcemia. One case developed pancreatitis after surgery even after achieving normocalcemia. We conclude that parathyroid adenomas, although uncommon in children, are an important cause of skeletal disease that may initially be confused with hypovitaminosis D.
[Mh] Termos MeSH primário: Hiperparatireoidismo Primário/diagnóstico
Osteomalacia/diagnóstico
Raquitismo/diagnóstico
Deficiência de Vitamina D/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biomarcadores/análise
Criança
Diagnóstico Diferencial
Seres Humanos
Hiperparatireoidismo Primário/etiologia
Hiperparatireoidismo Primário/cirurgia
Masculino
Imagem de Perfusão do Miocárdio
Osteomalacia/etiologia
Paratireoidectomia
Raquitismo/etiologia
Ultrassonografia
Vitamina D/análise
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE


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[PMID]:27604486
[Ti] Título:[Not Available].
[Ti] Título:Kinderorthopädie..
[So] Source:Unfallchirurg;119(9):704-5, 2016 Sep.
[Is] ISSN:1433-044X
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Maus-Tratos Infantis/diagnóstico
Fraturas de Estresse/epidemiologia
Fraturas do Úmero/terapia
Lacerações/diagnóstico
Raquitismo/epidemiologia
Pele/lesões
[Mh] Termos MeSH secundário: Causalidade
Criança
Maus-Tratos Infantis/classificação
Seres Humanos
Lacerações/classificação
Ortopedia/tendências
Pediatria/tendências
Prevalência
Pele/patologia
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160909
[St] Status:MEDLINE
[do] DOI:10.1007/s00113-016-0221-1



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