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[PMID]:29065144
[Au] Autor:Wagnac E; Aubin CÉ; Chaumoître K; Mac-Thiong JM; Ménard AL; Petit Y; Garo A; Arnoux PJ
[Ad] Endereço:Department of Mechanical Engineering, École de technologie supérieure, Montréal, Québec, Canada.
[Ti] Título:Substantial vertebral body osteophytes protect against severe vertebral fractures in compression.
[So] Source:PLoS One;12(10):e0186779, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent findings suggest that vertebral osteophytes increase the resistance of the spine to compression. However, the role of vertebral osteophytes on the biomechanical response of the spine under fast dynamic compression, up to failure, is unclear. Seventeen human spine specimens composed of three vertebrae (from T5-T7 to T11-L1) and their surrounding soft tissues were harvested from nine cadavers, aged 77 to 92 years. Specimens were imaged using quantitative computer tomography (QCT) for medical observation, classification of the intervertebral disc degeneration (Thomson grade) and measurement of the vertebral trabecular density (VTD), height and cross-sectional area. Specimens were divided into two groups (with (n = 9) or without (n = 8) substantial vertebral body osteophytes) and compressed axially at a dynamic displacement rate of 1 m/s, up to failure. Normalized force-displacement curves, videos and QCT images allowed characterizing failure parameters (force, displacement and energy at failure) and fracture patterns. Results were analyzed using chi-squared tests for sampling distributions and linear regression for correlations between VTD and failure parameters. Specimens with substantial vertebral body osteophytes present higher stiffness (2.7 times on average) and force at failure (1.8 times on average) than other segments. The presence of osteophytes significantly influences the location, pattern and type of fracture. VTD was a good predictor of the dynamic force and energy at failure for specimens without substantial osteophytes. This study also showed that vertebral body osteophytes provide a protective mechanism to the underlying vertebra against severe compression fractures.
[Mh] Termos MeSH primário: Fraturas por Compressão/patologia
Vértebras Lombares/patologia
Osteófito/patologia
Fraturas da Coluna Vertebral/patologia
Vértebras Torácicas/patologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Cadáver
Feminino
História do Século XVIII
Seres Humanos
Masculino
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186779


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[PMID]:28544542
[Au] Autor:Wu CL; McNeill J; Goon K; Little D; Kimmerling K; Huebner J; Kraus V; Guilak F
[Ad] Endereço:Washington University and Shriners Hospitals for Children, St. Louis, Missouri.
[Ti] Título:Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.
[So] Source:Arthritis Rheumatol;69(9):1772-1783, 2017 Sep.
[Is] ISSN:2326-5205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate whether short-term, systemic depletion of macrophages can mitigate osteoarthritis (OA) following injury in the setting of obesity. METHODS: CSF-1R-GFP+ macrophage Fas-induced apoptosis (MaFIA)-transgenic mice that allow conditional depletion of macrophages were placed on a high-fat diet and underwent surgery to induce knee OA. A small molecule (AP20187) was administrated to deplete macrophages in MaFIA mice. The effects of macrophage depletion on acute joint inflammation, OA severity, and arthritic bone changes were evaluated using histology and micro-computed tomography. Immunohistochemical analysis was performed to identify various immune cells. The levels of serum and synovial fluid cytokines were also measured. RESULTS: Macrophage-depleted mice had significantly fewer M1 and M2 macrophages in the surgically operated joints relative to controls and exhibited decreased osteophyte formation immediately following depletion. Surprisingly, macrophage depletion did not attenuate the severity of OA in obese mice; instead, it induced systemic inflammation and led to a massive infiltration of CD3+ T cells and particularly neutrophils, but not B cells, into the injured joints. Macrophage-depleted mice also demonstrated a markedly increased number of proinflammatory cytokines including granulocyte colony-stimulating factor, interleukin-1ß (IL-1ß), IL-6, IL-8, and tumor necrosis factor in both serum and joint synovial fluid, although the mice showed a trend toward decreased levels of insulin and leptin in serum after macrophage depletion. CONCLUSION: Our findings indicate that macrophages are vital for modulating homeostasis of immune cells in the setting of obesity and suggest that more targeted approaches of depleting specific macrophage subtypes may be necessary to mitigate inflammation and OA in the setting of obesity.
[Mh] Termos MeSH primário: Macrófagos/metabolismo
Obesidade/imunologia
Osteoartrite do Joelho/imunologia
[Mh] Termos MeSH secundário: Animais
Apoptose/imunologia
Proteínas Reguladoras de Apoptose
Citocinas/análise
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Obesos
Camundongos Transgênicos
Obesidade/sangue
Obesidade/complicações
Osteoartrite do Joelho/sangue
Osteoartrite do Joelho/etiologia
Osteófito/etiologia
Osteófito/imunologia
Índice de Gravidade de Doença
Líquido Sinovial/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apoptosis Regulatory Proteins); 0 (Cytokines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1002/art.40161


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[PMID]:28498070
[Au] Autor:Ikedo T; Nakamura K; Sano N; Nagata M; Okada Y; Kawakami T; Murata T
[Ad] Endereço:Department of Neurosurgery, Suisyoukai Murata Hospital, Osaka.
[Ti] Título:Extracranial internal carotid artery dissection caused by compression from a giant osteophyte due to atlantoaxial osteoarthritis: case report.
[So] Source:J Neurosurg Spine;27(4):410-414, 2017 Oct.
[Is] ISSN:1547-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deformed osseous structures have been reported as rare causes of extracranial internal carotid artery (ICA) dissection, including the styloid process and the hyoid bone. Here, the authors describe the first known case of symptomatic ICA dissection caused by a giant osteophyte due to atlantoaxial osteoarthritis. The left ICA was fixed at the skull base and at the ICA portion compressed by the osteophyte, and it was highly stretched and injured between the two portions during neck rotation. The patient was successfully treated with ligation of the affected ICA following balloon test occlusion. Atlantoaxial osteoarthritis should be considered in the differential diagnosis of ICA dissection in patients with a severely deformed cervical spine.
[Mh] Termos MeSH primário: Articulação Atlantoaxial
Infarto Encefálico/etiologia
Dissecação da Artéria Carótida Interna/etiologia
Osteoartrite/complicações
Osteófito/complicações
[Mh] Termos MeSH secundário: Idoso
Articulação Atlantoaxial/diagnóstico por imagem
Infarto Encefálico/diagnóstico por imagem
Infarto Encefálico/cirurgia
Artéria Carótida Interna/diagnóstico por imagem
Artéria Carótida Interna/cirurgia
Dissecação da Artéria Carótida Interna/diagnóstico por imagem
Dissecação da Artéria Carótida Interna/cirurgia
Seres Humanos
Ligadura
Masculino
Procedimentos Neurocirúrgicos
Osteoartrite/diagnóstico por imagem
Osteófito/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.3171/2017.1.SPINE161047


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[PMID]:28394713
[Au] Autor:Gutierrez NM; Granville C; Kaplan L; Baraga M; Jose J
[Ad] Endereço:Department of Radiology, University of Miami Hospital, Miami, Florida, USA.
[Ti] Título:Elbow MRI Findings Do Not Correlate With Future Placement on the Disabled List in Asymptomatic Professional Baseball Pitchers.
[So] Source:Sports Health;9(3):222-229, 2017 May/Jun.
[Is] ISSN:1941-0921
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Injury rates among professional baseball players may reach as high as 5.8 per 1000 encounters, with pitchers being most vulnerable on account of the excessive biomechanical load on the upper extremity during the throwing motion. Anatomically, the shoulder is the most common site of pitching-related injury, accounting for 30.7% of injuries, closely followed by the elbow at 26.3%. Characteristic valgus loading imparts a predictable constellation of stresses on the joint, including medial tension, lateral compression, and posterior medial shearing. The degenerative cohort of tissue changes that result are readily detected on magnetic resonance imaging (MRI). It is not yet known whether such findings predict future placement on the disabled list (DL) in asymptomatic Major League pitchers. HYPOTHESIS: Abnormal soft tissue and osseous changes detected on MRI of the throwing elbow in asymptomatic professional pitchers will impart an increased risk of subsequent transfer to the DL in the season after MRI. STUDY DESIGN: Retrospective cohort study. LEVEL OF EVIDENCE: Level 3. METHODS: The study aimed to examine a potential association between the total number of innings pitched (approximate lifetime valgus load) and the typical MRI degenerative changes, hypothesizing a rejection of the null hypothesis. A total of 26 asymptomatic professional pitchers from a single Major League Baseball (MLB) organization and its various minor league affiliates underwent MRI of their dominant elbow from 2003 to 2013 as a condition of their contract signing or trade. Twenty-one of those pitchers played at the Major League level while 5 played with the team's minor league affiliates including both the AA and AAA levels. Asymptomatic was defined as no related stints on the DL due to elbow injury in the 2 seasons prior to MRI. A fellowship-trained musculoskeletal radiologist reevaluated the studies after being blinded to patient name, injury history, and baseball history. A second investigator collected demographic data; this included total career number of innings pitched and any subsequent DL reports for each subject while remaining blinded to the MRI results. RESULTS: The mean age at the time of MRI was 29.6 years (range, 19-39 years). The mean number of innings pitched was 1111.7. Of the 26 pitchers, 13 had scar remodeling of the anterior bundle of the ulnar collateral ligament (UCL). Of those, 4 had partial-thickness tears of the anterior bundle of the UCL, ranging from 10% to 90% of the total thickness. Twelve had articular cartilage loss within the posteromedial margin of the ulnohumeral joint, and 12 had posteromedial olecranon marginal osteophytes. Seven pitchers had degeneration of the common extensor tendon origin, 10 had degeneration of the flexor pronator mass, 9 had insertional triceps tendinosis, 2 had enthesopathic spurs at the sublime tubercle, 3 had osteochondral intra-articular bodies, and 2 subjects had joint effusions. In the year after MRI, 6 pitchers were placed on the DL for elbow-related injuries. There was no robust correlation between any single MRI finding and subsequent transfer to the DL, and no statistically significant correlation between number of innings pitched and MRI findings, although some trends were observed for both. CONCLUSION: MRI findings in asymptomatic MLB pitchers were not associated with placement on the DL within the subsequent year. While a trend was observed with olecranon osteophytes and subsequent DL placement ( P = 0.07), this finding did not reach statistical significance. Furthermore, there was no robust correlation between the number of innings pitched with the presence of any of the aforementioned degenerative changes on MRI. CLINICAL RELEVANCE: The characteristic structural transformation that occurs in the throwing elbow of professional pitchers is predictable and readily detectable on MRI. However, this study suggests that these changes are not predictive of near-term placement on the DL in those who are asymptomatic. Abnormal findings on MRI, even high-grade partial UCL tears, do not correlate with near-term placement on the DL, mitigating their potential negative impact on signing decisions.
[Mh] Termos MeSH primário: Doenças Assintomáticas
Beisebol/lesões
Articulação do Cotovelo/diagnóstico por imagem
Articulação do Cotovelo/lesões
[Mh] Termos MeSH secundário: Adulto
Cartilagem Articular/diagnóstico por imagem
Cartilagem Articular/lesões
Cartilagem Articular/patologia
Ligamento Colateral Ulnar/diagnóstico por imagem
Ligamento Colateral Ulnar/lesões
Ligamento Colateral Ulnar/patologia
Articulação do Cotovelo/patologia
Seres Humanos
Imagem por Ressonância Magnética
Osteófito/diagnóstico por imagem
Osteófito/patologia
Estudos Retrospectivos
Fatores de Risco
Traumatismos dos Tendões/diagnóstico por imagem
Traumatismos dos Tendões/patologia
Tendões/diagnóstico por imagem
Tendões/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1177/1941738117701769


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[PMID]:28334010
[Au] Autor:Das Neves Borges P; Vincent TL; Marenzana M
[Ad] Endereço:Department of Bioengineering, Imperial College London, London, United Kingdom.
[Ti] Título:Automated assessment of bone changes in cross-sectional micro-CT studies of murine experimental osteoarthritis.
[So] Source:PLoS One;12(3):e0174294, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The degradation of articular cartilage, which characterises osteoarthritis (OA), is usually paired with excessive bone remodelling, including subchondral bone sclerosis, cysts, and osteophyte formation. Experimental models of OA are widely used to investigate pathogenesis, yet few validated methodologies for assessing periarticular bone morphology exist and quantitative measurements are limited by manual segmentation of micro-CT scans. The aim of this work was to chart the temporal changes in periarticular bone in murine OA by novel, automated micro-CT methods. METHODS: OA was induced by destabilisation of the medial meniscus (DMM) in 10-week old male mice and disease assessed cross-sectionally from 1- to 20-weeks post-surgery. A novel approach was developed to automatically segment subchondral bone compartments into plate and trabecular bone in micro-CT scans of tibial epiphyses. Osteophyte volume, as assessed by shape differences using 3D image registration, and by measuring total epiphyseal volume was performed. RESULTS: Significant linear and volumetric structural modifications in subchondral bone compartments and osteophytes were measured from 4-weeks post-surgery and showed progressive changes at all time points; by 20 weeks, medial subchondral bone plate thickness increased by 160±19.5 µm and the medial osteophyte grew by 0.124±0.028 µm3. Excellent agreement was found when automated measurements were compared with manual assessments. CONCLUSION: Our automated methods for assessing bone changes in murine periarticular bone are rapid, quantitative, and highly accurate, and promise to be a useful tool in future preclinical studies of OA progression and treatment. The current approaches were developed specifically for cross-sectional micro-CT studies but could be applied to longitudinal studies.
[Mh] Termos MeSH primário: Artrite Experimental/patologia
Tíbia/patologia
[Mh] Termos MeSH secundário: Animais
Artrite Experimental/diagnóstico por imagem
Epífises/diagnóstico por imagem
Epífises/patologia
Imagem Tridimensional/métodos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Osteófito/diagnóstico por imagem
Osteófito/patologia
Tíbia/diagnóstico por imagem
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174294


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[PMID]:28236082
[Au] Autor:Teitge RA
[Ad] Endereço:Detroit Medical Center, 3990 John R St., Detroit, MI, 48201, USA. rteitge@hotmail.com.
[Ti] Título:CORR Insights : Lateral-compartment Osteophytes are not Associated With Lateral-compartment Cartilage Degeneration in Arthritic Varus Knees.
[So] Source:Clin Orthop Relat Res;475(5):1393-1394, 2017 05.
[Is] ISSN:1528-1132
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Osteoartrite do Joelho
Osteófito
[Mh] Termos MeSH secundário: Cartilagem
Doenças das Cartilagens
Cartilagem Articular
Seres Humanos
Articulação do Joelho
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE
[do] DOI:10.1007/s11999-016-5192-6


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[PMID]:28191465
[Au] Autor:Klinger P; Lukassen S; Ferrazzi F; Ekici AB; Hotfiel T; Swoboda B; Aigner T; Gelse K
[Ad] Endereço:Department of Orthopaedic and Trauma Surgery, University Hospital Erlangen, Erlangen, Germany.
[Ti] Título:PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue.
[So] Source:Biomed Res Int;2017:7183516, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate the expression and target genes of pigment epithelium-derived factor (PEDF) in cartilage and chondrocytes, respectively. We analyzed the expression pattern of PEDF in different human cartilaginous tissues including articular cartilage, osteophytic cartilage, and fetal epiphyseal and growth plate cartilage, by immunohistochemistry and quantitative real-time (qRT) PCR. Transcriptome analysis after stimulation of human articular chondrocytes with rhPEDF was performed by RNA sequencing (RNA-Seq) and confirmed by qRT-PCR. Immunohistochemically, PEDF could be detected in transient cartilaginous tissue that is prone to undergo endochondral ossification, including epiphyseal cartilage, growth plate cartilage, and osteophytic cartilage. In contrast, PEDF was hardly detected in healthy articular cartilage and in the superficial zone of epiphyses, regions that are characterized by a permanent stable chondrocyte phenotype. RNA-Seq analysis and qRT-PCR demonstrated that rhPEDF significantly induced the expression of a number of matrix-degrading factors including SAA1, MMP1, MMP3, and MMP13. Simultaneously, a number of cartilage-specific genes including COL2A1, COL9A2, COMP, and LECT were among the most significantly downregulated genes. PEDF represents a marker for transient cartilage during all neonatal and postnatal developmental stages and promotes the termination of cartilage tissue by upregulation of matrix-degrading factors and downregulation of cartilage-specific genes. These data provide the basis for novel strategies to stabilize the phenotype of articular cartilage and prevent its degradation.
[Mh] Termos MeSH primário: Cartilagem/metabolismo
Cartilagem/patologia
Condrócitos/metabolismo
Condrócitos/patologia
Proteínas do Olho/metabolismo
Fatores de Crescimento Neural/metabolismo
Serpinas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Epífises/metabolismo
Proteínas do Olho/genética
Feto/metabolismo
Perfilação da Expressão Gênica
Regulação da Expressão Gênica
Lâmina de Crescimento/metabolismo
Seres Humanos
Imuno-Histoquímica
Articulações/metabolismo
Articulações/patologia
Fatores de Crescimento Neural/genética
Osteófito/genética
Osteófito/patologia
Fenótipo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Serpinas/genética
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Eye Proteins); 0 (Nerve Growth Factors); 0 (RNA, Messenger); 0 (Serpins); 0 (pigment epithelium-derived factor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1155/2017/7183516


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[PMID]:28166636
[Au] Autor:Xu Z; Chen T; Luo J; Ding S; Gao S; Zhang J
[Ad] Endereço:Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University , Chongqing 400016, China.
[Ti] Título:Cartilaginous Metabolomic Study Reveals Potential Mechanisms of Osteophyte Formation in Osteoarthritis.
[So] Source:J Proteome Res;16(4):1425-1435, 2017 Apr 07.
[Is] ISSN:1535-3907
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteophyte is one of the inevitable consequences of progressive osteoarthritis with the main characteristics of cartilage degeneration and endochondral ossification. The pathogenesis of osteophyte formation is not fully understood to date. In this work, metabolomic approaches were employed to explore potential mechanisms of osteophyte formation by detecting metabolic variations between extracts of osteophyte cartilage tissues (n = 32) and uninvolved control cartilage tissues (n = 34), based on the platform of ultraperformance liquid chromatography tandem quadrupole time-of-flight mass spectrometry, as well as the use of multivariate statistic analysis and univariate statistic analysis. The osteophyte group was significantly separated from the control group by the orthogonal partial least-squares discriminant analysis models, indicating that metabolic state of osteophyte cartilage had been changed. In total, 28 metabolic variations further validated by mass spectrum (MS) match, tandom mass spectrum (MS/MS) match, and standards match mainly included amino acids, sulfonic acids, glycerophospholipids, and fatty acyls. These metabolites were related to some specific physiological or pathological processes (collagen dissolution, boundary layers destroyed, self-restoration triggered, etc.) which might be associated with the procedure of osteophyte formation. Pathway analysis showed phenylalanine metabolism (PI = 0.168, p = 0.004) was highly correlative to this degenerative process. Our findings provided a direction for targeted metabolomic study and an insight into further reveal the molecular mechanisms of ostophyte formation.
[Mh] Termos MeSH primário: Cartilagem/metabolismo
Metabolômica
Osteoartrite/metabolismo
Osteófito/metabolismo
[Mh] Termos MeSH secundário: Idoso
Aminoácidos/genética
Cartilagem/patologia
Cromatografia Líquida de Alta Pressão
Feminino
Seres Humanos
Joelho/patologia
Redes e Vias Metabólicas/genética
Meia-Idade
Osteoartrite/genética
Osteoartrite/patologia
Osteófito/genética
Osteófito/patologia
Dor/genética
Dor/patologia
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jproteome.6b00676


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[PMID]:28028160
[Au] Autor:van Oudenaarde K; Jobke B; Oostveen AC; Marijnissen AC; Wolterbeek R; Wesseling J; Bierma-Zeinstra SM; Bloem HL; Reijnierse M; Kloppenburg M
[Ad] Endereço:Radiology, Leiden University Medical Center, Leiden, The Netherlands kvanoudenaarde@lumc.nl.
[Ti] Título:Predictive value of MRI features for development of radiographic osteoarthritis in a cohort of participants with pre-radiographic knee osteoarthritis-the CHECK study.
[So] Source:Rheumatology (Oxford);56(1):113-120, 2017 Jan.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether MRI features are associated with development of radiographic knee OA and can be used as a predictive tool in early knee OA. METHODS: In 148 participants of the Cohort Hip and Cohort Knee study (mean age 56 years, 78% women), with a Kellgren Lawrence (KL) score ⩽1, we obtained semi-quantitatively scored knee MRI scans and radiographs at baseline. After 5 years, we determined the development of radiographic knee OA (KL ⩾2). We calculated odds ratios (ORs), with 95% CIs adjusted for age, sex and BMI, to identify MRI features associated with OA development. With these MRI features, we constructed an internally validated prediction model, for which we measured the area under the receiver operating characteristics curve, sensitivity and specificity. RESULTS: Radiographic OA developed in 28% of the participants after 5 years. Statistically significant associations were: cartilage defects OR = 1.7 (95% CI: 1.1, 2.6), osteophytes OR = 3.1 (1.7, 5.7), bone marrow lesions OR = 2.0 (1.2, 3.4), effusion OR = 2.1 (1.2, 3.5) and meniscal pathology OR = 2.8 (1.3, 6.3). With the combined MRI features in a prediction model, the sensitivity was 66%, the specificity 67% and the optimism-corrected area under the receiver operating characteristics curve 0.685. CONCLUSION: In early knee OA, MRI depicts significantly associated pathology in cartilage, bone and menisci, whereas the radiograph fails to detect these changes. Although MRI has potential for identifying patients at risk for developing radiographic knee OA, it cannot be used as an absolute diagnostic tool in early knee OA due to its low discriminative ability.
[Mh] Termos MeSH primário: Medula Óssea/diagnóstico por imagem
Cartilagem Articular/diagnóstico por imagem
Articulação do Joelho/diagnóstico por imagem
Meniscos Tibiais/diagnóstico por imagem
Osteoartrite do Joelho/diagnóstico por imagem
Osteófito/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Estudos de Coortes
Progressão da Doença
Feminino
Seguimentos
Seres Humanos
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Razão de Chances
Prognóstico
Curva ROC
Radiografia
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kew368


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[PMID]:27997420
[Au] Autor:Juang JJ; Chen YH; Tsai SC; Lin WY
[Ad] Endereço:From the *Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung; and †Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
[Ti] Título:Collar Osteophytes Mimicking Osteonecrosis in Planar Bone Scintigraphy and Usefulness of SPECT/CT Images.
[So] Source:Clin Nucl Med;42(3):e163-e165, 2017 Mar.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of prednisolone is one major risk factor for osteonecrosis in patients with systemic lupus erythematosus. Bone scintigraphy can be a diagnostic tool for early diagnosis. We present a case who had collar osteophytes at the bilateral femoral heads, which mimicked osteonecrosis in the planar bone scintigram. An SPECT/CT scan avoided this pitfall and increased the diagnostic accuracy for osteonecrosis.
[Mh] Termos MeSH primário: Osteonecrose/diagnóstico por imagem
Osteófito/diagnóstico por imagem
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Seres Humanos
Osteonecrose/patologia
Osteófito/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001486



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