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[PMID]:29023477
[Au] Autor:Köhler K; Marcsik A; Zádori P; Biro G; Szeniczey T; Fábián S; Serlegi G; Marton T; Donoghue HD; Hajdu T
[Ad] Endereço:Institute of Archaeology, Research Centre for the Humanities, Hungarian Academy of Sciences, Budapest, Hungary.
[Ti] Título:Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary.
[So] Source:PLoS One;12(10):e0185966, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:At the Abony-Turjányos dulo site, located in Central Hungary, a rescue excavation was carried out. More than 400 features were excavated and dated to the Protoboleráz horizon, at the beginning of the Late Copper Age in the Carpathian Basin, between 3780-3650 cal BC. Besides the domestic and economic units, there were two special areas, with nine-nine pits that differed from the other archaeological features of the site. In the northern pit group seven pits contained human remains belonging to 48 individuals. Some of them were buried carefully, while others were thrown into the pits. The aim of this study is to present the results of the paleopathological and molecular analysis of human remains from this Late Copper Age site. The ratio of neonates to adults was high, 33.3%. Examination of the skeletons revealed a large number of pathological cases, enabling reconstruction of the health profile of the buried individuals. Based on the appearance and frequency of healed ante- and peri mortem trauma, inter-personal (intra-group) violence was characteristic in the Abony Late Copper Age population. However other traces of paleopathology were observed on the bones that appear not to have been caused by warfare or inter-group violence. The remains of one individual demonstrated a rare set of bone lesions that indicate the possible presence of leprosy (Hansen's disease). The most characteristic lesions occurred on the bones of the face, including erosion of the nasal aperture, atrophy of the anterior nasal spine, inflammation of the nasal bone and porosity on both the maxilla and the bones of the lower legs. In a further four cases, leprosy infection is suspected but other infections cannot be excluded. The morphologically diagnosed possible leprosy case significantly modifies our knowledge about the timescale and geographic spread of this specific infectious disease. However, it is not possible to determine the potential connections between the cases of possible leprosy and the special burial circumstances.
[Mh] Termos MeSH primário: Hanseníase
Mycobacterium leprae/genética
Paleopatologia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Sepultamento
Criança
Pré-Escolar
Feminino
História Antiga
Seres Humanos
Hungria
Hiperostose/patologia
Lactente
Hanseníase/epidemiologia
Hanseníase/história
Hanseníase/microbiologia
Masculino
Meia-Idade
Mycobacterium tuberculosis/genética
Adulto Jovem
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185966


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[PMID]:28594081
[Au] Autor:Rivera F; Mirazón Lahr M
[Ad] Endereço:Department of Archaeology & Anthropology, Leverhulme Centre for Human Evolutionary Studies, University of Cambridge, United Kingdom.
[Ti] Título:New evidence suggesting a dissociated etiology for cribra orbitalia and porotic hyperostosis.
[So] Source:Am J Phys Anthropol;164(1):76-96, 2017 Sep.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Porotic hyperostosis (PH), characterized by porotic lesions on the cranial vault, and cribra orbitalia (CO), a localized appearance of porotic lesions on the roof of the orbits, are relatively common osteological conditions. Their etiology has been the focus of several studies, and an association with anemia has long been suggested. Anemia often causes bone marrow hypertrophy or hyperplasia, leading to the expansion in trabecular or cranial diploic bone as a result of increased hematopoiesis. Hypertrophy and/or hyperplasia is often coupled with a disruption of the remodeling process of outer cortical bone, cranially and/or postcranially, leading to the externally visible porotic lesions reported in osteological remains. In this article, we investigate whether individuals with CO have increased thickness of the diploë, the common morphological direct effect of increased hematopoiesis, and thus test the relationship between the two conditions, as well as explore the type of anemia that underlie it. METHODS: An analysis of medical CT scans of a worldwide sample of 98 complete, young to middle-aged adult dry skulls from the Duckworth Collection was conducted on male and female cribrotic individuals (n = 23) and noncribrotic individuals (n = 75), all of whom lacked any evidence of porotic lesions on the vault. Measurements of total and partial cranial thickness were obtained by virtual landmark placement, using the Amira 5.4 software; all analyses were conducted in IBM SPSS 21. RESULTS: Cribriotic individuals have significantly thinner diploic bone and thicker outer and inner tables than noncribriotic individuals, contrary to the expected diploic expansion that would result from anemic conditions associated to bone marrow hypertrophy or hyperplasia. Additionally, individuals without CO and those with the condition have distinctive cranial thickness at particular locations across the skull and the severity to which CO is expressed also differentiates between those with mild and those with a moderate to severe form of the condition. CONCLUSIONS: Our results suggest a complex pattern of causality in relation to the pathologies that may lead to the formation of porotic lesions on the vault and the roof of the orbits. A form of anemia may be behind the osteological changes observed in PH and CO, but it is unlikely to be the same type of anemic condition that underlies both types of osteological lesions. We suggest that CO may be associated to anemias that lead to diploic bone hypocellularity and hypoplasia, such as those caused by anemia of chronic disease and, to a lesser extent, of renal failure, aplastic anemia, protein deficiency, and anemia of endocrine disorders, and not those that lead to bone marrow hypercellularity and hyperplasia and potential PH. This leads us to the conclusion that the terms PH and CO should be used to reflect different underlying conditions.
[Mh] Termos MeSH primário: Hiperostose
Órbita/patologia
Crânio/patologia
[Mh] Termos MeSH secundário: Adulto
Anemia
Antropologia Física
Feminino
Seres Humanos
Hiperostose/complicações
Hiperostose/diagnóstico por imagem
Hiperostose/patologia
Masculino
Meia-Idade
Órbita/diagnóstico por imagem
Escorbuto
Crânio/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23258


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[PMID]:28403046
[Au] Autor:Grote V; Silier CC; Voit AM; Jansson AF
[Ad] Endereço:From the Department of Rheumatology and Immunology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
[Ti] Título:Bacterial Osteomyelitis or Nonbacterial Osteitis in Children: A Study Involving the German Surveillance Unit for Rare Diseases in Childhood.
[So] Source:Pediatr Infect Dis J;36(5):451-456, 2017 May.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although bacterial osteomyelitis (BO) is a commonly recognized diagnosis in pediatrics, it is often difficult to distinguish from nonbacterial osteitis (NBO). The goal of our study was to distinguish between the 2 disease entities and better define NBO. METHODS: Using the German Surveillance Unit for Rare Diseases in Childhood (Erhebungseinheit für Seltene Paediatrische Erkrankungen in Deutschland), this prospective study during a 5-year period captured 657 patients at first diagnosis of either BO (n = 378) or NBO (n = 279) while analyzing epidemiologic, clinical and radiologic data. RESULTS: BO was reported in 1.2 per 100,000 children with a higher prevalence in younger male patients (58%), and NBO was reported in 0.45 per 100,000 children. BO patients tended to present with fevers (68%), elevated inflammation markers (82%) and local swelling (62%) but a shorter course of symptoms than NBO patients. NBO patients presented in good general health (86%) and were more likely to have multifocal lesions (66%). Staphylococcus aureus was the most prominent pathogen (83%), with only one methicillin-resistant S. aureus reported. Complications ranged from arthritis adjacent to the lesion to hyperostosis and vertebral fractures. CONCLUSIONS: BO and NBO can be distinguished based on symptoms, associated diseases and inflammation markers. NBO should always be considered in pediatric patients presenting with bone lesions and pain, especially in young female patients presenting with good general health, minimal inflammation markers and multifocal lesions in the vertebrae, clavicle and sternum.
[Mh] Termos MeSH primário: Osteíte/diagnóstico
Osteomielite/diagnóstico
Vigilância em Saúde Pública
Doenças Raras/diagnóstico
Infecções Estafilocócicas/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Diagnóstico Diferencial
Feminino
Fraturas Ósseas/diagnóstico
Fraturas Ósseas/epidemiologia
Fraturas Ósseas/etiologia
Fraturas Ósseas/patologia
Alemanha/epidemiologia
Seres Humanos
Hiperostose/diagnóstico
Hiperostose/epidemiologia
Hiperostose/etiologia
Hiperostose/patologia
Lactente
Masculino
Osteíte/complicações
Osteíte/epidemiologia
Osteíte/patologia
Osteomielite/complicações
Osteomielite/epidemiologia
Osteomielite/patologia
Estudos Prospectivos
Doenças Raras/complicações
Doenças Raras/epidemiologia
Doenças Raras/patologia
Coluna Vertebral/patologia
Infecções Estafilocócicas/complicações
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/patologia
Staphylococcus aureus/crescimento & desenvolvimento
Staphylococcus aureus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001469


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[PMID]:28237997
[Au] Autor:Yun YH; Oh MH; Kim JY; Kim SH
[Ad] Endereço:Department of Microbiology, Dankook University, Cheonan 31116, Republic of Korea.
[Ti] Título:, a Hybrid Histidine Kinase Gene, Is Essential for the Sexual Development and Virulence of .
[So] Source:J Microbiol Biotechnol;27(5):1010-1022, 2017 May 28.
[Is] ISSN:1738-8872
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Hybrid histidine kinase is part of a two-component system that is required for various stress responses and pathogenesis of pathogenic fungi. The gene in human pathogen encodes a hybrid histidine kinase and is important for pathogenesis. In this study, we identified a homolog, , in the maize pathogen by bioinformatics analysis. To explore the role of in the survival of under environmental stresses and its pathogenesis, mutants were constructed by allelic exchange. The growth of mutants was significantly impaired when they were cultured under hyperosmotic stress. The mutants exhibited increased resistance to antifungal agent fludioxonil. In particular, the mutants were unable to produce cytokinesis or conjugation tubes, and to develop fuzzy filaments, resulting in impaired mating between compatible strains. The expression levels of , and , which are involved in the pheromone pathway, were significantly decreased in the mutants. In inoculation tests to the host plant, the mutants showed significantly reduced ability in the production of anthocyanin pigments and tumor development on maize leaves. Overall, the combined results indicated that plays important roles in the survival under hyperosmotic stress, and contributes to cytokinesis, sexual development, and virulence of by regulating the expression of the genes involved in the pheromone pathway.
[Mh] Termos MeSH primário: Genes Fúngicos Tipo Acasalamento/genética
Histidina Quinase/genética
Desenvolvimento Sexual/genética
Ustilago/crescimento & desenvolvimento
Ustilago/patogenicidade
Virulência/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Antocianinas/metabolismo
Antifúngicos/farmacologia
Cultura Axênica
Biologia Computacional
Citocinese
DNA Fúngico/genética
Dioxóis/farmacologia
Escherichia coli/genética
Proteínas Fúngicas/metabolismo
Regulação Fúngica da Expressão Gênica
Proteínas de Grupo de Alta Mobilidade/metabolismo
Histidina Quinase/classificação
Hiperostose
Mutação
Pressão Osmótica
Fenótipo
Feromônios/metabolismo
Filogenia
Doenças das Plantas/microbiologia
Folhas de Planta/metabolismo
Proteínas de Plantas/metabolismo
Pirróis/farmacologia
RNA Mensageiro/análise
Receptores de Feromonas/metabolismo
Alinhamento de Sequência
Estresse Fisiológico/genética
Fatores de Transcrição/metabolismo
Ustilago/efeitos dos fármacos
Zea mays/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antifungal Agents); 0 (DNA, Fungal); 0 (Dioxoles); 0 (Fungal Proteins); 0 (High Mobility Group Proteins); 0 (Pheromones); 0 (Plant Proteins); 0 (Pyrroles); 0 (RNA, Messenger); 0 (Receptors, Pheromone); 0 (Transcription Factors); 0 (pheromone response factor 1, Ustilago maydis); EC 2.7.13.1 (Histidine Kinase); ENS9J0YM16 (fludioxonil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE
[do] DOI:10.4014/jmb.1702.02001


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[PMID]:28231372
[Au] Autor:Kumar S; Anand TS; Pal I
[Ad] Endereço:Department of ENT, College of Medicine and JNM Hospital, Kalyani, Nadia, West Bengal, India 741235. saumitra80@gmail.com.
[Ti] Título:Radiofrequency turbinate volume reduction vs. radiofrequency-assisted turbinectomy for nasal obstruction caused by inferior turbinate hypertrophy.
[So] Source:Ear Nose Throat J;96(2):E23-E26, 2017 Feb.
[Is] ISSN:1942-7522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Radiofrequency procedures are a well-accepted treatment for nasal obstruction. We conducted a randomized, noncontrolled study to compare the effectiveness of submucosal bipolar radiofrequency turbinate volume reduction (RFTVR) and bipolar radiofrequency-assisted turbinectomy (RFaT) in patients presenting with nasal obstruction caused by inferior turbinate hypertrophy. A total of 30 patients-15 males and 15 females, aged 15 to 60 years (mean: 32)-were randomly divided into one of the two homogeneous treatment groups. Outcomes were determined by comparisons of subjective symptom scores on a visual analog scale and by anterior active rhinomanometry at postoperative days 7, 14, and 28 and again at 6 months postoperatively. Both groups demonstrated significant and similar improvements in nasal airway function both subjectively and objectively. However, we noted that the incidence of adverse effects and postoperative morbidity was higher in the RFaT group. Therefore, we conclude that when surgery is indicated, RFTVR is the preferred treatment for nasal obstruction secondary to inferior turbinate hypertrophy. RFaT is equally effective, but it is associated with a slightly higher incidence of adverse effects.
[Mh] Termos MeSH primário: Ablação por Cateter/métodos
Hiperostose/complicações
Obstrução Nasal/cirurgia
Procedimentos Cirúrgicos Nasais/métodos
Conchas Nasais/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Hiperostose/cirurgia
Masculino
Meia-Idade
Obstrução Nasal/etiologia
Medição da Dor
Período Pós-Operatório
Rinomanometria
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:28137547
[Au] Autor:Wong T; Herschman Y; Patel NV; Patel T; Hanft S
[Ad] Endereço:Rutgers, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. Electronic address: twchunghin@gmail.com.
[Ti] Título:Repeat Intracranial Expansion After Skull Regrowth in Hyperostotic Disease: Technical Note.
[So] Source:World Neurosurg;102:555-560, 2017 Jun.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE AND IMPORTANCE: Camurati-Engelmann disease (CED) is a rare, autosomal-dominant genetic disorder resulting in hyperostosis of the long bones and skull. Patients often develop cranial nerve dysfunction and increased intracranial pressure secondary to stenosis of nerve foramina and hyperostosis. Surgical decompression may provide symptomatic relief in select patients; however, a small number of reports document the recurrence of symptoms due to bony regrowth. We present a patient who had been treated previously with bilateral frontal and parietal craniotomy who experienced recurrence of symptoms due to reossification of her cranial bones. This report underscores the progressive nature of CED and its influence on surgical management. Furthermore, we propose a novel surgical approach with multiple craniectomies and titanium mesh cranioplasties that could potentially offer long-term symptomatic relief. CLINICAL PRESENTATION: A 46-year-old female patient with CED who was treated with ventriculoperitoneal shunting, posterior fossa decompression, and multiple craniotomies 2 decades prior presented with signs and symptoms of increased intracranial pressure. Studies of the skull at presentation demonstrated rethickening of cranial bones that resulted in severely decreased intracranial volume. INTERVENTION: A radical craniectomy, requiring 4 separate bone flaps made up of bilateral frontal and parietal bones, was performed. The remaining coronal and sagittal bony struts were drilled to approximately 1 cm thick. Cranioplasties with 4 separate titanium meshes were performed to preserve the natural contour of the patient's skull. CONCLUSIONS: Although surgical decompression could provide some patients with CED symptomatic relief, clinicians should consider managing CED as a chronic condition. To the authors' knowledge, this is one of few case reports documenting the recurrence of symptoms in a patient with CED treated by surgical intervention. Furthermore, we propose that multiple craniectomies with titanium mesh cranioplasties confer more permanent symptomatic control, and, more importantly, lower the risk of recurrence secondary to cranial hyperostosis.
[Mh] Termos MeSH primário: Síndrome de Camurati-Engelmann/cirurgia
Hiperostose/fisiopatologia
Crânio/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Síndrome de Camurati-Engelmann/diagnóstico por imagem
Síndrome de Camurati-Engelmann/fisiopatologia
Craniotomia/métodos
Descompressão Cirúrgica/métodos
Feminino
Seres Humanos
Hiperostose/diagnóstico por imagem
Hiperostose/etiologia
Meia-Idade
Cuidados Pós-Operatórios/métodos
Complicações Pós-Operatórias/etiologia
Complicações Pós-Operatórias/fisiopatologia
Retalhos Cirúrgicos
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Derivação Ventriculoperitoneal/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; TECHNICAL REPORT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


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[PMID]:27254545
[Au] Autor:Elkhamary SM; Galindo-Ferreiro A; Akaishi P; Muiños-Diaz Y; Cechetti SP; Cintra MB; Cruz AAV
[Ad] Endereço:*Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, Egypt; †King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; ‡Department of Ophthalmology, Complejo Asistencial Palencia, Palencia, Spain; §Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil; ‖Ophthalmology Consultation, Hospital Nuestra Señora de Fátima, Vigo, Spain; and ¶Department of Radiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
[Ti] Título:Hyperostosis Following Orbital Exenteration.
[So] Source:Ophthal Plast Reconstr Surg;33(4):241-243, 2017 Jul/Aug.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe CT scan findings following orbital exenteration in 27 patients and to identify the factors involved in the development of post exenteration hyperostosis. METHODS: Noncomparative case series. The authors reviewed the charts of 27 patients ranging in age from 33 to 99 years, who underwent unilateral exenteration at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia and at the School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. Data regarding patient demographics, surgical procedure, clinical diagnosis, and preoperative and postoperative CT imaging of the orbits were obtained. The relationship between hyperostosis and postoperative time, gender, age, adjuvant radiotherapy, and cavity coverage was evaluated by multivariate stepwise logistic regression. RESULTS: Seventeen (73.9 %) orbits had postoperative orbital hyperostosis. No soft tissue masses were detected in the affected orbits except in 2 cases with tumor recurrence. The only factor associated with hyperostosis was immediate intraoperative socket rehabilitation (odds ratio = 0.13, 95% confidence interval: 0.01-0.89). There was an 87.0% lower chance of hyperostosis in patients whose socket was covered with musculocutaneous flaps. Sequential CT scans showed that orbital hyperostosis followed a specific pattern. Initially, bone thickening appeared as either uniform or undulating endo-osteal minimal thickening along the roof and then on the lateral and medial walls. More advanced hyperostosis had a laminated/lamellated appearance progressing to homogeneous and diffuse circumferential bone thickening. New bone formation and bone overgrowth were late findings. Hyperostosis extended to involve the adjacent facial bone, more obviously on the maxilla. Some patients had minimal thickening of the adjacent frontal and squamous temporal bone. Over-pneumatization of the paranasal sinuses was evident in all cases of hyperostosis. CONCLUSIONS: Development of hyperostosis following exenteration is not rare. Radiologists and surgeons should be aware of the need to monitor the orbital healing process closely to avoid misdiagnoses of tumor recurrence/radionecrosis or infection. Obliteration of the orbital cavity with musculocutaneous flaps significantly reduces the chances of bone hyperostosis.
[Mh] Termos MeSH primário: Hiperostose/etiologia
Exenteração Orbitária/efeitos adversos
Órbita/diagnóstico por imagem
Doenças Orbitárias/etiologia
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Seres Humanos
Hiperostose/diagnóstico
Masculino
Meia-Idade
Doenças Orbitárias/diagnóstico
Neoplasias Orbitárias/cirurgia
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000000719


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[PMID]:27928168
[Au] Autor:Browne NS; Scarratt WK; Robertson J
[Ad] Endereço:Virginia - Maryland Regional College of Veterinary Medicine, Phase 2, Duckpond Drive, Blacksburg, Virginia 24060, USA.
[Ti] Título:Hypertrophic osteopathy secondary to metastatic ovarian adenocarcinoma in a mare.
[So] Source:Can Vet J;57(12):1237-1241, 2016 Dec.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:A 10-year-old Andalusian mare was presented for evaluation of weight loss, increasing periods of recumbency, and swelling of the lower limbs. Radiographs revealed severe palisading to solid periosteal new bone formation in numerous locations. Necropsy revealed a metastatic malignant adenocarcinoma of ovarian origin with secondary hypertrophic osteopathy.
[Mh] Termos MeSH primário: Adenocarcinoma/veterinária
Doenças dos Cavalos/patologia
Hiperostose/veterinária
Neoplasias Ovarianas/veterinária
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Animais
Feminino
Doenças dos Cavalos/diagnóstico
Doenças dos Cavalos/etiologia
Cavalos
Hiperostose/etiologia
Neoplasias Ovarianas/complicações
Neoplasias Ovarianas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE


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[PMID]:27784318
[Au] Autor:Liu Y; Dutra EH; Reichenberger EJ; Chen IP
[Ad] Endereço:Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, 06030, USA.
[Ti] Título:Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia.
[So] Source:J Negat Results Biomed;15(1):18, 2016 Oct 26.
[Is] ISSN:1477-5751
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bones and flared metaphyses of long bones. We previously reported a knock-in (KI) mouse model (Ank ) for CMD and showed transiently lower serum phosphate (Pi) as well as significantly higher mRNA levels of fibroblast growth factor 23 (Fgf23) in Ank mice. FGF23 is secreted by bone and acts in kidney to promote Pi wasting which leads to lower serum Pi levels. Here, we examined whether increasing the Pi level can partially rescue the CMD-like skeletal phenotype by feeding Ank and Ank mice with high Pi (1.7 %) diet from birth for 6 weeks. We studied the Pi metabolism in Ank mice and CMD patients by examining the Pi regulators FGF23 and parathyroid hormone (PTH). RESULTS: High Pi diet did not correct CMD-like features, including massive jawbone, increased endosteal and periosteal perimeters and extensive trabeculation of femurs in Ank mice shown by computed microtomography (µCT). This unexpected negative result is, however, consistent with normal serum/plasma levels of the intact/active form of FGF23 and PTH in Ank mice and in CMD patients. In addition, FGF23 protein expression was unexpectedly normal in Ank femoral cortical bone as shown by immunohistochemistry despite increased mRNA levels for Fgf23. Renal expression of genes involved in the FGF23 bone-kidney axis, including mFgfr1, mKlotho, mNpt2a, mCyp24a1 and m1αOHase, were comparable between Ank and Ank mice as shown by quantitative real-time PCR. Different from normal FGF23 and PTH, serum 25-hydroxyvitamin D was significantly lower in Ank mice and vitamin D insufficiency was found in four out of seven CMD patients. CONCLUSIONS: Our data suggests that FGF23 signaling and Pi metabolism are not significantly affected in CMD and transiently low Pi level is not a major contributor to CMD.
[Mh] Termos MeSH primário: Doenças do Desenvolvimento Ósseo/tratamento farmacológico
Osso e Ossos/patologia
Anormalidades Craniofaciais/tratamento farmacológico
Dieta
Suplementos Nutricionais
Hiperostose/tratamento farmacológico
Hipertelorismo/tratamento farmacológico
Fosfatos/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Animais
Peso Corporal/efeitos dos fármacos
Doenças do Desenvolvimento Ósseo/sangue
Doenças do Desenvolvimento Ósseo/genética
Osso e Ossos/diagnóstico por imagem
Osso e Ossos/efeitos dos fármacos
Criança
Anormalidades Craniofaciais/sangue
Anormalidades Craniofaciais/genética
Modelos Animais de Doenças
Feminino
Fatores de Crescimento de Fibroblastos/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Hiperostose/sangue
Hiperostose/genética
Hipertelorismo/sangue
Hipertelorismo/genética
Rim/efeitos dos fármacos
Rim/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Meia-Idade
Tamanho do Órgão/efeitos dos fármacos
Hormônio Paratireóideo/sangue
Fenótipo
Fosfatos/farmacologia
Vitamina D/análogos & derivados
Vitamina D/sangue
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone); 0 (Phosphates); 0 (fibroblast growth factor 23); 1406-16-2 (Vitamin D); 62031-54-3 (Fibroblast Growth Factors); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE


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[PMID]:27628611
[Au] Autor:Hashida T; Yoshioka K; Kanda S; Fujibayashi D; Amino M; Ikari Y
[Ti] Título:Investigation of a Correlation between Thoracic Vertebra Hyperplasia and Relapse in Paroxysmal Atrial FIbrillation Patients Following Extended Pulmonary Vein Isolation.
[So] Source:Tokai J Exp Clin Med;41(3):163-8, 2016 Sep 20.
[Is] ISSN:2185-2243
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Pulmonary vein isolation (PVI) with radio-frequency catheter ablation (RFCA) is effective therapy for the patients with paroxysmal atrial fibrillation (pAF). However, it is not easy to predict relapse of pAF. Approximately 70% pAF patients were maintained sinus rhythm for 1 year after PVI in Japan. In this study, all of the cases were underwent chest computed tomography (CT) to check for the morphology and positional relationship of the left atrium. We detected relapse cases that exhibited spur formation in the thoracic vertebrae. Therefore, we conducted an investigation based on the hypothesis that, "Because hyperostosis involves proliferative changes in the synovium or pia mater cells with an inflammatory basis, it is related to the onset of atrial fibrillation." The study sample consisted of 24 sequential cases (males: 20, mean age: 66.2 ± 6.9 years) of drug-resistant pAF that underwent PVI at our hospital between January and May, 2015. When subjects were divided into a relapse group and a non-relapse group and 21 background factors were compared, it was found that the relapse group subjects were older than the non-relapse group subjects (70.3 ± 7.2 vs 64.1 ± 5.7, p = 0.04). The proportion of cases with thoracic vertebra hyperplasia was markedly high in the relapse group (6 cases [75%] vs. 3 cases [18%], p = 0.007). No statistically significant differences were observed between the two groups for any other background factors. Our results suggested that thoracic vertebra hyperplasia could be a marker for predicting relapse after PVI in pAF patients.
[Mh] Termos MeSH primário: Fibrilação Atrial/etiologia
Fibrilação Atrial/cirurgia
Ablação por Cateter/métodos
Veias Pulmonares/cirurgia
Vértebras Torácicas/patologia
Procedimentos Cirúrgicos Vasculares/métodos
[Mh] Termos MeSH secundário: Idade de Início
Idoso
Fibrilação Atrial/epidemiologia
Feminino
Previsões
Átrios do Coração/diagnóstico por imagem
Seres Humanos
Hiperostose
Hiperplasia
Masculino
Meia-Idade
Recidiva
Índice de Gravidade de Doença
Vértebras Torácicas/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE



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